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Article ; Online: Identification of Lactate as a Cardiac Protectant by Inhibiting Inflammation and Cardiac Hypertrophy Using a Zebrafish Acute Heart Failure Model

Elijah R. Haege / Hui-Chi Huang / Cheng-chen Huang

Pharmaceuticals, Vol 14, Iss 261, p

2021 Volume 261

Abstract: Acute heart failure (AHF) commonly arises from decompensated chronic heart failure or sudden structural and functional breakdown causing a decrease in cardiac contractility and consequently fluid accumulation and systemic congestion. Current treatment ... ...

Abstract	Acute heart failure (AHF) commonly arises from decompensated chronic heart failure or sudden structural and functional breakdown causing a decrease in cardiac contractility and consequently fluid accumulation and systemic congestion. Current treatment for AHF aims at reducing fluid overload and improving hemodynamic which results in quick symptom relief but still poor prognostic outcome. This study utilizes a zebrafish AHF model induced by aristolochic acid (AA) to look for natural products that could attenuate the progression of AHF. The project started off by testing nearly seventy herbal crude extracts. Two of the positive extracts were from Chinese water chestnuts and are further studied in this report. After several rounds of chromatographical chemical fractionation and biological tests, a near pure fraction, named A2-4-2-4, with several hydrophilic compounds was found to attenuate the AA-induced AHF. A2-4-2-4 appeared to inhibit inflammation and cardiac hypertrophy by reducing MAPK signaling activity. Chemical analyses revealed that the major compound in A2-4-2-4 is actually lactate. Pure sodium lactate showed attenuation of the AA-induced AHF and inflammation and cardiac hypertrophy suppression as well, suggesting that the AHF attenuation ability in A2-4-2-4 is attributable to lactate. Our studies identify lactate as a cardiac protectant and a new therapeutic agent for AHF.
Keywords	acute heart failure ; zebrafish ; lactate ; inflammation ; cardiac hypertrophy ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
Subject code	610
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hepatoprotective and antioxidant effects of Wu-Zi-Yuan-Chung-Wan against CCl-induced oxidative damage in rats

Hao-Yuan Cheng / Jung Chao / Chuan-Sung Chiu / I-Chien Hsieh / Hui-Chi Huang / Lung-Yuan Wu / Wen-Huang Peng

European Journal of Inflammation, Vol

2021 Volume 19

Abstract: This study was designed to investigate the hepatoprotective potentials of the Wu-Zi-Yuan-Chung-Wan (WZYCW) using an animal model of carbon tetrachloride (CCl 4 ) induced liver injury. CCl 4 induced chronic liver hepatotoxicity in adult Sprague-Dawley ... ...

Abstract	This study was designed to investigate the hepatoprotective potentials of the Wu-Zi-Yuan-Chung-Wan (WZYCW) using an animal model of carbon tetrachloride (CCl 4 ) induced liver injury. CCl 4 induced chronic liver hepatotoxicity in adult Sprague-Dawley rats. Excluding the control group, all of the rats with chronic liver fibrosis received 0.4% CCl 4 (1.5 mL/kg of body weight, ip) twice per week for 8 weeks. WZYCW (20, 100, and 500 mg/kg) and silymarin (200 mg/kg) were administered five times per week for 8 weeks. After 8 weeks, the rats were sacrificed, blood samples were obtained, and liver histological examinations were performed for subsequent assays. These results suggest that WZYCW considerably reduced Glutamic Oxaloacetic Transaminase (GOT), Glutamic Pyruvic Transaminase (GPT), Triglyceride (TG); and cholesterol activity; and the levels of malonaldehyde (MDA), nitric oxide (NO), and transforming growth factor-β 1 (TGF-β 1 ) in the liver. WZYCW also increased the level of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in liver tissue. WZYCW produced hepatoprotective and antifibrotic effects. This is the first study to demonstrate that WZYCW expressed hepatoprotective activity against CCl 4 induced acute hepatotoxicity in rat. In addition, the primary compound of WZCYW was analyzed using HPLC. The major peaks of WZCYW, including schizandrin. The results indicate that WZYCW not only enhances hepatic antioxidant enzyme activities and inhibits lipid peroxidation but also suppresses inflammatory responses in CCl 4 induced liver damage. Our findings provide evidence that WZYCW possesses a hepatoprotective activity to ameliorate chronic liver injury.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Antioxidant Effects and Phytochemical Properties of Seven Taiwanese Cirsium Species Extracts

Zi-Wei Zhao / Hung-Chi Chang / Hui Ching / Jin-Cherng Lien / Hui-Chi Huang / Chi-Rei Wu

Molecules, Vol 26, Iss 3935, p

2021 Volume 3935

Abstract: In the present investigation, we compared the radical-scavenging activities and phenolic contents of seven Taiwanese Cirsium species with a spectrophotometric method. We further analyzed their phytochemical profiles with high-performance liquid ... ...

