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Article ; Online: Kidney transplantation trends in South Korea during the COVID-19 pandemic.

Lee, Juhan / Huh, Kyu Ha

2020 Volume 98, Issue 2, Page(s) 512–513

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Kidney Transplantation ; Pandemics ; Pneumonia, Viral ; Republic of Korea ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-06-20
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2020.05.044
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparison of high-dose IVIG and rituximab versus rituximab as a preemptive therapy for de novo donor-specific antibodies in kidney transplant patients.

Kim, Hyung Woo / Lee, Juhan / Heo, Seok-Jae / Kim, Beom Seok / Huh, Kyu Ha / Yang, Jaeseok

Scientific reports

2023 Volume 13, Issue 1, Page(s) 7682

Abstract: De novo donor-specific antibody (dnDSA) is associated with a higher risk of kidney graft failure. However, it is unknown whether preemptive treatment of subclinical dnDSA is beneficial. Here, we assessed the efficacy of high-dose intravenous ... ...

Abstract	De novo donor-specific antibody (dnDSA) is associated with a higher risk of kidney graft failure. However, it is unknown whether preemptive treatment of subclinical dnDSA is beneficial. Here, we assessed the efficacy of high-dose intravenous immunoglobulin (IVIG) and rituximab combination therapy for subclinical dnDSA. An open-label randomized controlled clinical trial was conducted at two Korean institutions. Adult (aged ≥ 19 years) kidney transplant patients with subclinical class II dnDSA (mean fluorescence intensity ≥ 1000) were enrolled. Eligible participants were randomly assigned to receive rituximab or rituximab with IVIG at a 1:1 ratio. The primary endpoint was the change in dnDSA titer at 3 and 12 months after treatment. A total of 46 patients (24 for rituximab and 22 for rituximab with IVIG) were included in the analysis. The mean baseline estimated glomerular filtration rate was 66.7 ± 16.3 mL/min/1.73 m
MeSH term(s)	Adult ; Humans ; Kidney Transplantation/adverse effects ; Immunoglobulins, Intravenous/therapeutic use ; Rituximab/therapeutic use ; Isoantibodies ; Graft Rejection ; Graft Survival ; Retrospective Studies ; HLA Antigens
Chemical Substances	Immunoglobulins, Intravenous ; Rituximab (4F4X42SYQ6) ; Isoantibodies ; HLA Antigens
Language	English
Publishing date	2023-05-11
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-34804-6
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Article ; Online: Donor fat-to-muscle ratio and kidney transplant outcomes: A proposition of metabolic memory.

Kee, Youn Kyung / Lee, Juhan / Nam, Bo Young / Joo, Young Su / Kang, Shin-Wook / Huh, Kyu Ha / Park, Jung Tak

Diabetes/metabolism research and reviews

2024 Volume 40, Issue 2, Page(s) e3781

Abstract: Aims: The impact of donor abdominal fat-to-muscle ratio (FMR) on kidney transplant (KT) outcomes was assessed. Given the transient nature of the donor's metabolic environment in transplant recipients, this study investigated the capacity of body ... ...

