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Article ; Online: Highlights of the British Cardiovascular Society's Future of Cardiology Working Group paper.

Hudson, Sarah

2020 Volume 107, Issue 3, Page(s) 254–256

MeSH term(s)	COVID-19 ; Cardiology/trends ; Delivery of Health Care ; Forecasting ; Heart Diseases/diagnosis ; Heart Diseases/therapy ; Humans ; United Kingdom
Keywords	covid19
Language	English
Publishing date	2020-10-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/heartjnl-2020-318250
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Zs.MO 112: Show issues

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Article ; Online: Symmetry.

Hudson, Sarah

Families, systems & health : the journal of collaborative family healthcare

2019 Volume 36, Issue 4, Page(s) 549

Abstract: In family medicine, there is a symmetry of physicians' involvement in patients' lives, shepherding families through life transitions in the beginning, middle, and end. As a teaching physician, the author bears witness to another "birth" in the ... ...

Abstract	In family medicine, there is a symmetry of physicians' involvement in patients' lives, shepherding families through life transitions in the beginning, middle, and end. As a teaching physician, the author bears witness to another "birth" in the development of resident physicians. This poem on symmetry was born on a particularly poignant day: helping a new intern "catch" his first baby in the morning, then gathering with the author's own family in the evening for the passing of her grandmother. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
Language	English
Publishing date	2019-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1326859-4
ISSN	1939-0602 ; 1091-7527 ; 0736-1718
ISSN (online)	1939-0602
ISSN	1091-7527 ; 0736-1718
DOI	10.1037/fsh0000381
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Article ; Online: 'Never be mediocre': a conversation with Professor Nick Curzen, President-Elect of the British Cardiovascular Intervention Society.

Hudson, Sarah

Heart (British Cardiac Society)

2019 Volume 105, Issue 21, Page(s) 1680–1681

MeSH term(s)	Attitude of Health Personnel ; Cardiologists/education ; Cardiologists/psychology ; Cardiology/education ; Career Choice ; Education, Medical, Graduate ; Humans ; Mentors ; Self Concept ; Work-Life Balance
Language	English
Publishing date	2019-07-05
Publishing country	England
Document type	Interview ; Portrait
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/heartjnl-2019-315567
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Article ; Online: On the ethics of removing Entonox® from labour ward: beyond carbon dioxide equivalents and seeking justice for patients and the planet.

Hudson, Sarah / Muspratt-Tucker, Nadia / Kudsk-Iversen, Søren

Anaesthesia

2024

Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Editorial
ZDB-ID	80033-8
ISSN	1365-2044 ; 0003-2409
ISSN (online)	1365-2044
ISSN	0003-2409
DOI	10.1111/anae.16296
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Article ; Online: Pre-formulation of an additive combination of two antimicrobial agents, clofazimine and nisin A, to boost antimicrobial activity.

Naranjo, Mateo Flores / Kumar, Ajay / Ratrey, Poonam / Hudson, Sarah P

Journal of materials chemistry. B

2024 Volume 12, Issue 6, Page(s) 1558–1568

Abstract: According to the World Health Organization, antimicrobial resistance is one of the top ten issues that pose a major threat to humanity. The lack of investment by the pharmaceutical industry has meant fewer novel antimicrobial agents are in development, ... ...

Abstract	According to the World Health Organization, antimicrobial resistance is one of the top ten issues that pose a major threat to humanity. The lack of investment by the pharmaceutical industry has meant fewer novel antimicrobial agents are in development, exacerbating the problem. Emerging drug design strategies are exploring the repurposing of existing drugs and the utilization of novel drug candidates, like antimicrobial peptides, to combat drug resistance. This proactive approach is crucial in fighting global health threats. In this study, an additive combination of a repurposed anti-leprosy drug, clofazimine, and an antimicrobial peptide, nisin A, are preformulated using liquid antisolvent precipitation to generate a stable amorphous, ionized nanoparticle system to boost antimicrobial activity. The nanotechnology aims to improve the physicochemical properties of the inherently poorly water-soluble clofazimine molecules while also harnessing the previously unreported additive effect of clofazimine and nisin A. The approach transformed clofazimine into a more water-soluble salt, yielding amorphous nanoparticles stabilized by the antimicrobial peptide; and combined the two drugs into a more soluble and more active formulation. Blending pre-formulation strategies like amorphization, salt formation, and nanosizing to improve the inherent low aqueous solubility of drugs can open many new possibilities for the design of new antimicrobial agents. This fusion of pre-formulation technologies in combination with the multi-hurdle approach of selecting drugs with different effects on microbes could be key in the design platform of new antibiotics in the fight against antimicrobial resistance.
MeSH term(s)	Clofazimine/chemistry ; Anti-Infective Agents ; Antimicrobial Peptides ; Water ; Nisin
Chemical Substances	nisin A (EN8XKG133D) ; Clofazimine (D959AE5USF) ; Anti-Infective Agents ; Antimicrobial Peptides ; Water (059QF0KO0R) ; Nisin (1414-45-5)
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb01800h
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Article: Impact of Additives on Drug Particles during Liquid Antisolvent Crystallization and Subsequent Freeze-Drying.

