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  1. Book ; Thesis: Understanding the impact of somatic mosaic structural variation on human blood lineages using single cell multiomics

    Grimes, Karen / Huber, Wolfgang

    2021  

    Institution Universität Heidelberg
    Author's details presented by Karen Grimes ; referees: Dr. Wolfgang Huber, Prof. Dr. Michael Boutros
    Language English
    Size xiv, i, 151 Seiten, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruperto-Carola University of Heidelberg, Germany, 2021
    Note Text Englisch, Zusammenfassung in deutscher und englischer Sprache
    HBZ-ID HT021406061
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 E 725 order for loan Magazin

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  2. Book: The communist manifesto for the third millennium

    Huber, Wolfgang

    2001  

    Institution Patientenfront, Sozialistisches Patientenkollektiv
    Keywords Sozialistisches Patientenkollektiv
    Language English
    Size 51 S. : Ill., 21 cm
    Publisher KRRIM, Verl. für Krankheit
    Publishing place Mannheim
    Publishing country Germany
    Document type Book
    HBZ-ID HT013367606
    ISBN 3-926491-38-8 ; 978-3-926491-38-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 A 2873 order for loan Magazin

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  3. Article: Analoga zu den Langzeitfolgen von Post-COVID und Chronischem Erschöpfungssyndrom (ME/CFS)

    Huber, Wolfgang

    OM & Ernährung

    2022  Volume 181, Issue -, Page(s) F64

    Language German
    Document type Article
    ZDB-ID 2414995-0
    ISSN 1660-8631
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7189: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Comparison of transformations for single-cell RNA-seq data.

    Ahlmann-Eltze, Constantin / Huber, Wolfgang

    Nature methods

    2023  Volume 20, Issue 5, Page(s) 665–672

    Abstract: The count table, a numeric matrix of genes × cells, is the basic input data structure in the analysis of single-cell RNA-sequencing data. A common preprocessing step is to adjust the counts for variable sampling efficiency and to transform them so that ... ...

    Abstract The count table, a numeric matrix of genes × cells, is the basic input data structure in the analysis of single-cell RNA-sequencing data. A common preprocessing step is to adjust the counts for variable sampling efficiency and to transform them so that the variance is similar across the dynamic range. These steps are intended to make subsequent application of generic statistical methods more palatable. Here, we describe four transformation approaches based on the delta method, model residuals, inferred latent expression state and factor analysis. We compare their strengths and weaknesses and find that the latter three have appealing theoretical properties; however, in benchmarks using simulated and real-world data, it turns out that a rather simple approach, namely, the logarithm with a pseudo-count followed by principal-component analysis, performs as well or better than the more sophisticated alternatives. This result highlights limitations of current theoretical analysis as assessed by bottom-line performance benchmarks.
    MeSH term(s) Software ; Sequence Analysis, RNA/methods ; Single-Cell Gene Expression Analysis ; Single-Cell Analysis/methods ; Gene Expression Profiling/methods
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2169522-2
    ISSN 1548-7105 ; 1548-7091
    ISSN (online) 1548-7105
    ISSN 1548-7091
    DOI 10.1038/s41592-023-01814-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6022: Show issues Location:
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  5. Article ; Online: Reporting p Values.

    Huber, Wolfgang

    Cell systems

    2019  Volume 8, Issue 3, Page(s) 170–171

    Abstract: Cell Systems Editorial Board member Wolfgang Huber demonstrates how he thinks about small p values. ...

    Abstract Cell Systems Editorial Board member Wolfgang Huber demonstrates how he thinks about small p values.
    MeSH term(s) Probability ; Statistics as Topic
    Language English
    Publishing date 2019-03-28
    Publishing country United States
    Document type Editorial
    ZDB-ID 2854138-8
    ISSN 2405-4720 ; 2405-4712
    ISSN (online) 2405-4720
    ISSN 2405-4712
    DOI 10.1016/j.cels.2019.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Das Ende der Person?

    Huber, Wolfgang

    Zur Spannung zwischen Ethik und Gentechnologie

    (Reden und Aufsätze der Universität Ulm ; 8)

    2001  

    Author's details Wolfgang Huber
    Series title Reden und Aufsätze der Universität Ulm ; 8
    Collection
    Keywords Gentechnologie ; Moralisches Urteil ; Vortrag
    Subject Fachvortrag ; Ethisches Urteil ; Gentechnik ; Genchirurgie ; Genetic engineering ; Genetische Manipulation ; Genetische Technik ; Genmanipulation
    Language German
    Size 40 S.
    Publisher Univ.-Verl
    Publishing place Ulm
    Publishing country Germany
    Document type Book
    HBZ-ID HT013085477
    ISBN 3-89559-013-4 ; 978-3-89559-013-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 A 3648 order for loan Magazin

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  7. Book ; Online: Rechtfertigung und Recht

    Huber, Wolfgang

    2001  

    Abstract: Die Frage nach der Begründbarkeit des Rechts zeigt gegenwärtig ihre bleibende Aktualität. Obwohl offensichtliche Parallelen bestehen, sind theologische Beiträge zur Ethik des Rechts bis heute alles andere als selbstverständlich.Im ersten Teil der ... ...

