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  1. Book ; Thesis: Vergleich der diagnostischen Wertigkeit von D-Dimer-, TAT- und Prothrombinfragment-F-1+2-Bestimmungen

    Hüfner, Stefanie

    2006  

    Author's details eingereicht von Stefanie Hüfner
    Subject code 616.4
    Language German
    Size 95 S., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Leipzig, Univ., Diss., 2005
    HBZ-ID HT016185117
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 E 875 order for loan Magazin

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  2. Article ; Online: Evaluation of ABT-751, a novel anti-mitotic agent able to overcome multi-drug resistance, in melanoma cells.

    Mahgoub, Thamir M / Jordan, Emmet J / Mahdi, Amira F / Oettl, Veronika / Huefner, Stefanie / O'Donovan, Norma / Crown, John / Collins, Denis M

    Cancer chemotherapy and pharmacology

    2024  Volume 93, Issue 5, Page(s) 427–437

    Abstract: Purpose: Drug efflux transporter associated multi-drug resistance (MDR) is a potential limitation in the use of taxane chemotherapies for the treatment of metastatic melanoma. ABT-751 is an orally bioavailable microtubule-binding agent capable of ... ...

    Abstract Purpose: Drug efflux transporter associated multi-drug resistance (MDR) is a potential limitation in the use of taxane chemotherapies for the treatment of metastatic melanoma. ABT-751 is an orally bioavailable microtubule-binding agent capable of overcoming MDR and proposed as an alternative to taxane-based therapies.
    Methods: This study compares ABT-751 to taxanes in vitro, utilizing seven melanoma cell line models, publicly available gene expression and drug sensitivity databases, a lung cancer cell line model of MDR drug efflux transporter overexpression (DLKP-A), and drug efflux transporter ATPase assays.
    Results: Melanoma cell lines exhibit a low but variable protein and RNA expression of drug efflux transporters P-gp, BCRP, and MDR3. Expression of P-gp and MDR3 correlates with sensitivity to taxanes, but not to ABT-751. The anti-proliferative IC
    Conclusion: Our study confirms that ABT-751 is active against melanoma cell lines and models of MDR at physiologically relevant concentrations, it inhibits P-gp ATPase activity, and it may be a BCRP and/or MDR3 substrate. ABT-751 warrants further investigation alone or in tandem with other drug efflux transporter inhibitors for hard-to-treat MDR melanoma.
    MeSH term(s) Humans ; Melanoma/drug therapy ; Melanoma/pathology ; Melanoma/genetics ; Melanoma/metabolism ; Drug Resistance, Neoplasm/drug effects ; Sulfonamides/pharmacology ; Cell Line, Tumor ; Drug Resistance, Multiple/drug effects ; Taxoids/pharmacology ; Cell Proliferation/drug effects ; Antimitotic Agents/pharmacology ; Antineoplastic Agents/pharmacology ; ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; ATP Binding Cassette Transporter, Subfamily G, Member 2/antagonists & inhibitors
    Chemical Substances Sulfonamides ; ABT751 ; Taxoids ; Antimitotic Agents ; Antineoplastic Agents ; ATP Binding Cassette Transporter, Subfamily G, Member 2
    Language English
    Publishing date 2024-01-16
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 6820-2
    ISSN 1432-0843 ; 0344-5704 ; 0943-9404
    ISSN (online) 1432-0843
    ISSN 0344-5704 ; 0943-9404
    DOI 10.1007/s00280-023-04624-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1420: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Book ; Online ; Thesis: Untersuchungen zur tumorspezifischen Geninaktivierung über Methylierung in gastrointestinalen Karzinomen

    Hüfner, Stefanie

    2005  

    Author's details vorgelegt von Stefanie Hüfner
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--München, 2005
    Database Former special subject collection: coastal and deep sea fishing

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  4. Article: Vergleich der diagnostischen Wertigkeit von D-Dimer-, TAT- und Prothrombinfragment F1+2-Bestimmungen (Dissertationsschrift - Zusammenfassung)

    Hüfner, Stefanie

    Klinische Chemie

    2007  Volume 38, Issue 5, Page(s) 110

    Language German
    Document type Article
    ZDB-ID 841078-1
    ISSN 0173-6647
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1010: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Book ; Online ; Thesis: Untersuchungen zur tumorspezifischen Geninaktivierung über Methylierung in gastrointestinalen Karzinomen

    Hüfner, Stefanie [Verfasser]

    2005  

    Author's details vorgelegt von Stefanie Hüfner
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

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