Ghosh, Peuli / Rasmuson, Ake / Hudson, Sarah P

Organic process research & development

2023 Volume 27, Issue 11, Page(s) 2020–2034

Abstract: The impact of single or combinations of additives on the generation of nanosuspensions of two poorly water-soluble active pharmaceutical ingredients (APIs), fenofibrate (FF) and dalcetrapib (DCP), and their isolation to the dry state via antisolvent (AS) ...

Abstract	The impact of single or combinations of additives on the generation of nanosuspensions of two poorly water-soluble active pharmaceutical ingredients (APIs), fenofibrate (FF) and dalcetrapib (DCP), and their isolation to the dry state via antisolvent (AS) crystallization followed by freeze-drying was explored in this work. Combinations of polymeric and surfactant additives such as poly(vinyl alcohol) or hydroxypropyl methyl cellulose and sodium docusate were required to stabilize nanoparticles (∼200-300 nm) of both APIs in suspension before isolation to dryness. For both FF and DCP, multiple additives generated the narrowest, most-stable particle size distribution, with the smallest particles in suspension, compared with using a single additive. An industrially recognized freeze-drying process was used for the isolation of these nanoparticles to dryness. When processed by the liquid AS crystallization followed by freeze-drying in the presence of multiple additives, a purer monomorphic powder for FF resulted than when processed in the absence of any additive or in the presence of a single additive. It was noted that all nanoparticles freeze-dried in the presence of additives had a flat, flaky habit resulting in large surface areas. Agglomeration occurred during freeze-drying, resulting in micron-size particles. However, after freeze-drying, powders produced with single or multiple additives showed similar dissolution profiles, irrespective of aging time before drying, thus attenuating the advantage of multiple additives in terms of size observed before the freeze-drying process.
Language	English
Publishing date	2023-10-06
Publishing country	United States
Document type	Journal Article
ISSN	1083-6160
ISSN	1083-6160
DOI	10.1021/acs.oprd.3c00204
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Article ; Online: Synergistic antimicrobial interactions of nisin A with biopolymers and solubilising agents for oral drug delivery.

Flynn, James / Ryan, Aoibhín / Hudson, Sarah P

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

2022 Volume 171, Page(s) 29–38

Abstract: In order to develop bacteriocins, like the lantibiotic nisin A, into effective alternatives to existing antibiotics, their biophysical and physicochemical properties must first be assessed, from solubility, to susceptibility and absorption. It has been ... ...

Abstract	In order to develop bacteriocins, like the lantibiotic nisin A, into effective alternatives to existing antibiotics, their biophysical and physicochemical properties must first be assessed, from solubility, to susceptibility and absorption. It has been well established that formulation strategies at early drug development stages can be crucial for successful outcomes during preclinical and clinical phases of development, particularly for molecules with challenging physicochemical properties. This work elucidates the physicochemical challenges of nisin A in terms of its susceptibility to digestive enzymes like pepsin, pancreatin and proteinase K and its poor solubility at physiological pHs. Low solution concentrations, below the minimum inhibitory concentration against Staphylococcus aureus, were obtained in phosphate buffered saline (PBS, pH 7.4) and in fasted state simulated intestinal fluid (FaSSIF, pH 6.5), while higher solubilities at more acidic pH's such as in a KCl/HCl buffer (pH 2) and in fasted state simulated gastric fluid (FaSSGF, pH 1.6) are observed. Tween® 80 (0.01% v/v) significantly increased the solution concentration of nisin A in PBS (pH 7.4, 24 hr). Pancreatin doubled nisin A's solution concentration at pH 7.4 (PBS) but reduced its' inhibitory activity to ∼ 20%, and pepsin almost completely degraded nisin (after 24 hr), but retained activity at biologically relevant exposure times (∼15 min). Harnessing synergism between nisin A and either glycol chitosan or ε-poly lysine, combined with the solubilizing effect of Tween®, increased the antimicrobial activity of nisin A six fold in an in vitro oral administration model.
MeSH term(s)	Administration, Oral ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Biopolymers ; Drug Delivery Systems ; Drug Synergism ; Humans ; Microbial Sensitivity Tests ; Nisin/administration & dosage ; Nisin/chemistry ; Nisin/pharmacology ; Staphylococcus aureus/drug effects
Chemical Substances	Anti-Bacterial Agents ; Biopolymers ; Nisin (1414-45-5)
Language	English
Publishing date	2022-01-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1065368-5
ISSN	1873-3441 ; 0939-6411
ISSN (online)	1873-3441
ISSN	0939-6411
DOI	10.1016/j.ejpb.2021.12.010
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Article ; Online: What is 'normal' left ventricular ejection fraction?

