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Article ; Online: Tislelizumab plus chemotherapy is more cost-effective than chemotherapy alone as first-line therapy for advanced non-squamous non-small cell lung cancer

Xueyan Liang / Xiaoyu Chen / Huijuan Li / Yan Li

Frontiers in Public Health, Vol

2023 Volume 11

Abstract: Background and objectiveTislelizumab is a programmed cell death protein-1 (PD-1) inhibitor. Tislelizumab plus chemotherapy as first-line option for advanced non-squamous non-small cell lung cancer (NSCLC), compared with chemotherapy alone, resulted in ... ...

Abstract	Background and objectiveTislelizumab is a programmed cell death protein-1 (PD-1) inhibitor. Tislelizumab plus chemotherapy as first-line option for advanced non-squamous non-small cell lung cancer (NSCLC), compared with chemotherapy alone, resulted in significantly prolonged survival outcomes; however, evidence regarding its relative efficacy and cost is lacking. We aimed to evaluate the cost-effectiveness of tislelizumab plus chemotherapy compared with that of chemotherapy alone, from the health care perspective in China.MethodsA partitioned survival model (PSM) was used for this study. The survival data were obtained from the RATIONALE 304 trial. Cost-effectiveness was defined as incremental cost-effectiveness ratio (ICER) less than the willingness to pay (WTP) threshold. Incremental net health benefits (INHB), incremental net monetary benefits (INMB), and subgroup analyses were also assessed. Sensitivity analyses were further established to assess the model stability.ResultsCompared with chemotherapy alone, tislelizumab plus chemotherapy increased by 0.64 quality-adjusted life-years (QALYs) and 1.48 life-years, and yielded an increase of $16,631 in cost per patient. The INMB and INHB were $7,510 and 0.20 QALYs at a WTP threshold of $38,017/QALY, respectively. The ICER was $26,162/QALY. The outcomes were most sensitive to the HR of OS for tislelizumab plus chemotherapy arm. The probability of tislelizumab plus chemotherapy being considered cost-effective was 87.66% and >50% in most of the subgroups at the WTP threshold of $38,017/QALY. At the WTP threshold of $86,376/QALY, the probability achieved 99.81%. Furthermore, the probability of tislelizumab plus chemotherapy being considered cost-effective in subgroups of patients with liver metastases and PD–L1 expression ≥50% were 90.61 and 94.35%, respectively.ConclusionTislelizumab plus chemotherapy is likely to be cost-effective as a first-line treatment for advanced non-squamous NSCLC in China.
Keywords	tislelizumab ; chemotherapy ; non-small cell lung cancer ; partitioned survival model ; cost-effectiveness ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Behaviour and metabolism during tonic immobility (death-feigning) in Eucryptorrhynchus scrobiculatus and E. brandti (Coleoptera

Huijuan LI / Junbao WEN

European Journal of Entomology, Vol 118, Iss 1, Pp 322-

Curculionidae)

2021 Volume 329

Abstract: The antipredator behaviour, tonic immobility (TI) is a valuable defence that enables insects to increase their chance of survival and is a trade-off between fleeing and protection. How the TI strategies of insects respond to environmental factors, ... ...

Abstract	The antipredator behaviour, tonic immobility (TI) is a valuable defence that enables insects to increase their chance of survival and is a trade-off between fleeing and protection. How the TI strategies of insects respond to environmental factors, however, remains a largely understudied subject. In this paper the effect of four factors (mechanical stimulation, light, sound and temperature) and metabolic responses were used to evaluate TI behavioural and physiological adaptions in Eucryptorrhynchus scrobiculatus (ESCR) and Eucryptorrhynchus brandti (EBRA). In the behavioural experiment, the metaventrite, which is the stimulus-sensing region in ESCR and EBRA, was subjected to mechanical stimulation. Light lengthened the TI duration in ESCR males, while sound had the opposite effect in ESCR and EBRA. The effect of temperature on the duration of TI was variable: in ESCR, the duration was shorter at low (15°C) and high (32°C) temperatures, but in EBRA, it was longer at the low (15°C) temperature. In the metabolism experiment, ESCR and EBRA metabolic rates (MR), was significantly dependent on whether they were in a state of TI or not. The TIMR declined to 76.90% in ESCR and 71.40% in EBRA. These results indicate that TI in ESCR and EBRA differed under different external conditions and contributes to the understanding of the physiological regulation of ecological traits of insect TI.
Keywords	coleoptera ; curculionidae ; eucryptorrhynchus ; defence strategy ; anti-predator behaviour ; thanatosis ; death-feigning ; metabolic rate ; Zoology ; QL1-991
Subject code	590
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Institute of Entomology, Biology Centre, Czech Academy of Science
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Natural pigment zeaxanthin ameliorates lipopolysaccharides induced acute lung inflammation in both in vitro and in vivo models

