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  1. Article ; Conference proceedings: Abstracts / 10th International Podocyte Conference

    Huber, Tobias

    Nephron clinical practice 126 ,4, S. 159 - 227

    Freiburg, June 4 - 6, 2014

    2014  

    Event/congress International Podocyte Conference (10, 2014, FreiburgimBreisgau)
    Author's details guest ed. Tobias B. Huber
    Collection Nephron
    Language English
    Publishing place Basel [u.a.]
    Publishing country Switzerland
    Document type Article ; Conference proceedings
    HBZ-ID HT018354160
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Zs A 169 -126-

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  2. Article ; Online: Thrombotische Mikroangiopathien.

    Schmidt, Tilman / Huber, Tobias B

    Medizinische Klinik, Intensivmedizin und Notfallmedizin

    2023  Volume 118, Issue 1, Page(s) 14–20

    Abstract: In the emergency room, patients with anemia and thrombocytopenia are common. Although these findings can often be explained by the medical situation, thrombotic microangiopathy is an important differential diagnosis. In this case, occlusion of the ... ...

    Title translation Thrombotic microangiopathy.
    Abstract In the emergency room, patients with anemia and thrombocytopenia are common. Although these findings can often be explained by the medical situation, thrombotic microangiopathy is an important differential diagnosis. In this case, occlusion of the smallest vessels consequently leads to functional impairment of the affected organs. Patients generally present with symptoms of organ dysfunction, e.g., in the kidney or brain. Characteristically, Coombs-negative fragmentation of erythrocytes with hemolysis occurs in the area of the occluded vessels. Lactate dehydrogenase levels are elevated, and platelets and haptoglobin are reduced. Differential diagnoses beyond thrombotic microangiopathy that should be considered are numerous and diverse in their pathophysiology. Rapid workup is needed, because sometimes a specific treatment must be initiated rapidly. For example, thrombotic thrombocytopenic purpura leads to death in about 90% of patients if left untreated. However, by reconstitution of the underlying deficiency of the so-called ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) by plasma separation, survival can be ensured in most cases. Complement-mediated hemolytic uremic syndrome should also be considered and, if suspected, treated with complement inhibition. In many cases, however, thrombotic microangiopathy reflects a disorder elsewhere and may be a manifestation of severe hypertension or a coagulation disorder, such as disseminated intravascular coagulation or antiphospholipid syndrome. It can also be observed as a consequence of drug therapies or metabolic derangement. Systemic workup is therefore necessary for rapid clarification of differential diagnoses.
    MeSH term(s) Humans ; Thrombotic Microangiopathies/diagnosis ; Thrombotic Microangiopathies/therapy ; Purpura, Thrombotic Thrombocytopenic/diagnosis ; Purpura, Thrombotic Thrombocytopenic/therapy ; Hemolytic-Uremic Syndrome/diagnosis ; Hemolytic-Uremic Syndrome/therapy ; Disseminated Intravascular Coagulation
    Language German
    Publishing date 2023-01-12
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2636018-4
    ISSN 2193-6226 ; 1435-1420 ; 0723-5003 ; 2193-6218 ; 0175-3851
    ISSN (online) 2193-6226 ; 1435-1420
    ISSN 0723-5003 ; 2193-6218 ; 0175-3851
    DOI 10.1007/s00063-022-00984-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.120: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Insights into human kidney function from the study of Drosophila.

    Koehler, Sybille / Huber, Tobias B

    Pediatric nephrology (Berlin, Germany)

    2023  Volume 38, Issue 12, Page(s) 3875–3887

    Abstract: Biological and biomedical research using Drosophila melanogaster as a model organism has gained recognition through several Nobel prizes within the last 100 years. Drosophila exhibits several advantages when compared to other in vivo models such as mice ... ...

