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Article ; Online: Construction of Economic Security Early Warning System Based on Cloud Computing and Data Mining

Guanghui Yuan / Fei Xie / Huiling Tan

Computational Intelligence and Neuroscience, Vol

2022 Volume 2022

Abstract: Economic security is a core theoretical issue in economics. In modern economic conditions, the ups and downs caused by economic instability in any economic system will affect the stability of the financial market, bring huge losses to the economy, and ... ...

Abstract	Economic security is a core theoretical issue in economics. In modern economic conditions, the ups and downs caused by economic instability in any economic system will affect the stability of the financial market, bring huge losses to the economy, and affect the development of the whole national economy. Therefore, research on the regularity of economic security and economic fluctuations is one of the important contents to ensure economic stability and scientific development. Accurate monitoring and forecasting of economic security are an indispensable link in economic system regulation, and it is also an important reference factor for any economic organization to make decisions. This article focuses on the construction of an economic security early warning system as the main research content. It integrates cloud computing and data mining technologies and is supported by CNN-SVM algorithm and designs an early warning model that can adaptively evaluate and warn the economic security state. Experiments show that when the CNN network in the model uses ReLU activation function and SVM uses RBF function, the prediction accuracy can reach 0.98, and the prediction effect is the best. The data set is verified, and the output Q province’s 2018 economic security early warning comprehensive index is 0.893. The 2019 economic security early warning index is 0.829, which is consistent with the actual situation.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
Subject code	330
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Decoding force from deep brain electrodes in Parkinsonian patients.

Shah, Syed A / Huiling Tan / Brown, Peter

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2017 Volume 2016, Page(s) 5717–5720

Abstract: Limitations of many Brain Machine Interface (BMI) systems using invasive electrodes include reliance on single neurons and decoding limited to kinematics only. This study investigates whether force-related information is present in the local field ... ...

Abstract	Limitations of many Brain Machine Interface (BMI) systems using invasive electrodes include reliance on single neurons and decoding limited to kinematics only. This study investigates whether force-related information is present in the local field potential (LFP) recorded with deep brain electrodes using data from 14 patients with Parkinson's disease. A classifier based on logistic regression (LR) is developed to classify various force stages, using 10-fold cross validation. Least Absolute and Shrinkage Operator (Lasso) is then employed in order to identify the features with the most predictivity. The results show that force-related information is present in the LFP, and it is possible to distinguish between various force stages using certain frequency-domain (delta, beta, gamma) and time-domain (mobility) features in real-time.
MeSH term(s)	Biomechanical Phenomena ; Brain/physiopathology ; Brain-Computer Interfaces ; Electrodes ; Humans ; Neurons/physiology ; Parkinson Disease/physiopathology
Language	English
Publishing date	2017-03-06
Publishing country	United States
Document type	Journal Article
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC.2016.7592025
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dynamic modulation of subthalamic nucleus activity facilitates adaptive behavior.

Damian M Herz / Manuel Bange / Gabriel Gonzalez-Escamilla / Miriam Auer / Muthuraman Muthuraman / Martin Glaser / Rafal Bogacz / Alek Pogosyan / Huiling Tan / Sergiu Groppa / Peter Brown

PLoS Biology, Vol 21, Iss 6, p e

2023 Volume 3002140

Abstract: Adapting actions to changing goals and environments is central to intelligent behavior. There is evidence that the basal ganglia play a crucial role in reinforcing or adapting actions depending on their outcome. However, the corresponding ... ...

Abstract	Adapting actions to changing goals and environments is central to intelligent behavior. There is evidence that the basal ganglia play a crucial role in reinforcing or adapting actions depending on their outcome. However, the corresponding electrophysiological correlates in the basal ganglia and the extent to which these causally contribute to action adaptation in humans is unclear. Here, we recorded electrophysiological activity and applied bursts of electrical stimulation to the subthalamic nucleus, a core area of the basal ganglia, in 16 patients with Parkinson's disease (PD) on medication using temporarily externalized deep brain stimulation (DBS) electrodes. Patients as well as 16 age- and gender-matched healthy participants attempted to produce forces as close as possible to a target force to collect a maximum number of points. The target force changed over trials without being explicitly shown on the screen so that participants had to infer target force based on the feedback they received after each movement. Patients and healthy participants were able to adapt their force according to the feedback they received (P < 0.001). At the neural level, decreases in subthalamic beta (13 to 30 Hz) activity reflected poorer outcomes and stronger action adaptation in 2 distinct time windows (Pcluster-corrected < 0.05). Stimulation of the subthalamic nucleus reduced beta activity and led to stronger action adaptation if applied within the time windows when subthalamic activity reflected action outcomes and adaptation (Pcluster-corrected < 0.05). The more the stimulation volume was connected to motor cortex, the stronger was this behavioral effect (Pcorrected = 0.037). These results suggest that dynamic modulation of the subthalamic nucleus and interconnected cortical areas facilitates adaptive behavior.
Keywords	Biology (General) ; QH301-705.5
Subject code	150
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism

