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  1. Article ; Online: Facile synthesis of ultrasmall polydopamine-polyethylene glycol nanoparticles for cellular delivery.

    Harvey, Sean / Ng, David Yuen Wah / Szelwicka, Jolanta / Hueske, Lisa / Veith, Lothar / Raabe, Marco / Lieberwirth, Ingo / Fytas, George / Wunderlich, Katrin / Weil, Tanja

    Biointerphases

    2018  Volume 13, Issue 6, Page(s) 06D407

    Abstract: Very small polydopamine (PDA) polyethylene glycol (PEG) crosslinked copolymer (PDA-PEG) nanoparticles have been prepared following a convenient one-step procedure in aqueous solution. Particle sizes and colloidal stabilities have been optimized by ... ...

    Abstract Very small polydopamine (PDA) polyethylene glycol (PEG) crosslinked copolymer (PDA-PEG) nanoparticles have been prepared following a convenient one-step procedure in aqueous solution. Particle sizes and colloidal stabilities have been optimized by varying PEG in view of chain length and end group functionalities. In particular, amine-terminated PEG3000 [PEG
    MeSH term(s) Colloids/chemistry ; Fluorescent Dyes/metabolism ; Indoles/chemical synthesis ; Nanoparticles/chemistry ; Organic Chemistry Phenomena ; Particle Size ; Polyethylene Glycols/chemical synthesis ; Polymers/chemical synthesis
    Chemical Substances Colloids ; Fluorescent Dyes ; Indoles ; Polymers ; polydopamine ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2018-10-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2234510-3
    ISSN 1559-4106 ; 1934-8630
    ISSN (online) 1559-4106
    ISSN 1934-8630
    DOI 10.1116/1.5042640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ultrathin Polydopamine Films with Phospholipid Nanodiscs Containing a Glycophorin A Domain

    Marchesi D'Alvise, Tommaso / Harvey, Sean / Hueske, Lisa / Szelwicka, Jolanta / Veith, Lothar / Knowles, Tuomas P.J. / Kubiczek, Dennis / Flaig, Carolin / Port, Fabian / Gottschalk, Kay E. / Rosenau, Frank / Graczykowski, Bartlomiej / Fytas, George / Ruggeri, Francesco S. / Wunderlich, Katrin / Weil, Tanja

    Advanced Functional Materials

    2020  Volume 30, Issue 21

    Abstract: Cellular membranes have long served as an inspiration for nanomaterial research. The preparation of ultrathin polydopamine (PDA) films with integrated protein pores containing phospholipids and an embedded domain of a membrane protein glycophorin A as ... ...

    Abstract Cellular membranes have long served as an inspiration for nanomaterial research. The preparation of ultrathin polydopamine (PDA) films with integrated protein pores containing phospholipids and an embedded domain of a membrane protein glycophorin A as simplified cell membrane mimics is reported. Large area, ultrathin PDA films are obtained by electropolymerization on gold surfaces with 10–18 nm thickness and dimensions of up to 2.5 cm2. The films are transferred from gold to various other substrates such as nylon mesh, silicon, or substrates containing holes in the micrometer range, and they remain intact even after transfer. The novel transfer technique gives access to freestanding PDA films that remain stable even at the air interfaces with elastic moduli of ≈6–12 GPa, which are higher than any other PDA films reported before. As the PDA film thickness is within the range of cellular membranes, monodisperse protein nanopores, so-called “nanodiscs,” are integrated as functional entities. These nanodisc-containing PDA films can serve as semi-permeable films, in which the embedded pores control material transport. In the future, these simplified cell membrane mimics may offer structural investigations of the embedded membrane proteins to receive an improved understanding of protein-mediated transport processes in cellular membranes.
    Keywords freestanding ultrathin films ; glycophorin A ; membrane mimics ; nanodiscs ; polydopamine
    Subject code 620
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 2039420-2
    ISSN 1616-3028 ; 1616-301X
    ISSN (online) 1616-3028
    ISSN 1616-301X
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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