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  1. Article ; Online: Routine ultrasound screening for hip dysplasia in children with clubfoot is not supported.

    McLaughlin, Dell / De Salvo, Sara / Brewerton, Kathryn / Hui, Caitlyn / Bouchard, Maryse

    International orthopaedics

    2024  

    Abstract: Purpose: Despite the existence of guidelines for screening for developmental dysplasia of the hip (DDH), there remains controversy regarding the need for routine ultrasound screening for DDH in patients with clubfoot due to an unclear correlation ... ...

    Abstract Purpose: Despite the existence of guidelines for screening for developmental dysplasia of the hip (DDH), there remains controversy regarding the need for routine ultrasound screening for DDH in patients with clubfoot due to an unclear correlation between the two conditions. The purpose of this study is to determine whether ultrasound screening for DDH in this population improved the diagnostic accuracy of DDH over standard assessment for patient risk factors and physical exam.
    Methods: This is a retrospective cross-sectional review of infants diagnosed with idiopathic clubfoot who underwent hip ultrasounds to assess for DDH as identified by keyword search in an institutional radiological database at a tertiary care paediatric hospital. Patient demographics, risk factors for DDH, physical exam findings, and ultrasound results were recorded.
    Results: Of the 120 patients who met the inclusion criteria between 2003 and 2018, 8 had hip dysplasia confirmed on ultrasound (6.7%). All these patients either had known risk factors for hip dysplasia or had an abnormal physical exam finding suggestive of hip instability or dislocation as performed by an orthopaedic surgeon on their initial consultation.
    Conclusion: A detailed history to determine risk factors and a thorough physical exam are adequate to determine the need for hip ultrasound in infants with idiopathic clubfoot. Routine ultrasound screening of all patients with clubfoot is likely unnecessary and may pose a significant burden on the health care system.
    Language English
    Publishing date 2024-04-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80384-4
    ISSN 1432-5195 ; 0341-2695
    ISSN (online) 1432-5195
    ISSN 0341-2695
    DOI 10.1007/s00264-024-06169-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Case Report: A Case of Bone Marrow Necrosis and Hyperinflammation in a 10-Year-Old Boy after Plasmodium falciparum Infection.

    Hui, Caitlyn / Bosch, Alessandra / Mwizerwa, Oscar / McColl, Jeanine / Corbeil, Antoine / Malcolmson, Caroline / Levy, Deborah M / Bismilla, Zia / Morris, Shaun K

    The American journal of tropical medicine and hygiene

    2023  Volume 109, Issue 3, Page(s) 611–615

    Abstract: A 10-year-old boy with sickle cell disease (SCD) type SC presented with fever and abdominal pain after travel to Ghana and was diagnosed with Plasmodium falciparum infection. Despite adequate antimalarial treatment, he developed evidence of ... ...

    Abstract A 10-year-old boy with sickle cell disease (SCD) type SC presented with fever and abdominal pain after travel to Ghana and was diagnosed with Plasmodium falciparum infection. Despite adequate antimalarial treatment, he developed evidence of hyperinflammation with marked elevated ferritin, C-reactive protein, and triglycerides and subsequent bone marrow necrosis, characterized by elevated nucleated red blood cells and significant bone pain. This case report highlights the possible association between malaria and bone marrow necrosis in patients with SCD. Important considerations in treatment and workup of patients presenting with malaria and hyperinflammation are discussed.
    MeSH term(s) Male ; Humans ; Child ; Plasmodium falciparum ; Bone Marrow ; Malaria, Falciparum/complications ; Malaria, Falciparum/diagnosis ; Malaria, Falciparum/drug therapy ; Malaria/diagnosis ; Anemia, Sickle Cell ; Necrosis
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.22-0550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Anticipating Pediatric Patient Transfers From Intermediate to Intensive Care.