    Abstract Die Frage nach der Begründbarkeit des Rechts zeigt gegenwärtig ihre bleibende Aktualität. Obwohl offensichtliche Parallelen bestehen, sind theologische Beiträge zur Ethik des Rechts bis heute alles andere als selbstverständlich.Im ersten Teil der Untersuchung wird der Einfluß des christlichen Glaubens auf die europäische Rechtsentwicklung von der Christianisierung des römischen Reiches bis zur Diskussion universeller Menschenrechte in der Gegenwart gezeigt. Im zweiten Teil widmet sich das Werk der Rechtfertigungslehre bezüglich der für die neuzeitliche Entwicklung verantwortlichen drei Hauptschübe »Theodizee«, »Anthropodizee« und »Soziodizee«. Der dritte Teil behandelt die neuere Diskussion zur Rechtfertigungslehre, wobei die spezifische Verbindung von Rechtfertigung und Recht am Werk des aus der Schweiz stammenden evangelischen Theologen Karl Barth expliziert wird. Abschließend wird die Unterscheidung von Person und ihrem Handeln hervorgehoben. Dies läßt zu, die Sinnhaftigkeit des Lebens auch bei denjenigen Menschen noch zu bejahen, die im Handeln gescheitert sind. Der Vorrang der Person vor ihren Werken bietet die Grundlage für eine Personenwürde, unabhängig von Geschlecht, Alter, Fähigkeiten und Wohlstand
    Keywords Philosophy (General)
    Size 1 electronic resource ( pages)
    Publisher Nomos Verlagsgesellschaft mbH and Company KG
    Document type Book ; Online
    Note de ; Open Access
    HBZ-ID HT020307472
    ISBN 9783748902362 ; 3748902360
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Book ; Online: Comparison of lung water in COVID-19-patients vs. other patients with acute respiratory failure

    Huber, Wolfgang

    http://isrctn.com/

    2020  

    Keywords covid19
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Book ; Online
    DOI 10.1186/isrctn10077335
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Book: Multiple Chemikalien-Sensitivität (MCS)

    Hill, Hans-Ulrich / Huber, Wolfgang / Müller, Kurt E.

    ein Krankheitsbild der chronischen Multisystemerkrankungen (CMI) ; umweltmedizinische, toxikologische und sozialpolitische Aspekte ; ein Blick auf den aktuellen Forschungsstand

    (Berichte aus der Medizin)

    2010  

    Author's details Hans-Ulrich Hill ; Wolfgang Huber ; Kurt E. Müller
    Series title Berichte aus der Medizin
    Keywords Multiple chemical sensitivity
    Subject Umweltgift ; Chemikalienunverträglichkeit ; Multiple chemische Sensibilität ; MCS ; Vielfache Chemikalienüberempfindlichkeit ; MCS-Syndrom ; Idiopathic environmental illness ; IEI ; IEI-Syndrom ; Chemikalien-Syndrom ; Idiopathische Umweltintoleranz
    Subject code 616.98
    Language German
    Size 486 S. : Ill., graph. Darst.
    Edition 3., neu bearb. und erw. Aufl.
    Publisher Shaker
    Publishing place Aachen
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT016647781
    ISBN 978-3-8322-9046-7 ; 3-8322-9046-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2011 A 979 order for loan Magazin

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  10. Article ; Online: MsQuality: an interoperable open-source package for the calculation of standardized quality metrics of mass spectrometry data.

    Naake, Thomas / Rainer, Johannes / Huber, Wolfgang

    Bioinformatics (Oxford, England)

    2023  Volume 39, Issue 10

    Abstract: Motivation: Multiple factors can impact accuracy and reproducibility of mass spectrometry data. There is a need to integrate quality assessment and control into data analytic workflows.: Results: The MsQuality package calculates 43 low-level quality ... ...

    Abstract Motivation: Multiple factors can impact accuracy and reproducibility of mass spectrometry data. There is a need to integrate quality assessment and control into data analytic workflows.
    Results: The MsQuality package calculates 43 low-level quality metrics based on the controlled mzQC vocabulary defined by the HUPO-PSI on a single mass spectrometry-based measurement of a sample. It helps to identify low-quality measurements and track data quality. Its use of community-standard quality metrics facilitates comparability of quality assessment and control (QA/QC) criteria across datasets.
    Availability and implementation: The R package MsQuality is available through Bioconductor at https://bioconductor.org/packages/MsQuality.
    MeSH term(s) Software ; Reproducibility of Results ; Mass Spectrometry/methods
    Language English
    Publishing date 2023-10-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btad618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2374: Show issues Location:
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