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  1. AU="Huang, Zexiang"
  2. AU="Feleke, Sindew M"
  3. AU="van der Velden, Janielle"
  4. AU="Carmen Gonzalez"
  5. AU="Cheah, Jaime H"
  6. AU="Forte, Florence"
  7. AU="Anika Nier"
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  9. AU="Alvarado Pinedo, María F."
  10. AU="Scarlett, Garry"
  11. AU="Carlos G. Vanoye"
  12. AU=Lohrmann Jens
  13. AU="Petersen, Moritz"
  14. AU="Giovanni, L."
  15. AU="Liu, Xingzheng"
  16. AU="Głód, Mateusz"
  17. AU=Teo Kelvin Yi Chong
  18. AU="Khatmi, Aysan"
  19. AU="Erculiani, M"
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  21. AU="Lisnic, Vanda Juranic"
  22. AU="Seabloom, Eric W"
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  25. AU="Wonoh Lee"
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  27. AU="Douglas, David N"
  28. AU="King, Gary"
  29. AU="Barbera, Lauren"
  30. AU="Carlino, Antonio"
  31. AU="Shan, Qing-Hua"
  32. AU="Starko, S"
  33. AU="Lievre, Loïc"
  34. AU=Cammack N
  35. AU="Xia, Qin"
  36. AU="Ong, Ju Lynn"
  37. AU="Cullin, Christophe"
  38. AU="Georg K.S. Andersson"
  39. AU="Jeannel, Gaël-François"
  40. AU="Stuart Woods"
  41. AU="Shchegolev, A."
  42. AU="Nadeau, Pierre-Louis"
  43. AU="Gordon, David E A"
  44. AU="Shahid Mahmood"
  45. AU="Rosenblatt, Karin"
  46. AU="Dasgupta, Suvankar"
  47. AU=Nguyen Sylvain AU=Nguyen Sylvain

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  1. Artikel ; Online: Collecting differently sized particles on water surface by maneuvering pedal waves on the foot of the water snail

    Huang, Zexiang / Yang, Hao / Xu, Ke / Wu, Jianing / Zhang, Jinxiu

    Soft matter

    2022  Band 18, Heft 40, Seite(n) 7850–7858

    Abstract: The water snail ( ...

    Abstract The water snail (
    Mesh-Begriff(e) Animals ; Water ; Solid Waste ; Snails
    Chemische Substanzen Water (059QF0KO0R) ; Solid Waste
    Sprache Englisch
    Erscheinungsdatum 2022-10-19
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2191476-X
    ISSN 1744-6848 ; 1744-683X
    ISSN (online) 1744-6848
    ISSN 1744-683X
    DOI 10.1039/d2sm01113a
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Sexually dimorphic distribution of kiss1 and kiss2 in the brain of yellowtail clownfish, Amphiprion clarkii.

    Zhang, Yan-Yu / Zhang, Xian / Bu, Shao-Yang / Zhang, Wei-Wei / Li, Tian-Xiu / Zheng, De-Cai / Huang, Ze-Xiang / Wang, Qian

    Endocrine connections

    2022  Band 11, Heft 8

    Abstract: Kisspeptin system was shown to be a key factor in mediating social stress and reproduction. Yellowtail clownfish, Amphiprion clarkii, is a hermaphrodite fish, whose sex determination and gonadal development are affected by the social status of ... ...

    Abstract Kisspeptin system was shown to be a key factor in mediating social stress and reproduction. Yellowtail clownfish, Amphiprion clarkii, is a hermaphrodite fish, whose sex determination and gonadal development are affected by the social status of individuals. The yellowtail clownfish is a fantastic animal model to explore sex determination, but the social status and precise distribution of kiss mRNAs in the brain of this species are unknown. Hererin, a novel in situ hybridization technique, RNAscope, was used to investigate the distribution of kiss1 and kiss2 expressions in the brain of yellowtail clownfish. The coronal planes of brain showed that the kiss1 signal was mainly present in dorsal habenular nucleus (NHd) and kiss2 mRNA was widely expressed in telencephalon, midbrain, and hypothalamus, especially in dorsal part of the nucleus of the lateral recess (NRLd). Additionally, kiss1 and kiss2 signals have sexually dimorphic distribution. The kiss1 mRNA was distributed in NHd, the telencephalon, and lateral part of the diffuse nucleus of the inferior lobe (NDLIl) of females but in NHd and NDLIl of males. kiss2 signals were stronger in females than that in males. The distribution of kiss1 and kiss2 neurons in NHd of habenula and NRLd of hypothalamus may suggest that kiss genes associate environmental signaling and reproductive function in yellowtail clownfish.
    Sprache Englisch
    Erscheinungsdatum 2022-07-25
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2668428-7
    ISSN 2049-3614
    ISSN 2049-3614
    DOI 10.1530/EC-22-0136
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Regulation of the