Christoph Wiest / Flavie Torrecillos / Alek Pogosyan / Manuel Bange / Muthuraman Muthuraman / Sergiu Groppa / Natasha Hulse / Harutomo Hasegawa / Keyoumars Ashkan / Fahd Baig / Francesca Morgante / Erlick A Pereira / Nicolas Mallet / Peter J Magill / Peter Brown / Andrew Sharott / Huiling Tan

eLife, Vol

2023 Volume 12

Abstract: Periodic features of neural time-series data, such as local field potentials (LFPs), are often quantified using power spectra. While the aperiodic exponent of spectra is typically disregarded, it is nevertheless modulated in a physiologically relevant ... ...

Abstract	Periodic features of neural time-series data, such as local field potentials (LFPs), are often quantified using power spectra. While the aperiodic exponent of spectra is typically disregarded, it is nevertheless modulated in a physiologically relevant manner and was recently hypothesised to reflect excitation/inhibition (E/I) balance in neuronal populations. Here, we used a cross-species in vivo electrophysiological approach to test the E/I hypothesis in the context of experimental and idiopathic Parkinsonism. We demonstrate in dopamine-depleted rats that aperiodic exponents and power at 30–100 Hz in subthalamic nucleus (STN) LFPs reflect defined changes in basal ganglia network activity; higher aperiodic exponents tally with lower levels of STN neuron firing and a balance tipped towards inhibition. Using STN-LFPs recorded from awake Parkinson’s patients, we show that higher exponents accompany dopaminergic medication and deep brain stimulation (DBS) of STN, consistent with untreated Parkinson’s manifesting as reduced inhibition and hyperactivity of STN. These results suggest that the aperiodic exponent of STN-LFPs in Parkinsonism reflects E/I balance and might be a candidate biomarker for adaptive DBS.
Keywords	aperiodic exponent ; excitation/inhibition balance ; Parkinson's disease ; adaptive deep brain stimulation ; subthalamic nucleus ; local field potential ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fu Fang Zhen Zhu Tiao Zhi Capsules Protect against Myocardial Ischemia by Inhibiting Cardiomyocyte Pyroptosis

Xiaoqi Shao / Bingying Huang / Huiling Tan / Ruonan Wang / Xueying Huang / Hongtao Diao / Jiawen Cheng / Mengxian Sun / Dongwei Wang / Kaili Wu / Meiling Yan / Xianglu Rong / Yue Zhang / Jiao Guo

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: Background. Fu Fang Zhen Zhu Tiao Zhi (FTZ) is a traditional Chinese herbal prescription widely used to treat dyslipidemia, metabolic diseases, and diabetic coronary disorders. Cardiomyocyte death and loss of regenerative ability cause cardiac ... ...

Abstract	Background. Fu Fang Zhen Zhu Tiao Zhi (FTZ) is a traditional Chinese herbal prescription widely used to treat dyslipidemia, metabolic diseases, and diabetic coronary disorders. Cardiomyocyte death and loss of regenerative ability cause cardiac dysfunction and heart failure. FTZ can effectively treat diabetic cardiomyopathy and macrovascular diseases; however, the mechanism behind the phenomenon is still unclear. Here, we determined the mechanism of action of FTZ in treating myocardial infarction. Methods. Male C57BL/6 mice were treated with 2.4 or 1.2 g/kg FTZ, or administered saline by oral gavage daily for four weeks, and a 24-hour ligation was administered to the artery. Echocardiography was used to evaluate cardiac function. Hematoxylin and eosin and Evans blue/triphenyltetrazolium chloride staining were carried out by staining the cardiac tissue, used to evaluate cardiac function and infarct size. Using western blotting and reverse transcriptase-polymerase chain reaction, we determined the relative levels of NOD-like receptor protein (NLRP) 3, ASC, cleaved caspase-l (C-Caspase-1), GSDMD, and GSDMD-N. TUNEL, immunohistochemical, and immunofluorescence staining were used to determine cell death and NLRP3 expression. An enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of interleukin (IL)-1β and IL-18. Results. FTZ reduced ischemia-induced cardiomyocyte cell death in vivo and H2O2-induced cell death in vitro by maintaining cardiac architecture and restoring cardiac function. FTZ decreased the NLRP3 expression and inhibited pyroptosis-correlated genes, including NLRP3, ASC, GSDMD, C-Caspase-1, and GSDMD-N. NLRP3 overexpression impaired the efficacy of FTZ by inducing pyroptosis. Conclusion. FTZ could preserve cardiac function resulting from ischemic insult by inhibiting pyroptosis, which was partially reversed by NLRP3 overexpression, indicating that NLRP3 could be a potential target of FTZ in treating myocardial infarction.
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Role of filled PLGA in improving enantioselectivity of Glu-GO/PLGA composite membranes

Meng, Chenchen / Qibin Chen / Huiling Tan / Yujie Sheng / Honglai Liu

Journal of membrane science. 2018 June 01, v. 555

2018

Abstract: The primary aim of this investigation was to improve the chiral separation performance of graphene oxide (GO) based composite membranes via tuning the interlayer spacing between GO sheets using the association of poly(L-Glutamic acid sodium), PLGA, onto ... ...

