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Article ; Online: Herd immunity or suppression strategy to combat COVID-19.

Jung, F / Krieger, V / Hufert, F T / Küpper, J-H

Clinical hemorheology and microcirculation

2020 Volume 75, Issue 1, Page(s) 13–17

Abstract: Some months ago, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan, China, and spread rapidly around the world. Some states, such as the Netherlands, Germany, Great Britain, Sweden and the USA initially focused on keeping ... ...

Abstract	Some months ago, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan, China, and spread rapidly around the world. Some states, such as the Netherlands, Germany, Great Britain, Sweden and the USA initially focused on keeping the restrictions for economy and society as low as possible. The responsible authorities were of the opinion - and still are e.g. in Sweden - that it is sufficient enough to protect particularly vulnerable persons such as the elderly or people with pre-existing conditions. The idea behind this is that as soon as 60 to 70 percent of the population is infected with a pathogen, a so-called "herd immunity" has developed. However, the increasing numbers of deaths and modelling studies showed the expected overload of the hospitals. Therefore, most countries decided for a temporary lockdown with the exception of Sweden.Based on the number of the total population, three times more people died from COVID-19 in Sweden (2679 deaths per 10 million inhabitants) compared to Germany (6848 deaths per 80 million inhabitants). The comparison Sweden versus Taiwan is even worse because 1072 times more people died in Sweden based on the number of the population (6 deaths per 24 million inhabitants).In the face of the lack of an antiviral treatment and the lack of a protective vaccine one must state Taiwan has made the best out of the pandemic situation whereas Sweden failed completely.
MeSH term(s)	Betacoronavirus/immunology ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Female ; Humans ; Immunity, Herd ; Male ; Pandemics/prevention & control ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-06-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1381750-4
ISSN	1875-8622 ; 1386-0291
ISSN (online)	1875-8622
ISSN	1386-0291
DOI	10.3233/CH-209006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: How we should respond to the Coronavirus SARS-CoV-2 outbreak: A German perspective.

Jung, F / Krieger, V / Hufert, F T / Küpper, J-H

Clinical hemorheology and microcirculation

2020 Volume 74, Issue 4, Page(s) 363–372

Abstract: Background: In the early phase of the COVID-19 pandemic Germany missed to set up efficient containment measures. Consequently, the number of cases increased exponentially until a lockdown was implemented to suppress the spread of SARS-CoV-2. Fortunately, ...

Abstract	Background: In the early phase of the COVID-19 pandemic Germany missed to set up efficient containment measures. Consequently, the number of cases increased exponentially until a lockdown was implemented to suppress the spread of SARS-CoV-2. Fortunately, Germany has a high capability for coronavirus lab testing and more than 30,000 ICU beds. These capabilities and the lockdown turned out to be an advantage to combat the pandemic and to prevent a health-system overload. Aim: The aim was to predict the plateau day of SARS-CoV-2 infections or deaths. Results: The effect on the viral spread of the German measures taken and the impact on the peak of new infection cases is shown. By normalizing daily case numbers, the plateau day of the current outbreak in Germany could be calculated to be reached at April 12, 2020 (day 103 of 2020). Conclusion: Normalized case number curves are helpful to predict the time point at which no further new infections will occur if the epidemic situation remains stable. Upon reaching the plateau day during a lockdown phase, a residual time-period of about 2-3 weeks can be utilized to prepare a safe unlocking period. As can be learned from Asian countries such as South Korea and Taiwan there must be strict rules to keep the risk of infection low. Those include social distancing, face mask wearing in combination with digital contact tracing and serosurveillance studies. Following those rules, a safe dance around the infection curve allows to keep the population at a reduced infection rate.
MeSH term(s)	Betacoronavirus ; COVID-19 ; China/epidemiology ; Communicable Disease Control/methods ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Disease Outbreaks ; Germany/epidemiology ; Humans ; Infectious Disease Medicine/trends ; Intensive Care Units ; Linear Models ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; Quarantine ; SARS-CoV-2 ; World Health Organization
Keywords	covid19
Language	English
Publishing date	2020-05-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1381750-4
ISSN	1875-8622 ; 1386-0291
ISSN (online)	1875-8622
ISSN	1386-0291
DOI	10.3233/CH-209004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: How we should respond to the Coronavirus SARS-CoV-2 outbreak: A German perspective

Jung, F / Krieger, V / Hufert, F T / Küpper, J-H

Clin Hemorheol Microcirc

Abstract: BACKGROUND: In the early phase of the COVID-19 pandemic Germany missed to set up efficient containment measures. Consequently, the number of cases increased exponentially until a lockdown was implemented to suppress the spread of SARS-CoV-2. Fortunately, ...

