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Article ; Online: Therapeutic Applications of Biogenic Silver Nanomaterial Synthesized from the Paper Flower of Bougainvillea glabra (Miami, Pink)

Mohammad Oves / Mohd Ahmar Rauf / Huda A. Qari

Nanomaterials, Vol 13, Iss 615, p

2023 Volume 615

Abstract: In this research, Bougainvillea glabra paper flower extract was used to quickly synthesize biogenic silver nanoparticles (BAgNPs) utilizing green chemistry. Using the flower extract as a biological reducing agent, silver nanoparticles were generated by ... ...

Abstract	In this research, Bougainvillea glabra paper flower extract was used to quickly synthesize biogenic silver nanoparticles (BAgNPs) utilizing green chemistry. Using the flower extract as a biological reducing agent, silver nanoparticles were generated by the conversion of Ag + cations to Ag 0 ions. Data patterns obtained from physical techniques for characterizing BAgNPs, employing UV-visible, scattering electron microscope (SEM), transmission electron microscope (TEM), dynamic light scattering (DLS), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR), suggested that the nanoparticles have a spherical to oval form with size ranging from 10 to 50 nm. Spectroscopy and microscopic analysis were used to learn more about the antibacterial properties of the biologically produced BAgNPs from Bougainvillea glabra . Further, the potential mechanism of action of nanoparticles was investigated by studying their interactions in vitro with several bacterial strains and mammalian cancer cell systems. Finally, we can conclude that BAgNPs can be functionalized to dramatically inhibit bacterial growth and the growth of cancer cells in culture conditions, suggesting that biologically produced nanomaterials will provide new opportunities for a wide range of biomedical applications in the near future.
Keywords	biogenic ; biocompatible ; AgNPs ; Bougainvillea glabra ; antibacterial ; anticancer ; Chemistry ; QD1-999
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Rutin (Bioflavonoid) as Cell Signaling Pathway Modulator

Pratibha Pandey / Fahad Khan / Huda A. Qari / Mohammad Oves

Pharmaceuticals, Vol 14, Iss 1069, p

Prospects in Treatment and Chemoprevention

2021 Volume 1069

Abstract: Cancer is a complex ailment orchestrated by numerous intrinsic and extrinsic pathways. Recent research has displayed a deep interest in developing plant-based cancer therapeutics for better management of the disease and limited side effects. A wide range ...

Abstract	Cancer is a complex ailment orchestrated by numerous intrinsic and extrinsic pathways. Recent research has displayed a deep interest in developing plant-based cancer therapeutics for better management of the disease and limited side effects. A wide range of plant-derived compounds have been reported for their anticancer potential in the quest of finding an effective therapeutic approach. Rutin (vitamin P) is a low-molecular weight flavonoid glycoside (polyphenolic compound), abundantly present in various vegetables, fruits (especially berries and citrus fruits), and medicinal herbs. Numerous studies have delineated several pharmacological properties of rutin such as its antiprotozoal, antibacterial, anti-inflammatory, antitumor, antiviral, antiallergic, vasoactive, cytoprotective, antispasmodic, hypolipidemic, antihypertensive, and antiplatelet properties. Specifically, rutin-mediated anticancerous activities have been reported in several cancerous cell lines, but the most common scientific evidence, encompassing several molecular processes and interactions, including apoptosis pathway regulation, aberrant cell signaling pathways, and oncogenic genes, has not been thoroughly studied. In this direction, we attempted to project rutin-mediated oncogenic pathway regulation in various carcinomas. Additionally, we also incorporated advanced research that has uncovered the notable potential of rutin in the modulation of several key cellular functions via interaction with mRNAs, with major emphasis on elucidating direct miRNA targets of rutin as well as the process needed to transform these approaches for developing novel therapeutic interventions for the treatment of several cancers.
Keywords	rutin ; therapeutic potential ; cancer ; cell signaling pathways ; miRNA ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Assessment of Mineral Composition of Irrigated Water from Different Wells Around Ta’if City, Saudi Arabia

Huda A. Qari

Current World Environment, Vol 10, Iss 1, Pp 55-

2015 Volume 60

Abstract: The chemical composition of water collected from different wells in Ta’if city was evaluated in order to determine the suitability as a potable or at least for irrigation. This study indicated that most of the chemical parameters such as . Ba, Cd, Cr, Zn ...

