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Article: DXA-Derived vs Standard Anthropometric Measures for Predicting Cardiometabolic Risk in Middle-Aged Australian Men and Women.

Zhu, Kun / Walsh, John P / Murray, Kevin / Hunter, Michael / Hui, Jennie / Hung, Joseph

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

2022 Volume 25, Issue 3, Page(s) 299–307

Abstract: It is not clear if dual-energy X-ray absorptiometry (DXA) adiposity measures are superior to standard anthropometric measures for predicting cardiometabolic (CM) risk factors in a middle-aged general population. In the Busselton Healthy Ageing Study, we ... ...

Abstract	It is not clear if dual-energy X-ray absorptiometry (DXA) adiposity measures are superior to standard anthropometric measures for predicting cardiometabolic (CM) risk factors in a middle-aged general population. In the Busselton Healthy Ageing Study, we assessed a range of standard anthropometric and DXA-derived adiposity measures to predict metabolic syndrome (MetS) and CM risk factors in 4831 "baby boomers" aged 45-69 yr. Anthropometric and whole body DXA (GE Lunar Prodigy) measures were collected. Cross-sectional relationships of overall adiposity (BMI; DXA fat mass index, body fat %), central adiposity (waist circumference (WC); DXA trunk fat, android fat, abdominal visceral adipose tissue (VAT)) and ratio index (waist-to-hip ratio; DXA trunk/legs fat, android/gynoid ratio, VAT/total fat) with MetS and its components (as both continuous and binary outcomes) were evaluated using linear and logistic regression adjusting for age and lifestyle factors. Youden's Index was used to determine the optimal cut-points for predicting MetS. In linear regression analyses, central adiposity measures showed stronger associations with MetS score and CM risk factors than overall adiposity measures and fat ratio index, and DXA-VAT provided stronger associations than WC. Logistic regression models showed similar findings. For MetS diagnosis present in 35.9% of males and 24.4% of females, the highest odds ratio (95% CI) per SD change was observed for DXA-VAT (males: 5.02 [4.28, 5.88]; females: 3.91 [3.40, 4.49]), which remained significant (all p < 0.001) after further adjustment for BMI (males: 3.27 [2.65, 4.02]; females: 3.37 [2.79, 4.06]) or WC (males: 2.46 [1.95, 3.10]; females: 2.75 [2.21, 3.43]). The optimal DXA-VAT mass cut-point for predicting MetS was 1608 grams in males and 893 grams in females. DXA-VAT was superior to standard anthropometric and other DXA-derived adiposity measures for prediction of cardiometabolic risk factors, and has clinical utility for identifying middle-aged individuals at increased risk of MetS.
MeSH term(s)	Absorptiometry, Photon ; Adiposity ; Australia/epidemiology ; Body Mass Index ; Cardiovascular Diseases/epidemiology ; Female ; Humans ; Intra-Abdominal Fat/diagnostic imaging ; Male ; Metabolic Syndrome/epidemiology ; Middle Aged ; Obesity/epidemiology ; Obesity, Abdominal/metabolism ; Risk Factors ; Waist Circumference
Language	English
Publishing date	2022-01-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2040951-5
ISSN	1094-6950
ISSN	1094-6950
DOI	10.1016/j.jocd.2022.01.006
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Article ; Online: Longitudinal measurements of per- and poly-fluoroalkyl substances (PFAS) in archived human serum samples between 1975 and 1995 in Australia.

Nilsson, Sandra / Bräunig, Jennifer / Carey, Renee N / Hui, Jennie / Smurthwaite, Kayla / Toms, Leisa-Maree / Kirk, Martyn D / Mueller, Jochen F / Fritschi, Lin

Journal of hazardous materials

2022 Volume 443, Issue Pt B, Page(s) 130307

Abstract: Per- and poly-fluoroalkyl substances (PFAS) are a group of manmade compounds produced since the 1950 s and used in a range of industrial processes and consumer products. In Australia, PFAS serum concentrations have been measured in the general population ...