Abstract	Aims: The impact of donor abdominal fat-to-muscle ratio (FMR) on kidney transplant (KT) outcomes was assessed. Given the transient nature of the donor's metabolic environment in transplant recipients, this study investigated the capacity of body composition to induce metabolic memory effects. Materials and methods: KT patients (n = 895) who received allografts from living donors (2003-2013) were included. Donor fat and muscle were quantified using pre-KT abdominal computed tomography scans. Patients were categorised into donor FMR tertiles and followed up for graft outcomes. Additionally, genome-wide DNA methylation analysis was performed on 28 kidney graft samples from KT patients in the low- and high-FMR groups. Results: Mean recipient age was 42.9 ± 11.4 years and 60.9% were males. Donor FMR averaged 1.67 ± 0.79. Over a median of 120.9 ± 42.5 months, graft failure (n = 127) and death-censored graft failure (n = 109) were more frequent in the higher FMR tertiles. Adjusted hazard ratios for the highest versus lowest FMR tertile were 1.71 (95% CI, 1.06-2.75) for overall graft failure and 1.90 (95% CI, 1.13-3.20) for death-censored graft failure. Genome-wide DNA methylation analysis identified 58 differentially methylated regions (p < 0.05, \|Δβ\| > 0.2) and 35 genes showed differential methylation between the high- (FMR >1.91) and low-FMR (FMR <1.27) groups. Conclusions: Donors with increased fat and reduced muscle composition may negatively impact kidney allograft survival in recipients, possibly through the transmission of epigenetic changes, implying a body-composition-related metabolic memory effect.
MeSH term(s)	Male ; Humans ; Adult ; Middle Aged ; Female ; Kidney Transplantation/adverse effects ; Retrospective Studies ; Graft Survival/physiology ; Living Donors ; Muscles
Language	English
Publishing date	2024-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1470192-3
ISSN	1520-7560 ; 1520-7552
ISSN (online)	1520-7560
ISSN	1520-7552
DOI	10.1002/dmrr.3781
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Zs.A 2119: Show issues

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Article ; Online: Successful robotic kidney transplantation for surgeons with no experience in minimally invasive surgery: a single institution experience.

Kim, Hyun Jeong / Jeong, Wooju / Lee, Juhan / Yang, Seok Jeong / Lee, Jong Soo / Na, Joon Chae / Han, Woong Kyu / Huh, Kyu Ha

International journal of surgery (London, England)

2024 Volume 110, Issue 3, Page(s) 1586–1594

Abstract: Background: Robotic kidney transplantation (RKT) is a novel and welcomed innovation yielding good surgical outcomes. However, data on the feasibility and safety of performing RKT by surgeons with a lack of prior minimally invasive surgery (MIS) ... ...

Abstract	Background: Robotic kidney transplantation (RKT) is a novel and welcomed innovation yielding good surgical outcomes. However, data on the feasibility and safety of performing RKT by surgeons with a lack of prior minimally invasive surgery (MIS) experience are limited. The authors aimed to evaluate the surgical and functional results of RKT and present the learning curves (LC) of RKT by a single surgeon with no prior experience in MIS. Materials and methods: This was a retrospective study of all RKT performed between November 2019 and April 2023 at Severance Hospital in Seoul, South Korea. The authors analyzed surgical and functional outcomes, as well as complication rates of RKT in comparison to open kidney transplantation (OKT). The authors evaluated LCs using the cumulative summation method to describe the number of cases associated with the competency of a single surgeon. Results: A total of 50 patients who underwent RKT and 104 patients who underwent OKT were included in this study. In RKT group, the median surgical console time was 193 min (interquartile range, 172-222) and the median vascular anastomoses time was 38 min (35-44). Total operation time was 323 min (290-371) and rewarming time was 62.5 min (56.0-70.0) in RKT group compared to 210 min (190-239) and 25 min (21-30), respectively, in OKT group. Despite extended surgical durations with a robotic technique, both groups had comparable intraoperative and postoperative outcomes, as well as renal function. Estimated blood loss and post-transplant hospital stays were significantly lower in RKT group than in OKT group. LC analysis of RKT by the single surgeon revealed that surgical competence was achieved after 15 cases. Conclusion: Even if surgeons do not have prior experience with MIS, they can rapidly overcome the LC and safely perform RKT with adequate preparation and acquisition of basic robotic surgical techniques.
MeSH term(s)	Humans ; Kidney Transplantation/methods ; Robotic Surgical Procedures/adverse effects ; Retrospective Studies ; Minimally Invasive Surgical Procedures/adverse effects ; Surgeons
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1097/JS9.0000000000000977
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Zs.A 6502: Show issues

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Article: Kidney transplantation trends in South Korea during the COVID-19 pandemic

Lee, Juhan / Huh, Kyu Ha

Kidney Int

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #609344
Database	COVID19

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Article ; Online: Kidney transplantation trends in South Korea during the COVID-19 pandemic

Lee, Juhan / Huh, Kyu Ha

Kidney International

2020 Volume 98, Issue 2, Page(s) 512–513

Keywords	Nephrology ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2020.05.044
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Zs.A 797: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Successful treatment of renal malakoplakia via the reduction of immunosuppression and antimicrobial therapy after kidney transplantation: a case report.