Abstract	The chemical composition of water collected from different wells in Ta’if city was evaluated in order to determine the suitability as a potable or at least for irrigation. This study indicated that most of the chemical parameters such as . Ba, Cd, Cr, Zn & Fe do not fall within the permissible limit. Anions varied greatly between water sampled collected from different wells. Cl- varied between 32 - 955 mg L-1,which is higher than EPA standards (200 mg L-1). NO3-2 ranged between 14.6- 2088 mg L-1, which is much higher that allowed levels by EPA (10 mg L-1). Similarly, NH4 was relatively higher than standards of 10 mg L-1 in three wells out of the ten wells examined. Cations also showed similar trend, as they showed maximum in samples collected from some wells and lower concentrations and even BDL in samples collected from others. Na+ and Mg+ exceeded the standard levels (200 and 30mg L-1 respectively). K+ was lower than EPA standards of 30 mg L-1 in all samples Five metals out of the 10 elements analysed in the water samples from suburban water wells were found in concentrations exceeding various standards, which are Al, B, P , Cu and Pb However other trace metals (Fe, Ba, Cd, Cr and Zn) were not detected in all water samples.
Keywords	Ground water ; Irrigation ; T race metals ; Anion ; Cations ; Environmental sciences ; GE1-350 ; Geography. Anthropology. Recreation ; G
Language	English
Publishing date	2015-04-01T00:00:00Z
Publisher	Enviro Research Publishers
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Novel Approach to Unraveling the Apoptotic Potential of Rutin (Bioflavonoid) via Targeting Jab1 in Cervical Cancer Cells

Pratibha Pandey / Fahad Khan / Faisal Abdulrahman Alzahrani / Huda A. Qari / Mohammad Oves

Molecules, Vol 26, Iss 5529, p

2021 Volume 5529

Abstract: Rutin has been well recognized for possessing numerous pharmacological and biological activities in several human cancer cells. This research has addressed the inhibitory potential of rutin against the Jab1 oncogene in SiHa cancer cells, which is known ... ...

Abstract	Rutin has been well recognized for possessing numerous pharmacological and biological activities in several human cancer cells. This research has addressed the inhibitory potential of rutin against the Jab1 oncogene in SiHa cancer cells, which is known to inactivate various tumor suppressor proteins including p53 and p27 . Further, the inhibitory efficacy of rutin via Jab1 expression modulation in cervical cancer has not been yet elucidated. Hence, we hypothesized that rutin could exhibit strong inhibitory efficacy against Jab1 and, thereby, induce significant growth arrest in SiHa cancer cells in a dose-dependent manner. In our study, the cytotoxic efficacy of rutin on the proliferation of a cervical cancer cell line (SiHa) was exhibited using MTT and LDH assays. The correlation between rutin and Jab1 mRNA expression was assessed by RT-PCR analysis and the associated events (a mechanism) with this downregulation were then explored via performing ROS assay, DAPI analysis, and expression analysis of apoptosis-associated signaling molecules such as Bax , Bcl-2 , and Caspase-3 and -9 using qRT-PCR analysis. Results exhibit that rutin produces anticancer effects via inducing modulation in the expression of oncogenes as well as tumor suppressor genes. Further apoptosis induction, caspase activation, and ROS generation in rutin-treated SiHa cancer cells explain the cascade of events associated with Jab1 downregulation in SiHa cancer cells. Additionally, apoptosis induction was further confirmed by the FITC-Annexin V/PI double staining method. Altogether, our research supports the feasibility of developing rutin as one of the potent drug candidates in cervical cancer management via targeting one such crucial oncogene associated with cervical cancer progression.
Keywords	cervical cancer ; rutin ; Jab1 ; apoptosis ; Caspase-3 ; ROS ; Organic chemistry ; QD241-441
Subject code	610
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Revolutionization in Cancer Therapeutics via Targeting Major Immune Checkpoints PD-1, PD-L1 and CTLA-4

Pratibha Pandey / Fahad Khan / Huda A. Qari / Tarun Kumar Upadhyay / Abdulhameed F. Alkhateeb / Mohammad Oves

Pharmaceuticals, Vol 15, Iss 335, p

2022 Volume 335

Abstract: Numerous research reports have witnessed dramatic advancements in cancer therapeutic approaches through immunotherapy. Blocking immunological checkpoint pathways (mechanisms employed by malignant cells to disguise themselves as normal human body ... ...

