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  1. AU="Hucke Andreas"
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  1. Book: Präzisierung der Gefahrkriterien

    Baltz, Rüdiger / Hucke, Andreas

    (DMT-Berichte aus Forschung und Entwicklung ; ...)

    2005  

    Author's details von Rüdiger Baltz ... [Projektl.: A. Hucke]
    Series title DMT-Berichte aus Forschung und Entwicklung
    ...
    Language German
    Dates of publication 2005-9999
    Publisher DMT, Geschäftsfeld Bergbau-Service
    Publishing place Essen
    Document type Book
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  2. Book: Fazielle, petrographische und geotechnische Untersuchung zur Festigkeit von Sandsteinen des Ruhrkarbons (Westfal B2/C)

    Hucke, Andreas

    (DMT-Berichte aus Forschung und Entwicklung ; 137)

    2002  

    Author's details von Andreas Hucke
    Series title DMT-Berichte aus Forschung und Entwicklung ; 137
    Keywords Steinkohlenlagerstätte ; Gesteinsmechanik ; Sandstein ; Lagerstätte ; Gesteinskunde ; Forschung ; Festigkeit ; Bergbau ; Deutschland ; Ruhrgebiet
    Language German
    Size VI, 236 S., 88 Anl, Ill., graph. Darst., Kt, 30 cm
    Publisher DMT, Mines & More Div
    Publishing place Essen
    Document type Book
    Note Literaturverz. S. 224 - 236
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Article ; Online: Riociguat prevents fibrotic tissue remodelling and improves survival in salt-sensitive Dahl rats

    Hucke Andreas / Lawrenz Bettina / Evgenov Oleg V / Sharkovska Yuliya / Kretschmer Axel / Geschka Sandra / Hocher Berthold / Stasch Johannes-Peter

    BMC Pharmacology, Vol 11, Iss Suppl 1, p P

    2011  Volume 28

    Keywords Therapeutics. Pharmacology ; RM1-950 ; Medicine ; R ; DOAJ:Therapeutics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2011-08-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Soluble guanylate cyclase stimulation prevents fibrotic tissue remodeling and improves survival in salt-sensitive Dahl rats.

    Geschka, Sandra / Kretschmer, Axel / Sharkovska, Yuliya / Evgenov, Oleg V / Lawrenz, Bettina / Hucke, Andreas / Hocher, Berthold / Stasch, Johannes-Peter

    PloS one

    2011  Volume 6, Issue 7, Page(s) e21853

    Abstract: Background: A direct pharmacological stimulation of soluble guanylate cyclase (sGC) is an emerging therapeutic approach to the management of various cardiovascular disorders associated with endothelial dysfunction. Novel sGC stimulators, including ... ...

    Abstract Background: A direct pharmacological stimulation of soluble guanylate cyclase (sGC) is an emerging therapeutic approach to the management of various cardiovascular disorders associated with endothelial dysfunction. Novel sGC stimulators, including riociguat (BAY 63-2521), have a dual mode of action: They sensitize sGC to endogenously produced nitric oxide (NO) and also directly stimulate sGC independently of NO. Little is known about their effects on tissue remodeling and degeneration and survival in experimental malignant hypertension.
    Methods and results: Mortality, hemodynamics and biomarkers of tissue remodeling and degeneration were assessed in Dahl salt-sensitive rats maintained on a high salt diet and treated with riociguat (3 or 10 mg/kg/d) for 14 weeks. Riociguat markedly attenuated systemic hypertension, improved systolic heart function and increased survival from 33% to 85%. Histological examination of the heart and kidneys revealed that riociguat significantly ameliorated fibrotic tissue remodeling and degeneration. Correspondingly, mRNA expression of the pro-fibrotic biomarkers osteopontin (OPN), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and plasminogen activator inhibitor-1 (PAI-1) in the myocardium and the renal cortex was attenuated by riociguat. In addition, riociguat reduced plasma and urinary levels of OPN, TIMP-1, and PAI-1.
    Conclusions: Stimulation of sGC by riociguat markedly improves survival and attenuates systemic hypertension and systolic dysfunction, as well as fibrotic tissue remodeling in the myocardium and the renal cortex in a rodent model of pressure and volume overload. These findings suggest a therapeutic potential of sGC stimulators in diseases associated with impaired cardiovascular and renal functions.
    MeSH term(s) Animals ; Biomarkers/blood ; Biomarkers/urine ; Blood Pressure/drug effects ; Body Weight/drug effects ; Echocardiography ; Fibrosis ; Gene Expression Regulation/drug effects ; Guanylate Cyclase/metabolism ; Heart Rate/drug effects ; Hemodynamics/drug effects ; Kidney/drug effects ; Kidney/pathology ; Kidney/physiopathology ; Kidney Function Tests ; Myocardium/pathology ; Organ Size/drug effects ; Organ Specificity/drug effects ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Inbred Dahl ; Receptors, Cytoplasmic and Nuclear/metabolism ; Soluble Guanylyl Cyclase ; Survival Analysis ; Systole/drug effects
    Chemical Substances Biomarkers ; Pyrazoles ; Pyrimidines ; RNA, Messenger ; Receptors, Cytoplasmic and Nuclear ; Guanylate Cyclase (EC 4.6.1.2) ; Soluble Guanylyl Cyclase (EC 4.6.1.2) ; riociguat (RU3FE2Y4XI)
    Language English
    Publishing date 2011-07-18
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0021853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: NO-independent activation of soluble guanylate cyclase prevents disease progression in rats with 5/6 nephrectomy.