Xiaru Lou / Huijuan Li / Sulaiman Ali Alharbi / Thamaraiselvan Rengarajan / Jianyu Wang

Arabian Journal of Chemistry, Vol 17, Iss 3, Pp 105569- (2024)

2024

Abstract: Natural pigments obtained from plants, animals, and microbes are not only a potent alternative to synthetic dyes in the food, textile, and cosmetic industries, but they also possess immense pharmacological properties. Carmine acids, carotenoids, ... ...

Abstract	Natural pigments obtained from plants, animals, and microbes are not only a potent alternative to synthetic dyes in the food, textile, and cosmetic industries, but they also possess immense pharmacological properties. Carmine acids, carotenoids, flavonoids, indigo, anthocyanin, melanins, and curcumin are such natural pigments that have proven pharmacological properties. Zeaxanthin is one such natural water-soluble antioxidant pigment that belongs to the xanthophyll family and is predominantly accumulated in the retina of the eyes. The potency of zeaxanthin against LPS-induced inflammation in in vitro and in vivo conditions was examined. RAW264.7 cells were treated with zeaxanthin and challenged with LPS. The LPS-induced zeaxanthin-treated cells were subjected to assessments of cytotoxicity and inflammatory markers. For the in vivo study, BALB/c male mice were induced to have acute lung inflammation by LPS. The ALI-induced mice were treated with 25 and 50 mg/kg concentrations of zeaxanthin. BALF was collected from zeaxanthin-treated ALI-induced mice and was sacrificed for the excision of lung tissue. Pulmonary edema was examined in the lung tissues. Immune cell infiltration and protein content were examined in the BALF collected. Oxidative stress induction was analyzed in the lung tissue of ALI-induced mice. The inflammatory markers iNOS, COX-2, and PGE-2 were quantified in the lung tissues of zeaxanthin-treated ALI-induced mice. Zeaxanthin effectively prevented lung edema and immune cell infiltration. Oxidative stress and inflammatory cytokine synthesis induced by LPS in the lungs were significantly decreased with zeaxanthin treatment. Histopathological analysis also confirms our in vitro and in vivo biochemical analyses. Overall, our findings corroborate that zeaxanthin is a potent anti-inflammatory agent that effectively inhibits LPS-induced ALI in both in vitro and in vivo conditions.
Keywords	Natural pigments ; Zeaxanthin ; RAW264.7 cells ; BALB/c mice ; Inflammation ; Oxidative stress ; Chemistry ; QD1-999
Subject code	630
Language	English
Publishing date	2024-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sugemalimab plus chemotherapy vs. chemotherapy for metastatic non-small-cell lung cancer

Xueyan Liang / Xiaoyu Chen / Huijuan Li / Xiaoxia Liu / Yan Li

Frontiers in Public Health, Vol

A cost-effectiveness analysis

2023 Volume 11

Abstract: BackgroundSugemalimab is a newly developed inhibitor of programmed death ligand 1 (PD-L1). As a first-line treatment for metastatic non-small-cell lung cancer (NSCLC), sugemalimab plus chemotherapy (Sugema-Chemo) has been proven effective. Still, its ... ...

