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Article ; Online: Care home staff perceptions of implementing a quality of life instrument into routine care practice: A qualitative study.

Hughes, Laura J / Daley, Stephanie / Farina, Nicolas / Tabet, Naji / Banerjee, Sube

2022 Volume 30, Issue 6, Page(s) e6500–e6510

Abstract: Quality of life is an important outcome in older-adult care. Measuring resident quality of life may offer ways to improve it and to improve quality of care. However, in the UK quality of life is rarely measured as a part of routine care. Our study aimed ... ...

Abstract	Quality of life is an important outcome in older-adult care. Measuring resident quality of life may offer ways to improve it and to improve quality of care. However, in the UK quality of life is rarely measured as a part of routine care. Our study aimed to understand the views of care home staff about using a quality of life instrument as a part of routine care in order to support its implementation into routine practice. In a qualitative study, we conducted 35 interviews with care home staff and two focus groups with four care home managers from three care homes in East Sussex, England. Data were collected between September 2015 and February 2016. Care staff and managers were aged on average 40 (SD = 12.2) and 43.7 (SD = 14.4) years and had worked in the care sector an average of 11.4 (SD = 10.2) and 23.7 (SD = 14.1) years, respectively. Participants were predominantly female and white British. Interviews and focus groups were analysed using thematic analysis. Findings identified two overarching themes of 'Perceived gains' and 'Implementation'. Overall, there was a lot of positivity towards using a quality of life instrument in routine practice. This positivity was an important feature in how the instrument was perceived as fitting into practice. Participants identified several barriers and discussed how to overcome them. Results from the study demonstrate that routine measurement of quality of life is positively received by care staff. They believed that measuring quality of life as a part of care practice could lead to improvements in resident quality of life, staff knowledge and understanding and care practices. The findings suggest that routinely measuring quality of life as a part of normal care could also have more far-reaching effects on the provision of person-centred care provided by care staff.
MeSH term(s)	Adult ; Female ; Humans ; Aged ; Male ; Nursing Homes ; Quality of Life ; Dementia ; Qualitative Research ; Focus Groups
Language	English
Publishing date	2022-10-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1155902-0
ISSN	1365-2524 ; 0966-0410
ISSN (online)	1365-2524
ISSN	0966-0410
DOI	10.1111/hsc.14095
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Zs.A 3728: Show issues

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Article ; Online: Measuring adolescent attitudes towards dementia: The revalidation and refinement of the A-ADS.

Farina, Nicolas / Griffiths, Alys W / Hughes, Laura J / Parveen, Sahdia

Journal of health psychology

2020 Volume 27, Issue 2, Page(s) 374–385

Abstract: The A-ADS is one the first validated measures of attitudes of dementia in adolescents, though further validation is needed. 630 adolescents were recruited from secondary schools in England. A Principal Component Analysis was completed ( ...

Abstract	The A-ADS is one the first validated measures of attitudes of dementia in adolescents, though further validation is needed. 630 adolescents were recruited from secondary schools in England. A Principal Component Analysis was completed (
MeSH term(s)	Adolescent ; Attitude ; Dementia/diagnosis ; Factor Analysis, Statistical ; Humans ; Psychometrics ; Reproducibility of Results ; Surveys and Questionnaires
Language	English
Publishing date	2020-09-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2021897-7
ISSN	1461-7277 ; 1359-1053
ISSN (online)	1461-7277
ISSN	1359-1053
DOI	10.1177/1359105320953479
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Article ; Online: The Relationship Between Physical Activity and Health-Related Quality of Life in People With Dementia: An Observational Study.

Farina, Nicolas / Hughes, Laura J / Thomas, Serena / Lowry, Ruth G / Banerjee, Sube

Journal of aging and physical activity

2021 Volume 30, Issue 4, Page(s) 626–634

Abstract: Recent research suggests the positive effect of physical activity on health-related quality of life in people with dementia may be mediated through improved activities of daily living and reduced depressive symptoms. One hundred and twenty-four people ... ...

