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  1. Article ; Online: Multi-locus homozygosity promotes actuarial senescence in a wild mammal.

    Hudson, Dave W / McKinley, Trevelyan J / Benton, Clare H / Delahay, Richard / McDonald, Robbie A / Hodgson, Dave J

    The Journal of animal ecology

    2023  Volume 92, Issue 9, Page(s) 1881–1892

    Abstract: Genome-wide homozygosity, caused for example by inbreeding, is expected to have deleterious effects on survival and/or reproduction. Evolutionary theory predicts that any fitness costs are likely to be detected in late life because natural selection will ...

    Abstract Genome-wide homozygosity, caused for example by inbreeding, is expected to have deleterious effects on survival and/or reproduction. Evolutionary theory predicts that any fitness costs are likely to be detected in late life because natural selection will filter out negative impacts on younger individuals with greater reproductive value. Here we infer associations between multi-locus homozygosity (MLH), sex, disease and age-dependent mortality risks using Bayesian analysis of the life histories of wild European badgers Meles meles in a population naturally infected with Mycobacterium bovis (the causative agent of bovine tuberculosis [bTB]). We find important effects of MLH on all parameters of the Gompertz-Makeham mortality hazard function, but particularly in later life. Our findings confirm the predicted association between genomic homozygosity and actuarial senescence. Increased homozygosity is particularly associated with an earlier onset, and greater rates of actuarial senescence, regardless of sex. The association between homozygosity and actuarial senescence is further amplified among badgers putatively infected with bTB. These results recommend further investigation into the ecological and behavioural processes that result in genome-wide homozygosity, and focused work on whether homozygosity is harmful or beneficial during early life-stages.
    MeSH term(s) Animals ; Cattle ; Bayes Theorem ; Mycobacterium bovis ; Tuberculosis, Bovine/epidemiology ; Mustelidae ; Cattle Diseases
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3024-7
    ISSN 1365-2656 ; 0021-8790
    ISSN (online) 1365-2656
    ISSN 0021-8790
    DOI 10.1111/1365-2656.13979
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  2. Article ; Online: Multi‐locus homozygosity promotes actuarial senescence in a wild mammal

    Hudson, Dave W. / McKinley, Trevelyan J. / Benton, Clare H. / Delahay, Richard / McDonald, Robbie A. / Hodgson, Dave J.

    Journal of Animal Ecology. 2023 Sept., v. 92, no. 9 p.1881-1892

    2023  

    Abstract: Genome‐wide homozygosity, caused for example by inbreeding, is expected to have deleterious effects on survival and/or reproduction. Evolutionary theory predicts that any fitness costs are likely to be detected in late life because natural selection will ...

    Abstract Genome‐wide homozygosity, caused for example by inbreeding, is expected to have deleterious effects on survival and/or reproduction. Evolutionary theory predicts that any fitness costs are likely to be detected in late life because natural selection will filter out negative impacts on younger individuals with greater reproductive value. Here we infer associations between multi‐locus homozygosity (MLH), sex, disease and age‐dependent mortality risks using Bayesian analysis of the life histories of wild European badgers Meles meles in a population naturally infected with Mycobacterium bovis (the causative agent of bovine tuberculosis [bTB]). We find important effects of MLH on all parameters of the Gompertz–Makeham mortality hazard function, but particularly in later life. Our findings confirm the predicted association between genomic homozygosity and actuarial senescence. Increased homozygosity is particularly associated with an earlier onset, and greater rates of actuarial senescence, regardless of sex. The association between homozygosity and actuarial senescence is further amplified among badgers putatively infected with bTB. These results recommend further investigation into the ecological and behavioural processes that result in genome‐wide homozygosity, and focused work on whether homozygosity is harmful or beneficial during early life‐stages.
    Keywords Bayesian theory ; Meles meles ; Mycobacterium bovis ; animal ecology ; bovine tuberculosis ; etiological agents ; genomics ; homozygosity ; mammals ; mortality ; natural selection ; reproduction
    Language English
    Dates of publication 2023-09
    Size p. 1881-1892.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 3024-7
    ISSN 1365-2656 ; 0021-8790
    ISSN (online) 1365-2656
    ISSN 0021-8790
    DOI 10.1111/1365-2656.13979
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 72/708: Show issues
    Z 2600: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: Analysis of Lifetime Mortality Trajectories in Wildlife Disease Research: BaSTA and Beyond

    Hudson, Dave W / Delahay, Richard / Hodgson, Dave J / McDonald, Robbie A / McKinley, Trevelyan J

    Diversity. 2019 Oct. 01, v. 11, no. 10

    2019  

    Abstract: Wildlife hosts are important reservoirs of a wide range of human and livestock infections worldwide, and in some instances, wildlife populations are threatened by disease. Yet wildlife diseases are difficult to monitor, and we often lack an understanding ...

    Abstract Wildlife hosts are important reservoirs of a wide range of human and livestock infections worldwide, and in some instances, wildlife populations are threatened by disease. Yet wildlife diseases are difficult to monitor, and we often lack an understanding of basic epidemiological parameters that might inform disease management and the design of targeted interventions. The impacts of disease on host survival are generally associated with age, yet traditional epidemiological models tend to use simplistic categories of host age. Mortality trajectory analysis provides the opportunity to understand age-specific impacts of disease and uncover epidemiological patterns across complete life histories. Here, we use Bayesian survival trajectory analysis (BaSTA) software to analyse capture-mark-recapture data from a population of wild badgers Meles meles naturally infected with Mycobacterium bovis, the causative agent of tuberculosis in badgers and cattle. We reveal non-constant mortality trajectories, and show that infection exaggerates an age-dependent increase in late-life mortality. This study provides evidence for actuarial senescence in badgers, a species previously believed to display constant mortality throughout life. Our case study demonstrates the application of mortality trajectory analysis in wildlife disease research, but also highlights important limitations. We recommend BaSTA for mortality trajectory analysis in epidemiological research, but also suggest combining approaches that can include diagnostic uncertainty and the movement of hosts between disease states as they age. We recommend future combinations of multi-state and multi-event modelling frameworks for complex systems incorporating age-varying disease states.
    Keywords badgers ; Bayesian theory ; case studies ; cattle ; computer software ; disease control ; etiological agents ; hosts ; humans ; life history ; Meles meles ; models ; mortality ; Mycobacterium bovis ; tuberculosis ; uncertainty ; wildlife ; wildlife diseases
    Language English
    Dates of publication 2019-1001
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518137-3
    ISSN 1424-2818
    ISSN 1424-2818
    DOI 10.3390/d11100182
    Database NAL-Catalogue (AGRICOLA)

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