    Kalk, Philipp / Godes, Michael / Relle, Katharina / Rothkegel, Christiane / Hucke, Andreas / Stasch, Johannes-Peter / Hocher, Berthold

    British journal of pharmacology

    2006  Volume 148, Issue 6, Page(s) 853–859

    Abstract: 1. Chronic renal disease is associated with oxidative stress, reduced nitric oxide (NO) availability and soluble guanylate cyclase (sGC) dysfunction. Recently, we discovered BAY 58-2667, a compound activating heme-deficient or oxidized sGC in a NO- ... ...

    Abstract 1. Chronic renal disease is associated with oxidative stress, reduced nitric oxide (NO) availability and soluble guanylate cyclase (sGC) dysfunction. Recently, we discovered BAY 58-2667, a compound activating heme-deficient or oxidized sGC in a NO-independent manner. 2. We assessed potential of BAY 58-2667 in preventing cardiac and renal target organ damage in rats with 5/6 nephrectomy. 3. Male Wistar rats were allocated to three groups: 5/6 nephrectomy, 5/6 nephrectomy treated with BAY 58-2667 and sham operation. Study period was 18 weeks: blood pressure and creatinine clearance were assessed repeatedly. At study end blood samples were taken and hearts and kidneys harvested for histological studies. 4. BAY 58-2667 markedly lowered blood pressure in animals with 5/6 nephrectomy (untreated versus treated animals: 189+/-14 versus 146+/-11 mmHg, P<0.001). Left ventricular weight, cardiac myocyte diameter as well as cardiac arterial wall thickness significantly decreased in comparison to untreated animals with 5/6 nephrectomy. Natriuretic peptide plasma levels were also improved by BAY 58-2667. Kidney function and morphology as assessed by creatinine clearance, glomerulosclerosis, interstitial and perivascular fibrosis of intrarenal arteries were likewise significantly improved by BAY 58-2667. 5. This is the first study showing that BAY 58-2667 effectively lowers blood pressure, reduces left ventricular hypertrophy and slows renal disease progression in rats with 5/6 nephrectomy by targeting mainly oxidized sGC. Therefore, BAY 58-2667 represents a novel pharmacological principle with potential clinical value in treatment of chronic renal disease.
    MeSH term(s) Albuminuria/drug therapy ; Animals ; Benzoates/blood ; Benzoates/therapeutic use ; Blood Pressure/drug effects ; Creatinine/metabolism ; Disease Progression ; Guanylate Cyclase/physiology ; Kidney/pathology ; Kidney Diseases/drug therapy ; Kidney Diseases/enzymology ; Kidney Diseases/pathology ; Male ; Myocardium/pathology ; Natriuretic Peptide, Brain/blood ; Nephrectomy ; Nitric Oxide/physiology ; Rats ; Rats, Wistar
    Chemical Substances Benzoates ; Natriuretic Peptide, Brain (114471-18-0) ; Nitric Oxide (31C4KY9ESH) ; BAY 58-2667 (329773-35-5) ; Creatinine (AYI8EX34EU) ; Guanylate Cyclase (EC 4.6.1.2)
    Language English
    Publishing date 2006-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1038/sj.bjp.0706792
    Database MEDical Literature Analysis and Retrieval System OnLINE

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