Abstract	Per- and poly-fluoroalkyl substances (PFAS) are a group of manmade compounds produced since the 1950 s and used in a range of industrial processes and consumer products. In Australia, PFAS serum concentrations have been measured in the general population since 2002. However, few studies have retrospectively measured PFAS concentrations in serum samples representative of a general population prior to 2000, none of which have been conducted in Australia. To understand the general population's exposure to PFAS prior to 2002, longitudinal PFAS serum concentration measurements are required. In the current study, we accessed 'The Busselton Health Study Data Bank' to analyse archived serum samples for PFAS. Repeat serum samples collected in 1975, 1981 and 1995 were obtained from 17 participants. Of the 35 PFAS analysed, 13 PFAS were detected in the serum samples collected in 1975. Both the detection frequency and ∑PFAS serum concentrations increased between 1975 and 1995. Median ∑PFAS serum concentration increased over 7-fold; from 3.3 ng/mL in 1975-26 ng/mL in 1995. The increase in serum concentrations reflects the global production history of these PFAS during this period in time.
MeSH term(s)	Humans ; Fluorocarbons ; Retrospective Studies ; Australia ; Industry
Chemical Substances	Fluorocarbons
Language	English
Publishing date	2022-11-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2022.130307
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Article ; Online: Serum testosterone and sex hormone-binding globulin are inversely associated with leucocyte telomere length in men: a cross-sectional analysis of the UK Biobank study.

Marriott, Ross J / Murray, Kevin / Budgeon, Charley A / Codd, Veryan / Hui, Jennie / Arscott, Gillian M / Beilby, John P / Hankey, Graeme J / Wittert, Gary A / Wu, Frederick C W / Yeap, Bu B

European journal of endocrinology

2023 Volume 188, Issue 2

Abstract: Objective: Older men on an average have lower testosterone concentrations, compared with younger men, and more age-related comorbidities. Whether lower testosterone concentrations contribute to biological ageing remains unclear. Shorter telomeres are a ... ...

Abstract	Objective: Older men on an average have lower testosterone concentrations, compared with younger men, and more age-related comorbidities. Whether lower testosterone concentrations contribute to biological ageing remains unclear. Shorter telomeres are a marker for biological age. We tested the hypothesis that testosterone concentrations are associated with leucocyte telomere length (LTL), in middle- to older-aged men. Design: Cross-sectional analysis of the UK Biobank study, involving community-dwelling men aged 40-69 years. Methods: Serum testosterone and sex hormone-binding globulin (SHBG) were assayed. Free testosterone was calculated (cFT). Leucocyte telomere length was measured using polymerase chain reaction. Multivariable models were used to assess associations of hormones with standardised LTL. Results: In 167 706 men, median age 58 years, adjusting for sociodemographic, lifestyle, and medical factors, total testosterone was inversely associated with standardised LTL, which was 0.09 longer (95% confidence interval [CI], 0.08-0.10, P < .001) in men with total testosterone at median of lowest quintile [Q1] vs highest [Q5]. This relationship was attenuated after additional adjustment for SHBG (0.03 longer, CI = 0.02-0.05, P = .003). The association between cFT and LTL was similar in direction but lower in magnitude. In multivariable analysis, SHBG was inversely associated with standardised LTL, which was 0.12 longer (CI = 0.10-0.13, P < .001) for SHBG at median Q1 vs Q5. Results were similar with testosterone included in the model (0.10 longer, CI = 0.08-0.12, P < .001). Conclusions: Total testosterone and SHBG were independently and inversely associated with LTL. Men with higher testosterone or SHBG had shorter telomeres, arguing against a role for testosterone to slow biological ageing in men.
MeSH term(s)	Humans ; Male ; Middle Aged ; Biological Specimen Banks ; Cross-Sectional Studies ; Sex Hormone-Binding Globulin/analysis ; Telomere ; Testosterone ; United Kingdom
Chemical Substances	Sex Hormone-Binding Globulin ; Testosterone (3XMK78S47O)
Language	English
Publishing date	2023-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1183856-5
ISSN	1479-683X ; 0804-4643
ISSN (online)	1479-683X
ISSN	0804-4643
DOI	10.1093/ejendo/lvad015
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Article ; Online: The prevalence and comorbidities of obstructive sleep apnea in middle-aged men and women: the Busselton Healthy Ageing Study.

