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  1. Article: Truth be told-perspectives on openness.

    Hughes, R E / Richards, J

    Current oncology (Toronto, Ont.)

    2014  Volume 21, Issue 3, Page(s) e525–7

    Language English
    Publishing date 2014-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3747/co.21.1734
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    Zs.A 4305: Show issues Location:
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  2. Article ; Online: Probable pulmonary embolism with repeat administration of prothrombin complex concentrate in a factor Xa inhibitor patient.

    King, G S / Cottingham, L G / Hughes, R E / Ratliff, P D

    Journal of clinical pharmacy and therapeutics

    2018  Volume 43, Issue 6, Page(s) 903–905

    Abstract: What is known and objective: Prothrombin complex concentrate (PCC) is a plasma-derived concentrate used to replenish clotting factors. There are limited recommendations for treating coagulopathy induced by direct oral anticoagulants (DOAC). Data are ... ...

    Abstract What is known and objective: Prothrombin complex concentrate (PCC) is a plasma-derived concentrate used to replenish clotting factors. There are limited recommendations for treating coagulopathy induced by direct oral anticoagulants (DOAC). Data are limited regarding both total dose and repeated dosing with this population.
    Case summary: We describe a case of an adult patient anticoagulated with apixaban who received two 35 unit/kg doses of PCC resulting in suspected pulmonary embolism.
    What is new and conclusion: Treatment of DOAC-induced bleeding remains an "off-label" indication for PCC. Additional doses should be given with caution if given at all and patients monitored closely.
    MeSH term(s) Aged ; Blood Coagulation Factors/administration & dosage ; Blood Coagulation Factors/adverse effects ; Factor Xa Inhibitors/administration & dosage ; Factor Xa Inhibitors/adverse effects ; Hemorrhage/chemically induced ; Hemorrhage/therapy ; Humans ; Male ; Off-Label Use ; Pulmonary Embolism/etiology ; Pulmonary Embolism/pathology ; Pyrazoles/administration & dosage ; Pyrazoles/adverse effects ; Pyridones/administration & dosage ; Pyridones/adverse effects
    Chemical Substances Blood Coagulation Factors ; Factor Xa Inhibitors ; Pyrazoles ; Pyridones ; prothrombin complex concentrates (37224-63-8) ; apixaban (3Z9Y7UWC1J)
    Language English
    Publishing date 2018-06-09
    Publishing country England
    Document type Case Reports
    ZDB-ID 639006-7
    ISSN 1365-2710 ; 0269-4727
    ISSN (online) 1365-2710
    ISSN 0269-4727
    DOI 10.1111/jcpt.12719
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  3. Article ; Online: Readmission Rates for One Versus Two-Midnight Length of Stay for Primary Total Knee Arthroplasty: Analysis of the Michigan Arthroplasty Registry Collaborative Quality Initiative (MARCQI) Database.

    Charpentier, P M / Srivastava, A K / Zheng, H / Ostrander, J D / Hughes, R E

    The Journal of bone and joint surgery. American volume

    2018  Volume 100, Issue 20, Page(s) 1757–1764

    Abstract: Background: The length of stay (LOS) in the hospital for total knee arthroplasty (TKA) has been declining over recent decades. The purpose of this study was to determine if patients with an LOS for TKA that includes only 1 midnight have an increased ... ...

