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Article: A test of the interpretation of X-ray patterns of micelles.

HUGHES, E W

2004 Volume 165, Issue 4208, Page(s) 1017

MeSH term(s)	Colloids ; Micelles ; Soaps ; Solutions ; X-Rays
Chemical Substances	Colloids ; Micelles ; Soaps ; Solutions
Language	English
Publishing date	2004-08-03
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/1651017a0
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Bact. coli meningitis in adults.

HUGHES, E W / MANNING, G C

British medical journal

2003 Volume 1, Issue 4909, Page(s) 333–339

MeSH term(s)	Adult ; Bacterial Load ; Bacteriology ; Escherichia coli ; Escherichia coli Infections ; Humans ; Meningitis/microbiology
Language	English
Publishing date	2003-07-22
Publishing country	England
Document type	Journal Article
ZDB-ID	80088-0
ISSN	0007-1447 ; 0267-0623 ; 0959-8138 ; 0959-8146
ISSN	0007-1447 ; 0267-0623 ; 0959-8138 ; 0959-8146
DOI	10.1136/bmj.1.4909.333
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Article: A Staphylococcus aureus paraspinal abscess associated with epidural analgesia in labour.

Hill, J S / Hughes, E W / Robertson, P A

Anaesthesia

2001 Volume 56, Issue 9, Page(s) 873–878

Abstract: A case is described in which a parturient developed a Staphylococcus aureus paraspinal abscess following epidural analgesia in labour. We compared this case with other reported cases of paraspinal abscesses in obstetric patients. The presentation, ... ...

Abstract	A case is described in which a parturient developed a Staphylococcus aureus paraspinal abscess following epidural analgesia in labour. We compared this case with other reported cases of paraspinal abscesses in obstetric patients. The presentation, diagnosis and management of these cases were reviewed. Anaesthetists need to be aware that non-spinal-epidural abscesses can occur in patients with an associated labour epidural.
MeSH term(s)	Abscess/diagnosis ; Abscess/etiology ; Adult ; Analgesia, Epidural/adverse effects ; Analgesia, Obstetrical/adverse effects ; Female ; Humans ; Magnetic Resonance Imaging ; Pregnancy ; Soft Tissue Infections/diagnosis ; Soft Tissue Infections/etiology ; Spinal Diseases/diagnosis ; Spinal Diseases/etiology ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/etiology
Language	English
Publishing date	2001-09
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	80033-8
ISSN	1365-2044 ; 0003-2409
ISSN (online)	1365-2044
ISSN	0003-2409
DOI	10.1046/j.1365-2044.2001.02130-2.x
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Zs.A 388: Show issues

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Article: Carcinoid syndrome: the combined use of ketanserin and octreotide in the management of an acute crisis during anaesthesia.

Hughes, E W / Hodkinson, B P

Anaesthesia and intensive care

1989 Volume 17, Issue 3, Page(s) 367–370

MeSH term(s)	Anesthesia ; Breast Neoplasms/complications ; Carcinoid Tumor/complications ; Carcinoid Tumor/metabolism ; Female ; Humans ; Hypertension/drug therapy ; Hypertension/etiology ; Intraoperative Complications ; Ketanserin/therapeutic use ; Liver Neoplasms/complications ; Lymphatic Metastasis ; Middle Aged ; Octreotide/therapeutic use ; Spinal Cord Compression/etiology ; Spinal Cord Compression/surgery ; Syndrome
Chemical Substances	Ketanserin (97F9DE4CT4) ; Octreotide (RWM8CCW8GP)
Language	English
Publishing date	1989-08
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	187524-3
ISSN	1448-0271 ; 0310-057X
ISSN (online)	1448-0271
ISSN	0310-057X
DOI	10.1177/0310057X8901700324
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Zs.A 1017: Show issues

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Article: Proteoglycan-collagen relationships in developing chick and bovine tendons. Influence of the physiological environment.

Scott, J E / Hughes, E W

Connective tissue research

1986 Volume 14, Issue 4, Page(s) 267–278

Abstract: Developing and mature flexor digitorum tendons of chick and bovine origin were analyzed for nucleic acid, hydroxyproline, hyaluronate, chondroitin sulfate and sulfated glycosaminoglycan hexuronate. Collagen fibril diameters were determined by electron ... ...

