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Article ; Online: Critical Importance of a One Health Approach to Antimicrobial Resistance.

White, Allison / Hughes, James M

2019 Volume 16, Issue 3, Page(s) 404–409

MeSH term(s)	Animals ; Animals, Wild ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial/drug effects ; Drug Resistance, Bacterial/genetics ; Drug Resistance, Bacterial/physiology ; Environment ; Global Health ; Guidelines as Topic ; Health Policy ; Humans ; Internationality ; Livestock ; One Health ; World Health Organization
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2019-06-28
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	2164327-1
ISSN	1612-9210 ; 1612-9202
ISSN (online)	1612-9210
ISSN	1612-9202
DOI	10.1007/s10393-019-01415-5
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Article ; Online: The fundamental ultrasonic edge wave mode: Propagation characteristics and potential for distant damage detection.

Hughes, James M / Mohabuth, Munawwar / Kotousov, Andrei / Ng, Ching-Tai

Ultrasonics

2021 Volume 114, Page(s) 106369

Abstract: Engineering structures are often composed of thin elements containing features such as free edges, welds, ribs, and holes, which makes distant safety inspections based on guided waves difficult due to wave scattering. However, these features can ... ...

Abstract	Engineering structures are often composed of thin elements containing features such as free edges, welds, ribs, and holes, which makes distant safety inspections based on guided waves difficult due to wave scattering. However, these features can themselves generate so-called 'feature-guided' waves, which can potentially be utilised for damage detection. One such example are flexural wedge waves, which have been investigated extensively both theoretically and experimentally in the past. Another example is edge waves. These waves, which are a natural analogue of Rayleigh waves propagating in a finite thickness plate, have received relatively little attention, specifically with respect to their possible use in distant damage inspections and Structural Health Monitoring systems. The current paper is aimed to address this gap, and it is focused on the investigation of the fundamental mode of edge waves (ES
Language	English
Publishing date	2021-02-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	200839-7
ISSN	1874-9968 ; 0041-624X
ISSN (online)	1874-9968
ISSN	0041-624X
DOI	10.1016/j.ultras.2021.106369
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Article ; Online: Preserving the lifesaving power of antimicrobial agents.

Hughes, James M

JAMA

2011 Volume 305, Issue 10, Page(s) 1027–1028

MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/drug therapy ; Drug Approval ; Drug Discovery ; Drug Industry ; Drug Resistance, Bacterial ; Humans ; Inappropriate Prescribing ; International Cooperation ; Population Surveillance ; Practice Patterns, Physicians' ; Public Health ; United States ; United States Food and Drug Administration
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2011-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2011.279
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Article: Antimicrobial Resistance, Food Safety, and One Health: The Need for Convergence.

Lammie, Samantha L / Hughes, James M

Annual review of food science and technology

2016 Volume 7, Page(s) 287–312

Abstract: Antimicrobial resistance is a complex, multifaceted, urgent global health problem. There is increasing concern about the emergence of multidrug-resistant superbugs. These superbugs result in infections responsive to treatment with few if any currently ... ...

Abstract	Antimicrobial resistance is a complex, multifaceted, urgent global health problem. There is increasing concern about the emergence of multidrug-resistant superbugs. These superbugs result in infections responsive to treatment with few if any currently available antimicrobial agents, reviving memories of the preantibiotic era and evoking concerns about a postantibiotic era. Use of antibiotics exerts selective pressure on pathogens as well as on commensal organisms that are part of the normal flora of humans, animals, and the environment; this favors the emergence of resistant strains and sometimes involves the food supply. Addressing this urgent threat requires implementation of a multifaceted strategy that has been articulated in the past few years; implementation will require sustained political will, investment in systems and research, and a One Health approach involving improved communication, cooperation, and collaboration among the many professional disciplines and organizations with important roles to play at the intersection of human, animal, and environmental health. Priorities include strengthened human and animal health surveillance and monitoring for resistant organisms, antimicrobial stewardship programs, infection-control programs, development and approval of new antimicrobial agents, research on innovative therapeutic approaches, development of rapid diagnostic tests and new vaccines, and educational programs that target professional groups and the public.
MeSH term(s)	Animals ; Anti-Bacterial Agents/adverse effects ; Campylobacter jejuni ; Clostridium difficile ; Drug Resistance, Microbial ; Enterobacteriaceae/enzymology ; Food Microbiology ; Food Safety ; Foodborne Diseases/microbiology ; Health Policy ; Health Promotion/methods ; Humans ; Interdisciplinary Communication ; Methicillin-Resistant Staphylococcus aureus ; Salmonella ; beta-Lactamases/biosynthesis
Chemical Substances	Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2516759-5
ISSN	1941-1421 ; 1941-1413
ISSN (online)	1941-1421
ISSN	1941-1413
DOI	10.1146/annurev-food-041715-033251
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Visual and auditory brain areas share a representational structure that supports emotion perception.