    Bu, Shao-Yang / Zhang, Yan-Yu / Zhang, Xian / Li, Tian-Xiu / Zheng, De-Cai / Huang, Ze-Xiang / Wang, Qian

    Frontiers in endocrinology

    2022  Band 13, Seite(n) 902737

    Abstract: Kisspeptin plays a vital role in mediating the stress-induced reproductive regulation. Cortisol, known as a stress-related hormone, is involved in gonadal development and sexual differentiation by binding with glucocorticoid receptor (GR) to regulate the ...

    Abstract Kisspeptin plays a vital role in mediating the stress-induced reproductive regulation. Cortisol, known as a stress-related hormone, is involved in gonadal development and sexual differentiation by binding with glucocorticoid receptor (GR) to regulate the expression of
    Mesh-Begriff(e) Animals ; HEK293 Cells ; Humans ; Hydrocortisone/metabolism ; Hydrocortisone/pharmacology ; Perciformes/genetics ; Promoter Regions, Genetic ; Receptors, Glucocorticoid/genetics
    Chemische Substanzen Receptors, Glucocorticoid ; Hydrocortisone (WI4X0X7BPJ)
    Sprache Englisch
    Erscheinungsdatum 2022-08-03
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.902737
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Bcl-2 small interfering RNA sensitizes cisplatin-resistant human lung adenocarcinoma A549/DDP cell to cisplatin and diallyl disulfide.

    Huang, Zexiang / Lei, Xiaoyong / Zhong, Miao / Zhu, Bingyang / Tang, Shengsong / Liao, Duanfang

    Acta biochimica et biophysica Sinica

    2007  Band 39, Heft 11, Seite(n) 835–843

    Abstract: Bcl-2 is overexpressed in a variety of human tumors and is involved in tumorigenesis and chemoresistance. In this study, we investigated the inhibitory effect of the hairpin Bcl-2 small interfering (si)RNA on the expression of the Bcl-2 gene in the ... ...

    Abstract Bcl-2 is overexpressed in a variety of human tumors and is involved in tumorigenesis and chemoresistance. In this study, we investigated the inhibitory effect of the hairpin Bcl-2 small interfering (si)RNA on the expression of the Bcl-2 gene in the cisplatin (DDP)-resistant human lung adenocarcinoma cell line A549/DDP, and the effect of Bcl-2 siRNA on drug sensitization in A549/DDP cells. Bcl-2 siRNA and negative siRNA plasmids were constructed and stably transfected into A549/DDP cells. Reverse transcription-polymerase chain reaction, immunofluorescence microscopy and Western blot analysis were used to detect the target gene expression. Spontaneous cell apoptosis was detected by acridine orange and ethidium bromide staining. Drug sensitivity of the cells to DDP and diallyl disulfide (DADS) was analyzed by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay and flow cytometry. Expression levels of Bcl-2 mRNA and protein in siRNA stable transfectants were clearly reduced compared with negative siRNA transfectants and untreated cells. MTT results indicated that Bcl-2 transfectants had a higher cell inhibition rate after treatment with 0.2-200 microg/ml DDP or 50-200 microM DADS. Flow cytometry revealed increased apoptosis in Bcl-2 siRNA cells. After the addition of 20 microg/ml DDP or 100 microM DADS, siRNA targeting of the Bcl-2 gene specifically down-regulated gene expression in A549/DDP cells, increased spontaneous apoptosis, and sensitized cells to DDP and DADS.
    Mesh-Begriff(e) Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Adenocarcinoma/prevention & control ; Allyl Compounds/administration & dosage ; Antineoplastic Agents/administration & dosage ; Apoptosis ; Cell Line, Tumor ; Cisplatin/administration & dosage ; Disulfides/administration & dosage ; Drug Resistance, Neoplasm/genetics ; Gene Silencing ; Genetic Therapy/methods ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Lung Neoplasms/prevention & control ; Proto-Oncogene Proteins c-bcl-2/genetics ; RNA, Small Interfering/genetics ; RNA, Small Interfering/therapeutic use
    Chemische Substanzen Allyl Compounds ; Antineoplastic Agents ; Disulfides ; Proto-Oncogene Proteins c-bcl-2 ; RNA, Small Interfering ; diallyl disulfide (5HI47O6OA7) ; Cisplatin (Q20Q21Q62J)
    Sprache Englisch
    Erscheinungsdatum 2007-10-30
    Erscheinungsland China
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175256-4
    ISSN 1745-7270 ; 0582-9879 ; 1672-9145
    ISSN (online) 1745-7270
    ISSN 0582-9879 ; 1672-9145
    DOI 10.1111/j.1745-7270.2007.00356.x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Bcl-XL small interfering RNA sensitizes cisplatin-resistant human lung adenocarcinoma cells.

