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  1. Article ; Online: Clozapine-related tachycardia: A conundrum to identify and treat.

    Brennan, Dermot / Lal, Sweta / Hugo, Frans / Waters, Flavie / Shymko, Gordon

    Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

    2024  Volume 32, Issue 1, Page(s) 84–88

    Abstract: Objective: This study examined the rates and persistence of clozapine-induced tachycardia and heart-rate differences in patients treated with β-blockers in the largest sample of patients with a psychotic disorder to date.: Method: An audit of medical ...

    Abstract Objective: This study examined the rates and persistence of clozapine-induced tachycardia and heart-rate differences in patients treated with β-blockers in the largest sample of patients with a psychotic disorder to date.
    Method: An audit of medical files for 101 patients who attended a clozapine community clinic and analysis of monthly measurements of resting heart rates.
    Results: 51% met the clinical criteria for tachycardia. Heart rates were stable over time. β-blockers were associated with small but significant reductions in heart rates.
    Conclusion: The cardiovascular risks of clozapine are often overlooked. β-blockers are useful in lowering heart rates but they may be insufficient to reduce cardiac risk.
    MeSH term(s) Humans ; Clozapine/adverse effects ; Tachycardia/chemically induced ; Adrenergic beta-Antagonists/pharmacology ; Adrenergic beta-Antagonists/therapeutic use ; Psychotic Disorders/drug therapy
    Chemical Substances Clozapine (J60AR2IKIC) ; Adrenergic beta-Antagonists
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2213198-X
    ISSN 1440-1665 ; 1039-8562
    ISSN (online) 1440-1665
    ISSN 1039-8562
    DOI 10.1177/10398562231224156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6220: Show issues Location:
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    Zs.MO 581: Show issues

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  2. Article: Malingering in clinical practice with specific reference to psychiatry and psychology.

    Hugo, Frans J / Hemp, Frances

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

    2002  Volume 92, Issue 5, Page(s) 354

    MeSH term(s) Disability Evaluation ; Humans ; Malingering/diagnosis ; Malingering/economics ; Psychiatry ; Psychology
    Language English
    Publishing date 2002-05
    Publishing country South Africa
    Document type Editorial
    ZDB-ID 390968-2
    ISSN 2078-5135 ; 0256-9574 ; 0038-2469
    ISSN (online) 2078-5135
    ISSN 0256-9574 ; 0038-2469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.406: Show issues Location:
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    Zs.MO 645: Show issues

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  3. Article ; Online: Normative data for the Tygerberg Cognitive Battery and Mini-Mental Status Examination in a South African population.

    Roos, Annerine / Calata, Dorothy / Jonkers, Liesl / Maritz, Stephan J / Kidd, Martin / Daniels, Willie M U / Hugo, Frans J

    Comprehensive psychiatry

    2010  Volume 51, Issue 2, Page(s) 207–216

    Abstract: Background: Normative data for the Tygerberg Cognitive Battery (TCB) and Mini-Mental Status Examination (MMSE) (in South Africa) have not been formally examined before. The TCB was developed for the bedside pen-and-paper screening of cognitive ... ...

    Abstract Background: Normative data for the Tygerberg Cognitive Battery (TCB) and Mini-Mental Status Examination (MMSE) (in South Africa) have not been formally examined before. The TCB was developed for the bedside pen-and-paper screening of cognitive impairment in each of the 6 main cognitive domains, including attention and concentration, speech, memory, praxis, gnosis, and executive functioning. The test is also used to diagnose different neuropsychiatric conditions. The MMSE is an established screen of cognitive status, which is often used as a comparative standard for novel screening tests such as the TCB. The TCB was initially developed in English and Afrikaans, and a Xhosa version was also initiated with this study so that the 3 most common languages of the region could be accommodated.
    Aims: The first aim of the study was to estimate normative test performance on the TCB and MMSE among controls, and the second aim was to develop a Xhosa version of the TCB.
    Methods: Assessments of the TCB and MMSE were carried out in a population of healthy individuals (n = 157). In addition, healthy Xhosa-speaking participants (n = 14) were screened using a Xhosa version of the TCB.
    Results: Reliability scores for all forms of the TCB were satisfactory. Age and education correlated significantly with TCB scores (r = -0.26, P < .01; r = 0.64, P < .01, respectively), whereas only education significantly correlated with MMSE scores (r = 0.32, P < .05). Normative values were calculated accordingly, that is, controlled for the effects of age and education. The TCB scores also correlated significantly with MMSE scores (r = 0.49, P < .05), demonstrating the potential of the TCB to serve as an alternate cognitive assessment tool, along with the MMSE, to focus neuropsychiatric investigations. Scores on the Xhosa version differed significantly on speech, praxis, and gnosis between the Afrikaans and English participant scores.
    Conclusion: These normative data can be used to increase precision and to provide an impartial evaluation when applying TCB to evaluate the cognitive ability of neuropsychiatrically impaired adult patients. However, age and education effects should be considered when computing the results of cognitive assessment.
    MeSH term(s) Adolescent ; Adult ; African Continental Ancestry Group ; Age Factors ; Aged ; Aged, 80 and over ; Attention ; Cognition ; Cognition Disorders/diagnosis ; Cognition Disorders/physiopathology ; Education ; Female ; Humans ; Language ; Male ; Memory ; Middle Aged ; Neuropsychological Tests/standards ; South Africa ; Speech ; Young Adult
    Language English
    Publishing date 2010-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 127556-2
    ISSN 1532-8384 ; 0010-440X
    ISSN (online) 1532-8384
    ISSN 0010-440X
    DOI 10.1016/j.comppsych.2009.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 106: Show issues Location:
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