Sievers, Beau / Parkinson, Carolyn / Kohler, Peter J / Hughes, James M / Fogelson, Sergey V / Wheatley, Thalia

Current biology : CB

2021 Volume 31, Issue 23, Page(s) 5192–5203.e4

Abstract: Emotionally expressive music and dance occur together across the world. This may be because features shared across the senses are represented the same way even in different sensory brain areas, putting music and movement in directly comparable terms. ... ...

Abstract	Emotionally expressive music and dance occur together across the world. This may be because features shared across the senses are represented the same way even in different sensory brain areas, putting music and movement in directly comparable terms. These shared representations may arise from a general need to identify environmentally relevant combinations of sensory features, particularly those that communicate emotion. To test the hypothesis that visual and auditory brain areas share a representational structure, we created music and animation stimuli with crossmodally matched features expressing a range of emotions. Participants confirmed that each emotion corresponded to a set of features shared across music and movement. A subset of participants viewed both music and animation during brain scanning, revealing that representations in auditory and visual brain areas were similar to one another. This shared representation captured not only simple stimulus features but also combinations of features associated with emotion judgments. The posterior superior temporal cortex represented both music and movement using this same structure, suggesting supramodal abstraction of sensory content. Further exploratory analysis revealed that early visual cortex used this shared representational structure even when stimuli were presented auditorily. We propose that crossmodally shared representations support mutually reinforcing dynamics across auditory and visual brain areas, facilitating crossmodal comparison. These shared representations may help explain why emotions are so readily perceived and why some dynamic emotional expressions can generalize across cultural contexts.
MeSH term(s)	Acoustic Stimulation ; Auditory Perception ; Brain ; Brain Mapping ; Emotions ; Humans ; Magnetic Resonance Imaging ; Music/psychology ; Visual Perception
Language	English
Publishing date	2021-10-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2021.09.043
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Article ; Online: hOA-DN30: a highly effective humanized single-arm MET antibody inducing remission of 'MET-addicted' cancers.

Martinelli, Ilaria / Modica, Chiara / Chiriaco, Cristina / Basilico, Cristina / Hughes, James M / Corso, Simona / Giordano, Silvia / Comoglio, Paolo M / Vigna, Elisa

Journal of experimental & clinical cancer research : CR

2022 Volume 41, Issue 1, Page(s) 112

Abstract: Background: The tyrosine kinase receptor encoded by the MET oncogene is a major player in cancer. When MET is responsible for the onset and progression of the transformed phenotype (MET-addicted cancers), an efficient block of its oncogenic activation ... ...

Abstract	Background: The tyrosine kinase receptor encoded by the MET oncogene is a major player in cancer. When MET is responsible for the onset and progression of the transformed phenotype (MET-addicted cancers), an efficient block of its oncogenic activation results in potent tumor growth inhibition. Methods: Here we describe a molecular engineered MET antibody (hOA-DN30) and validate its pharmacological activity in MET-addicted cancer models in vitro and in vivo. Pharmacokinetics and safety profile in non-human primates have also been assessed. Results: hOA-DN30 efficiently impaired MET activation and the intracellular signalling cascade by dose and time dependent removal of the receptor from the cell surface (shedding). In vitro, the antibody suppressed cell growth by blocking cell proliferation and by concomitantly inducing cell death in multiple MET-addicted human tumor cell lines. In mice xenografts, hOA-DN30 induced an impressive reduction of tumor masses, with a wide therapeutic window. Moreover, the antibody showed high therapeutic efficacy against patient-derived xenografts generated from MET-addicted gastric tumors, leading to complete tumor regression and long-lasting effects after treatment discontinuation. Finally, hOA-DN30 showed a highly favorable pharmacokinetic profile and substantial tolerability in Cynomolgus monkeys. Conclusions: hOA-DN30 unique ability to simultaneously erase cell surface MET and release the 'decoy' receptor extracellular region results in a paramount MET blocking action. Its remarkable efficacy in a large number of pre-clinical models, as well as its pharmacological features and safety profile in non-human primates, strongly envisage a successful clinical application of this novel single-arm MET therapeutic antibody for the therapy of MET-addicted cancers.
MeSH term(s)	Animals ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Mice ; Proto-Oncogene Proteins c-met/metabolism ; Signal Transduction ; Stomach Neoplasms
Chemical Substances	Proto-Oncogene Proteins c-met (EC 2.7.10.1)
Language	English
Publishing date	2022-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	803138-1
ISSN	1756-9966 ; 0392-9078
ISSN (online)	1756-9966
ISSN	0392-9078
DOI	10.1186/s13046-022-02320-6
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Article: EZH2-Mediated H3K27me3 Targets Transcriptional Circuits of Neuronal Differentiation.

Buontempo, Serena / Laise, Pasquale / Hughes, James M / Trattaro, Sebastiano / Das, Vivek / Rencurel, Chantal / Testa, Giuseppe

Frontiers in neuroscience

2022 Volume 16, Page(s) 814144

Abstract: The Polycomb Repressive Complex 2 (PRC2) plays important roles in the epigenetic regulation of cellular development and differentiation through H3K27me3-dependent transcriptional repression. Aberrant PRC2 activity has been associated with cancer and ... ...