    Abstract Background: The length of stay (LOS) in the hospital for total knee arthroplasty (TKA) has been declining over recent decades. The purpose of this study was to determine if patients with an LOS for TKA that includes only 1 midnight have an increased odds of 90-day readmission compared with those with a 2-midnight LOS. We also sought to identify any predictors of 90-day hospital readmission among those readmitted during our period of analysis.
    Methods: A retrospective review of the Michigan Arthroplasty Registry Collaborative Quality Initiative (MARCQI) database was performed to identify patients with a 1-midnight or 2-midnight LOS for TKA during a 5-year period. The primary end point of this study was inpatient readmission within the 90-day postoperative period. A multiple logistic regression model and propensity score matching were used to compare the odds of 90-day readmission between 1-midnight and 2-midnight LOS. The secondary end points of this study were 90-day complications.
    Results: There were 96,250 TKA procedures identified in the database, and 46,709 met our inclusion criteria for LOS. No difference in 90-day-readmission odds between patients with a 1-midnight LOS and those with a 2-midnight LOS for primary TKA was identified. Male sex, single marital status, age of ≥80 years, type-I diabetes, previous smoking, narcotic use prior to surgery, and a higher American Society of Anesthesiologists (ASA) scores increased the odds of 90-day readmission. Patients in the age group of ≥50 to <65 years, those with a higher preoperative hemoglobin level, and those with a positive social history of alcohol use were found to have decreased odds of readmission.
    Conclusions: We found no association between the LOS for primary TKA (1 midnight compared with 2 midnights) and the 90-day readmission risk.
    Level of evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
    MeSH term(s) Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Knee ; Databases, Factual ; Female ; Humans ; Length of Stay/statistics & numerical data ; Male ; Michigan ; Middle Aged ; Patient Readmission/statistics & numerical data ; Postoperative Complications/epidemiology ; Registries ; Retrospective Studies ; Time Factors
    Language English
    Publishing date 2018-10-18
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 220625-0
    ISSN 1535-1386 ; 0021-9355
    ISSN (online) 1535-1386
    ISSN 0021-9355
    DOI 10.2106/JBJS.18.00166
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    Zs.MO 464: Show issues

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  4. Article: The use of homocysteine in the estimation of dehydroascorbic acid.

    HUGHES, R E

    The Biochemical journal

    2003  Volume 64, Issue 1, Page(s) 203–208

    MeSH term(s) Ascorbic Acid/analogs & derivatives ; Cysteine/analogs & derivatives ; Dehydroascorbic Acid ; Homocysteine ; Vitamins
    Chemical Substances Vitamins ; Homocysteine (0LVT1QZ0BA) ; Cysteine (K848JZ4886) ; Ascorbic Acid (PQ6CK8PD0R) ; Dehydroascorbic Acid (Y2Z3ZTP9UM)
    Language English
    Publishing date 2003-07-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2969-5
    ISSN 1470-8728 ; 0264-6021 ; 0006-2936 ; 0306-3275
    ISSN (online) 1470-8728
    ISSN 0264-6021 ; 0006-2936 ; 0306-3275
    DOI 10.1042/bj0640203
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  5. Article: Effect of optimization criterion on spinal force estimates during asymmetric lifting.

    Hughes, R E

    Journal of biomechanics

    2000  Volume 33, Issue 2, Page(s) 225–229

    Abstract: Optimization-based muscle force prediction models of the lumbar region are used in research and ergonomic practice, usually as a subroutine of a job analysis software package. Various optimization criteria have been put forward for use in rationally ... ...

    Abstract Optimization-based muscle force prediction models of the lumbar region are used in research and ergonomic practice, usually as a subroutine of a job analysis software package. Various optimization criteria have been put forward for use in rationally selecting a set of muscle forces to satisfy moment equilibrium, including the sum of cubed muscle contraction intensities and a double linear programming procedure for minimizing the spinal compression force and maximum muscle contraction intensity. A laboratory study was conducted to determine whether these two model formulations produce significantly different estimates of spinal forces for a dynamic asymmetric lift. Although statistically significant differences were found between the predictions of the two models, the difference in peak spinal compression force was only 1.1%.
    MeSH term(s) Adult ; Compressive Strength ; Female ; Forecasting ; Humans ; Lumbosacral Region ; Male ; Muscle Contraction/physiology ; Muscle, Skeletal/physiology ; Spine/physiology ; Weight Lifting/physiology
    Language English
    Publishing date 2000-02
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 218076-5
    ISSN 1873-2380 ; 0021-9290
    ISSN (online) 1873-2380
    ISSN 0021-9290
    DOI 10.1016/s0021-9290(99)00153-0
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    Zs.A 700: Show issues Location:
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  6. Article: Mauritian Endemic Medicinal Plant Extracts Induce G2/M Phase Cell Cycle Arrest and Growth Inhibition of Oesophageal Squamous Cell Carcinoma in Vitro.

    Rummun, N / Hughes, R E / Beesoo, R / Li, W W / Aldulaimi, O / Macleod, K G / Bahorun, T / Carragher, N O / Kagansky, A / Neergheen-Bhujun, V S

    Acta naturae

    2019  Volume 11, Issue 1, Page(s) 81–90

    Abstract: Terrestrial plants have contributed massively to the development of modern oncologic drugs. Despite the wide acceptance of Mauritian endemic flowering plants in traditional medicine, scientific evidence of their chemotherapeutic potential is lacking. ... ...