Abstract	Recent research suggests the positive effect of physical activity on health-related quality of life in people with dementia may be mediated through improved activities of daily living and reduced depressive symptoms. One hundred and twenty-four people with dementia and their informal carers were recruited from the South East of England for this observational study. A subset of participants wore an accelerometer for 30 days. A series of bivariate analyses were completed, alongside mediation analyses. In people with mild to moderate severity dementia, weak positive associations were widely reported between physical activity indices and health-related quality of life, though only a single association reached statistical significance (rs = .25, p = .03). Mediation analysis revealed no significant indirect effects across the models after controlling for cognition. Future research needs to explore such relationships with a greater emphasis on the modality and psychosocial components of physical activity rather than just frequency, duration, and intensity.
MeSH term(s)	Activities of Daily Living ; Caregivers/psychology ; Dementia/psychology ; Exercise ; Humans ; Quality of Life
Language	English
Publishing date	2021-10-22
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ISSN	1543-267X
ISSN (online)	1543-267X
DOI	10.1123/japa.2021-0189
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Use of Physical Activity Questionnaires in People With Dementia: A Scoping Review.

Farina, Nicolas / Hughes, Laura J / Watts, Amber / Lowry, Ruth G

Journal of aging and physical activity

2019 Volume 27, Issue 3, Page(s) 413–421

Abstract: Physical activity questionnaires are an important means to assess habitual physical activity. It remains unclear what questionnaires are used and whether they are appropriate for people with dementia who have impaired information recall but are also ... ...

Abstract	Physical activity questionnaires are an important means to assess habitual physical activity. It remains unclear what questionnaires are used and whether they are appropriate for people with dementia who have impaired information recall but are also often largely sedentary. This scoping review aimed to identify and quantify the use of physical activity questionnaires within a dementia population. Eighteen studies met the inclusion criteria for this review. The majority of studies used questionnaires that were validated for use within an older adult population (e.g., Modified Baecke Questionnaire for the Elderly), though none had specifically been validated for use in people with dementia. Interestingly, just over half of the studies (
MeSH term(s)	Aged ; Alzheimer Disease/physiopathology ; Alzheimer Disease/psychology ; Exercise/physiology ; Female ; Humans ; Quality of Life ; Reproducibility of Results ; Surveys and Questionnaires
Language	English
Publishing date	2019-03-13
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1543-267X
ISSN (online)	1543-267X
DOI	10.1123/japa.2018-0031
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Adolescents' experiences and perceptions of dementia.

Farina, Nicolas / Hughes, Laura J / Griffiths, Alys W / Parveen, Sahdia

Aging & mental health

2019 Volume 24, Issue 7, Page(s) 1175–1181

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Adolescent ; Attitude ; Dementia ; England ; Female ; Humans ; Male ; Surveys and Questionnaires
Language	English
Publishing date	2019-05-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1474804-6
ISSN	1364-6915 ; 1360-7863
ISSN (online)	1364-6915
ISSN	1360-7863
DOI	10.1080/13607863.2019.1613343
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Zs.A 5081: Show issues

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Article ; Online: Adaptation of the DEMQOL-Proxy for routine use in care homes: a cross-sectional study of the reliability and validity of DEMQOL-CH.

Hughes, Laura J / Farina, Nicolas / Page, Thomas E / Tabet, Naji / Banerjee, Sube

BMJ open

2019 Volume 9, Issue 8, Page(s) e028045

Abstract: Objective: To investigate the routine use of a measure of quality of life (QoL) in care homes and assess its psychometric properties when used by care staff.: Design: A cross-sectional two-phase study.: Setting and participants: Data were ... ...