Abstract	The primary aim of this investigation was to improve the chiral separation performance of graphene oxide (GO) based composite membranes via tuning the interlayer spacing between GO sheets using the association of poly(L-Glutamic acid sodium), PLGA, onto the surface of GO sheets. Results show that: i) compared with conventional chiral separation membranes, these membranes exhibit superior chiral resolution properties, which are 1–2 orders of magnitude higher in the flux and greater in the enantioselectivity; ii) compared with pristine L-Glutamic modified GO membranes, they also afford a significant improvement in enantioselectivity with a slight reduction in flux. In present work, it is demonstrated that in such composite membranes, the incorporated PLGA can not only serve as an additional chiral recognizing agent, facilitating the transport of D-isomer of the chiral probe, but also as a kind of filler, reducing the size of pores or channels between GO sheets. Especially, both roles can significantly contribute to enhancing the enantioselectivitiy of composite membranes. Our findings indicate that the combination of GO-based materials and polypeptides might offer unusual control in the selectivity and the flux of the corresponding composite membranes, achieved by regulating the interlayer spacing between GO sheets, and thus such composite membranes have a potential to simultaneously facilitate high-flux and high-selectivity and a promising application in a great number of enantio- and bio-separations.
Keywords	asymmetric membranes ; enantioselectivity ; glutamic acid ; graphene oxide ; polypeptides
Language	English
Dates of publication	2018-0601
Size	p. 398-406.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	194516-6
ISSN	0376-7388
ISSN	0376-7388
DOI	10.1016/j.memsci.2018.03.040
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients

Yongzhi Huang / Bomin Sun / Jean Debarros / Chao Zhang / Shikun Zhan / Dianyou Li / Chencheng Zhang / Tao Wang / Peng Huang / Yijie Lai / Peter Brown / Chunyan Cao / Huiling Tan

eLife, Vol

2021 Volume 10

Abstract: Lateral habenula is believed to encode negative motivational stimuli and plays key roles in the pathophysiology of psychiatric disorders. However, how habenula activities are modulated during the processing of emotional information is still poorly ... ...

Abstract	Lateral habenula is believed to encode negative motivational stimuli and plays key roles in the pathophysiology of psychiatric disorders. However, how habenula activities are modulated during the processing of emotional information is still poorly understood. We recorded local field potentials from bilateral habenula areas with simultaneous cortical magnetoencephalography in nine patients with psychiatric disorders during an emotional picture-viewing task. Transient activity in the theta/alpha band (5–10 Hz) within the habenula and prefrontal cortical regions, as well as the coupling between these structures, is increased during the perception and processing of negative emotional stimuli compared to positive emotional stimuli. The increase in theta/alpha band synchronization in the frontal cortex-habenula network correlated with the emotional valence but not the arousal score of the stimuli. These results provide direct evidence for increased theta/alpha synchrony within the habenula area and prefrontal cortex-habenula network in the perception of negative emotion in human participants.
Keywords	habenula ; prefrontal cortex-habenula network ; emotional stimuli ; theta / alpha oscillations ; deep brain stimulation ; depression ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	150
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Exceptional chiral separation of amino acid modified graphene oxide membranes with high-flux

Meng, Chenchen / Honglai Liu / Huiling Tan / Qibin Chen / Yujie Sheng

Journal of membrane science. 2017 Mar. 15, v. 526

2017

Abstract: The primary aim of this investigation was to achieve chiral separations via fabricating graphene oxide (GO) based membranes with high separation performances, derived from incorporating a chiral selector (L-Glutamic acid) into GO flakes, based on ... ...

