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  1. Article ; Online: The autonomic cardiac nervous system and arrhythmogenesis: risk stratification in the foreseeable future.

    Huikuri, Heikki

    Herzschrittmachertherapie & Elektrophysiologie

    2021  Volume 32, Issue 3, Page(s) 320–322

    Abstract: Both experimental and clinical studies have shown that the autonomic nervous system plays an important role in arrhythmogenesis. Many methods describing cardiovascular autonomic regulation have been developed and tested for use as predictors of ... ...

    Title translation Vegetatives kardiales Nervensystem und Entstehung von Herzrhythmusstörungen – Risikostratifizierung in absehbarer Zukunft.
    Abstract Both experimental and clinical studies have shown that the autonomic nervous system plays an important role in arrhythmogenesis. Many methods describing cardiovascular autonomic regulation have been developed and tested for use as predictors of arrhythmic and other cardiovascular events. The majority of studies have focused on patients with known cardiac disease, such as prior myocardial infarction or congestive heart failure. All-cause mortality, as well as non-sudden and sudden cardiac death have been used as main endpoints. Sudden cardiac death has often been considered to be equivalent to arrhythmic cardiac arrest. Despite promising results in this field, markers of the autonomic nervous system are still not routinely used in clinical practice, mainly due to the fact that measurement of these markers does not result in evidence-based therapeutic implications. There is still a lack of randomized trials using autonomic markers as pre-defined variables in selecting patients for the studies, which would have yielded results that an intervention reduces the arrhythmic or other endpoint in those with abnormal or impaired autonomic regulation. Hence, at present, the possible use of autonomic assessment in predicting life-threatening arrhythmias is restricted to individual cases at the borders of intervention guidelines.
    MeSH term(s) Arrhythmias, Cardiac/diagnosis ; Autonomic Nervous System ; Death, Sudden, Cardiac/prevention & control ; Heart ; Humans ; Risk Assessment
    Language English
    Publishing date 2021-07-13
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1082953-2
    ISSN 1435-1544 ; 0938-7412
    ISSN (online) 1435-1544
    ISSN 0938-7412
    DOI 10.1007/s00399-021-00777-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3286: Show issues Location:
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  2. Book ; Online: Heart Rate Variability: Clinical Applications and Interaction between HRV and Heart Rate

    Sacha, Jerzy / Huikuri, Heikki Veli / Trimmel, Karin

    2015  

    Abstract: Over the last decades, assessment of heart rate variability (HRV) has increased in various fields of research. HRV describes changes in heartbeat intervals, which are caused by autonomic neural regulation, i.e. by the interplay of the sympathetic and the ...

    Abstract Over the last decades, assessment of heart rate variability (HRV) has increased in various fields of research. HRV describes changes in heartbeat intervals, which are caused by autonomic neural regulation, i.e. by the interplay of the sympathetic and the parasympathetic nervous systems. The most frequent application of HRV is connected to cardiological issues, most importantly to the monitoring of post-myocardial infarction patients and the prediction of sudden cardiac death. Analysis of HRV is also frequently applied in relation to diabetes, renal failure, neurological and psychiatric conditions, sleep disorders, psychological phenomena such as stress, as well as drug and addiction research including alcohol and smoking. The widespread application of HRV measurements is based on the fact that they are noninvasive, easy to perform, and in general reproducible - if carried out under standardized conditions. However, the amount of parameters to be analysed is still rising.-

    Well-established time domain and frequency domain parameters are discussed controversially when it comes to their physiological interpretation and their psychometric properties like reliability and validity, and the sensitivity to cardiovascular properties of the variety of parameters seems to be a topic for further research. Recently introduced parameters like pNNxx and new dynamic methods such as approximate entropy and detrended fluctuation analysis offer new potentials and warrant standardization. However, HRV is significantly associated with average heart rate (HR) and one can conclude that HRV actually provides information on two quantities, i.e. on HR and its variability. It is hard to determine which of these two plays a principal role in the clinical value of HRV. The association between HRV and HR is not only a physiological phenomenon but also a mathematical one which is due to non-linear (mathematical) relationship between RR interval and HR.-

    If one normalizes HRV to its average RR interval, one may get 'pure' variability free from the mathematical bias. Recently, a new modification method of the association between HRV and HR has been developed which enables us to completely remove the HRV dependence on HR (even the physiological one), or conversely enhance this dependence. Such an approach allows us to explore the HR contribution to the clinical significance of HRV, i.e. whether HR or its variability plays a main role in the HRV clinical value. This Research Topic covers recent advances in the application of HRV, methodological issues, basic underlying mechanisms as well as all aspects of the interaction between HRV and HR.
    Keywords Science (General) ; Physiology
    Size 1 electronic resource (166 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020091842
    ISBN 9782889196524 ; 2889196526
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Early repolarization in the left posterior leads of the electrocardiogram: A new challenge for the existence of idiopathic ventricular fibrillation.

