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  1. Book ; Online ; Thesis: Generierung eines CRISPR/Cas9-Knockouts des Kardiomyopathie-Gens Nexilin im Zebrafisch und Untersuchungen zu Nexilin-Interaktoren

    Huber, Magdalena [Verfasser]

    2021  

    Author's details Magdalena Huber
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universität Ulm
    Publishing place Ulm
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy.

    Brichkina, Anna / Suezov, Roman / Huber, Magdalena

    Signal transduction and targeted therapy

    2023  Volume 8, Issue 1, Page(s) 448

    MeSH term(s) Methyltransferases
    Chemical Substances Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2023-12-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-023-01696-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Kalk überall.

    Huber, Magdalena / Vogele, Daniel / Kloth, Christopher / Beer, Meinrad / Haggenmüller, Benedikt

    Radiologie (Heidelberg, Germany)

    2023  Volume 63, Issue 9, Page(s) 688–692

    Title translation Calcification everywhere.
    MeSH term(s) Humans ; Calcinosis/diagnosis ; Calcification, Physiologic
    Language German
    Publishing date 2023-08-18
    Publishing country Germany
    Document type Journal Article
    ISSN 2731-7056
    ISSN (online) 2731-7056
    DOI 10.1007/s00117-023-01186-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: CRISPR/Cas9-mediated nexilin deficiency interferes with cardiac contractile function in zebrafish in vivo.

    Hofeichner, Janessa / Gahr, Bernd Martin / Huber, Magdalena / Boos, Alena / Rottbauer, Wolfgang / Just, Steffen

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 22679

    Abstract: Nexilin (NEXN) plays a crucial role in stabilizing the sarcomeric Z-disk of striated muscle fibers and, when mutated, leads to dilated cardiomyopathy in humans. Due to its early neonatal lethality in mice, the detailed impact of the constitutive ... ...

    Abstract Nexilin (NEXN) plays a crucial role in stabilizing the sarcomeric Z-disk of striated muscle fibers and, when mutated, leads to dilated cardiomyopathy in humans. Due to its early neonatal lethality in mice, the detailed impact of the constitutive homozygous NEXN knockout on heart and skeletal muscle morphology and function is insufficiently investigated. Here, we characterized a constitutive homozygous CRISPR/Cas9-mediated nexn knockout zebrafish model. We found that Nexn deficient embryos developed significantly reduced cardiac contractility and under stressed conditions also impaired skeletal muscle organization whereas skeletal muscle function seemed not to be affected. Remarkably, in contrast to nexn morphants, CRISPR/Cas9 nexn
    MeSH term(s) Humans ; Animals ; Mice ; Zebrafish/genetics ; Zebrafish/metabolism ; Microfilament Proteins/metabolism ; CRISPR-Cas Systems ; Muscle Contraction/genetics ; Muscle, Skeletal/metabolism ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
    Chemical Substances Microfilament Proteins ; Zebrafish Proteins ; NEXN protein, mouse
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50065-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online ; Thesis: Pro-inflammatorische, Interleukin-17 produzierende CD8+ T-Lymphozyten in Multipler Sklerose und duktalem Adenokarzinom des Pankreas

    Picard, Felix Simon Ruben [Verfasser] / Huber, Magdalena [Akademischer Betreuer]

    2022  

    Author's details Felix Simon Ruben Picard ; Betreuer: Magdalena Huber
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Philipps-Universität Marburg
    Publishing place Marburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article ; Online: Tc17 biology and function: Novel concepts.

    Lückel, Christina / Picard, Felix S R / Huber, Magdalena

    European journal of immunology

    2020  Volume 50, Issue 9, Page(s) 1257–1267

    Abstract: Research over the past years has provided increasing understanding about IL-17-producing ... ...