    Abstract Biological and biomedical research using Drosophila melanogaster as a model organism has gained recognition through several Nobel prizes within the last 100 years. Drosophila exhibits several advantages when compared to other in vivo models such as mice and rats, as its life cycle is very short, animal maintenance is easy and inexpensive and a huge variety of transgenic strains and tools are publicly available. Moreover, more than 70% of human disease-causing genes are highly conserved in the fruit fly. Here, we explain the use of Drosophila in nephrology research and describe two kidney tissues, Malpighian tubules and the nephrocytes. The latter are the homologous cells to mammalian glomerular podocytes and helped to provide insights into a variety of signaling pathways due to the high morphological similarities and the conserved molecular make-up between nephrocytes and podocytes. In recent years, nephrocytes have also been used to study inter-organ communication as links between nephrocytes and the heart, the immune system and the muscles have been described. In addition, other tissues such as the eye and the reproductive system can be used to study the functional role of proteins being part of the kidney filtration barrier.
    MeSH term(s) Humans ; Animals ; Rats ; Mice ; Drosophila/metabolism ; Drosophila melanogaster/genetics ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Kidney/metabolism ; Animals, Genetically Modified ; Podocytes/metabolism ; Mammals/metabolism
    Chemical Substances Drosophila Proteins
    Language English
    Publishing date 2023-05-12
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-023-05996-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2196: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Kidneys control inter-organ homeostasis.

    Puelles, Victor G / Huber, Tobias B

    Nature reviews. Nephrology

    2022  Volume 18, Issue 4, Page(s) 207–208

    MeSH term(s) Aldehydes ; DNA Damage ; Homeostasis/physiology ; Humans ; Kidney
    Chemical Substances Aldehydes
    Language English
    Publishing date 2022-02-14
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-022-00549-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6334: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 107: Show issues

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  5. Article ; Online: Precision nephrology: from molecular diagnostics to an individualized therapy.

    Mühlig, Anne K / Oh, Jun / Huber, Tobias B

    Kidney international

    2023  Volume 103, Issue 3, Page(s) 464–466

    Abstract: The diagnosis of glomerular disease still mostly relies on the conventional histologic and immunohistochemical analysis of biopsies, thereby failing to provide a molecular disease understanding and stratification as the fundamental basis for an ... ...

    Abstract The diagnosis of glomerular disease still mostly relies on the conventional histologic and immunohistochemical analysis of biopsies, thereby failing to provide a molecular disease understanding and stratification as the fundamental basis for an individualized therapy. It is out of the question that nephrology will be transformed into a field of systemic molecular precision diagnostics and individualized therapies. However, the time scale and efficiency of such transformation will depend on more studies exemplifying successful translational strategies. The highly heterogeneous glomerular disease entities of minimal change disease and focal segmental glomerular sclerosis seem ideally suited to exploring and ensuring the advancement of an individualized precision nephrology.
    MeSH term(s) Humans ; Nephrology ; Pathology, Molecular ; Kidney Diseases/pathology ; Kidney Glomerulus/pathology ; Glomerulosclerosis, Focal Segmental/pathology
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.12.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: From bench to bedside: lessons learned from translational podocyte research.

    Lenoir, Olivia / Huber, Tobias B / Tharaux, Pierre-Louis

    Kidney international

    2023  Volume 103, Issue 6, Page(s) 1018–1020

    Abstract: Polat et al. report that mice with a podocyte-specific expression of a constitutively active Rac1 form displayed similar injury and albuminuria, regardless of transient receptor potential canonical 5 activity. This article confirms the pathogenic role of ...

    Abstract Polat et al. report that mice with a podocyte-specific expression of a constitutively active Rac1 form displayed similar injury and albuminuria, regardless of transient receptor potential canonical 5 activity. This article confirms the pathogenic role of deregulated Rac1 and challenges models involving the role of transient receptor potential canonical 5 in podocytes. We learned from this study and propose a roadmap for this controversial field to help new drug candidates succeed in clinical trials and safely reach patients.
    MeSH term(s) Mice ; Animals ; Podocytes/pathology ; Albuminuria/metabolism
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Immune-mediated glomerular diseases: new basic concepts and clinical implications.