Abstract	Objective: To investigate the routine use of a measure of quality of life (QoL) in care homes and assess its psychometric properties when used by care staff. Design: A cross-sectional two-phase study. Setting and participants: Data were collected from care staff in seven care homes in East Sussex, England. Method: Phase I: The ability of care staff from two care homes to use the DEMQOL-Proxy without interviewer administration was assessed using agreement analysis between a self-administered and interviewer-administered version of the instrument. Based on these findings, DEMQOL-Proxy was adapted into a new version, DEMQOL-CH, for use as a self-administered instrument in care homes. We assessed agreement between the new DEMQOL-CH and DEMQOL-Proxy to ensure DEMQOL-CH was used correctly. Phase II: A preliminary assessment of the psychometric properties of DEMQOL-CH when used routinely was completed in a further five care homes. Results: Phase I: Nineteen care staff from two care homes completed QoL measurements for residents. Systematic error was identified when staff self-completed the DEMQOL-Proxy without an interviewer. We modified the DEMOoL-Proxy to create DEMQOL-CH; this reduced the error, producing a version that could be used more accurately by care staff. Phase II: Eleven care staff from five care homes rated resident QoL routinely. DEMQOL-CH showed acceptable psychometric properties with satisfactory reliability and validity and a clear factor structure. Conclusions: The research presents positive preliminary data on the acceptability, feasibility and performance of routine QoL measurement in care homes using an adapted version of DEMQOL-Proxy, the DEMQOL-CH. Results provide evidence to support the concept that routine measurement of QoL may be possible in care homes. Research is needed to refine and test the methodology and instrument further and to explore the potential for benefits to residents, staff and care homes in larger and more representative populations.
MeSH term(s)	Adolescent ; Adult ; Aged ; Caregivers ; Cognitive Dysfunction ; Cross-Sectional Studies ; Dementia/psychology ; Diagnostic Self Evaluation ; England ; Female ; Humans ; Male ; Middle Aged ; Psychometrics/instrumentation ; Quality of Life/psychology ; Reproducibility of Results ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2019-08-08
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Validation Study
ZDB-ID	2747269-3
ISSN	2044-6055 ; 2044-6055 ; 2053-3624
ISSN (online)	2044-6055
ISSN	2044-6055 ; 2053-3624
DOI	10.1136/bmjopen-2018-028045
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Article ; Online: Psychometric properties and feasibility of use of dementia specific quality of life instruments for use in care settings: a systematic review.

Hughes, Laura J / Farina, Nicolas / Page, Thomas E / Tabet, Naji / Banerjee, Sube

International psychogeriatrics

2019 Volume 33, Issue 9, Page(s) 917–931

Abstract: Background: Over 400,000 people live in care home settings in the UK. One way of understanding and improving the quality of care provided is by measuring and understanding the quality of life (QoL) of those living in care homes. This review aimed to ... ...

Abstract	Background: Over 400,000 people live in care home settings in the UK. One way of understanding and improving the quality of care provided is by measuring and understanding the quality of life (QoL) of those living in care homes. This review aimed to identify and examine the psychometric properties including feasibility of use of dementia-specific QoL measures developed or validated for use in care settings. Design: Systematic review. Methods: Instruments were identified using four electronic databases (PubMed, PsycINFO, Web of Science, and CINAHL) and lateral search techniques. Searches were conducted in January 2017. Studies which reported on the development and/or validation of dementia specific QoL instruments for use in care settings written in English were eligible for inclusion. The methodological quality of the studies was assessed using the COSMIN checklist. Feasibility was assessed using a checklist developed specifically for the review. Results: Six hundred and sixteen articles were identified in the initial search. After de-duplication, screening and further lateral searches were performed, 25 studies reporting on 9 dementia-specific QoL instruments for use in care home settings were included in the review. Limited evidence was available on the psychometric properties of many instruments identified. Higher-quality instruments were not easily accessible or had low feasibility of use. Conclusions: Few high-quality instruments of QoL validated for use in care home settings are readily or freely available. This review highlights the need to develop a well-validated measure of QoL for use within care homes that is also feasible and accessible.
MeSH term(s)	Checklist ; Dementia/therapy ; Feasibility Studies ; Humans ; Psychometrics ; Quality of Life
Language	English
Publishing date	2019-01-03
Publishing country	England
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	1038825-4
ISSN	1741-203X ; 1041-6102
ISSN (online)	1741-203X
ISSN	1041-6102
DOI	10.1017/S1041610218002259
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Zs.A 2621: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 513: Show issues

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Article: Comparison of Zika virus inactivation methods for reagent production and disinfection methods

Chida, Asiya S. / Goldstein, Jason M. / Lee, Joo / Tang, Xiaoling / Bedi, Kanwar / Herzegh, Owen / Moon, Jonathan L. / Petway, David / Bagarozzi, Dennis A. / Hughes, Laura J.

Journal of virological methods. 2021 Jan., v. 287

2021

Abstract: Zika virus (ZIKV) infection remains a public health concern necessitating demand for long-term virus production for diagnostic assays and R&D activities. Inactivated virus constitutes an important component of the Trioplex rRT-PCR assay and serological ... ...