Abstract	In the present investigation, we compared the radical-scavenging activities and phenolic contents of seven Taiwanese Cirsium species with a spectrophotometric method. We further analyzed their phytochemical profiles with high-performance liquid chromatography–photodiode array detection (HPLC–DAD). We found that the flower part of Cirsium japonicum var. australe (CJF) showed the best radical-scavenging activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and the hypochlorite ion, for which the equivalents were 6.44 ± 0.17 mg catechin/g, 54.85 ± 0.66 mmol Trolox/g and 418.69 ± 10.52 mmol Trolox/g respectively. CJF also had the highest contents of total phenolics (5.23 ± 0.20 mg catechin/g) and phenylpropanoids (29.73 ± 0.72 mg verbascoside/g). According to the Pearson’s correlation coefficient, there was a positive correlation between the total phenylpropanoid content and ABTS radical-scavenging activities (r = 0.979). The radical-scavenging activities of the phenylpropanoids are closely related to their reducing power (r = 0.986). HPLC chromatograms obtained in validated HPLC conditions confirm that they have different phytochemical profiles by which they can be distinguished. Only CJF contained silicristin (0.66 ± 0.03 mg/g) and silydianin (9.13 ± 0.30 mg/g). CJF contained the highest contents of apigenin (5.56 ± 0.09 mg/g) and diosmetin (2.82 ± 0.10 mg/g). Among the major constituents, silicristin had the best radical-scavenging activities against DPPH (71.68 ± 0.66 mg catechin/g) and ABTS (3.01 ± 0.01 mmol Trolox/g). However, diosmetin had the best reducing power and radical-scavenging activity against the hypochlorite anion (41.57 ± 1.14 mg mmol Trolox/g). Finally, we found that flavonolignans (especial silicristin and silydianin) and diosmetin acted synergistically in scavenging radicals.
Keywords	Cirsium species ; silymarin ; silicristin ; antioxidant activities ; phytochemical profiles ; HPLC–DAD ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Polyoxygenated Terpenoids and Polyketides from the Roots of Flueggea virosa and Their Inhibitory Effect against SARS-CoV-2-Induced Inflammation

Ju-Chien Cheng / Yi-Ju Chen / Chi-Wen Chuang / Ya-Hsuan Chao / Hui-Chi Huang / Chia-Chi Lin / Chih-Hua Chao

Molecules, Vol 27, Iss 8548, p

2022 Volume 8548

Abstract: Six new polyoxygenated terpenoids, podovirosanes A–F ( 1 – 6 ), and two known polyketides ( 7 and 8 ) were isolated from the roots of F. virosa . Their structures, along with absolute configurations, were deduced using spectroscopic analysis as well as ... ...

Abstract	Six new polyoxygenated terpenoids, podovirosanes A–F ( 1 – 6 ), and two known polyketides ( 7 and 8 ) were isolated from the roots of F. virosa . Their structures, along with absolute configurations, were deduced using spectroscopic analysis as well as computational calculations, including TDDFT calculation of ECD spectra and GIAO NMR calculations combined with DP4+ probability analysis. Compounds 2 , 3 , 5 , and 8 were found to reduce the phosphorylation levels of NF- κ B p65 in SARS-CoV-2 pseudovirus-stimulated PMA-differentiated THP-1 cells.
Keywords	SARS-CoV-2 ; anti-inflammatory ; podovirosanes A–F ; Flueggea virosa ; DP4+ ; Organic chemistry ; QD241-441
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Computationally Assisted Structural Elucidation of Cembranoids from the Soft Coral Sarcophyton tortuosum

Chih-Hua Chao / Kuan-Hua Lin / Chiung-Yao Huang / Tsong-Long Hwang / Chang-Feng Dai / Hui-Chi Huang / Jyh-Horng Sheu

Marine Drugs, Vol 20, Iss 297, p

2022 Volume 297

Abstract: A persistent study on soft coral Sarcophyton tortuosum resulted in the characterization of two new cembranolides, tortuolides A and B ( 1 and 2 ), and a new related diterpene, epi -sarcophytonolide Q. Their structures were determined not only by ... ...