Abstract	Numerous research reports have witnessed dramatic advancements in cancer therapeutic approaches through immunotherapy. Blocking immunological checkpoint pathways (mechanisms employed by malignant cells to disguise themselves as normal human body components) has emerged as a viable strategy for developing anticancer immunity. Through the development of effective immune checkpoint inhibitors (ICIs) in multiple carcinomas, advances in cancer immunity have expedited a major breakthrough in cancer therapy. Blocking a variety of ICIs, such as PD-1 (programmed cell death-1), programmed cell death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) has improved the immune system’s efficacy in combating cancer cells. Recent studies also supported the fact that ICIs combined with other potent antitumor candidates, such as angiogenic agents, could be a solid promising chemopreventive therapeutic approach in improving the effectiveness of immune checkpoint inhibitors. Immune checkpoint blockade has aided antiangiogenesis by lowering vascular endothelial growth factor expression and alleviating hypoxia. Our review summarized recent advances and clinical improvements in immune checkpoint blocking tactics, including combinatorial treatment of immunogenic cell death (ICD) inducers with ICIs, which may aid future researchers in creating more effective cancer-fighting strategies.
Keywords	cancer therapeutics ; immunotherapy ; immunogenic cell death ; immune checkpoints ; PD-L1/PD-1 ; CTLA-4 ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evidence of Metallic and Polyether Ionophores as Potent Therapeutic Drug Candidate in Cancer Management

Pratibha Pandey / Fahad Khan / Huda A. Qari / Tarun Kumar Upadhyay / Abdulhameed F. Alkhateeb / Mohammad Oves

Molecules, Vol 27, Iss 4708, p

2022 Volume 4708

Abstract: Cancer remains one of the most crucial human malignancies with a higher mortality rate globally, and is predicted to escalate soon. Dysregulated ion homeostasis in cancerous cells prompted the researchers to investigate further ion homeostasis impeding ... ...

Abstract	Cancer remains one of the most crucial human malignancies with a higher mortality rate globally, and is predicted to escalate soon. Dysregulated ion homeostasis in cancerous cells prompted the researchers to investigate further ion homeostasis impeding agents as potent anticancerous agents. Reutilization of FDA-approved non-cancerous drugs has emerged as a practical approach to developing potent, cost-effective drugs for cancer treatment. Across the globe, most nations are incapable of fulfilling the medical demands of cancer patients due to costlier cancerous drugs. Therefore, we have inclined our review towards emphasizing recent advancements in cancer therapies involving ionophores utilization in exploring potent anticancer drugs. Numerous research reports have established the significant anticancerous potential of ionophores in several pre-clinical reports via modulating aberrant cell signaling pathways and enhancing antitumor immunity in immune cells. This review has mainly summarized the most significant ion homeostasis impeding agents, including copper, zinc, calcium, and polyether, that presented remarkable potential in cancer therapeutics via enhanced antitumor immunity and apoptosis induction. Altogether, this study could provide a robust future perspective for developing cost-effective anticancerous drugs rapidly and cost-effectively, thereby combating the limitations of currently available drugs used in cancer treatment.
Keywords	drug repurposing ; ionophores ; cancer ; ion homeostasis ; cell signaling pathways ; Organic chemistry ; QD241-441
Subject code	610
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The performance of silver modified tungsten oxide for the removal of 2-CP and 2-NP in sunlight exposure

M. Aslam / M. Tahir Soomro / Iqbal M.I. Ismail / Numan Salah / M. Waqar Ashraf / Huda A. Qari / A. Hameed

Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 2632-

Optical, electrochemical and photocatalytic properties

2019 Volume 2643

Abstract: The optical and electrochemical characterization of the synthesized Ag+ modified WO3 photocatalysts was performed and its photocatalytic activity was estimated in the visible region (420–800 nm) of sunlight for the degradation of 2-chloro and 2- ... ...

Abstract	The optical and electrochemical characterization of the synthesized Ag+ modified WO3 photocatalysts was performed and its photocatalytic activity was estimated in the visible region (420–800 nm) of sunlight for the degradation of 2-chloro and 2-nitrophenol. The catalysts with the varying loading of Ag+ ranging from 0.5% to 10%, exhibited significantly higher activity as compared to pure WO3. Attempts were made to correlate the enhanced activity of Ag+ loaded catalysts with the optical and electrochemical properties. At lower loading (up to 1% Ag+), the enhanced degradation was attributed to the excited electron trap and transfer ability of surface mounted Ag+ species, while the synergic effect between the WO3 support and surface Ag2O resulted the same at higher loadings. The electrochemical properties of the synthesized powders, in comparison with pure WO3, also supported the same findings. The identification of the intermediates and the estimation of the released anions evidenced the contribution of both hydroxyl radicals (HO·) and superoxide anion (O2·−) radicals in the degradation process. The identification of aliphatic oxygenates as majority intermediates and release of respective ions verified the replacement of Cl− and NO2 groups, insertion of oxygen and aromatic ring cleavage. Keywords: Visible light, Photocatalysis, 2-Chlorophenol, 2-Nitrophenol, Ag+ impregnated WO3
Keywords	Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2019-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Graphene Decorated Zinc Oxide and Curcumin to Disinfect the Methicillin-Resistant Staphylococcus aureus

Mohammad Oves / Mohd. Ahmar Rauf / Mohammad Omaish Ansari / Aftab Aslam Parwaz Khan / Huda A Qari / Mohamed F. Alajmi / Samaresh Sau / Arun K Iyer

Nanomaterials, Vol 10, Iss 1004, p

2020 Volume 1004

Abstract: Sometimes, life-threatening infections are initiated by the biofilm formation facilitated at the infection site by the drug-resistant bacteria Staphylococcus aureus . The aggregation of the same type of bacteria leads to biofilm formation on the delicate ...