Hudson, Sarah / Pettit, Stephen

Heart (British Cardiac Society)

2020 Volume 106, Issue 18, Page(s) 1445–1446

MeSH term(s)	Clinical Decision-Making ; Echocardiography ; Humans ; Predictive Value of Tests ; Prognosis ; Reference Values ; Reproducibility of Results ; Stroke Volume ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Left/therapy ; Ventricular Function, Left
Keywords	covid19
Language	English
Publishing date	2020-07-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/heartjnl-2020-317604
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Zs.MO 112: Show issues

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Article ; Online: Anionic liposome formulation for oral delivery of thuricin CD, a potential antimicrobial peptide therapeutic.

Viera Herrera, Camila / O'Connor, Paula M / Ratrey, Poonam / Paul Ross, R / Hill, Colin / Hudson, Sarah P

International journal of pharmaceutics

2024 Volume 654, Page(s) 123918

Abstract: Thuricin CD is a two-peptide antimicrobial produced by Bacillus thuringiensis. Unlike previous antibiotics, it has shown narrow spectrum activity against Clostridioides difficile, a bacterium capable of causing infectious disease in the colon. However, ... ...

Abstract	Thuricin CD is a two-peptide antimicrobial produced by Bacillus thuringiensis. Unlike previous antibiotics, it has shown narrow spectrum activity against Clostridioides difficile, a bacterium capable of causing infectious disease in the colon. However, peptide antibiotics have stability, solubility, and permeability problems that can affect their performance in vivo. This work focuses on the bioactivity and bioavailability of thuricin CD with a view to developing a formulation for delivery of active thuricin CD peptides through the gastrointestinal tract (GIT) for local delivery in the colon. The results indicate that thuricin CD is active at low concentrations only when both peptides are present. While thuricin CD was degraded by proteases and was unstable and poorly soluble in gastric fluid, it showed increased solubility in intestinal fluid, probably due to micelle encapsulation. Based on this, thuricin CD was encapsulated in anionic liposomes, which showed increased activity compared to the free peptide, maintained activity after exposure to pepsin in gastric fluid and intestinal fluid, was stable in suspension for over 21 days at room temperature and for 60 days at 4 °C, and exhibited no toxicity to epithelial intestinal cells. These findings suggest that an anionic lipid-based nano formulation may be a promising approach for local oral delivery of thuricin CD.
MeSH term(s)	Liposomes ; Antimicrobial Peptides ; Bacteriocins ; Anti-Bacterial Agents/pharmacology
Chemical Substances	thuricin (37311-35-6) ; Liposomes ; Antimicrobial Peptides ; Bacteriocins ; Anti-Bacterial Agents
Language	English
Publishing date	2024-02-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2024.123918
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Article ; Online: Pre-formulation and delivery strategies for the development of bacteriocins as next generation antibiotics.

Flynn, James / Ryan, Aoibhín / Hudson, Sarah P

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

2021 Volume 165, Page(s) 149–163

Abstract: Bacteriocins, a class of antimicrobial peptide produced by bacteria, may offer a potential alternative to traditional antibiotics, an important step towards mitigating the ever-increasing antimicrobial resistance crisis. They are active against a range ... ...

Abstract	Bacteriocins, a class of antimicrobial peptide produced by bacteria, may offer a potential alternative to traditional antibiotics, an important step towards mitigating the ever-increasing antimicrobial resistance crisis. They are active against a range of clinically relevant Gram-positive and Gram-negative bacteria. Bacteriocins have been discussed in the literature for over a century. Although they are used as preservatives in food, no medicine based on their antimicrobial activity exists on the market today. In order to formulate them into clinical antibiotics, pre-formulation studies on their biophysical and physicochemical properties that will influence their activity in vivo and their stability during manufacture must be elucidated. Thermal, pH and enzymatic stability of bacteriocins are commonly studied and regularly reported in the literature. Solubility, permeability and aggregation properties on the other hand are less frequently reported for many bacteriocins, which may contribute to their poor clinical progression. Promising cytotoxicity studies report that bacteriocins exhibit few cytotoxic effects on a variety of mammalian cell lines, at active concentrations. This review highlights the lack of quantitative data and in many cases even qualitative data, on bacteriocins' solubility, stability, aggregation, permeability and cytotoxicity. The formulation strategies that have been explored to date, proposed routes of administration, trends in in vitro/in vivo behaviour and efforts in clinical development are discussed. The future promise of bacteriocins as a new generation of antibiotics may require tailored local delivery strategies to fulfil their potential as a force to combat antimicrobial-resistant bacterial infections.
MeSH term(s)	Animals ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacokinetics ; Bacterial Infections/drug therapy ; Bacteriocins/administration & dosage ; Bacteriocins/chemistry ; Bacteriocins/pharmacokinetics ; Biological Availability ; Disease Models, Animal ; Drug Carriers/chemistry ; Drug Compounding/methods ; Drug Development/trends ; Drug Evaluation, Preclinical ; Drug Resistance, Bacterial ; Drug Stability ; Humans
Chemical Substances	Anti-Bacterial Agents ; Bacteriocins ; Drug Carriers
Language	English
Publishing date	2021-05-18
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1065368-5
ISSN	1873-3441 ; 0939-6411
ISSN (online)	1873-3441
ISSN	0939-6411
DOI	10.1016/j.ejpb.2021.05.015
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