Abstract	A persistent study on soft coral Sarcophyton tortuosum resulted in the characterization of two new cembranolides, tortuolides A and B ( 1 and 2 ), and a new related diterpene, epi -sarcophytonolide Q. Their structures were determined not only by extensive spectroscopic analysis but also by DFT calculations of ECD and NMR data, the latter of which was combined with statistical analysis methods, e.g., DP4+ and J -DP4 approaches. Anti-inflammatory and cytotoxicity activities were evaluated in this study.
Keywords	tortuolide A ; tortuolide B ; epi -sarcophytonolide ; DP4+ ; J -DP4 ; Sarcophyton tortuosum ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Anti-inflammatory constituents from Phyllostachys makinoi Hayata

Liaw, Chia-Ching / Lin, Yu-Chi / Wu, Shao-Yu / Kuo, Jenny Chun-Ling / Lin, Zhi-Hu / Lin, Kai-Wei / Hui-Chi, Huang / Yang Kuo, Li-Ming / Kuo, Yao-Haur

Natural Product Research. 2022 Mar. 19, v. 36, no. 6 p.1425-1432

2022

Abstract: A novel chromone analogue, phyllomakin A (1), and a new flavonolignan, (-)-quiquelignan C (2), along with 18 phenolic and 2 triterpenoids, were isolated from the leaves of Phyllostachys makinoi Hayata. The structures of 1–22 were elucidated by an ... ...

Abstract	A novel chromone analogue, phyllomakin A (1), and a new flavonolignan, (-)-quiquelignan C (2), along with 18 phenolic and 2 triterpenoids, were isolated from the leaves of Phyllostachys makinoi Hayata. The structures of 1–22 were elucidated by an application of various spectroscopic analyses (1D & 2D NMR and MS) and compared with reported data. A biological evaluation showed that compound 3 had very potent anti-NO production activity (IC₅₀ = 4.80 µM), while compounds 2, 6, 11, and 15 showed moderate inhibitory effects (IC₅₀ = 10.19, 13.26, 13.56, and 10.96 µM, respectively) without affecting cell viability at 20 μM.
Keywords	Phyllostachys ; biological assessment ; cell viability ; research ; spectroscopy ; triterpenoids ; Phyllostachys makinoi ; Phyllomakin A ; Quiquelignan C ; Anti-NO production
Language	English
Dates of publication	2022-0319
Size	p. 1425-1432.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2021.1885406
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2

Fang-Ju Cheng / Chien-Yi Ho / Tzong-Shiun Li / Yeh Chen / Yi-Lun Yeh / Ya-Ling Wei / Thanh Kieu Huynh / Bo-Rong Chen / Hung-Yu Ko / Chen-Si Hsueh / Ming Tan / Yang-Chang Wu / Hui-Chi Huang / Chih-Hsin Tang / Chia-Hung Chen / Chih-Yen Tu / Wei-Chien Huang

Cell & Bioscience, Vol 13, Iss 1, Pp 1-

2023 Volume 19

Abstract: Abstract Background Artemisia argyi (A. argyi), also called Chinese mugwort, has been widely used to control pandemic diseases for thousands of years since ancient China due to its anti-microbial infection, anti-allergy, and anti-inflammation activities. ...

Abstract	Abstract Background Artemisia argyi (A. argyi), also called Chinese mugwort, has been widely used to control pandemic diseases for thousands of years since ancient China due to its anti-microbial infection, anti-allergy, and anti-inflammation activities. Therefore, the potential of A. argyi and its constituents in reducing the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was investigated in this study. Results Among the phytochemicals in A. argyi, eriodictyol and umbelliferone were identified to target transmembrane serine protease 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2) proteins, the essential factors for the cellular entry of SARS-CoV-2, in both FRET-based enzymatic assays and molecular docking analyses. These two ingredients of A. argyi suppressed the infection of ACE2-expressed HEK-293 T cells with lentiviral-based pseudo-particles (Vpp) expressing wild-type and variants of SARS-CoV-2 spike (S) protein (SARS-CoV-2 S-Vpp) via interrupting the interaction between S protein and cellular receptor ACE2 and reducing the expressions of ACE2 and TMPRSS2. Oral administration with umbelliferone efficiently prevented the SARS-CoV-2 S-Vpp-induced inflammation in the lung tissues of BALB/c mice. Conclusions Eriodictyol and umbelliferone, the phytochemicals of Artemisia argyi, potentially suppress the cellular entry of SARS-CoV-2 by preventing the protein binding activity of the S protein to ACE2.
Keywords	Artemisia argyi ; Eriodictyol ; Umbelliferone ; TMPRSS2 ; ACE2 ; SARS-CoV-2 variants ; Biotechnology ; TP248.13-248.65 ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
Subject code	572
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cuscuta chinensis and C. campestris Attenuate Scopolamine-Induced Memory Deficit and Oxidative Damage in Mice

Ming-Kuem Lin / Meng-Shiou Lee / Hui-Chi Huang / Tun-Jen Cheng / Yih-Dih Cheng / Chi-Rei Wu

Molecules, Vol 23, Iss 12, p

2018 Volume 3060

Abstract: The seeds of Cuscuta chinensis Lam. and C. campestris Yuncker have been commonly used as Chinese medical material for preventing aging. Our previous studies have found that C. chinensis and C. campestris possess anti-inflammatory activities in rodents. ... ...