Cunningham, Jordan / Hunter, Michael / Budgeon, Charley / Murray, Kevin / Knuiman, Matthew / Hui, Jennie / Hillman, David / Singh, Bhajan / James, Alan

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

2021 Volume 17, Issue 10, Page(s) 2029–2039

Abstract: Study objectives: Population surveys suggest the prevalence of obstructive sleep apnea (OSA) is high and increasing and that risk factors and outcomes differ between sexes. To explore these relationships we assessed current OSA prevalence, potential ... ...

Abstract	Study objectives: Population surveys suggest the prevalence of obstructive sleep apnea (OSA) is high and increasing and that risk factors and outcomes differ between sexes. To explore these relationships we assessed current OSA prevalence, potential risk factors and comorbidities, and their changes relative to previous estimates in the same community. Methods: All adults on the Busselton, Australia, electoral roll born 1946-1964 were invited to participate in a general health survey. Of the 5,037 (62% response rate) respondents, 3,686 successfully completed overnight 2-channel (oximetry, airflow) sleep studies. These were scored and categorized as nil, mild, moderate, or severe OSA based on apnea-hypopnea index (< 5, ≥ 5 to < 15, ≥ 15 to < 30, and ≥ 30 events/h, respectively). Sleep scores were related to participant characteristics and health profiles. OSA prevalence was compared with previous surveys in the community. Results: Prevalences of any and moderate-severe OSA were 57.7% and 20.2% in males and 41.7% and 10.0% in females. Matched for age group, the prevalence of moderate-severe OSA was similar to that in 2007 (males 24.6%, females 9.8%) and was higher than in 1995 (males 4.7%). OSA was associated with age, body mass index, and alcohol intake in males and age and body mass index in females. Conditions associated with OSA included hypertension and current depression in males and hypertension, skin cancer, and diabetes in females. Conclusions: Prevalence of OSA in a middle-aged, predominantly White population in 2010-2015 was high, has increased since 1995, and has remained stable since 2007. Sex differences exist in associated features, including potential risk factors and comorbidities. Citation: Cunningham J, Hunter M, Budgeon C, et al. The prevalence and comorbidities of obstructive sleep apnea in middle-aged men and women: the Busselton Healthy Ageing Study.
MeSH term(s)	Adult ; Female ; Healthy Aging ; Humans ; Male ; Middle Aged ; Polysomnography ; Prevalence ; Risk Factors ; Sleep ; Sleep Apnea, Obstructive/epidemiology
Language	English
Publishing date	2021-11-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2397213-0
ISSN	1550-9397 ; 1550-9389
ISSN (online)	1550-9397
ISSN	1550-9389
DOI	10.5664/jcsm.9378
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Article ; Online: Metabolic phenotyping of BMI to characterize cardiometabolic risk: evidence from large population-based cohorts.

Beyene, Habtamu B / Giles, Corey / Huynh, Kevin / Wang, Tingting / Cinel, Michelle / Mellett, Natalie A / Olshansky, Gavriel / Meikle, Thomas G / Watts, Gerald F / Hung, Joseph / Hui, Jennie / Cadby, Gemma / Beilby, John / Blangero, John / Moses, Eric K / Shaw, Jonathan E / Magliano, Dianna J / Meikle, Peter J

Nature communications

2023 Volume 14, Issue 1, Page(s) 6280

Abstract: Obesity is a risk factor for type 2 diabetes and cardiovascular disease. However, a substantial proportion of patients with these conditions have a seemingly normal body mass index (BMI). Conversely, not all obese individuals present with metabolic ... ...

