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  1. Article ; Online: Diagnostic value of artificial intelligence based on computed tomography (CT) density in benign and malignant pulmonary nodules

    Wei Fan / Huitong Liu / Yan Zhang / Xiaolong Chen / Minggang Huang / Bingqiang Xu

    PeerJ, Vol 12, p e

    a retrospective investigation

    2024  Volume 16577

    Abstract: Objective To evaluate the diagnostic value of artificial intelligence (AI) in the detection and management of benign and malignant pulmonary nodules (PNs) using computed tomography (CT) density. Methods A retrospective analysis was conducted on the ... ...

    Abstract Objective To evaluate the diagnostic value of artificial intelligence (AI) in the detection and management of benign and malignant pulmonary nodules (PNs) using computed tomography (CT) density. Methods A retrospective analysis was conducted on the clinical data of 130 individuals diagnosed with PNs based on pathological confirmation. The utilization of AI and physicians has been employed in the diagnostic process of distinguishing benign and malignant PNs. The CT images depicting PNs were integrated into AI-based software. The gold standard for evaluating the accuracy of AI diagnosis software and physician interpretation was the pathological diagnosis. Results Out of 226 PNs screened from 130 patients diagnosed by AI and physician reading based on CT, 147 were confirmed by pathology. AI had a sensitivity of 94.69% and radiologists had a sensitivity of 85.40% in identifying PNs. The chi-square analysis indicated that the screening capacity of AI was superior to that of physician reading, with statistical significance (p < 0.05). 195 of the 214 PNs suggested by AI were confirmed pathologically as malignant, and 19 were identified as benign; among the 29 PNs suggested by AI as low risk, 13 were confirmed pathologically as malignant, and 16 were identified as benign. From the physician reading, 193 PNs were identified as malignant, 183 were confirmed malignant by pathology, and 10 appeared benign. Physician reading also identified 30 low-risk PNs, 19 of which were pathologically malignant and 11 benign. The physician readings and AI had kappa values of 0.432 and 0.547, respectively. The physician reading and AI area under curves (AUCs) were 0.814 and 0.798, respectively. Both of the diagnostic techniques had worthy diagnostic value, as indicated by their AUCs of >0.7. Conclusion It is anticipated that the use of AI-based CT diagnosis in the detection of PNs would increase the precision in early detection of lung carcinoma, as well as yield more precise evidence for clinical management.
    Keywords Artificial intelligence ; Antioxidants/phytochemicals ; Benign and malignant pulmonary nodules pulmonary nodules ; Lung cancer ; Screening ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher PeerJ Inc.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Early Steroid-Induced Osteonecrosis of Rabbit Femoral Head and Panax notoginseng Saponins

    Hui Qiang / Huitong Liu / Ming Ling / Kunzheng Wang / Chen Zhang

    Evidence-Based Complementary and Alternative Medicine, Vol

    Mechanism and Protective Effects

    2015  Volume 2015

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Publishing date 2015-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Early Steroid-Induced Osteonecrosis of Rabbit Femoral Head and Panax notoginseng Saponins

    Hui Qiang / Huitong Liu / Ming Ling / Kunzheng Wang / Chen Zhang

    Evidence-Based Complementary and Alternative Medicine, Vol

    Mechanism and Protective Effects

    2015  Volume 2015

    Abstract: Background. This study was aimed at investigating the pathogenesis of oxidative stress in steroid-induced avascular necrosis of the femoral head (SANFH) and at exploring the mechanism and protective effects of Panax notoginseng saponins (PNS) on early ... ...

    Abstract Background. This study was aimed at investigating the pathogenesis of oxidative stress in steroid-induced avascular necrosis of the femoral head (SANFH) and at exploring the mechanism and protective effects of Panax notoginseng saponins (PNS) on early SANFH. Methods. 80 adult New Zealand rabbits were randomly divided into control group, model group, and PNS group. In model group, equine serum was injected into auricular vein; then methylprednisolone was injected into gluteus. In PNS group, PNS was applied for 14 consecutive days before methylprednisolone management. At different time points, serum and femoral heads were prepared for T-AOC, SOD, GSH-PX, ·OH, and MDA determination. Two weeks after steroid management, all femoral heads were assessed with MRI and HE staining. Results. Typical early osteonecrosis symptoms were observed in model group. Our results showed that PNS could significantly ameliorate the decrease of T-AOC level, improve SOD and GSH-PX activity, suppress ·OH ability, and augment MDA level. Besides, PNS improved MRI and pathological changes of the femoral head, markedly reducing the incidence of osteonecrosis. Conclusion. Based on our research, we found oxidative stress played a positive role in the occurrence of SANFH where reactive oxygen species was the direct cause. PNS could protect rabbits against early steroid-induced osteonecrosis of femoral head by its antioxidative effect.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 630
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Early Steroid-Induced Osteonecrosis of Rabbit Femoral Head and Panax notoginseng Saponins

    Hui Qiang / Huitong Liu / Ming Ling / Kunzheng Wang / Chen Zhang

    Evidence-Based Complementary and Alternative Medicine, Vol

    Mechanism and Protective Effects

    2015  Volume 2015

    Keywords Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: The Clinical and Medicolegal Analysis of Electrical Shocked Rats

    Huitong Liu / Qiaofeng Wang / Ze Zhao / Yanan Xie / Suzhen Ding / Zhenyuan Wang

    BioMed Research International, Vol

    Based on the Serological and Histological Methods

    2016  Volume 2016

    Abstract: This research was aimed at discovering the serological and histological changes in cardiac and hepatic tissue after electric shock. The CK-MB, ALT, and AMS indexes were tested with serological methods. Moreover, the Bcl-2, Bax, and Hsp-60 expression ... ...

    Abstract This research was aimed at discovering the serological and histological changes in cardiac and hepatic tissue after electric shock. The CK-MB, ALT, and AMS indexes were tested with serological methods. Moreover, the Bcl-2, Bax, and Hsp-60 expression levels were carefully measured. An electrical injury model was established by giving rats electric shocks at 110 V with alternating electric current. Blood samples from the rats were analyzed for the biochemical indexes. The degrees of pathological changes in the heart and liver were evaluated using IHC staining for Bcl-2, Bax, and Hsp-60. The levels of CK-MB in the electrical injury group rapidly peaked at 0.5 hours after the electric shock. Additionally, the levels of Bcl-2, Bax, and Hsp-60 in the cardiac and hepatic tissues changed regularly after the electrical injury and exhibited apparent differences from the levels in the control group. CK-MB, ALT, and AMS were altered regularly after electric shock, and these results provide significant information for clinical and medicolegal practice. This research has shed light on the assessment of electrical injury without obvious electrical burns. Furthermore, the findings obtained for Bcl-2/Bax and Hsp-60 can also facilitate pathological diagnosis and the identification of antemortem and postmortem electrical injury.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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