    Cheng, Daryl R / Hui, Caitlyn / Langrish, Kate / Beck, Carolyn E

    Hospital pediatrics

    2020  Volume 10, Issue 4, Page(s) 347–352

    Abstract: Objectives: To explore characteristics of patients who were admitted to the intermediate care (IC) unit at a tertiary academic institution. In particular, we sought to compare the characteristics of IC patients who were transferred with the ... ...

    Abstract Objectives: To explore characteristics of patients who were admitted to the intermediate care (IC) unit at a tertiary academic institution. In particular, we sought to compare the characteristics of IC patients who were transferred with the characteristics of those who were not transferred to PICU care and evaluate predictors of patient transfer.
    Methods: Data were collected on all admitted IC patients between July 2016 and June 2018. Patients whose index IC admission was from the PICU were excluded. Data collected included demographics and physiologic characteristics: heart rate, respiratory rate, temperature, oxygen therapy, as well as Bedside Pediatric Early Warning System (BPEWS) score.
    Results: In this time period, 427 eligible patient visits occurred, with 66 patients (15.46%) being transferred to the PICU. Patients were commonly transferred early in their IC course (1.41 days into admission [0.66-3.87]); transferred patients had higher median admission BPEWS scores (7 [4.25-9] vs 5 [3-7];
    Conclusions: The need for close monitoring of physiologic parameters remains paramount, especially in the first 48 hours of admission, in predicting the need for transfer from the IC to PICU. The need for any form of respiratory support is predictive of transfer. Situational awareness and assessment including BPEWS score is of critical importance.
    MeSH term(s) Child ; Critical Care ; Hospitalization ; Humans ; Intensive Care Units, Pediatric ; Patient Transfer/statistics & numerical data ; Retrospective Studies
    Language English
    Publishing date 2020-03-27
    Publishing country United States
    Document type Journal Article
    ISSN 2154-1671
    ISSN (online) 2154-1671
    DOI 10.1542/hpeds.2019-0260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Addition of plasma exchange to red cell exchange improves outcomes of fat embolism syndrome in sickle cell disease.

    Tsitsikas, Dimitris A / Rowe, Susan / Bosch, Alessandra / Hui, Caitlyn / Sadasivam, Nandini / Palaskas, Nicolaos J / Pancham, Shivan / Rizvi, Syed / Taylor, Joseph / Greaves, Paul / Glenthøj, Andreas / Hoffmann, Marianne / Drasar, Emma / Eleftheriou, Perla

    British journal of haematology

    2023  Volume 200, Issue 6, Page(s) e50–e52

    MeSH term(s) Humans ; Plasma Exchange ; Anemia, Sickle Cell/therapy ; Erythrocytes ; Plasmapheresis ; Embolism, Fat/therapy
    Language English
    Publishing date 2023-01-03
    Publishing country England
    Document type Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Detecting Secreted Analytes from Immune Cells: An Overview of Technologies.

    Pike, Kelly A / Hui, Caitlyn / Krawczyk, Connie M

    Methods in molecular biology (Clifton, N.J.)

    2016  Volume 1458, Page(s) 111–124

    Abstract: The tumor microenvironment is largely shaped by secreted factors and infiltrating immune cells and the nature of this environment can profoundly influence tumor growth and progression. As such, there is an increasing need to identify and quantify ... ...

    Abstract The tumor microenvironment is largely shaped by secreted factors and infiltrating immune cells and the nature of this environment can profoundly influence tumor growth and progression. As such, there is an increasing need to identify and quantify secreted factors by tumor cells, tumor-associated cells, and infiltrating immune cells. To meet this need, the dynamic range of immunoassays such as ELISAs and ELISpots have been improved and the scope of reagents commercially available has been expanded. In addition, new bead-based and membrane-based screening arrays have been developed to allow for the simultaneous detection of multiple analytes in one sample. Similarly, the optimization of intracellular staining for flow cytometry now allows for the quantitation of multiple cytokines from either a purified cell population or a complex mixed cell suspension. Herein, we review the rapidly evolving technologies that are currently available to detect secreted analytes. Emphasis is placed on discussing the advantages and disadvantages of these assays and their applications.
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-3801-8_9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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