Abstract	Sometimes, life-threatening infections are initiated by the biofilm formation facilitated at the infection site by the drug-resistant bacteria Staphylococcus aureus . The aggregation of the same type of bacteria leads to biofilm formation on the delicate tissue, dental plaque, and skin. In the present investigation, a Graphene (Gr)-based nano-formulation containing Curcumin (C.C.M.) and Zinc oxide nanoparticles (ZnO-NPs) showed a wide range of anti-microbial activity against Methicillin-resistant Staphylococcus aureus (MRSA) biofilm and demonstrated the anti-microbial mechanism of action. The anti-microbial effect of GrZnO nanocomposites, i.e., GrZnO-NCs, suggests that the integrated graphene-based nanocomposites effectively suppressed both sensitive as well as MRSA ATCC 43300 and BAA-1708 isolates. The S. aureus inhibitory effect of GrZnO-NCs improved >5-fold when combined with C.C.M., and demonstrated a M.I.C. of 31.25 µg/mL contrasting with the GrZnO-NCs or C.C.M. alone having M.I.C. value of 125 µg/mL each. The combination treatment of GrZnO-NCs or C.C.M. inhibited the M.R.S.A. topical dermatitis infection in a mice model with a significant decrease in the CFU count to ~64%. Interestingly, the combination of C.C.M. and GrZnO-NCs damaged the bacterial cell wall structure, resulting in cytoplasm spillage, thereby diminishing their metabolism. Thus, owing to the ease of synthesis and highly efficient anti-microbial properties, the present graphene-based curcumin nano-formulations can cater to a new treatment methodology against M.R.S.A.
Keywords	GrZnO nanocomposites ; antibacterial ; anti-biofilm ; Graphene ; MRSA ; Curcumin ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction

Mohammad Oves / Mohd. Ahmar Rauf / Mohammad Omaish Ansari / Aftab Aslam Parwaz Khan / Huda A. Qari / Mohamed F. Alajmi / Samaresh Sau / Arun K. Iyer

Nanomaterials, Vol 10, Iss 1453, p

Oves M, et al. Graphene Decorated Zinc Oxide and Curcumin to Disinfect the Methicillin-Resistant Staphylococcus aureus. Nanomaterials 2020, 10 (5), 1004

2020 Volume 1453

Abstract: The authors wish to make the following corrections to this paper [.] ...

Abstract	The authors wish to make the following corrections to this paper [.]
Keywords	n/a ; Chemistry ; QD1-999
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Recent Advances in Metal Decorated Nanomaterials and Their Various Biological Applications

Asim Ali Yaqoob / Hilal Ahmad / Tabassum Parveen / Akil Ahmad / Mohammad Oves / Iqbal M. I. Ismail / Huda A. Qari / Khalid Umar / Mohamad Nasir Mohamad Ibrahim

Frontiers in Chemistry, Vol

A Review

2020 Volume 8

Abstract: Nanoparticles (nanoparticles) have received much attention in biological application because of their unique physicochemical properties. The metal- and metal oxide–supported nanomaterials have shown significant therapeutic effect in medical science. The ... ...

Abstract	Nanoparticles (nanoparticles) have received much attention in biological application because of their unique physicochemical properties. The metal- and metal oxide–supported nanomaterials have shown significant therapeutic effect in medical science. The mechanisms related to the interaction of nanoparticles with animal and plant cells can be used to establish its significant role and to improve their activity in health and medical applications. Various attempts have been made to discuss the antibiotic resistance and antimicrobial activity of metal-supported nanoparticles. Despite all these developments, there is still a need to investigate their performance to overcome modern challenges. In this regard, the present review examines the role of various types of metal-supported nanomaterials in different areas such as antibacterial, antifungal, anticancer, and so on. Based on the significant ongoing research and applications, it is expected that metal-supported nanomaterials play an outstanding role not only in medical but also in other important areas.
Keywords	nanomaterials ; metal oxide ; biological application ; therapeutics ; tissue engineering ; Chemistry ; QD1-999
Subject code	620
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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