Abstract	The Polycomb Repressive Complex 2 (PRC2) plays important roles in the epigenetic regulation of cellular development and differentiation through H3K27me3-dependent transcriptional repression. Aberrant PRC2 activity has been associated with cancer and neurodevelopmental disorders, particularly with respect to the malfunction of sits catalytic subunit EZH2. Here, we investigated the role of the EZH2-mediated H3K27me3 apposition in neuronal differentiation. We made use of a transgenic mouse model harboring
Language	English
Publishing date	2022-05-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2022.814144
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Article ; Online: Correction: hOA-DN30: a highly effective humanized single-arm MET antibody inducing remission of 'MET-addicted' cancers.

Martinelli, Ilaria / Modica, Chiara / Chiriaco, Cristina / Basilico, Cristina / Hughes, James M / Corso, Simona / Giordano, Silvia / Comoglio, Paolo M / Vigna, Elisa

Journal of experimental & clinical cancer research : CR

2022 Volume 41, Issue 1, Page(s) 180

Language	English
Publishing date	2022-05-24
Publishing country	England
Document type	Published Erratum
ZDB-ID	803138-1
ISSN	1756-9966 ; 0392-9078
ISSN (online)	1756-9966
ISSN	0392-9078
DOI	10.1186/s13046-022-02398-y
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Article: Prioritizing a One Health Approach in the Immediate Fight Against Antimicrobial Resistance

Ogawa, V. Ayano / Hughes, James M / King, Lonnie J / Shah, Cecilia M

EcoHealth. 2019 Sept., v. 16, no. 3

2019

Abstract: Antimicrobial resistance is a major threat to global health security. While the global community has made recent advances to mitigate the threat of antimicrobial resistance, we continue to face challenges in creating solutions and concrete actions that ... ...

Abstract	Antimicrobial resistance is a major threat to global health security. While the global community has made recent advances to mitigate the threat of antimicrobial resistance, we continue to face challenges in creating solutions and concrete actions that will yield the greatest immediate impact. To examine the critical areas in human, animal and environmental health that contribute to the emergence and spread of antimicrobial resistance, the Forum on Microbial Threats of the U.S. National Academies of Sciences, Engineering and Medicine hosted a public workshop on June 20–21, 2017 in Washington, DC. This article summarizes the final synthesis discussion that took place at the workshop on suggestions for immediate actions and implementation that are feasible and cost-effective for combating antimicrobial resistance across the One Health domains. The priorities that emerged from the participants’ discussions addressed the following topics: (1) Surveillance; (2) Stewardship, Infection Prevention and Behavior Modification; (3) Basic and Applied Research and Development; and (4) Global Policy and Coordination.
Keywords	antibiotic resistance ; applied research ; behavior modification ; cost effectiveness ; environmental health ; human health ; issues and policy ; monitoring ; One Health initiative ; research and development
Language	English
Dates of publication	2019-09
Size	p. 410-413.
Publishing place	Springer US
Document type	Article
ZDB-ID	2164327-1
ISSN	1612-9210 ; 1612-9202
ISSN (online)	1612-9210
ISSN	1612-9202
DOI	10.1007/s10393-018-1325-6
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Prioritizing a One Health Approach in the Immediate Fight Against Antimicrobial Resistance.

Ogawa, V Ayano / Shah, Cecilia M / Hughes, James M / King, Lonnie J

EcoHealth

2018 Volume 16, Issue 3, Page(s) 410–413

Abstract	Antimicrobial resistance is a major threat to global health security. While the global community has made recent advances to mitigate the threat of antimicrobial resistance, we continue to face challenges in creating solutions and concrete actions that will yield the greatest immediate impact. To examine the critical areas in human, animal and environmental health that contribute to the emergence and spread of antimicrobial resistance, the Forum on Microbial Threats of the U.S. National Academies of Sciences, Engineering and Medicine hosted a public workshop on June 20-21, 2017 in Washington, DC. This article summarizes the final synthesis discussion that took place at the workshop on suggestions for immediate actions and implementation that are feasible and cost-effective for combating antimicrobial resistance across the One Health domains. The priorities that emerged from the participants' discussions addressed the following topics: (1) Surveillance; (2) Stewardship, Infection Prevention and Behavior Modification; (3) Basic and Applied Research and Development; and (4) Global Policy and Coordination.
MeSH term(s)	Animals ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/pharmacology ; Antimicrobial Stewardship/organization & administration ; Communicable Disease Control/organization & administration ; Drug Resistance, Bacterial/drug effects ; Drug Resistance, Bacterial/genetics ; Drug Resistance, Bacterial/physiology ; Global Health ; Guidelines as Topic ; Health Policy ; Humans ; Livestock ; One Health ; Population Surveillance/methods ; Research/organization & administration
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2018-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2164327-1
ISSN	1612-9210 ; 1612-9202
ISSN (online)	1612-9210
ISSN	1612-9202
DOI	10.1007/s10393-018-1325-6
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