    Huikuri, Heikki / Junttila, M Juhani

    Heart rhythm

    2023  Volume 20, Issue 12, Page(s) 1737–1738

    MeSH term(s) Humans ; Ventricular Fibrillation/diagnosis ; Heart Conduction System ; Electrocardiography
    Language English
    Publishing date 2023-09-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2023.09.007
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  4. Article ; Online: Prediction of Fatal or Near-Fatal Cardiac Arrhythmias: Where Are We Now?

    Huikuri, Heikki V / Junttila, Juhani M

    JACC. Clinical electrophysiology

    2022  Volume 8, Issue 4, Page(s) 424–425

    MeSH term(s) Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/epidemiology ; Humans ; Ventricular Fibrillation
    Language English
    Publishing date 2022-03-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2022.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sudden cardiac death-Progress in epidemiology limited by time.

    Junttila, M Juhani / Holmström, Lauri T A / Huikuri, Heikki V

    Heart rhythm

    2023  Volume 20, Issue 11, Page(s) 1510–1511

    MeSH term(s) Humans ; Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/prevention & control ; Risk Factors
    Language English
    Publishing date 2023-08-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2023.08.024
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  6. Article ; Online: Non-dipping blood pressure pattern is associated with cardiovascular events in a 21-year follow-up study.

    Lempiäinen, Päivi A / Ylitalo, Antti / Huikuri, Heikki / Kesäniemi, Y Antero / Ukkola, Olavi H

    Journal of human hypertension

    2024  

    Abstract: Non-dipping blood pressure (BP) pattern is a predictor for cardiovascular (CV) events and mortality. We evaluated dipping status change and its association with incidence of non-fatal CV events in middle-aged subjects. The OPERA study was carried out ... ...

    Abstract Non-dipping blood pressure (BP) pattern is a predictor for cardiovascular (CV) events and mortality. We evaluated dipping status change and its association with incidence of non-fatal CV events in middle-aged subjects. The OPERA study was carried out during the years 1991-1993, with a follow-up study 21.7 years later. In this study, we included 452 participants with 24-h ambulatory BP measurements (ABPM) available in both surveys. The study population was divided into four groups according to the dipping pattern change: dipping-dipping (n = 152/33.6%), dipping-non-dipping (n = 198/43.8%), non-dipping-dipping (n = 20/4.4%), and non-dipping-non-dipping (n = 82/18.1%). Sixty-five participants experienced a CV event (14.4%) during the 21.7 (SD 0.8) years of follow-up. The incidence of events was highest (28%) in the non-dipping-non-dipping group, and lowest (6.6%) in the dipping-dipping group (p < 0.001). In Cox regression analyses the covariates were age, sex, total cholesterol, hypertension and use of antihypertensive medication, systolic office BP and ambulatory mean or nighttime systolic BP, as well as the change in the variables during the follow-up period. After adjustments, the association of the non-dipping-non-dipping pattern with CV events compared with the dipping-dipping pattern remained significant (HR 4.01; 95% CI 1.89-8.67, p < 0.001). In summary, non-dipping-non-dipping pattern was associated with non-fatal CV events in the long term, and the effect was independent of the conventional risk factors including office and ambulatory BP levels.
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/s41371-024-00909-2
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  7. Article ; Online: Differences in characteristics between J-wave syndrome patients.

    Huikuri, Heikki V

    Heart rhythm

    2017  Volume 14, Issue 4, Page(s) 562–563

    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2016.12.035
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  8. Article ; Online: Prediction of benefits from prophylactic implantable cardioverter-defibrillator therapy.

    Huikuri, Heikki V

    International journal of cardiology

    2017  Volume 243, Page(s) 274–275

    Language English
    Publishing date 2017-09-15
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2017.04.112
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    Zs.A 1673: Show issues Location:
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  9. Article ; Online: Sudden cardiac death and atrial depolarization in coronary artery disease-Authors' reply.

    Perkiömäki, Juha S / Hekkanen, Jenni J / Junttila, M Juhani / Huikuri, Heikki V

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

    2023  Volume 25, Issue 5

    MeSH term(s) Humans ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/physiopathology ; Atrial Fibrillation ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/prevention & control ; Risk Factors ; Heart Rate
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1449879-0
    ISSN 1532-2092 ; 1099-5129
    ISSN (online) 1532-2092
    ISSN 1099-5129
    DOI 10.1093/europace/euad111
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  10. Article ; Online: Editorial Commentary: Atrial fibrillation: Challenges and opportunities.

    Huikuri, Heikki V

    Trends in cardiovascular medicine

    2017  Volume 27, Issue 7, Page(s) 504–505

    Language English
    Publishing date 2017-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2017.05.007
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