Abstract	Obesity is a risk factor for type 2 diabetes and cardiovascular disease. However, a substantial proportion of patients with these conditions have a seemingly normal body mass index (BMI). Conversely, not all obese individuals present with metabolic disorders giving rise to the concept of "metabolically healthy obese". We use lipidomic-based models for BMI to calculate a metabolic BMI score (mBMI) as a measure of metabolic dysregulation associated with obesity. Using the difference between mBMI and BMI (mBMIΔ), we identify individuals with a similar BMI but differing in their metabolic health and disease risk profiles. Exercise and diet associate with mBMIΔ suggesting the ability to modify mBMI with lifestyle intervention. Our findings show that, the mBMI score captures information on metabolic dysregulation that is independent of the measured BMI and so provides an opportunity to assess metabolic health to identify "at risk" individuals for targeted intervention and monitoring.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/complications ; Body Mass Index ; Obesity/complications ; Obesity/epidemiology ; Obesity/metabolism ; Risk Factors ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/complications ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/complications
Language	English
Publishing date	2023-10-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-41963-7
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Article ; Online: Longitudinal Asthma Phenotypes from Childhood to Middle-Age: A Population-based Cohort Study.

Tan, Daniel J / Lodge, Caroline J / Walters, E Haydn / Lowe, Adrian J / Bui, Dinh S / Bowatte, Gayan / Pham, Jonathan / Erbas, Bircan / Hui, Jennie / Hamilton, Garun S / Thomas, Paul S / Hew, Mark / Washko, George / Wood-Baker, Richard / Abramson, Michael J / Perret, Jennifer L / Dharmage, Shyamali C

American journal of respiratory and critical care medicine

2023 Volume 208, Issue 2, Page(s) 132–141

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Child ; Humans ; Cohort Studies ; Asthma/genetics ; Longitudinal Studies ; Pulmonary Disease, Chronic Obstructive ; Phenotype ; Risk Factors
Language	English
Publishing date	2023-05-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202208-1569OC
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Article: Plasma lipoprotein subclass variation in middle-aged and older adults: Sex-stratified distributions and associations with health status and cardiometabolic risk factors.

Masuda, Reika / Wist, Julien / Lodge, Samantha / Kimhofer, Torben / Hunter, Michael / Hui, Jennie / Beilby, John P / Burnett, John R / Dwivedi, Girish / Schlaich, Markus P / Bong, Sze-How / Loo, Ruey Leng / Holmes, Elaine / Nicholson, Jeremy K / Yeap, Bu B

Journal of clinical lipidology

2023 Volume 17, Issue 5, Page(s) 677–687

Abstract: Background: Circulating lipids and lipoproteins mediate cardiovascular risk, however routine plasma lipid biochemistry provides limited information on pro-atherogenic remnant particles.: Objective: We analysed plasma lipoprotein subclasses including ... ...

Abstract	Background: Circulating lipids and lipoproteins mediate cardiovascular risk, however routine plasma lipid biochemistry provides limited information on pro-atherogenic remnant particles. Objective: We analysed plasma lipoprotein subclasses including very low-density and intermediate-density lipoprotein (VLDL and IDL); and assessed their associations with health and cardiometabolic risk. Methods: From 1,976 community-dwelling adults aged 45-67 years, 114/1071 women (10.6%) and 153/905 men (16.9%) were categorised as very healthy. Fasting plasma lipoprotein profiles comprising 112 parameters were measured using Results: HDL cholesterol was higher, and IDL and VLDL cholesterol and triglycerides lower, in very healthy women compared to other women, and women compared to men. IDL and VLDL cholesterol and triglyceride were lower in very healthy men compared to other men. HDL cholesterol and apolipoprotein (apo) A-I were inversely, and IDL and VLDL cholesterol, apoB-100, and apoB-100/apoA-I ratio directly associated with body mass index (BMI) in women and men. In women, LDL, IDL and VLDL cholesterol increased with age. Women with diabetes and cardiovascular disease had higher cholesterol, triglycerides, phospholipids and free cholesterol across IDL and VLDL fractions, with similar trends for men with diabetes. Conclusion: Lipoprotein subclasses and density fractions, and their lipid and apolipoprotein constituents, are differentially distributed by sex, health status and BMI. Very healthy women and men are distinguished by favorable lipoprotein profiles, particularly lower concentrations of VLDL and IDL, providing reference intervals for comparison with general populations and adults with cardiometabolic risk factors.
MeSH term(s)	Male ; Middle Aged ; Humans ; Female ; Aged ; Apolipoprotein B-100 ; Cholesterol, VLDL ; Cholesterol, HDL ; Cardiometabolic Risk Factors ; Lipoproteins ; Lipoproteins, VLDL ; Cholesterol ; Triglycerides ; Diabetes Mellitus ; Health Status
Chemical Substances	Apolipoprotein B-100 ; Cholesterol, VLDL ; Cholesterol, HDL ; Lipoproteins ; Lipoproteins, VLDL ; Cholesterol (97C5T2UQ7J) ; Triglycerides
Language	English
Publishing date	2023-07-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2365061-8
ISSN	1876-4789 ; 1933-2874
ISSN (online)	1876-4789
ISSN	1933-2874
DOI	10.1016/j.jacl.2023.06.004
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Article ; Online: Airway microbial communities, smoking and asthma in a general population sample.