Abstract	BackgroundSugemalimab is a newly developed inhibitor of programmed death ligand 1 (PD-L1). As a first-line treatment for metastatic non-small-cell lung cancer (NSCLC), sugemalimab plus chemotherapy (Sugema-Chemo) has been proven effective. Still, its cost-effectiveness has not yet been determined. The objective of this study was to assess the cost-effectiveness of Sugema-Chemo from a health care perspective in China.MethodsA partitioned survival model was used. According to the GEMSTONE-302 trial, the clinical characteristics and outcomes of the patients were obtained. The outcomes were costs, quality-adjusted life-years (QALYs), incremental cost-effectiveness ratio (ICER), incremental net health benefits (INHB) and incremental net monetary benefits (INMB). The robustness of the model was further evaluated, as well as subgroup analyses. When the ICER was lower than the willingness to pay (WTP) threshold ($38,017/QALY or $86,376/QALY, defined as three times the per capita gross domestic product value of the general region and Beijing), the cost-effectiveness of Sugema-Chemo was assumed for general regions or Beijing.ResultsCompared with chemotherapy alone, Sugema-Chemo resulted in an incremental gain of 0.82 QALYs, an incremental gain of 1.26 life-years, as well as an average increase cost of $72,472. The ICER was $88,744/QALY. Model outcomes were susceptible to average body weight and cost of sugemalimab. Sugema-Chemo was cost-effective at a WTP threshold of 86,376/QALY if the average body weight was <62.44 kg or if the price of sugemalimab was <$2.996/mg. As well, Sugema-Chemo was also cost-effective when the cost of sugemalimab was <$1.839/mg for a WTP threshold of $38,017/QALY. Sugema-Chemo had a probability of > 50% being considered cost-effective in most subgroups at the $86,376/QALY threshold. However, Sugema-Chemo did not achieve cost-effectiveness (0%) in any of the subgroups when WTP was set at $38,017/QALY.ConclusionSugema-Chemo might not be cost-effective in patients with metastatic NSCLC ...
Keywords	sugemalimab ; partitioned survival model ; non-small cell lung cancers ; chemotherapy ; cost-effectiveness ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Finite-Time Lyapunov Functions and Impulsive Control Design

Huijuan Li / Qingxia Ma

Complexity, Vol

2020 Volume 2020

Abstract: In this paper, we introduce finite-time Lyapunov functions for impulsive systems. The relaxed sufficient conditions for asymptotic stability of an equilibrium of an impulsive system are given via finite-time Lyapunov functions. A converse finite-time ... ...

Abstract	In this paper, we introduce finite-time Lyapunov functions for impulsive systems. The relaxed sufficient conditions for asymptotic stability of an equilibrium of an impulsive system are given via finite-time Lyapunov functions. A converse finite-time Lyapunov theorem for controlling the impulsive system is proposed. Three examples are presented to show how to analyze the stability of an equilibrium of the considered impulsive system via finite-time Lyapunov functions. Furthermore, according to the results, we design an impulsive controller for a chaotic system modified from the Lorenz system.
Keywords	Electronic computers. Computer science ; QA75.5-76.95
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi-Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cognitive cost of empathizing with mothers and strangers by Chinese college students

Huijuan Li / Gaowei Wang / Entao Zhang / Hongqing Shi / Weijia Huang

Heliyon, Vol 8, Iss 9, Pp e10306- (2022)

2022

Abstract: Background: Empathy is a choice and the product of a dynamic decision process based on motivation. The value trade-off in empathy is object-specific and people are more likely to empathize with ingroup, especially empathize with whom we are particularly ... ...

Abstract	Background: Empathy is a choice and the product of a dynamic decision process based on motivation. The value trade-off in empathy is object-specific and people are more likely to empathize with ingroup, especially empathize with whom we are particularly concerned. The mother is an integral part of the self-concept, but the status of the mother in the self-concept of the eastern and western subjects was different. Previous studies have shown that mother is integrated in self-concept and share the same motivational hierarchy with self in Chinese brain. Objectives: The study's purpose is to investigate the empathic choice for mothers in Chinese culture and its regulatory mechanism. Methods: Three experiments were conducted to investigate whether Chinese college students would choose to empathize with their mothers. Experiment 1 used the Empathy Selection Task to examine the empathic choices between mother-other and stranger-other conditions with two blocks of 50 trials, and used the NASA Task Load Index to evaluate the cognitive costs for each deck option presented; Experiment 2 induced a disagreeable emotional state and replicate the same conditions of the experiment 1; Experiment 3 induced an agreeable emotional state and replicate the same conditions of the experiment one. Results and conclusions: The results showed that: (1) participants tended to avoid empathizing with their mothers and strangers for to the cognitive cost; (2) participants were more likely to choose empathy when the target was their mother rather than when the target was a stranger-other, due to the social reward; and (3) participants were more likely to opt to empathize with their mothers when positive emotions towards their mothers were primed. The results suggested that empathy is a choice and the product of a dynamic decision process based on motivation and the value trade-off in empathy is object-specific.
Keywords	Empathy ; Motivational ; Cognitive costs ; Social reward ; Choice ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	150
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Generation of dorsoventral human spinal cord organoids via functionalizing composite scaffold for drug testing