    Lei, Xiaoyong / Huang, Zexiang / Zhong, Miao / Zhu, Bingyang / Tang, Shengsong / Liao, Duanfang

    Acta biochimica et biophysica Sinica

    2007  Band 39, Heft 5, Seite(n) 344–350

    Abstract: Bcl-XL is overexpressed in a variety of human tumors and is involved in tumorigenesis and chemoresistance. This study investigated the inhibitory effect of the hairpin Bcl-XL small interfering RNA (siRNA) on the expression of the Bcl-XL gene in the ... ...

    Abstract Bcl-XL is overexpressed in a variety of human tumors and is involved in tumorigenesis and chemoresistance. This study investigated the inhibitory effect of the hairpin Bcl-XL small interfering RNA (siRNA) on the expression of the Bcl-XL gene in the cisplatin (DDP)-resistant human lung adenocarcinoma cell line A549/DDP, and the effect of Bcl-XL siRNA on drug sensitization in A549/DDP cells. Bcl-XL siRNA and negative siRNA plasmids were constructed and stably transfected into A549/DDP cells. Reverse transcription-polymerase chain reaction and Western blot analysis were used to detect the target gene expression. Spontaneous apoptosis of cells was detected by acridine orange and ethidium bromide staining. Drug sensitivity of the cells to DDP was analyzed with dimethylthiazol-diphenyltetrazolium bromide (MTT) and flow cytometry. Expression levels of Bcl-XL mRNA and protein in siRNA stable transfectants were clearly reduced as compared with negative siRNA transfectants and untreated cells. MTT results indicated that Bcl-XL transfectants had a higher cell inhibition rate than the negative vector or untreated cells after treatment with 0.2-200 micarog/ml DDP. Flow cytometry revealed increased apoptosis in Bcl-XL siRNA cells. After the addition of 20 microg/ml DDP, siRNA targeting of the Bcl-XL gene specifically down-regulated gene expression in A549/DDP cells, increased spontaneous apoptosis, and sensitized cells to DDP. The results showed that Bcl-XL siRNA contributed to an increase of DDP-induced cell death in non-small-cell lung cancer and sensitized cells to DDP, leading to increased the effectiveness of the drug in treating non-small-cell lung cancer.
    Mesh-Begriff(e) Adenocarcinoma/drug therapy ; Adenocarcinoma/metabolism ; Antineoplastic Agents/pharmacology ; Apoptosis ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Line, Tumor ; Cisplatin/pharmacology ; Drug Resistance, Neoplasm ; Flow Cytometry ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; RNA, Small Interfering/chemistry ; Reverse Transcriptase Polymerase Chain Reaction ; Tetrazolium Salts/pharmacology ; Thiazoles/pharmacology ; Transfection ; bcl-X Protein/metabolism ; bcl-X Protein/physiology
    Chemische Substanzen Antineoplastic Agents ; RNA, Small Interfering ; Tetrazolium Salts ; Thiazoles ; bcl-X Protein ; thiazolyl blue (EUY85H477I) ; Cisplatin (Q20Q21Q62J)
    Sprache Englisch
    Erscheinungsdatum 2007-05-05
    Erscheinungsland China
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175256-4
    ISSN 1745-7270 ; 1672-9145 ; 0582-9879
    ISSN (online) 1745-7270
    ISSN 1672-9145 ; 0582-9879
    DOI 10.1111/j.1745-7270.2007.00286.x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: [Efficacy and safety of Fufang Biejia Ruangan tablet in patients with chronic hepatitis B complicated with hepatic fibrosis].

    Chen, Ju-mei / Yang, Yong-ping / Chen, De-yong / Han, Jin / Jin, Xue-yuan / Huang, Ze-xiang / Xu, Cheng-bin / Shen, Yan-ming

    Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology

    2007  Band 21, Heft 4, Seite(n) 358–360

    Abstract: Objective: To study the clinical therapeutic effects and safety of Fufang Biejia Ruangan tablet (FBRt) in patients with chronic hepatitis B complicated with hepatic fibrosis.: Methods: Totally 420 patients were randomly divided into two groups, FBRt ... ...