Abstract	Developing and mature flexor digitorum tendons of chick and bovine origin were analyzed for nucleic acid, hydroxyproline, hyaluronate, chondroitin sulfate and sulfated glycosaminoglycan hexuronate. Collagen fibril diameters were determined by electron microscopy. Results are compared with similar data from rat tail tendon. Tissue hydroxyproline (mg/g) increased rapidly in early embryogenesis, while collagen fibril diameters remained relatively constant and small. Hyaluronate and chondroitin sulfate were present in considerable quantities, (phase I). A rapid increase in fibril diameters in midterm 'pregnancy' coincided with a decrease in hyaluronate and chondroitin sulfate contents (phase II). The transition from phase I to phase II was associated with the first loading by active muscles of the tendon, independently of whether the animal was pre- or post partum. The probable existence of a developmental program intrinsic to tendon itself, is discussed. The data are compared with predictions from three different simple models. Hyaluronate is concluded to be entirely interfibrillar, chondroitin sulfate is probably similarly distributed, whereas dermatan sulfate is entirely fibril-surface associated. The 'small' dermatan sulfate proteoglycan is assigned to the 'd' band in the gap zone.
MeSH term(s)	Animals ; Cattle ; Chick Embryo ; Chickens ; Chondroitin Sulfates/metabolism ; Collagen/metabolism ; Hyaluronic Acid/metabolism ; Hydroxyproline/metabolism ; Microscopy, Electron ; Nucleic Acids/metabolism ; Proteoglycans/metabolism ; Rats ; Tendons/embryology ; Tendons/growth & development
Chemical Substances	Nucleic Acids ; Proteoglycans ; Hyaluronic Acid (9004-61-9) ; Chondroitin Sulfates (9007-28-7) ; Collagen (9007-34-5) ; Hydroxyproline (RMB44WO89X)
Language	English
Publishing date	1986
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	185551-7
ISSN	1607-8438 ; 0300-8207 ; 0091-1690
ISSN (online)	1607-8438
ISSN	0300-8207 ; 0091-1690
DOI	10.3109/03008208609017470
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Zs.A 1093: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: The effects of KF-4317, a novel combined alpha- and beta 1-adrenoreceptor antagonist, on the rat isolated right ventricle and aorta.

Doggrell, S A / Hughes, E W

Journal of autonomic pharmacology

1986 Volume 6, Issue 1, Page(s) 25–32

Abstract: The effects of KF-4317 on the accumulation of radioactivity from [3H]-noradrenaline, and on the subsequent spontaneous and noradrenergic nerve-evoked outflow of radioactivity have been investigated in the rat isolated right ventricle. In addition the ... ...