Turek, Elena M / Cox, Michael J / Hunter, Michael / Hui, Jennie / James, Phillip / Willis-Owen, Saffron A G / Cuthbertson, Leah / James, Alan / Musk, A William / Moffatt, Miriam F / Cookson, William O C M

EBioMedicine

2021 Volume 71, Page(s) 103538

Abstract: Background: Normal airway microbial communities play a central role in respiratory health but are poorly characterized. Cigarette smoking is the dominant global environmental influence on lung function, and asthma has become the most prevalent chronic ... ...

Abstract	Background: Normal airway microbial communities play a central role in respiratory health but are poorly characterized. Cigarette smoking is the dominant global environmental influence on lung function, and asthma has become the most prevalent chronic respiratory disease worldwide. Both conditions have major microbial components that are incompletely defined. Methods: We investigated airway bacterial communities in a general population sample of 529 Australian adults. Posterior oropharyngeal swabs were analyzed by sequencing of the 16S rRNA gene. The microbiota were characterized according to their prevalence, abundance and network memberships. Findings: The microbiota were similar across the general population, and were strongly organized into co-abundance networks. Smoking was associated with diversity loss, negative effects on abundant taxa, profound alterations to network structure and expansion of Streptococcus spp. By contrast, the asthmatic microbiota were selectively affected by an increase in Neisseria spp. and by reduced numbers of low abundance but prevalent organisms. Interpretation: Our study shows that the healthy airway microbiota in this population were contained within a highly structured ecosystem, suggesting balanced relationships between the microbiome and human host factors. The marked abnormalities in smokers may contribute to chronic obstructive pulmonary disease (COPD) and lung cancer. The narrow spectrum of abnormalities in asthmatics encourages investigation of damaging and protective effects of specific bacteria. Funding: The study was funded by the Asmarley Trust and a Wellcome Joint Senior Investigator Award to WOCC and MFM (WT096964MA and WT097117MA). The Busselton Healthy Ageing Study is supported by the Government of Western Australia (Office of Science, Department of Health) the City of Busselton, and private donations.
MeSH term(s)	Adult ; Aged ; Asthma/epidemiology ; Asthma/etiology ; Australia/epidemiology ; Computational Biology/methods ; Disease Susceptibility ; Female ; Humans ; Male ; Metagenomics/methods ; Microbiota ; Middle Aged ; Population Surveillance ; RNA, Ribosomal, 16S ; Respiratory Mucosa/microbiology ; Smoking/adverse effects ; Smoking/epidemiology ; Tobacco Smoking
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2021-08-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2021.103538
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Article ; Online: Early-Life Exposure to Oral Antibiotics and Lung Function Into Early Adulthood.

Santos, Karoliny Dos / Lodge, Caroline J / Abramson, Michael J / Erbas, Bircan / Bennett, Catherine M / Hui, Jennie / Dharmage, Shyamali C / Lowe, Adrian J

Chest

2019 Volume 157, Issue 2, Page(s) 334–341

Abstract: Background: Although there is ongoing debate regarding the impact of early postnatal exposure to antibiotics on the development of asthma, the possibility that antibiotic exposure may impair lung function has not previously been examined. Furthermore, ... ...