Abstract	BACKGROUND: In the early phase of the COVID-19 pandemic Germany missed to set up efficient containment measures. Consequently, the number of cases increased exponentially until a lockdown was implemented to suppress the spread of SARS-CoV-2. Fortunately, Germany has a high capability for coronavirus lab testing and more than 30,000 ICU beds. These capabilities and the lockdown turned out to be an advantage to combat the pandemic and to prevent a health-system overload. AIM: The aim was to predict the plateau day of SARS-CoV-2 infections or deaths. RESULTS: The effect on the viral spread of the German measures taken and the impact on the peak of new infection cases is shown. By normalizing daily case numbers, the plateau day of the current outbreak in Germany could be calculated to be reached at April 12, 2020 (day 103 of 2020). CONCLUSION: Normalized case number curves are helpful to predict the time point at which no further new infections will occur if the epidemic situation remains stable. Upon reaching the plateau day during a lockdown phase, a residual time-period of about 2-3 weeks can be utilized to prepare a safe unlocking period. As can be learned from Asian countries such as South Korea and Taiwan there must be strict rules to keep the risk of infection low. Those include social distancing, face mask wearing in combination with digital contact tracing and serosurveillance studies. Following those rules, a safe dance around the infection curve allows to keep the population at a reduced infection rate.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32390611
Database	COVID19

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Article: Herd immunity or suppression strategy to combat COVID-19

Jung, F / Krieger, V / Hufert, F T / Küpper, J-H

Clin Hemorheol Microcirc

Abstract	Some months ago, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan, China, and spread rapidly around the world. Some states, such as the Netherlands, Germany, Great Britain, Sweden and the USA initially focused on keeping the restrictions for economy and society as low as possible. The responsible authorities were of the opinion - and still are e.g. in Sweden - that it is sufficient enough to protect particularly vulnerable persons such as the elderly or people with pre-existing conditions. The idea behind this is that as soon as 60 to 70 percent of the population is infected with a pathogen, a so-called "herd immunity" has developed. However, the increasing numbers of deaths and modelling studies showed the expected overload of the hospitals. Therefore, most countries decided for a temporary lockdown with the exception of Sweden.Based on the number of the total population, three times more people died from COVID-19 in Sweden (2679 deaths per 10 million inhabitants) compared to Germany (6848 deaths per 80 million inhabitants). The comparison Sweden versus Taiwan is even worse because 1072 times more people died in Sweden based on the number of the population (6 deaths per 24 million inhabitants).In the face of the lack of an antiviral treatment and the lack of a protective vaccine one must state Taiwan has made the best out of the pandemic situation whereas Sweden failed completely.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #601851
Database	COVID19

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Article ; Online: A lab-on-a-chip for preconcentration of bacteria and nucleic acid extraction.

Hügle, M / Dame, G / Behrmann, O / Rietzel, R / Karthe, D / Hufert, F T / Urban, G A

RSC advances

2018 Volume 8, Issue 36, Page(s) 20124–20130

Abstract: To improve detection sensitivity, molecular diagnostics require preconcentration of low concentrated samples followed by rapid nucleic acid extraction. This is usually achieved by multiple centrifugation, lysis and purification steps, for instance, using ...

Abstract	To improve detection sensitivity, molecular diagnostics require preconcentration of low concentrated samples followed by rapid nucleic acid extraction. This is usually achieved by multiple centrifugation, lysis and purification steps, for instance, using chemical reagents, spin columns or magnetic beads. These require extensive infrastructure as well as time consuming manual handling steps and are thus not suitable for point of care testing (POCT). To overcome these challenges, we developed a microfluidic chip combining free-flow electrophoretic (FFE) preconcentration (1 ml down to 5 μl) and thermoelectric lysis of bacteria as well as purification of nucleic acids by gel-electrophoresis. The integration of these techniques in a single chip is unique and enables fast, easy and space-saving sample pretreatment without the need for laboratory facilities, making it ideal for the integration into small POCT devices. A preconcentration efficiency of nearly 100% and a lysis/gel-electrophoresis efficiency of about 65% were achieved for the detection of
Language	English
Publishing date	2018-06-01
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c8ra02177e
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction: A lab-on-a-chip for preconcentration of bacteria and nucleic acid extraction.