Abstract	The effects of KF-4317 on the accumulation of radioactivity from [3H]-noradrenaline, and on the subsequent spontaneous and noradrenergic nerve-evoked outflow of radioactivity have been investigated in the rat isolated right ventricle. In addition the effects of KF-4317 on the contractions of the electrically-driven directly muscle stimulated rat right ventricle to isoprenaline and of the rat isolated aorta to phenylephrine and 5-hydroxytryptamine are reported. KF-4317 at 1 microM had no effect on the ability of the rat right ventricle to accumulate radioactivity from [3H]-noradrenaline. The spontaneous outflow of radioactivity, following loading of the ventricle with [3H]-noradrenaline, was increased by KF-4317 at 1 microM by a cocaine-insensitive mechanism. KF-4317 at 1 microM had no effect on the noradrenergic nerve-evoked outflow or radioactivity, and therefore is not an alpha 2-adrenoreceptor antagonist, but reduced the associated contractile response probably mainly by acting as an antagonist at postjunctional beta 1-adrenoreceptors. KF-4317 caused a parallel rightward shift of the concentration-response curve of the electrically-driven directly muscle stimulated rat right ventricle to isoprenaline. However the inhibitory effect, X9.0 and X237.2 in the presence of 0.1 and 1 microM KF-4317, was not closely concentration-related. At 1 microM, KF-4317 also depressed the maximum responses to isoprenaline. This suggests that in addition to beta 1-adrenoreceptor antagonism, KF-4317 probably exerts membrane stabilizing activity. The responses of the rat isolated aorta to phenylephrine were inhibited in a non-concentration related manner by KF-4317.(ABSTRACT TRUNCATED AT 250 WORDS)
MeSH term(s)	Adrenergic alpha-Antagonists/pharmacology ; Adrenergic beta-Antagonists/pharmacology ; Animals ; Aorta/drug effects ; Aorta/metabolism ; Benzeneacetamides ; Cocaine/pharmacology ; Drug Interactions ; Electric Stimulation ; Heart Ventricles/drug effects ; Heart Ventricles/metabolism ; In Vitro Techniques ; Isoproterenol/pharmacology ; Male ; Myocardial Contraction/drug effects ; Phenylephrine/antagonists & inhibitors ; Propanolamines/pharmacology ; Rats ; Rats, Inbred Strains ; Serotonin Antagonists/pharmacology ; Tritium/metabolism
Chemical Substances	Adrenergic alpha-Antagonists ; Adrenergic beta-Antagonists ; Benzeneacetamides ; Propanolamines ; Serotonin Antagonists ; Tritium (10028-17-8) ; Phenylephrine (1WS297W6MV) ; KF 4317 (76805-48-6) ; Cocaine (I5Y540LHVR) ; Isoproterenol (L628TT009W)
Language	English
Publishing date	1986-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604626-5
ISSN	1365-2680 ; 0144-1795
ISSN (online)	1365-2680
ISSN	0144-1795
DOI	10.1111/j.1474-8673.1986.tb00627.x
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Article: On the assessment of the beta-adrenoceptor blocking activity of propranolol using the rat isolated right ventricle.

Doggrell, S A / Hughes, E W

Journal of pharmacological methods

1986 Volume 15, Issue 2, Page(s) 119–131

Abstract: Two methods for determining pA2 values, the Schild regression and the use of the formula pA2 = pAx + log(x - 1), have been reassessed. The effects of propranolol on the contractile responses of the rat isolated right ventricle to isoprenaline were ... ...

Abstract	Two methods for determining pA2 values, the Schild regression and the use of the formula pA2 = pAx + log(x - 1), have been reassessed. The effects of propranolol on the contractile responses of the rat isolated right ventricle to isoprenaline were studied. The inhibitory effect with the lower concentrations of propranolol tested (3 X 10(-9) -10(-7) M) was solely competitive. Thus there was a parallel dextral displacement of the concentration-response curves to isoprenaline with no depression of the maximal responses. Dual antagonism was observed with the higher concentrations of propranolol tested (10(-6) and 3 X 10(-6) M), thereby showing a parallel displacement of the concentration-response curve to the lower concentrations of isoprenaline with a depression of the maximal responses. Without analysis of data for individual concentrations of propranolol on concentration-response curves to isoprenaline, Schild regression did not clearly illustrate that the antagonism was not solely competitive with the higher concentrations of propranolol. We suggest that data for individual concentrations of antagonist should always be analyzed to ascertain whether there has been a parallel shift of the concentration-response curves to agonist prior to determining pA2 values.
MeSH term(s)	Adrenergic beta-Antagonists/pharmacology ; Animals ; Heart/drug effects ; Hydrocortisone/pharmacology ; In Vitro Techniques ; Isoproterenol/pharmacology ; Male ; Myocardial Contraction/drug effects ; Phentolamine/pharmacology ; Propranolol/pharmacology ; Rats ; Rats, Inbred Strains ; Stimulation, Chemical
Chemical Substances	Adrenergic beta-Antagonists ; Propranolol (9Y8NXQ24VQ) ; Isoproterenol (L628TT009W) ; Hydrocortisone (WI4X0X7BPJ) ; Phentolamine (Z468598HBV)
Language	English
Publishing date	1986-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	435215-4
ISSN	1875-0206 ; 0160-5402
ISSN (online)	1875-0206
ISSN	0160-5402
DOI	10.1016/0160-5402(86)90061-6
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Article: Comparison of the effects of labetalol and SCH 19927, the R1R isomer of labetalol, on the rat isolated right ventricle and aorta.