Yim, Seung Hyuk / Min, Eun-Ki / Kim, Hyun Jeong / Lim, Beom Jin / Huh, Kyu Ha

Korean journal of transplantation

2022 Volume 36, Issue 4, Page(s) 289–293

Abstract: Malakoplakia is a rare, granulomatous disease that usually affects immunocompromised individuals and is generally associated with poor graft and patient survival. We present a case of renal malakoplakia after kidney transplantation (KT). A 33-year-old ... ...

Abstract	Malakoplakia is a rare, granulomatous disease that usually affects immunocompromised individuals and is generally associated with poor graft and patient survival. We present a case of renal malakoplakia after kidney transplantation (KT). A 33-year-old female patient with chronic kidney disease underwent living-donor KT at Severance Hospital. The patient was administered 375 mg/m
Language	English
Publishing date	2022-12-14
Publishing country	Korea (South)
Document type	Case Reports
ISSN	2671-8804
ISSN (online)	2671-8804
DOI	10.4285/kjt.22.0048
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Article ; Online: Pregnancy outcomes after living kidney donation from a nationwide population-based cohort study from Korea.

Lee, Juhan / Huh, Kyu Ha / Yoon, So Ra / Lee, Soo Yeun / Lee, Hyung Soon

Scientific reports

2022 Volume 12, Issue 1, Page(s) 22412

Abstract: While most living kidney donors experience good outcomes and high rates of satisfaction, kidney donation can increase the risk of gestational hypertension or preeclampsia. However, pregnancy outcomes in non-white donors are limited. We conducted a ... ...

Abstract	While most living kidney donors experience good outcomes and high rates of satisfaction, kidney donation can increase the risk of gestational hypertension or preeclampsia. However, pregnancy outcomes in non-white donors are limited. We conducted a nationwide cohort study of 112 living kidney donors and 672 matched healthy non-donors using the Korean National Health Insurance Claims Database. Donors and healthy non-donors were matched according to age, year of cohort entry, residency, income, number of pregnancies, and the time to the first pregnancy after cohort entry. We assessed pregnancy outcomes of live kidney donors compared with matched healthy non-donors using the nationwide database. Gestational hypertension or preeclampsia was more common in kidney donors than in non-donors (8.9% vs. 1.8%; adjusted odds ratio, 2.68; 95% confidence interval, 1.11-6.50). However, the incidence of severe gestational hypertension or preeclampsia that required antihypertensive medication was comparable (2.7% vs. 0.9%; P = 0.121). The time from donation to delivery within 5 years and primiparity were risk factors for preeclampsia in donors. Low birth weight, stillbirth, and ectopic pregnancy were not significantly different between the two groups. Maternal death occurred in two non-donor cases, but none occurred in donors compared to non-donors. Our findings indicate that kidney donors are associated with an increased risk of gestational hypertension or preeclampsia than matched healthy non-donors. However, the probabilities of serious maternal and fetal outcomes remained low and are not increased significantly after kidney donation.
MeSH term(s)	Pregnancy ; Female ; Humans ; Pregnancy Outcome ; Pre-Eclampsia/epidemiology ; Pre-Eclampsia/etiology ; Hypertension, Pregnancy-Induced ; Cohort Studies ; Kidney ; Republic of Korea/epidemiology
Language	English
Publishing date	2022-12-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-27094-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Machine Learning-Derived Integer-Based Score and Prediction of Tertiary Hyperparathyroidism among Kidney Transplant Recipients: An Integer-Based Score to Predict Tertiary Hyperparathyroidism.

Hong, Namki / Lee, Juhan / Kim, Hyung Woo / Jeong, Jong Ju / Huh, Kyu Ha / Rhee, Yumie

Clinical journal of the American Society of Nephrology : CJASN

2022 Volume 17, Issue 7, Page(s) 1026–1035

Abstract: Background and objectives: Tertiary hyperparathyroidism in kidney allograft recipients is associated with bone loss, allograft dysfunction, and cardiovascular mortality. Accurate pretransplant risk prediction of tertiary hyperparathyroidism may support ... ...