    Panzer, Ulf / Huber, Tobias B

    Cell and tissue research

    2021  Volume 385, Issue 2, Page(s) 277–279

    MeSH term(s) Humans ; Kidney Diseases/immunology ; Kidney Diseases/physiopathology ; Kidney Glomerulus/immunology ; Kidney Glomerulus/physiopathology
    Language English
    Publishing date 2021-08-31
    Publishing country Germany
    Document type Editorial
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-021-03509-5
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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.94: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Cisplatin Nephrotoxicity Is Critically Mediated by the Availability of BECLIN1.

    Bork, Tillmann / Hernando-Erhard, Camila / Liang, Wei / Tian, Zhejia / Yamahara, Kosuke / Huber, Tobias B

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: Cisplatin nephrotoxicity is a critical limitation of solid cancer treatment. Until now, the complex interplay of various pathophysiological mechanisms leading to proximal tubular cell apoptosis after cisplatin exposure has not been fully understood. In ... ...

    Abstract Cisplatin nephrotoxicity is a critical limitation of solid cancer treatment. Until now, the complex interplay of various pathophysiological mechanisms leading to proximal tubular cell apoptosis after cisplatin exposure has not been fully understood. In our study, we assessed the role of the autophagy-related protein BECLIN1 (ATG6) in cisplatin-induced acute renal injury (AKI)-a candidate protein involved in autophagy and with putative impact on apoptosis by harboring a B-cell lymphoma 2 (BCL2) interaction site of unknown significance. By using mice with heterozygous deletion of
    MeSH term(s) Mice ; Animals ; Cisplatin/pharmacology ; Beclin-1/metabolism ; Acute Kidney Injury/metabolism ; Autophagy ; Apoptosis
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Beclin-1
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The International Society of Glomerular Disease: Building the Future of Glomerular Medicine.

    Damashek, Laurel J / Adler, Sharon G / Tarnoff, Joshua M / Huber, Tobias B

    Glomerular diseases

    2023  Volume 3, Issue 1, Page(s) 230–232

    Language English
    Publishing date 2023-10-10
    Publishing country Switzerland
    Document type Editorial
    ISSN 2673-3633
    ISSN (online) 2673-3633
    DOI 10.1159/000534536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A protective role for <i>Drosophila</i> Filamin in nephrocytes via Yorkie mediated hypertrophy.

    Koehler, Sybille / Huber, Tobias B / Denholm, Barry

    Life science alliance

    2022  Volume 5, Issue 12

    Abstract: Podocytes are specialized epithelial cells of the kidney glomerulus and are an essential part of the filtration barrier. Because of their position, they are exposed to constant biomechanical forces such as shear stress and hydrostatic pressure. These ... ...

    Abstract Podocytes are specialized epithelial cells of the kidney glomerulus and are an essential part of the filtration barrier. Because of their position, they are exposed to constant biomechanical forces such as shear stress and hydrostatic pressure. These forces increase during disease, resulting in podocyte injury. It is likely podocytes have adaptative responses to help buffer against deleterious mechanical force and thus reduce injury. However, these responses remain largely unknown. Here, using the Drosophila model, we show the mechanosensor Cheerio (dFilamin) provides a key protective role in nephrocytes. We found expression of an activated mechanosensitive variant of Cheerio rescued filtration function and induced compensatory and hypertrophic growth in nephrocytes depleted of the nephrocyte diaphragm proteins Sns or Duf. Delineating the protective pathway downstream of Cheerio we found repression of the Hippo pathway induces nephrocyte hypertrophy, whereas Hippo activation reversed the Cheerio-mediated hypertrophy. Furthermore, we find Yorkie was activated upon expression of active Cheerio. Taken together, our data suggest that Cheerio acts via the Hippo pathway to induce hypertrophic growth, as a protective response in abnormal nephrocytes.
    MeSH term(s) Animals ; Drosophila/metabolism ; Drosophila Proteins/metabolism ; Filamins/metabolism ; Hypertrophy/metabolism ; Podocytes/metabolism
    Chemical Substances Drosophila Proteins ; Filamins
    Language English
    Publishing date 2022-08-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.202101281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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