    Abstract Research over the past years has provided increasing understanding about IL-17-producing CD8
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/immunology ; Humans ; Interleukin-17/immunology ; T-Lymphocyte Subsets/immunology
    Chemical Substances Interleukin-17
    Language English
    Publishing date 2020-08-02
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202048627
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 85: Show issues

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  7. Article ; Online: IL18 Receptor Signaling Inhibits Intratumoral CD8

    Nasiri, Elena / Student, Malte / Roth, Katrin / Siti Utami, Nadya / Huber, Magdalena / Buchholz, Malte / Gress, Thomas M / Bauer, Christian

    Cells

    2023  Volume 12, Issue 3

    Abstract: In pancreatic ductal adenocarcinoma (PDAC), the infiltration of ... ...

    Abstract In pancreatic ductal adenocarcinoma (PDAC), the infiltration of CD8
    MeSH term(s) Animals ; Mice ; Carcinoma, Pancreatic Ductal ; CD8-Positive T-Lymphocytes ; Cell Movement ; Interleukin-18 ; Pancreatic Neoplasms ; Pancreatic Neoplasms
    Chemical Substances Interleukin-18 ; Il18r1 protein, mouse
    Language English
    Publishing date 2023-01-31
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12030456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Utility and Drawbacks of Chimeric Antigen Receptor T Cell (CAR-T) Therapy in Lung Cancer.

    Kandra, Prameela / Nandigama, Rajender / Eul, Bastian / Huber, Magdalena / Kobold, Sebastian / Seeger, Werner / Grimminger, Friedrich / Savai, Rajkumar

    Frontiers in immunology

    2022  Volume 13, Page(s) 903562

    Abstract: The present treatments for lung cancer include surgical resection, radiation, chemotherapy, targeted therapy, and immunotherapy. Despite advances in therapies, the prognosis of lung cancer has not been substantially improved in recent years. Chimeric ... ...

    Abstract The present treatments for lung cancer include surgical resection, radiation, chemotherapy, targeted therapy, and immunotherapy. Despite advances in therapies, the prognosis of lung cancer has not been substantially improved in recent years. Chimeric antigen receptor (CAR)-T cell immunotherapy has attracted growing interest in the treatment of various malignancies. Despite CAR-T cell therapy emerging as a novel potential therapeutic option with promising results in refractory and relapsed leukemia, many challenges limit its therapeutic efficacy in solid tumors including lung cancer. In this landscape, studies have identified several obstacles to the effective use of CAR-T cell therapy including antigen heterogeneity, the immunosuppressive tumor microenvironment, and tumor penetration by CAR-T cells. Here, we review CAR-T cell design; present the results of CAR-T cell therapies in preclinical and clinical studies in lung cancer; describe existing challenges and toxicities; and discuss strategies to improve therapeutic efficacy of CAR-T cells.
    MeSH term(s) Humans ; Immunotherapy, Adoptive/adverse effects ; Immunotherapy, Adoptive/methods ; Lung Neoplasms/therapy ; Receptors, Chimeric Antigen/genetics ; T-Lymphocytes ; Tumor Microenvironment
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2022-06-02
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.903562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Change of paradigm: CD8+ T cells as important helper for CD4+ T cells during asthma and autoimmune encephalomyelitis.

    Huber, Magdalena / Lohoff, Michael

    Allergo journal international

    2015  Volume 24, Issue 1, Page(s) 8–15

    Abstract: The activation of naive CD4+ and CD8+ T cells in response to antigen and their subsequent proliferation and differentiation into effectors are important features of a cell-mediated immune response. CD4+ T cells (also known as T helper cells, Th) ... ...