    Abstract Terrestrial plants have contributed massively to the development of modern oncologic drugs. Despite the wide acceptance of Mauritian endemic flowering plants in traditional medicine, scientific evidence of their chemotherapeutic potential is lacking. This study aimed to evaluate the
    Language English
    Publishing date 2019-02-08
    Publishing country Russia (Federation)
    Document type Journal Article
    ISSN 2075-8251
    ISSN 2075-8251
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  7. Article: Upper extremity musculoskeletal disorders at a pulp and paper mill.

    Silverstein, B A / Hughes, R E

    Applied ergonomics

    2004  Volume 27, Issue 3, Page(s) 189–194

    Abstract: A small cross-sectional study of upper extremity disorders was conducted in two departments of a pulp and paper mill. The objective of the study was to determine the prevalence of upper extremity disorders and identify any associated work place risk ... ...

    Abstract A small cross-sectional study of upper extremity disorders was conducted in two departments of a pulp and paper mill. The objective of the study was to determine the prevalence of upper extremity disorders and identify any associated work place risk factors in long cycle jobs with multiple tasks of varying duration. Physical exams and health status interviews were conducted on 23 employees (77%) in the paper machine department and on 17 employees (59%) of the power and recovery department. All participants completed questionnaires on physical and psychosocial job characteristics. There was a statistically significant difference in hand and wrist disorders between the two departments at the p < 0.05 level (34.8% in the power and recovery department, and 5.9% in the paper machine area). Multiple logistic regression models showed a significant relationship between the use of a steel lance and shoulder disorders. Elbow arthritis was also associated with lance usage. There was evidence that the job analysis was not able to fully describe the risk factors present in the paper machine department. Biomechanical exposures existing prior to the time of the study may not have been adequately characterized. An important aspect of this study is that the jobs studied were not typical repetitive jobs that are commonly studied.
    Language English
    Publishing date 2004-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2003513-5
    ISSN 1872-9126 ; 0003-6870
    ISSN (online) 1872-9126
    ISSN 0003-6870
    DOI 10.1016/0003-6870(95)00076-3
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  8. Article ; Online: British Journal of Dermatology: a fresh complexion.

    Bleiker, T O / Hughes, R E M

    The British journal of dermatology

    2009  Volume 162, Issue 1, Page(s) 1–3

    MeSH term(s) Dermatology ; Information Dissemination ; Peer Review, Research ; Periodicals as Topic ; Publishing
    Language English
    Publishing date 2009-11-18
    Publishing country England
    Document type Editorial
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/j.1365-2133.2009.09612.x
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  9. Article: RESPIRATORY QUOTIENT OF SCORBUTIC GUINEA PIGS.

    EVANS, J R / HUGHES, R E

    Life sciences (1962)

    2003  Volume 3, Page(s) 15–17

    MeSH term(s) Animals ; Ascorbic Acid Deficiency ; Carbon Dioxide ; Guinea Pigs ; Minerals/metabolism ; Oxygen ; Research ; Respiratory Function Tests ; Sulfates ; Sulfur
    Chemical Substances Minerals ; Sulfates ; Carbon Dioxide (142M471B3J) ; Sulfur (70FD1KFU70) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2003-10-03
    Publishing country United States
    Document type Journal Article
    ISSN 0161-5564
    ISSN 0161-5564
    DOI 10.1016/0024-3205(64)90220-6
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  10. Article: The rise and fall of the "antiscorbutics": some notes on the traditional cures for "land scurvy".

    Hughes, R E

    Medical history

    1990  Volume 34, Issue 1, Page(s) 52–64

    MeSH term(s) Ascorbic Acid/analysis ; Europe ; History, 16th Century ; History, 17th Century ; Humans ; Phytotherapy/history ; Plants, Medicinal/analysis ; Scurvy/classification ; Scurvy/drug therapy ; Scurvy/history
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 1990-01
    Publishing country England
    Document type Historical Article ; Journal Article
    ZDB-ID 214353-7
    ISSN 2048-8343 ; 0025-7273
    ISSN (online) 2048-8343
    ISSN 0025-7273
    DOI 10.1017/s0025727300050262
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