    Abstract Objective: To study the clinical therapeutic effects and safety of Fufang Biejia Ruangan tablet (FBRt) in patients with chronic hepatitis B complicated with hepatic fibrosis.
    Methods: Totally 420 patients were randomly divided into two groups, FBRt group (300 cases) were treated with Fufang Biejia Ruangan tablets and control group (120 cases) were treated with He Luo Shu Gan capsule, the patients in both groups were treated for 6 months.
    Results: The cure rate and total effective rate of FBRt group were significantly higher than those of control group (55.67 percent and 81.67 percent vs. 15.8 percent and 60.00 percent, P less than 0.01).
    Conclusion: Fufang Biejia Ruangan tablet could alleviate clinical symptoms and hepatic fibrosis. Fufang Biejia Ruangan tablet is effective and safe in treatment of patients with chronic hepatitis B complicated with liver fibrosis.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Alanine Transaminase/blood ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/drug therapy ; Hepatitis B, Chronic/pathology ; Humans ; Liver/pathology ; Liver/physiopathology ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/etiology ; Liver Cirrhosis/pathology ; Medicine, Chinese Traditional ; Middle Aged ; Tablets
    Chemische Substanzen Tablets ; Alanine Transaminase (EC 2.6.1.2)
    Sprache Chinesisch
    Erscheinungsdatum 2007-12
    Erscheinungsland China
    Dokumenttyp English Abstract ; Journal Article ; Randomized Controlled Trial
    ISSN 1003-9279
    ISSN 1003-9279
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Apoptosis induced by diallyl disulfide in human breast cancer cell line MCF-7.

    Lei, Xiao-yong / Yao, Shu-qiong / Zu, Xu-yu / Huang, Ze-xiang / Liu, Li-juan / Zhong, Miao / Zhu, Bing-yang / Tang, Sheng-song / Liao, Duan-fang

    Acta pharmacologica Sinica

    2008  Band 29, Heft 10, Seite(n) 1233–1239

    Abstract: Aim: To investigate the effect of diallyl disulfide (DADS), a component of garlic, on apoptosis in human mammary cancer cell line (MCF-7) and its mechanisms.: Methods: Cytotoxicity was analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium ...

    Abstract Aim: To investigate the effect of diallyl disulfide (DADS), a component of garlic, on apoptosis in human mammary cancer cell line (MCF-7) and its mechanisms.
    Methods: Cytotoxicity was analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide assays. Morphology of apoptotic cells was detected by acridine orange and ethidium bromide staining. Apoptotic cells stained with propidium iodide were examined using flow cytometry. Protein levels were detected by Western blot analysis.
    Results: DADS inhibited the proliferation of MCF-7 cells and induced the apoptotic ratio to increase rapidly. Cleavage of the caspase-3 and caspase-3 substrate poly(ADP-ribose) polymerase was observed in MCF-7 cells after 24 h of treatment with DADS. When the MCF-7 cells were treated with 200 micromol x L DADS, the stress-activated protein kinase extracellular signal-regulated kinase (ERK), a mitogen-activated protein kinase, was inhibited after 6 h; c-Jun N-terminal kinase (JNK), that is stress-activated protein kinase (SAPK), and p38 mitogen-activated protein kinase were activated after 6 h.
    Conclusion: These results suggest that DADS both inhibits the proliferation of MCF-7 cells and induces apoptosis of MCF-7 cells. The mechanisms may include the inhibition of ERK and the activation of the SAPK/JNK and p38 pathways.
    Mesh-Begriff(e) Allyl Compounds/pharmacology ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Breast Neoplasms/pathology ; Caspase 3/metabolism ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Enzyme Activation/drug effects ; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors ; Extracellular Signal-Regulated MAP Kinases/physiology ; Female ; Humans ; MAP Kinase Kinase 4/metabolism ; Mitogen-Activated Protein Kinases/physiology ; Poly(ADP-ribose) Polymerases/metabolism ; Sulfides/pharmacology ; Tumor Suppressor Protein p53/biosynthesis ; Tumor Suppressor Protein p53/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism
    Chemische Substanzen Allyl Compounds ; Antineoplastic Agents, Phytogenic ; Sulfides ; Tumor Suppressor Protein p53 ; allyl sulfide (60G7CF7CWZ) ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; MAP Kinase Kinase 4 (EC 2.7.12.2) ; Caspase 3 (EC 3.4.22.-)
    Sprache Englisch
    Erscheinungsdatum 2008-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1360774-1
    ISSN 1745-7254 ; 0253-9756 ; 1671-4083
    ISSN (online) 1745-7254
    ISSN 0253-9756 ; 1671-4083
    DOI 10.1111/j.1745-7254.2008.00851.x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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