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  1. Article ; Online: Wat steekt daar uit de anus?

    Huisman, Lydian A / Faut, Marloes / Koopmans, Jan

    Nederlands tijdschrift voor geneeskunde

    2023  Volume 167

    Abstract: A 26-year-old female patient presented to our emergency department with anal protrusion of her ventriculo-peritoneal shunt. She had no complaints other than slight abdominal discomfort. Laboratory values were normal. Laparoscopy was performed, revealing ... ...

    Title translation Anal protrusion of a ventriculo-peritoneal shunt.
    Abstract A 26-year-old female patient presented to our emergency department with anal protrusion of her ventriculo-peritoneal shunt. She had no complaints other than slight abdominal discomfort. Laboratory values were normal. Laparoscopy was performed, revealing that the shunt entered the colon mid-descedens. Here, the shunt was cut and the puncture site was closed with a suture. The patient recovered without complications.
    MeSH term(s) Female ; Humans ; Adult ; Ventriculoperitoneal Shunt/adverse effects ; Anal Canal/surgery ; Prostheses and Implants ; Laparoscopy/adverse effects ; Punctures ; Hydrocephalus/surgery
    Language Dutch
    Publishing date 2023-06-28
    Publishing country Netherlands
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  2. Article: VEGF-Targeted Multispectral Optoacoustic Tomography and Fluorescence Molecular Imaging in Human Carotid Atherosclerotic Plaques.

    Steinkamp, Pieter J / Vonk, Jasper / Huisman, Lydian A / Meersma, Gert-Jan / Diercks, Gilles F H / Hillebrands, Jan-Luuk / Nagengast, Wouter B / Zeebregts, Clark J / Slart, Riemer H J A / Boersma, Hendrikus H / van Dam, Gooitzen M

    Diagnostics (Basel, Switzerland)

    2021  Volume 11, Issue 7

    Abstract: Vulnerable atherosclerotic carotid plaques are prone to rupture, resulting in ischemic strokes. In contrast to radiological imaging techniques, molecular imaging techniques have the potential to assess plaque vulnerability by visualizing diseases- ... ...

    Abstract Vulnerable atherosclerotic carotid plaques are prone to rupture, resulting in ischemic strokes. In contrast to radiological imaging techniques, molecular imaging techniques have the potential to assess plaque vulnerability by visualizing diseases-specific biomarkers. A risk factor for rupture is intra-plaque neovascularization, which is characterized by overexpression of vascular endothelial growth factor-A (VEGF-A). Here, we study if administration of bevacizumab-800CW, a near-infrared tracer targeting VEGF-A, is safe and if molecular assessment of atherosclerotic carotid plaques in vivo is possible using multispectral optoacoustic tomography (MSOT). Healthy volunteers and patients with symptomatic carotid artery stenosis scheduled for carotid artery endarterectomy were imaged with MSOT. Secondly, patients were imaged two days after intravenous administration of 4.5 bevacizumab-800CW. Ex vivo fluorescence molecular imaging of the surgically removed plaque specimen was performed and correlated with histopathology. In this first-in-human MSOT and fluorescence molecular imaging study, we show that administration of 4.5 mg bevacizumab-800CW appeared to be safe in five patients and accumulated in the carotid atherosclerotic plaque. Although we could visualize the carotid bifurcation area in all subjects using MSOT, bevacizumab-800CW-resolved signal could not be detected with MSOT in the patients. Future studies should evaluate tracer safety, higher doses of bevacizumab-800CW or develop dedicated contrast agents for carotid atherosclerotic plaque assessment using MSOT.
    Language English
    Publishing date 2021-07-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics11071227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Feasibility of ex vivo fluorescence imaging of angiogenesis in (non-) culprit human carotid atherosclerotic plaques using bevacizumab-800CW.

    Huisman, Lydian A / Steinkamp, Pieter J / Hillebrands, Jan-Luuk / Zeebregts, Clark J / Linssen, Matthijs D / Jorritsma-Smit, Annelies / Slart, Riemer H J A / van Dam, Gooitzen M / Boersma, Hendrikus H

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 2899

    Abstract: Vascular endothelial growth factor-A (VEGF-A) is assumed to play a crucial role in the development and rupture of vulnerable plaques in the atherosclerotic process. We used a VEGF-A targeted fluorescent antibody (bevacizumab-IRDye800CW [bevacizumab-800CW] ...

    Abstract Vascular endothelial growth factor-A (VEGF-A) is assumed to play a crucial role in the development and rupture of vulnerable plaques in the atherosclerotic process. We used a VEGF-A targeted fluorescent antibody (bevacizumab-IRDye800CW [bevacizumab-800CW]) to image and visualize the distribution of VEGF-A in (non-)culprit carotid plaques ex vivo. Freshly endarterectomized human plaques (n = 15) were incubated in bevacizumab-800CW ex vivo. Subsequent NIRF imaging showed a more intense fluorescent signal in the culprit plaques (n = 11) than in the non-culprit plaques (n = 3). A plaque received from an asymptomatic patient showed pathologic features similar to the culprit plaques. Cross-correlation with VEGF-A immunohistochemistry showed co-localization of VEGF-A over-expression in 91% of the fluorescent culprit plaques, while no VEGF-A expression was found in the non-culprit plaques (p < 0.0001). VEGF-A expression was co-localized with CD34, a marker for angiogenesis (p < 0.001). Ex vivo near-infrared fluorescence (NIRF) imaging by incubation with bevacizumab-800CW shows promise for visualizing VEGF-A overexpression in culprit atherosclerotic plaques in vivo.
    MeSH term(s) Aged ; Asymptomatic Diseases ; Benzenesulfonates/chemistry ; Bevacizumab/chemistry ; Bevacizumab/pharmacology ; Carotid Stenosis/diagnosis ; Carotid Stenosis/etiology ; Carotid Stenosis/pathology ; Carotid Stenosis/surgery ; Endarterectomy, Carotid ; Feasibility Studies ; Female ; Fluorescent Dyes/chemistry ; Humans ; Indoles/chemistry ; Male ; Middle Aged ; Molecular Imaging/methods ; Optical Imaging/methods ; Plaque, Atherosclerotic/complications ; Plaque, Atherosclerotic/pathology ; Plaque, Atherosclerotic/surgery ; Severity of Illness Index ; Vascular Endothelial Growth Factor A/analysis ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances Benzenesulfonates ; Fluorescent Dyes ; IRDye 800CW ; Indoles ; VEGFA protein, human ; Vascular Endothelial Growth Factor A ; Bevacizumab (2S9ZZM9Q9V)
    Language English
    Publishing date 2021-02-03
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-82568-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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