Doggrell, S A / Hughes, E W

Journal of autonomic pharmacology

1985 Volume 5, Issue 4, Page(s) 279–288

Abstract: The effects of labetalol and its R1R isomer, SCH 19927, on the accumulation of radioactivity from [3H]-noradrenaline, and on the subsequent spontaneous and nerve-evoked outflow of radioactivity have been investigated in the rat isolated right ventricle. ... ...

Abstract	The effects of labetalol and its R1R isomer, SCH 19927, on the accumulation of radioactivity from [3H]-noradrenaline, and on the subsequent spontaneous and nerve-evoked outflow of radioactivity have been investigated in the rat isolated right ventricle. In addition, the effect of these agents on the contractions of the electrically-driven rat right ventricle to isoprenaline and of the rat isolated aorta to phenylephrine and 5-hydroxytryptamine are reported. Labetalol and SCH 19927 (both at 10(-6)M) inhibited the accumulation of radioactivity from [3H]-noradrenaline by 26 and 37%, respectively. The spontaneous outflow of radioactivity, following loading of the ventricle with [3H]-noradrenaline, was increased by labetalol and SCH 19927 (both at 10(-6)M) by a cocaine and idazoxan-insensitive mechanism. The nerve-evoked outflow of radioactivity was increased by labetalol and SCH 19927 (both at 10(-6)M). The ability of labetalol and SCH 19927, to increase nerve-evoked outflow was maintained in the presence of cocaine (10(-5)M) or idazoxan (10(-7)M) but reversed in the presence of cocaine and idazoxan. It is suggested that labetalol and its R1R isomer act both to inhibit neuronal uptake of noradrenaline and as antagonists at prejunctional alpha 2-adrenoreceptors. Labetalol and SCH 19927 reduced the contractile responses associated with the nerve-evoked outflow of radioactivity probably mainly by acting as antagonists at postjunctional beta 1-adrenoreceptors. The contractile responses of the electrically-driven rat right ventricle to isoprenaline were inhibited by labetalol and SCH 19927. SCH 12297 (pA2 = 8.9) was 4 times more potent than labetalol (pA2 = 8.3) as a beta 1-adrenoreceptor antagonist. The ability of labetalol and SCH 19927 at greater than or equal to 10(-7)M to depress maximal responses to isoprenaline may represent membrane stabilizing activity. The contractile responses of rat aorta to phenylephrine were inhibited by labetalol and SCH 19927. Labetalol (pA2 = 7.5) was 4X more potent than SCH 19927 (pA2 = 6.9) as an alpha 1-adrenoreceptor antagonist. SCH 19927 and labetalol had no effect on contractile responses to 5-hydroxytryptamine.
MeSH term(s)	Animals ; Aorta/drug effects ; Cocaine/pharmacology ; Dioxanes/pharmacology ; Dose-Response Relationship, Drug ; Drug Interactions ; Electric Stimulation ; Idazoxan ; In Vitro Techniques ; Isoproterenol/pharmacology ; Labetalol/pharmacology ; Male ; Myocardial Contraction/drug effects ; Norepinephrine/metabolism ; Phenylephrine/pharmacology ; Rats ; Rats, Inbred Strains ; Serotonin/pharmacology ; Stereoisomerism ; Vasoconstriction/drug effects
Chemical Substances	Dioxanes ; Phenylephrine (1WS297W6MV) ; Serotonin (333DO1RDJY) ; Cocaine (I5Y540LHVR) ; Isoproterenol (L628TT009W) ; Labetalol (R5H8897N95) ; Norepinephrine (X4W3ENH1CV) ; Idazoxan (Y310PA316B)
Language	English
Publishing date	1985-12
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604626-5
ISSN	1365-2680 ; 0144-1795
ISSN (online)	1365-2680
ISSN	0144-1795
DOI	10.1111/j.1474-8673.1985.tb00551.x
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Article: The effects of amosulalol, a novel combined alpha- and beta-adrenoreceptor antagonist, on the rat isolated right ventricle and aorta.

