LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: Adverse cardiovascular events are common during dexmedetomidine administration in neonates and infants during intensive care.

    Tervonen, Miikka / Cajanus, Johanna / Kallio, Merja / Huhtamäki, Heikki / Pokka, Tytti / Peltoniemi, Outi

    Acta paediatrica (Oslo, Norway : 1992)

    2023  Volume 112, Issue 11, Page(s) 2338–2345

    Abstract: Aim: This study aimed to assess the safety of a commonly used sedative, dexmedetomidine in neonates and infants during intensive care.: Methods: A retrospective cohort study was conducted in the paediatric intensive care unit at Oulu University ... ...

    Abstract Aim: This study aimed to assess the safety of a commonly used sedative, dexmedetomidine in neonates and infants during intensive care.
    Methods: A retrospective cohort study was conducted in the paediatric intensive care unit at Oulu University Hospital. The study population consisted of all children from birth up to 6 months of age who received dexmedetomidine during 2010-2016. Adverse cardiovascular outcomes were defined as abnormal heart rates or blood pressure values according to the Paediatric Early Warning Score.
    Results: Of the 172 infants, 56% had congenital malformation, and 48% had undergone surgery. Neonates and 1-3-month-olds experienced bradycardia (86% vs. 73% in 1-3-month-olds and 50% in 3-6-month-olds, p = 0.001) and severe bradycardia (17% vs. 14% in 1-3-month-olds and 0% in 3-6-month-olds, p = 0.005) more often than older patients. The median maximum rate of dexmedetomidine infusion was 0.86 μg/kg/h (IQR = 0.60-1.71 μg/kg/h). A dose-dependent increase in bradycardia and severe hypotension was found. Adverse cardiovascular events were managed with additional fluid boluses and discontinuation of the infusion.
    Conclusion: Adverse cardiovascular events were common during dexmedetomidine administration in neonates and infants. Lower dexmedetomidine doses may be required in sedating neonates.
    MeSH term(s) Infant, Newborn ; Child ; Humans ; Infant ; Dexmedetomidine/adverse effects ; Bradycardia/chemically induced ; Bradycardia/epidemiology ; Retrospective Studies ; Hypnotics and Sedatives/adverse effects ; Critical Care
    Chemical Substances Dexmedetomidine (67VB76HONO) ; Hypnotics and Sedatives
    Language English
    Publishing date 2023-08-11
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.16933
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.95: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: The incidence, hospitalisations and deaths in acutely ill children with dysnatraemias.

    Lehtiranta, Saara / Honkila, Minna / Anttila, Silja / Huhtamäki, Heikki / Pokka, Tytti / Tapiainen, Terhi

    Acta paediatrica (Oslo, Norway : 1992)

    2022  Volume 111, Issue 8, Page(s) 1630–1637

    Abstract: Aim: The aim was to evaluate the incidence, hospitalisations and deaths in acutely ill children with dysnatraemias.: Methods: This was a register-based cohort study of 46 518 acutely ill children aged <16 years who visited a paediatric emergency ... ...

    Abstract Aim: The aim was to evaluate the incidence, hospitalisations and deaths in acutely ill children with dysnatraemias.
    Methods: This was a register-based cohort study of 46 518 acutely ill children aged <16 years who visited a paediatric emergency department. Risk factors were assessed using two nested case-control studies.
    Results: Moderate to severe hypernatraemia occurred in 92 children (0.20%; 95% confidence interval [CI]: 0.16%-0.24%) and moderate to severe hyponatraemia in 131 children (0.28%; 95% CI: 0.24%-0.33%). Underlying medical conditions increased the risk of both moderate to severe hypernatraemia (odds ratio [OR]: 17; 95% 5.5-51) and moderate to severe hyponatraemia (OR: 3.5; 95% CI: 2.0-5.9). The use of a feeding tube (OR: 14; 95% CI: 3.2-66) and intellectual disability (OR: 7.3; 95% CI: 3.0-18) was associated with moderate to severe hypernatraemia. The risk of death was associated with moderate to severe hypernatraemia (OR: 19; 95% CI: 2.0-2564) and moderate to severe hyponatraemia (OR: 33; 95% CI: 3.7-4311).
    Conclusions: Severe dysnatraemias were more prevalent in acutely ill children with underlying medical conditions and were markedly associated with the risk for death.
    MeSH term(s) Child ; Cohort Studies ; Hospitalization ; Humans ; Hypernatremia/epidemiology ; Hypernatremia/etiology ; Hyponatremia/epidemiology ; Hyponatremia/etiology ; Incidence
    Language English
    Publishing date 2022-04-08
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.16348
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.95: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Parental Ability to Assess Pediatric Vital Signs.

    Pöyry, Hilla / Aarnivala, Henri / Huhtamäki, Heikki / Pokka, Tytti / Renko, Marjo / Valmari, Pekka / Tapiainen, Terhi

    The Journal of pediatrics

    2022  Volume 252, Page(s) 177–182.e2

    Abstract: Objective: To evaluate parents' ability to accurately assess their child's heart and respiratory rates (RRs) in the context of potential utility for telehealth visits.: Study design: In this controlled study of 203 child-parent pairs, parents ... ...