    Abstract The activation of naive CD4+ and CD8+ T cells in response to antigen and their subsequent proliferation and differentiation into effectors are important features of a cell-mediated immune response. CD4+ T cells (also known as T helper cells, Th) differentiate into several subpopulations including Th1, Th2, Th9, Th17, Tfh and Treg cells, characterized by specific cytokine profiles and effector functions. However, recent evidence indicates that CD8+ T cells (termed cytotoxic T lymphocytes, CTLs or Tc cells) can differentiate into subpopulations with similar characteristics denoted as Tc2, Tc9, Tc17 and CD8+ Treg cells in addition to CTLs. Although these subpopulations accomplish important protective functions, their uncontrolled responses cause immunopathology including allergy and autoimmunity. Our recent findings indicate a change of paradigm: during these pathologic responses, CD8+ T cell subpopulations act as strong helpers for the activity of CD4+ T cells rather than being cytotoxic. In this review, we focus on the role of Th2, Th9, Th17 as well as Tc9 and Tc17 cells in asthma and autoimmune encephalomyelitis and on their interaction during these immunopathologic responses.
    Language English
    Publishing date 2015-02-09
    Publishing country Germany
    Document type Review ; Journal Article
    ISSN 2197-0378
    ISSN 2197-0378
    DOI 10.1007/s40629-015-0038-4
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  10. Article ; Online: Reciprocal crosstalk between Th17 and mesothelial cells promotes metastasis-associated adhesion of ovarian cancer cells.

    Neuhaus, Felix / Lieber, Sonja / Shinkevich, Veronika / Steitz, Anna Mary / Raifer, Hartmann / Roth, Kathrin / Finkernagel, Florian / Worzfeld, Thomas / Burchert, Andreas / Keber, Corinna / Nist, Andrea / Stiewe, Thorsten / Reinartz, Silke / Beutgen, Vanessa M / Graumann, Johannes / Pauck, Kim / Garn, Holger / Gaida, Matthias / Müller, Rolf /
    Huber, Magdalena

    Clinical and translational medicine

    2024  Volume 14, Issue 4, Page(s) e1604

    Abstract: Background: IL-17A and TNF synergistically promote inflammation and tumorigenesis. Their interplay and impact on ovarian carcinoma (OC) progression are, however, poorly understood. We addressed this question focusing on mesothelial cells, whose ... ...

    Abstract Background: IL-17A and TNF synergistically promote inflammation and tumorigenesis. Their interplay and impact on ovarian carcinoma (OC) progression are, however, poorly understood. We addressed this question focusing on mesothelial cells, whose interaction with tumor cells is known to play a pivotal role in transcoelomic metastasis formation.
    Methods: Flow-cytometry and immunohistochemistry experiments were employed to identify cellular sources of IL-17A and TNF. Changes in transcriptomes and secretomes were determined by bulk and single cell RNA sequencing as well as affinity proteomics. Functional consequences were investigated by microscopic analyses and tumor cell adhesion assays. Potential clinical implications were assessed by immunohistochemistry and survival analyses.
    Results: We identified Th17 cells as the main population of IL-17A- and TNF producers in ascites and detected their accumulation in early omental metastases. Both IL-17A and its receptor subunit IL-17RC were associated with short survival of OC patients, pointing to a role in clinical progression. IL-17A and TNF synergistically induced the reprogramming of mesothelial cells towards a pro-inflammatory mesenchymal phenotype, concomitantly with a loss of tight junctions and an impairment of mesothelial monolayer integrity, thereby promoting cancer cell adhesion. IL-17A and TNF synergistically induced the Th17-promoting cytokines IL-6 and IL-1β as well as the Th17-attracting chemokine CCL20 in mesothelial cells, indicating a reciprocal crosstalk that potentiates the tumor-promoting role of Th17 cells in OC.
    Conclusions: Our findings reveal a novel function for Th17 cells in the OC microenvironment, which entails the IL-17A/TNF-mediated induction of mesothelial-mesenchymal transition, disruption of mesothelial layer integrity and consequently promotion of OC cell adhesion. These effects are potentiated by a positive feedback loop between mesothelial and Th17 cells. Together with the observed clinical associations and accumulation of Th17 cells in omental micrometastases, our observations point to a potential role in early metastases formation and thus to new therapeutic options.
    MeSH term(s) Humans ; Female ; Th17 Cells ; Interleukin-17/metabolism ; Cytokines/metabolism ; Ovarian Neoplasms/metabolism ; Inflammation/metabolism ; Tumor Microenvironment
    Chemical Substances Interleukin-17 ; Cytokines
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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