Weiwei Xue / Bo Li / Huihui Liu / Yujie Xiao / Lei Ren / Huijuan Li / Zhicheng Shao

iScience, Vol 26, Iss 1, Pp 105898- (2023)

2023

Abstract: Summary: The spinal cord possesses highly complex, finely organized cytoarchitecture guided by two dorsoventral morphogenic organizing centers. Thus, generation of human spinal cord tissue in vitro is challenging. Here, we demonstrated a novel method for ...

Abstract	Summary: The spinal cord possesses highly complex, finely organized cytoarchitecture guided by two dorsoventral morphogenic organizing centers. Thus, generation of human spinal cord tissue in vitro is challenging. Here, we demonstrated a novel method for generation of human dorsoventral spinal cord organoids using composite scaffolds. Specifically, the spinal cord ventralizing signaling Shh agonist (SAG) was loaded into a porous chitosan microsphere (PCSM), then thermosensitive Matrigel was coated on the surface to form composite microspheres with functional sustained-release SAG, termed as PCSM-Matrigel@SAG. Using PCSM-Matrigel@SAG as the core to induce 3D engineering of human spinal cord organoids from human pluripotent stem cells (ehSC-organoids), we found ehSC-organoids could form dorsoventral spinal cord-like cytoarchitecture with major domain-specific progenitors and neurons. Besides, these ehSC-organoids also showed functional calcium activity. In summary, these ehSC-organoids are of great significance for modeling spinal cord development, drug screening as 3D models for motor neuron diseases, and spinal cord injury repair.
Keywords	Neuroscience ; Materials science ; Biomaterials ; Science ; Q
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: New Approach for Targeted Treatment of Mild COVID-19 by Honeysuckle through Network Pharmacology Analysis

Huijuan Li / Yan Li / Chunxiang Luo / Xueyan Liang / Zixuan Liu / Yu Liu / Yunzhi Ling

Computational and Mathematical Methods in Medicine, Vol

2022 Volume 2022

Abstract: Objective. To investigate the potential pharmacological value of extracts from honeysuckle on patients with mild coronavirus disease 2019 (COVID-19) infection. Methods. The active components and targets of honeysuckle were screened by Traditional Chinese ...

Abstract	Objective. To investigate the potential pharmacological value of extracts from honeysuckle on patients with mild coronavirus disease 2019 (COVID-19) infection. Methods. The active components and targets of honeysuckle were screened by Traditional Chinese Medicine Database and Analysis Platform (TCMSP). SwissADME and pkCSM databases predict pharmacokinetics of ingredients. The Gene Expression Omnibus (GEO) database collected transcriptome data for mild COVID-19. Data quality control, differentially expressed gene (DEG) identification, enrichment analysis, and correlation analysis were implemented by R toolkit. CIBERSORT evaluated the infiltration of 22 immune cells. Results. The seven active ingredients of honeysuckle had good oral absorption and medicinal properties. Both the active ingredient targets of honeysuckle and differentially expressed genes of mild COVID-19 were significantly enriched in immune signaling pathways. There were five overlapping immunosignature genes, among which RELA and MAP3K7 expressions were statistically significant (P<0.05). Finally, immune cell infiltration and correlation analysis showed that RELA, MAP3K7, and natural killer (NK) cell are with highly positive correlation and highly negatively correlated with hematopoietic stem cells. Conclusion. Our analysis suggested that honeysuckle extract had a safe and effective protective effect against mild COVID-19 by regulating a complex molecular network. The main mechanism was related to the proportion of infiltration between NK cells and hematopoietic stem cells.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	572
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sesquiterpenes and Monoterpenes from the Leaves and Stems of Illicium simonsii and Their Antibacterial Activity

Huijuan Li / Xinghui Song / Huiru Li / Lifei Zhu / Shengbo Cao / Jifeng Liu

Molecules, Vol 27, Iss 1115, p

2022 Volume 1115

Abstract: Two undescribed ether derivatives of sesquiterpenes, 1-ethoxycaryolane-1, 9 β -diol ( 1 ) and 2-ethoxyclovane-2 β , 9 α -diol ( 3 ), and one new monoterpene glycoside, p-menthane-1 α ,2 α ,8-triol-4-O- β -D-glucoside ( 5 ), were obtained, together with ... ...