Abstract	Background: Although there is ongoing debate regarding the impact of early postnatal exposure to antibiotics on the development of asthma, the possibility that antibiotic exposure may impair lung function has not previously been examined. Furthermore, it is unclear if specific types of antibiotics may have a greater effect, or if children with genetic mutations in the oxidative stress response glutathione S-transferase (GST) superfamily may be at greater risk. Methods: Parent-reported data of childhood antibiotic use from birth to 2 years, including type and indication, were collected from a birth cohort of 620 infants with a family history of allergy. Spirometry was performed at age 12 and 18 years, and results are presented as z scores. Participants were genotyped for GST-P, GST-M, and GST-T polymorphisms. Linear regression models were used to investigate the associations while adjusting for confounding factors. Results: Neither increasing days of exposure nor earlier exposure to antibiotics was associated with reduced FEV Conclusions: Increasing exposure to oral antibiotics in early postnatal life was not associated with reduced lung function in children with a family history of allergic diseases. Although unwarranted use of antibiotics in children should be minimized, concerns regarding long-term lung health should not be a driving influence for this rationalization of use.
MeSH term(s)	Adolescent ; Anti-Bacterial Agents/therapeutic use ; Asthma/epidemiology ; Asthma/genetics ; Asthma/physiopathology ; Child ; Dermatitis, Atopic ; Family ; Female ; Food Hypersensitivity ; Forced Expiratory Volume/genetics ; Forced Expiratory Volume/physiology ; Gene-Environment Interaction ; Glutathione S-Transferase pi/genetics ; Glutathione Transferase/genetics ; Humans ; Infant ; Infant, Newborn ; Linear Models ; Longitudinal Studies ; Lung/physiopathology ; Macrolides/therapeutic use ; Male ; Oxidative Stress/genetics ; Penicillins/therapeutic use ; Polymorphism, Genetic ; Rhinitis, Allergic ; Risk Factors ; Sulfonamides/therapeutic use ; Vital Capacity/genetics ; Vital Capacity/physiology
Chemical Substances	Anti-Bacterial Agents ; Macrolides ; Penicillins ; Sulfonamides ; glutathione S-transferase T1 (EC 2.5.1.-) ; GSTP1 protein, human (EC 2.5.1.18) ; Glutathione S-Transferase pi (EC 2.5.1.18) ; Glutathione Transferase (EC 2.5.1.18) ; glutathione S-transferase M1 (EC 2.5.1.18)
Language	English
Publishing date	2019-10-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2019.10.004
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Article ; Online: Effects of androgen deprivation therapy on telomere length.

Cheung, Ada S / Yeap, Bu B / Hoermann, Rudolf / Hui, Jennie / Beilby, John P / Grossmann, Mathis

Clinical endocrinology

2017 Volume 87, Issue 4, Page(s) 381–385

Abstract: Objective: Recent evidence suggests that androgens either directly or via aromatisation to oestradiol may regulate telomere length, hence providing a mechanism whereby reproductive steroids are linked to biological ageing in men. Using men with prostate ...

Abstract	Objective: Recent evidence suggests that androgens either directly or via aromatisation to oestradiol may regulate telomere length, hence providing a mechanism whereby reproductive steroids are linked to biological ageing in men. Using men with prostate cancer initiating androgen deprivation therapy (ADT), we tested the hypothesis that severe sex steroid deprivation would accelerate telomere shortening. Design: We conducted a secondary analysis of a 2-year prospective controlled study among 65 men with nonmetastatic prostate cancer newly commencing adjuvant ADT (n=40) and age- and radiotherapy-matched prostate cancer controls (n=25). Methods: We measured leucocyte telomere length (LTL) expressed as telomeric/single copy control gene (T/S) ratio at baseline, 6, 12 and 24 months. Generalized linear models determined the mean adjusted difference (MAD) (95% confidence interval) between groups during follow-up. Results: Compared to controls over 24 months, men receiving ADT had no change in LTL, MAD for T/S ratio (0.105 [-0.004; 0.213], P=.235). Conclusions: Using men with prostate cancer receiving ADT as a model we found no evidence that prolonged and profound sex steroid deprivation is associated with accelerated telomere shortening. Larger studies will be required to confirm or refute these findings.
Language	English
Publishing date	2017-10
Publishing country	England
Document type	Journal Article
ZDB-ID	121745-8
ISSN	1365-2265 ; 0300-0664
ISSN (online)	1365-2265
ISSN	0300-0664
DOI	10.1111/cen.13382
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