    Abstract Objective: To evaluate parents' ability to accurately assess their child's heart and respiratory rates (RRs) in the context of potential utility for telehealth visits.
    Study design: In this controlled study of 203 child-parent pairs, parents measured their child's heart rate (HR) using 4 methods: palpation, auscultation, and 2 photoplethysmographic smartphone applications. Parents measured RR by inspecting the child and tapping the smartphone application. The gold standards were electrocardiogram for the HR and the child's breaths measured by a health care professional for 60 seconds for the RR. We plotted the measurements using a Bland-Altman plot with 95% limits of agreement.
    Results: Parents underestimated HR by palpation with a calculated bias of -18 beats per minute (bpm) (SD, 19), with limits of agreement ranging from -56 to 19 bpm. Parents overestimated and underestimated HR by auscultation with limits of agreement ranging from -53 to 46 bpm. Smartphone applications did not improve the accuracy of measurements. The accuracy of parental RR measurements was low. For young children, bias was -0.8 breaths per minute (brpm) (SD, 9.8) with limits of agreement from -20 to 19 brpm, and for older children, bias was 0.9 brpm (SD 7.4) with limits of agreement from 6 to 15 brpm. The sensitivity of parental subjective opinion to recognize accelerated RR was 37% (95% CI, 25%-51%).
    Conclusion: Parents were not able to assess their child's RR or HR accurately. Digital remote assessment of children should not rely on parental measurements of vital signs.
    MeSH term(s) Child ; Humans ; Adolescent ; Child, Preschool ; Parents ; Vital Signs ; Respiratory Rate ; Heart Rate ; Electrocardiography
    Language English
    Publishing date 2022-08-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2022.08.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.116: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Early-onset group B streptococcal infections in five Nordic countries with different prevention policies, 1995 to 2019.

    Björklund, Verna / Saxén, Harri / Hertting, Olof / Malchau Carlsen, Emma Louise / Hoffmann, Steen / Håkansson, Stellan / Stefánsson Thors, Valtýr / Haraldsson, Ásgeir / Brigtsen, Anne Karin / Döllner, Henrik / Huhtamäki, Heikki / Pokka, Tytti / Ruuska, Terhi Susanna

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2023  Volume 29, Issue 3

    Abstract: BackgroundNeonatal early-onset disease caused by group ... ...

    Abstract BackgroundNeonatal early-onset disease caused by group B
    MeSH term(s) Infant ; Pregnancy ; Humans ; Female ; Pregnancy Complications, Infectious/drug therapy ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/prevention & control ; Antibiotic Prophylaxis ; Streptococcal Infections/drug therapy ; Streptococcal Infections/epidemiology ; Streptococcal Infections/prevention & control ; Mass Screening ; Scandinavian and Nordic Countries/epidemiology ; Streptococcus agalactiae ; Infectious Disease Transmission, Vertical/prevention & control ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-12-27
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    DOI 10.2807/1560-7917.ES.2024.29.3.2300193
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5066: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Nasopharyngeal detection of atypical bacteria by multiplex polymerase chain reaction panel in acutely ill children was associated with an increased risk of pneumonia.

    Mattila, Suvi / Sarlin, Suvi / Heikkilä, Reetta / Leinonen, Emilia / Nurmi, Violetta / Riikonen, Jonni / Paalanne, Niko / Honkila, Minna / Huhtamäki, Heikki / Pokka, Tytti / Koskela, Ulla / Renko, Marjo / Tapiainen, Terhi

    Acta paediatrica (Oslo, Norway : 1992)

    2023  Volume 112, Issue 4, Page(s) 830–836

    Abstract: Aim: We aimed to assess whether detection of respiratory bacteria by multiplex polymerase chain reaction (PCR) testing associates with clinical outcomes in acutely ill children.: Methods: This cross-sectional study enrolled children under the age of ... ...

    Abstract Aim: We aimed to assess whether detection of respiratory bacteria by multiplex polymerase chain reaction (PCR) testing associates with clinical outcomes in acutely ill children.
    Methods: This cross-sectional study enrolled children under the age of 18 with a suspected respiratory infection treated in a paediatric emergency department of Oulu University Hospital, Finland from January 2015 through December 2015. Nasopharyngeal samples were routinely analysed for 16 respiratory viruses and later, after storage, analysed with a multiplex PCR panel for seven respiratory bacteria.
    Results: At least one bacterial pathogen was detected in 600 out of the 1195 children (50%). The mean age was 3.3 (SD 3.7) years and 54% were boys. Atypical bacteria were associated with a risk of pneumonia (adjusted odds ratio [aOR] 14.1, 95% CI 3.98-50.1). Co-detection of rhinovirus with Streptococcus pneumoniae was not associated with risk of pneumonia (aOR 2.39, 95% CI 0.78-7.30). Detection of Streptococcus pneumoniae, Haemophilus influenzae or both was not associated with the risk of hospital admission or prescription of antibiotics.
    Conclusion: Nasopharyngeal detection of atypical bacteria in acutely ill children was associated with a markedly increased risk of pneumonia. The clinical utility of wide testing for other respiratory bacteria needs further evaluation.
    MeSH term(s) Male ; Humans ; Child ; Infant ; Child, Preschool ; Female ; Multiplex Polymerase Chain Reaction ; Pneumonia, Bacterial/diagnosis ; Pneumonia, Bacterial/microbiology ; Cross-Sectional Studies ; Bacteria ; Streptococcus pneumoniae/genetics ; Respiratory Tract Infections/diagnosis
    Language English
    Publishing date 2023-01-28
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.16672
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.95: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top