Abstract	Two undescribed ether derivatives of sesquiterpenes, 1-ethoxycaryolane-1, 9 β -diol ( 1 ) and 2-ethoxyclovane-2 β , 9 α -diol ( 3 ), and one new monoterpene glycoside, p-menthane-1 α ,2 α ,8-triol-4-O- β -D-glucoside ( 5 ), were obtained, together with eight known compounds from the stems and leaves of I. simonsii . Their structures were elucidated by spectroscopic methods. Compounds 1 – 11 were evaluated for their potency against Staphylococcus aureus and clinical methicillin-resistant S. aureus (MRSA). Among them, compound 3 was weakly active against S. aureus (MIC = 128 μg/mL), and compounds 6 and 7 exhibited good antibacterial activity against S. aureus and MRSA (MICs = 2–8 µg/mL). A primary mechanism study revealed that compounds 6 and 7 could kill bacteria by destroying bacterial cell membranes. Moreover, compounds 6 and 7 were not susceptible to drug resistance development.
Keywords	Illicium simonsii ; sesquiterpene ; monoterpene ; antibacterial ; MRSA ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correlation of hemoglobin with osteoporosis in elderly Chinese population

Yichen Liu / Yue Zeng / Jun Lu / Xiaoya Zhang / Zikai Zhang / Huijuan Li / Peipei Liu / Bin Ma / Yiqun Gu / Lige Song

Frontiers in Public Health, Vol

A cross-sectional study

2023 Volume 11

Abstract: IntroductionIn the elder population, both low hemoglobin (Hb)/anemia and osteoporosis (OP) are highly prevalent. However, the relationship between Hb and OP is still poorly understood. This study was to evaluate the correlation between Hb and OP in ... ...

Abstract	IntroductionIn the elder population, both low hemoglobin (Hb)/anemia and osteoporosis (OP) are highly prevalent. However, the relationship between Hb and OP is still poorly understood. This study was to evaluate the correlation between Hb and OP in Chinese elderly population.MethodsOne thousand and sisty-eight individuals aged 55–85 years were enrolled into this cross-sectional study during June 2019–November 2019. Data on the demographics and clinical characteristics were recorded. Detections of complete blood count, liver/kidney function, glucose metabolism and lipid profile, and thoracolumbar X-ray were performed, and bone mineral density (BMD) at lumbar spine 1–4, femur neck, and total hip was measured by dual-energy X-ray absorptiometry (DXA). Univariate and multivariate linear regression analyses were employed to evaluate the correlation between Hb with BMD T-score. Logistic regression analysis was performed to access the correlation between different Hb levels and the odds ratio (OR) for OP.ResultsCompared with non-OP group, OP patients had lower level of Hb. Univariate linear regression analysis indicated Hb level was positively related to the BMD of lumbar spine 1–4, femur neck and total hip, and this relationship remained after adjusting confounding variables [gender, age, body mass index (BMI), diabetes mellitus (DM) and morphological vertebral fracture]. Logistic regression analysis showed the ORs for OP decreased with the increase of Hb. Compared with the subjects with the lowest quartile of Hb, the OR for OP in the highest quartile group was 0.60 (0.41–0.89) after adjusting for gender, age and BMI, and the OR for OP was 0.62 (0.41–0.92) after further adjustment for gender, age, BMI, DM, and lipid indexes.DiscussionIn conclusion, Lower Hb level is related to lower BMD in the elderly population. However, whether Hb level could be used to predict the risk of OP needs to be further determined in more longitudinal clinical studies.
Keywords	hemoglobin ; osteoporosis ; bone mineral density ; elderly population ; Chinese ; Public aspects of medicine ; RA1-1270
Subject code	616
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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