Hügle, M / Dame, G / Behrmann, O / Rietzel, R / Karthe, D / Hufert, F T / Urban, G A

RSC advances

2018 Volume 8, Issue 47, Page(s) 26817

Abstract: This corrects the article DOI: 10.1039/C8RA02177E.]. ...

Abstract	[This corrects the article DOI: 10.1039/C8RA02177E.].
Language	English
Publishing date	2018-07-27
Publishing country	England
Document type	Published Erratum
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c8ra90058b
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: 1. Quantitativer Schnellnachweis von Bunyaviridae mittels TaqMan TM -PCR-Technologie, 2. Entwicklung eines "Line assay" zum Nachweis von Antikörpern gegen das Krim-Kongo/Virus

Hufert, F. T / Weidmann, M

Abschlussbericht = 1. Rapid identification and quantification of Bunyaviridae using TaqMan TM -PCR technology, 2. Development of a line assay to detect antibodies against Crimean-Congo-Virus

(Forschungsbericht aus der Wehrmedizin ; 05,2)

2005

Title variant	Development of a line assay to detect antibodies against Crimean-Congo-Virus ; Entwicklung eines "Line assay" zum Nachweis von Antikörpern gegen das Krim-Kongo/Virus ; Rapid identification and quantification of Bunyaviridae using TaqMan TM -PCR technology
Author's details	Vertragnehmer F. T. Hufert; Bearb. M. Weidmann
Series title	Forschungsbericht aus der Wehrmedizin ; 05,2
Language	German
Size	V, 37 S, Ill., graph. Darst
Edition	Als Ms. gedr
Publisher	Streitkräfteamt, Abt. 3, Fachinformationszentrum der Bundeswehr
Publishing place	Bonn
Document type	Book
Note	Abschlussbericht eines aus 2 Teilen bestehenden Forschungsprojektes
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: A new approach for diagnosis of bovine coronavirus using a reverse transcription recombinase polymerase amplification assay

Amer, H.M / Abd El Wahed, A / Shalaby, M.A / Almajhdi, F.N / Hufert, F.T / Weidmann, M

Journal of virological methods. 2013 Nov., v. 193, no. 2

2013

Abstract: Bovine coronavirus (BCoV) is an economically significant cause of calf scours and winter dysentery of adult cattle, and may induce respiratory tract infections in cattle of all ages. Early diagnosis of BCoV helps to diminish its burden on the dairy and ... ...

Abstract	Bovine coronavirus (BCoV) is an economically significant cause of calf scours and winter dysentery of adult cattle, and may induce respiratory tract infections in cattle of all ages. Early diagnosis of BCoV helps to diminish its burden on the dairy and beef industry. Real-time RT-PCR assay for the detection of BCoV has been described, but it is relatively expensive, requires well-equipped laboratories and is not suitable for on-site screening. A novel assay, using reverse transcription recombinase polymerase amplification (RT-RPA), for the detection of BCoV is developed. The BCoV RT-RPA was rapid (10–20min) and has an analytical sensitivity of 19 molecules. No cross-reactivity with other viruses causing bovine gastrointestinal and/or respiratory infections was observed. The assay performance on clinical samples was validated by testing 16 fecal and 14 nasal swab specimens and compared to real-time RT-PCR. Both assays provided comparable results. The RT-RPA assay was significantly more rapid than the real-time RT-PCR assay. The BCoV RT-RPA constitutes a suitable accurate, sensitive and rapid alternative to the common measures used for BCoV diagnosis. In addition, the use of a portable fluorescence reading device extends its application potential to use in the field and point-of-care diagnosis.
Keywords	Bovine coronavirus ; adults ; beef industry ; calves ; detection limit ; dysentery ; early diagnosis ; fluorescence ; gastrointestinal system ; nose ; respiratory tract diseases ; reverse transcriptase polymerase chain reaction ; reverse transcription ; screening ; viruses ; covid19
Language	English
Dates of publication	2013-11
Size	p. 337-340.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	8013-5
ISSN	1879-0984 ; 0166-0934
ISSN (online)	1879-0984
ISSN	0166-0934
DOI	10.1016/j.jviromet.2013.06.027
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A new approach for diagnosis of bovine coronavirus using a reverse transcription recombinase polymerase amplification assay.