Abstract	Zika virus (ZIKV) infection remains a public health concern necessitating demand for long-term virus production for diagnostic assays and R&D activities. Inactivated virus constitutes an important component of the Trioplex rRT-PCR assay and serological IgM assay (MAC-ELISA). The aim of our study is to establish standard methods of ZIKV inactivation while maintaining antigenicity and RNA integrity. We tested viral supernatants by four different inactivation methods: 1. Heat inactivation at 56 °C and 60 °C; 2. Gamma-Irradiation; 3. Chemical inactivation by Beta-propiolactone (BPL) and 4. Fast-acting commercial disinfecting agents. Effectivity was measured by cytopathic effect (CPE) and plaque assay. RNA stability and antigenicity were measured by RT-PCR and MAC-ELISA, respectively. Results: Heat inactivation: Low titer samples, incubated at 56 °C for 2 h, showed neither CPE or plaques compared to high titer supernatants that required 2.5 h. Inactivation occurred at 60 °C for 60 min with all virus titers. Gamma irradiation: Samples irradiated at ≥3 Mrad for low virus concentrations and ≥5Mrad for high virus titer completely inactivated virus. Chemical Inactivation: Neither CPE nor plaques were observed with ≥0.045 % BPL inactivation of ZIKV. Disinfectant: Treatment of viral supernatants with Micro-Chem Plus™, inactivated virus in 2 min, whereas, Ethanol (70 %) and STERIS Coverage® Spray TB inactivated the virus in 5 min.
Keywords	RNA ; Zika virus ; cytopathogenicity ; disinfectants ; disinfection ; ethanol ; gamma radiation ; heat inactivation ; public health ; viral load ; viruses
Language	English
Dates of publication	2021-01
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	8013-5
ISSN	1879-0984 ; 0166-0934
ISSN (online)	1879-0984
ISSN	0166-0934
DOI	10.1016/j.jviromet.2020.114004
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 1565: Show issues

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Article: Design and Optimization of a

Taha, Taha Y / Townsend, Michael B / Pohl, Jan / Karem, Kevin L / Damon, Inger K / Mbala Kingebeni, Placide / Muyembe Tamfum, Jean-Jacques / Martin, James W / Pittman, Phillip R / Huggins, John W / Satheshkumar, Panayampalli S / Bagarozzi, Dennis A / Reynolds, Mary G / Hughes, Laura J

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 3

Abstract: Monkeypox virus (MPXV), a member of ... ...

Abstract	Monkeypox virus (MPXV), a member of the
Language	English
Publishing date	2023-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12030396
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Article ; Online: COVID-19 health information needs of older adults from ethnic minority groups in the UK: a qualitative study.

Paudyal, Priyamvada / Skinner, Emily / Majeed-Hajaj, Saliha / Hughes, Laura J / Magar, Naresh Khapangi / Keeling, Debbie Isobel / Armes, Jo / Kulasabanathan, Kavian / Ford, Elizabeth / Sharp, Rebecca / Cassell, Jackie A

BMJ open

2022 Volume 12, Issue 6, Page(s) e059844

Abstract: Objective: This study aimed to identify the COVID-19 health information needs of older adults from ethnic minority groups in the UK.: Study design: A qualitative study using semistructured interviews.: Setting and participants: Indian and Nepalese ...

Abstract	Objective: This study aimed to identify the COVID-19 health information needs of older adults from ethnic minority groups in the UK. Study design: A qualitative study using semistructured interviews. Setting and participants: Indian and Nepalese older adults (≥65 years), their families (≥18 years) and healthcare professionals (HCPs) (≥18 years) engaging with these communities. Participants were recruited between July and December 2020 from Kent, Surrey and Sussex through community organisations. Results: 24 participants took part in the study; 13 older adults, 7 family members and 4 HCPs. Thirteen participants were female, and the majority (n=17) spoke a language other than English at home. Older participants mostly lived in multigenerational households, and family and community were key for providing support and communicating about healthcare needs. Participants' knowledge of COVID-19 varied widely; some spoke confidently about the subject, while others had limited information. Language and illiteracy were key barriers to accessing health information. Participants highlighted the need for information in multiple formats and languages, and discussed the importance of culturally appropriate avenues, such as community centres and religious sites, for information dissemination. Conclusion: This study, undertaken during the COVID-19 pandemic, provides insight into how health information can be optimised for ethnic minority older adults in terms of content, format and cultural relevance. The study highlights that health information interventions should recognise the intersection between multigenerational living, family structure, and the health and well-being of older adults, and should promote intergenerational discussion.
MeSH term(s)	Aged ; COVID-19/epidemiology ; Ethnic and Racial Minorities ; Ethnicity ; Female ; Humans ; Male ; Minority Groups ; Pandemics ; Qualitative Research ; United Kingdom/epidemiology
Language	English
Publishing date	2022-06-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-059844
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