Abstract	The primary aim of this investigation was to achieve chiral separations via fabricating graphene oxide (GO) based membranes with high separation performances, derived from incorporating a chiral selector (L-Glutamic acid) into GO flakes, based on considerations of GO membranes having the inherently high throughput nature. The GO membrane was fabricated via a simple vacuum filtration method, in which L-Glutamic acid not only provided the stacked GO nanosheets with the necessary stability to overcome their inherent dispensability in water environment but also finely tuned spacing of the GO nanosheets and the resulting performance. The corresponding membrane structure together with GO and amino acid modified GO nanosheets was systematically characterized by SEM, TEM, AFM, XPS, XRD, FT-IR and so on. Finally, enantioseparation performances of amino acid modified GO membranes toward 3, 4-Dihydroxy-D, L-phenylalanine were detected. Results show that such membranes exhibit extraordinary chiral resolution properties, which are 1−2 orders of magnitude higher in the flux and greater in selectivity, compared to common chiral separation membranes. Our findings demonstrate that the modified GO membranes might provide another general approach to simultaneously facilitate high-flux and high-selectivity for a host of enantio- and bio-separations.
Keywords	artificial membranes ; atomic force microscopy ; filtration ; Fourier transform infrared spectroscopy ; glutamic acid ; graphene oxide ; nanosheets ; phenylalanine ; scanning electron microscopy ; transmission electron microscopy ; X-ray diffraction ; X-ray photoelectron spectroscopy
Language	English
Dates of publication	2017-0315
Size	p. 25-31.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	194516-6
ISSN	0376-7388
ISSN	0376-7388
DOI	10.1016/j.memsci.2016.12.019
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Subthalamic beta-targeted neurofeedback speeds up movement initiation but increases tremor in Parkinsonian patients

Shenghong He / Abteen Mostofi / Emilie Syed / Flavie Torrecillos / Gerd Tinkhauser / Petra Fischer / Alek Pogosyan / Harutomo Hasegawa / Yuanqing Li / Keyoumars Ashkan / Erlick Pereira / Peter Brown / Huiling Tan

eLife, Vol

2020 Volume 9

Abstract: Previous studies have explored neurofeedback training for Parkinsonian patients to suppress beta oscillations in the subthalamic nucleus (STN). However, its impacts on movements and Parkinsonian tremor are unclear. We developed a neurofeedback paradigm ... ...

Abstract	Previous studies have explored neurofeedback training for Parkinsonian patients to suppress beta oscillations in the subthalamic nucleus (STN). However, its impacts on movements and Parkinsonian tremor are unclear. We developed a neurofeedback paradigm targeting STN beta bursts and investigated whether neurofeedback training could improve motor initiation in Parkinson’s disease compared to passive observation. Our task additionally allowed us to test which endogenous changes in oscillatory STN activities are associated with trial-to-trial motor performance. Neurofeedback training reduced beta synchrony and increased gamma activity within the STN, and reduced beta band coupling between the STN and motor cortex. These changes were accompanied by reduced reaction times in subsequently cued movements. However, in Parkinsonian patients with pre-existing symptoms of tremor, successful volitional beta suppression was associated with an amplification of tremor which correlated with theta band activity in STN local field potentials, suggesting an additional cross-frequency interaction between STN beta and theta activities.
Keywords	beta oscillations ; neurofeedback ; beta burst ; parkinson's disease ; parkinsonian tremor ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	796 ; 150
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bilateral functional connectivity of the basal ganglia in patients with Parkinson's disease and its modulation by dopaminergic treatment.

Simon Little / Huiling Tan / Anam Anzak / Alek Pogosyan / Andrea Kühn / Peter Brown

PLoS ONE, Vol 8, Iss 12, p e

2013 Volume 82762

Abstract: Parkinson's disease is characterised by excessive subcortical beta oscillations. However, little is known about the functional connectivity of the two basal ganglia across hemispheres and specifically the role beta plays in this. We recorded local field ... ...

Abstract	Parkinson's disease is characterised by excessive subcortical beta oscillations. However, little is known about the functional connectivity of the two basal ganglia across hemispheres and specifically the role beta plays in this. We recorded local field potentials from the subthalamic nucleus bilaterally in 23 subjects with Parkinson's disease at rest, on and off medication. We found suppression of low beta power in response to levodopa (t22 = -4.4, p<0.001). There was significant coherence between the two sides in the beta range in 19 of the subjects. Coherence was selectively attenuated in the low beta range following levodopa (t22 = -2.7; p = 0.01). We also separately analysed amplitude co-modulation and phase synchronisation in the beta band and found significant amplitude co-modulation and phase locking values in 17 and 16 subjects respectively, off medication. There was a dissociable effect of levodopa on these measures, with a significant suppression only in low beta phase locking value (t22 = -2.8, p = 0.01) and not amplitude co-modulation. The absolute mean values of amplitude co-modulation (0.40 ± 0.03) and phase synchronisation (0.29 ± 0.02) off medication were, however, relatively low, suggesting that the two basal ganglia networks may have to be approached separately with independent sensing and stimulation during adaptive deep brain stimulation. In addition, our findings highlight the functional distinction between the lower and upper beta frequency ranges and between amplitude co-modulation and phase synchronization across subthalamic nuclei.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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