Abstract	The seeds of Cuscuta chinensis Lam. and C. campestris Yuncker have been commonly used as Chinese medical material for preventing aging. Our previous studies have found that C. chinensis and C. campestris possess anti-inflammatory activities in rodents. However, their other biological activities, such as memory-improving properties, have not yet been explored. In the present study, we examined the memory-improving effects of the extracts of C. chinensis and C. campestris on scopolamine (SCOP)-induced memory deficit and explored their underlying mechanism in mice. Both Cuscuta species improved SCOP-induced memory deficits in the passive avoidance test, elevated plus-maze, and spatial performance test of the Morris water maze in mice. In addition, compared with mice injected with SCOP, mice pretreated with both Cuscuta species stayed for a longer time on the platform for the probe test of the Morris water maze. Moreover, both Cuscuta species reduced brain acetylcholinesterase activity and malondialdehyde levels that were increased by SCOP, and the species restored the activities of antioxidant enzymes (superoxide dismutase and catalase) and the levels of glutathione that were decreased by SCOP in the brains of mice. Both Cuscuta species further decreased brain interleukin-1β and tumor necrosis factor-α levels that were elevated by SCOP. We demonstrated that both Cuscuta species exhibited a protective activity against SCOP-induced memory deficit, cholinergic dysfunction, oxidative damage, and neuroinflammation in mice, and C. campestris has better potential than C. chinensis . In addition, we provided evidence that the seeds of C. campestris can be used as Cuscutae Semen in Traditional Chinese Medicine.
Keywords	Cuscutae Semen ; Cuscuta campestris ; Cuscuta chinensis ; memory-improving properties ; scopolamine ; Organic chemistry ; QD241-441
Language	English
Publishing date	2018-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Anti-inflammatory constituents from

Liaw, Chia-Ching / Lin, Yu-Chi / Wu, Shao-Yu / Kuo, Jenny Chun-Ling / Lin, Zhi-Hu / Lin, Kai-Wei / Hui-Chi, Huang / Yang Kuo, Li-Ming / Kuo, Yao-Haur

Natural product research

2021 Volume 36, Issue 6, Page(s) 1425–1432

Abstract: A novel chromone analogue, phyllomakin A ( ...

Abstract	A novel chromone analogue, phyllomakin A (
MeSH term(s)	Anti-Inflammatory Agents/chemistry ; Molecular Structure ; Phenols/analysis ; Plant Leaves/chemistry ; Spectrum Analysis ; Triterpenes/chemistry
Chemical Substances	Anti-Inflammatory Agents ; Phenols ; Triterpenes
Language	English
Publishing date	2021-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2021.1885406
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Potential Herbal Adjuvant Combined With a Peptide-Based Vaccine Acts Against HPV-Related Tumors Through Enhancing Effector and Memory T-Cell Immune Responses

Ying-Chyi Song / Hui-Chi Huang / Cherry Yin-Yi Chang / Hui-Ju Lee / Chuan-Teng Liu / Hsin-Yi Lo / Tin-Yun Ho / Wu-Chou Lin / Hung-Rong Yen

Frontiers in Immunology, Vol

2020 Volume 11

Abstract: Viral infection is associated with many types of tumorigenesis, including human papillomavirus (HPV)-induced cervical cancer. The induction of a specific T-cell response against virus-infected cells is desired to develop an efficient therapeutic approach ...

Abstract	Viral infection is associated with many types of tumorigenesis, including human papillomavirus (HPV)-induced cervical cancer. The induction of a specific T-cell response against virus-infected cells is desired to develop an efficient therapeutic approach for virus-associated cancer. Chinese herbal medicine (CHM) has a long history in the treatment of cancer patients in Asian countries. Hedyotis diffusa Willd (Bai Hua She She Cao, BHSSC) is frequently used clinically and has been shown to inhibit tumor growth in vitro. However, in vivo data demonstrating the antitumor efficacy of BHSSC are still lacking. We showed that BHSSC induces murine and human antigen-presenting cell (APC) activation via the MAPK signaling pathway and enhances antigen presentation in bone marrow-derived dendritic cells (BMDCs) in vitro. Furthermore, we identified that treatment with BHSSC leads to improved specific effector and memory T-cell responses in vivo. Variant peptide-based vaccines combined with BHSSC improved antitumor activity in preventive, therapeutic, and recurrent HPV-related tumor models. Furthermore, we showed that rutin, one of the ingredients in BHSSC, induces a strong specific immune response against HPV-related tumors in vivo. In summary, we demonstrated that BHSSC extract and its active compound, rutin, can be used as adjuvants in peptide-based vaccines to increase immunogenicity and to bypass the requirement of a conditional adjuvant.
Keywords	cervical cancer ; Chinese herbal medicine ; Hedyotis diffusa Willd ; peptide-based cancer vaccine ; human papillomavirus ; Immunologic diseases. Allergy ; RC581-607
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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