Abstract	Background and objectives: Tertiary hyperparathyroidism in kidney allograft recipients is associated with bone loss, allograft dysfunction, and cardiovascular mortality. Accurate pretransplant risk prediction of tertiary hyperparathyroidism may support individualized treatment decisions. We aimed to develop an integer score system that predicts the risk of tertiary hyperparathyroidism using machine learning algorithms. Design, setting, participants, & measurements: We used two separate cohorts: a derivation cohort with the data of kidney allograft recipients ( Results: Tertiary hyperparathyroidism requiring parathyroidectomy occurred in 5% and 2% of the derivation and validation cohorts, respectively. Three top predictors (dialysis duration, pretransplant intact parathyroid hormone, and serum calcium level measured at the time of admission for kidney transplantation) were identified to create an integer score system (dialysis duration, pretransplant serum parathyroid hormone level, and pretransplant calcium level [DPC] score; 0-15 points) to predict tertiary hyperparathyroidism. The median DPC score was higher in participants with post-transplant parathyroidectomy than in those without (13 versus three in derivation; 13 versus four in external validation; Conclusions: A simple integer-based score predicted the risk of tertiary hyperparathyroidism in kidney allograft recipients, with improved classification by serial measurement compared with single-time measurement. Clinical trial registry name and registration number: Korean Cohort Study for Outcome in Patients with Kidney Transplantation (KNOW-KT), NCT02042963 PODCAST: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2022_06_10_CJN15921221.mp3.
MeSH term(s)	Calcium ; Cohort Studies ; Humans ; Hyperparathyroidism/diagnosis ; Hyperparathyroidism/etiology ; Kidney Transplantation/adverse effects ; Machine Learning ; Parathyroid Hormone ; Parathyroidectomy ; Retrospective Studies
Chemical Substances	Parathyroid Hormone ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-06-10
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.15921221
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Zs.A 6584: Show issues

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Article ; Online: The first successful eculizumab rescue therapy of a kidney transplant recipient with atypical hemolytic uremic syndrome in South Korea: a case report.

Min, Eun-Ki / Kim, Hyun Jeong / Kim, Sinyoung / Jung, Minsun / Kim, Jin Seok / Han, Seung Hyeok / Huh, Kyu Ha

Korean journal of transplantation

2023 Volume 37, Issue 1, Page(s) 57–62

Abstract: Atypical hemolytic uremic syndrome (aHUS) is a form of thrombotic microangiopathy (TMA) that can result in end-stage renal disease. Patients with aHUS often have predisposing dysfunction in the complement pathway, and continuous activation of complement ... ...

Abstract	Atypical hemolytic uremic syndrome (aHUS) is a form of thrombotic microangiopathy (TMA) that can result in end-stage renal disease. Patients with aHUS often have predisposing dysfunction in the complement pathway, and continuous activation of complement proteins can be triggered after transplantation. Here, we report the first successful case of aHUS treatment in a kidney transplant recipient with early use of a C5 inhibitor, eculizumab, in South Korea. The patient was a 32-year-old man, and the donor was his 60-year-old mother. The graft showed immediate good function. On postoperative day (POD) 3, the clinical diagnosis of TMA was made. Persistent renal dysfunction despite 10 plasma exchange (PE) sessions prompted eculizumab treatment on POD 18 under suspicion of aHUS. Next-generation sequencing reported gene mutations classified as variants of unknown significance in coagulation-associated genes. The patient was discharged after three doses of eculizumab with serum creatinine of 1.82 mg/dL. In total, 16 doses of eculizumab were administered. At the last follow-up, 21 months after eculizumab discontinuation, the graft was well functioning.
Language	English
Publishing date	2023-01-20
Publishing country	Korea (South)
Document type	Case Reports
ISSN	2671-8804
ISSN (online)	2671-8804
DOI	10.4285/kjt.22.0050
Database	MEDical Literature Analysis and Retrieval System OnLINE

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