Hughes, E W / Doggrell, S A

Journal of autonomic pharmacology

1985 Volume 5, Issue 3, Page(s) 169–176

Abstract: The effect of amosulalol on the accumulation of radioactivity from [3H]-noradrenaline and on the subsequent spontaneous and nerve stimulation-evoked outflow of radioactivity have been investigated in the rat isolated right ventricle. In addition the ... ...

Abstract	The effect of amosulalol on the accumulation of radioactivity from [3H]-noradrenaline and on the subsequent spontaneous and nerve stimulation-evoked outflow of radioactivity have been investigated in the rat isolated right ventricle. In addition the effect of amosulalol on the contractions of the electrically-driven directly muscle stimulated rat right ventricle to isoprenaline and of the rat isolated aorta to phenylephrine and 5-hydroxytryptamine are reported. Amosulalol at 10(-6)M did not prevent the accumulation of radioactivity from a solution containing [3H]-noradrenaline. The spontaneous outflow of radioactivity, following loading of the ventricle with [3H]-noradrenaline, was increased by amosulalol at 10(-6)M by a cocaine- and idazoxan- insensitive mechanism. The nerve stimulation-evoked outflow of radioactivity was increased by amosulalol (10(-6)M), cocaine (10(-5)M) and idazoxan (10(-7)M). The ability of amosulalol to increase nerve-evoked outflow was maintained in the presence of cocaine but prevented by pretreatment with idazoxan. This suggests that amusulalol is an alpha 2-adrenoreceptor antagonist. The contractile response of the electrically-driven directly muscle stimulated right ventricle to isoprenaline were inhibited by amosulalol at 10(-7) and 10(-6)M with apparent pA2 values of 7.5 and 8.1, respectively. It is suggested that amosulalol at 10(-6)M may have an action additional to beta 1-adrenoreceptor antagonism on the right ventricle. The contractile responses of the rat aorta to phenylephrine were inhibited by amosulalol at 10(-7) and 10(-6)M with a pA2 of 8.6 which was independent of concentration. Amosulalol also reduced the magnitude of the maximal responses of the aorta to 5-hydroxytryptamine.
MeSH term(s)	Adrenergic alpha-Antagonists/pharmacology ; Adrenergic beta-Antagonists/pharmacology ; Animals ; Aorta, Thoracic/drug effects ; Electric Stimulation ; Ethanolamines/pharmacology ; Heart/drug effects ; In Vitro Techniques ; Isoproterenol/pharmacology ; Male ; Muscle Contraction/drug effects ; Muscle, Smooth, Vascular/drug effects ; Myocardial Contraction/drug effects ; Myocardium/metabolism ; Norepinephrine/metabolism ; Phenylephrine/pharmacology ; Rats ; Rats, Inbred Strains ; Serotonin/pharmacology
Chemical Substances	Adrenergic alpha-Antagonists ; Adrenergic beta-Antagonists ; Ethanolamines ; Phenylephrine (1WS297W6MV) ; Serotonin (333DO1RDJY) ; amosulalol (C69JI1BAU8) ; Isoproterenol (L628TT009W) ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	1985-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604626-5
ISSN	1365-2680 ; 0144-1795
ISSN (online)	1365-2680
ISSN	0144-1795
DOI	10.1111/j.1474-8673.1985.tb00117.x
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Article: FAMILIAL INTERSTITIAL PULMONARY FIBROSIS.

HUGHES, E W

Thorax

1964 Volume 19, Page(s) 515–525

MeSH term(s)	Adrenocorticotropic Hormone ; Anemia ; Anti-Bacterial Agents ; Antibiotics, Antitubercular ; Biopsy ; Genetics, Medical ; Geriatrics ; Pathology ; Prednisolone ; Pulmonary Fibrosis ; Radiography, Thoracic
Chemical Substances	Anti-Bacterial Agents ; Antibiotics, Antitubercular ; Adrenocorticotropic Hormone (9002-60-2) ; Prednisolone (9PHQ9Y1OLM)
Language	English
Publishing date	1964-11
Publishing country	England
Document type	Journal Article
ZDB-ID	204353-1
ISSN	1468-3296 ; 0040-6376
ISSN (online)	1468-3296
ISSN	0040-6376
DOI	10.1136/thx.19.6.515
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