Amer, H M / Abd El Wahed, A / Shalaby, M A / Almajhdi, F N / Hufert, F T / Weidmann, M

Journal of virological methods

2013 Volume 193, Issue 2, Page(s) 337–340

Abstract	Bovine coronavirus (BCoV) is an economically significant cause of calf scours and winter dysentery of adult cattle, and may induce respiratory tract infections in cattle of all ages. Early diagnosis of BCoV helps to diminish its burden on the dairy and beef industry. Real-time RT-PCR assay for the detection of BCoV has been described, but it is relatively expensive, requires well-equipped laboratories and is not suitable for on-site screening. A novel assay, using reverse transcription recombinase polymerase amplification (RT-RPA), for the detection of BCoV is developed. The BCoV RT-RPA was rapid (10-20 min) and has an analytical sensitivity of 19 molecules. No cross-reactivity with other viruses causing bovine gastrointestinal and/or respiratory infections was observed. The assay performance on clinical samples was validated by testing 16 fecal and 14 nasal swab specimens and compared to real-time RT-PCR. Both assays provided comparable results. The RT-RPA assay was significantly more rapid than the real-time RT-PCR assay. The BCoV RT-RPA constitutes a suitable accurate, sensitive and rapid alternative to the common measures used for BCoV diagnosis. In addition, the use of a portable fluorescence reading device extends its application potential to use in the field and point-of-care diagnosis.
MeSH term(s)	Animals ; Cattle ; Cattle Diseases/diagnosis ; Cattle Diseases/virology ; Coronavirus Infections/diagnosis ; Coronavirus Infections/veterinary ; Coronavirus Infections/virology ; Coronavirus, Bovine/genetics ; Coronavirus, Bovine/isolation & purification ; Feces/virology ; Molecular Diagnostic Techniques/methods ; Nasal Cavity/virology ; Nucleic Acid Amplification Techniques/methods ; Point-of-Care Systems ; Recombinases/metabolism ; Reverse Transcription ; Sensitivity and Specificity ; Time Factors ; Veterinary Medicine/methods ; Virology/methods
Chemical Substances	Recombinases
Keywords	covid19
Language	English
Publishing date	2013-06-28
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	8013-5
ISSN	1879-0984 ; 0166-0934
ISSN (online)	1879-0984
ISSN	0166-0934
DOI	10.1016/j.jviromet.2013.06.027
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Viruskrankheiten bei Tropenrückkehrern.

Hufert, F T / Schmitz, H

Therapeutische Umschau. Revue therapeutique

1994 Volume 51, Issue 8, Page(s) 569–576

Abstract: The high density of populations and insufficient sanitary conditions increases the risk to acquire viral diseases in tropical areas. This holds true for ubiquitous as well as for regional viral infections. Hepatitis and AIDS are found worldwide, but play ...

Title translation	Virus diseases in patients returning from the tropics.
Abstract	The high density of populations and insufficient sanitary conditions increases the risk to acquire viral diseases in tropical areas. This holds true for ubiquitous as well as for regional viral infections. Hepatitis and AIDS are found worldwide, but play a dominant role in tropical areas. Classical tropical viral infections are zoonoses. They are primarily infections of nonhuman vertebrates (e.g. rodents) and of arthropod vectors and can be transmitted to man. According to the clinical outcome these viral infections can be divided into three groups: influenza-like disease with arthralgia, encephalitis and hemorrhagic fevers. The majority of infections belong to the first group, followed by encephalitis cases. Viral hemorrhagic fevers are rare in visitors of tropical areas. Antibody detection is the method of choice in the diagnosis of tropical viral infections. In special situations (e.g. Lassa fever) the direct detection of the virus by PCR can be helpful. Tests for the detection of arboviruses, filoviruses and arenaviruses are only performed at a few centers worldwide.
MeSH term(s)	Animals ; Diagnosis, Differential ; Disease Vectors ; Encephalitis, Viral/prevention & control ; Humans ; Influenza, Human/prevention & control ; Travel ; Tropical Climate ; Virus Diseases/diagnosis ; Virus Diseases/prevention & control ; Virus Diseases/transmission ; Viruses/isolation & purification
Language	German
Publishing date	1994-08
Publishing country	Switzerland
Document type	English Abstract ; Journal Article
ZDB-ID	82044-1
ISSN	1664-2864 ; 0040-5930
ISSN (online)	1664-2864
ISSN	0040-5930
Database	MEDical Literature Analysis and Retrieval System OnLINE

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