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Article ; Online: Mesenchymal Stem Cells Accelerate Recovery of Acetic Acid-Induced Chronic Gastric Ulcer by Regulating Ekt/Akt/TRIM29 Axis

Feiyue Zhao / Zhibin Fan / Ruikang Jia / Qichao Liu / Menglei Wang / Jianliang Sui / Huiyun Liu

Stem Cells International, Vol

2024 Volume 2024

Abstract: Chronic gastric ulcer (CGU), a prevalent digestive disease, has a high incidence and is seriously harmful to human health. Mesenchymal stem cells (MSCs) have been proven to have beneficial therapeutic effects in many human diseases. Here, a CGU model ... ...

Abstract	Chronic gastric ulcer (CGU), a prevalent digestive disease, has a high incidence and is seriously harmful to human health. Mesenchymal stem cells (MSCs) have been proven to have beneficial therapeutic effects in many human diseases. Here, a CGU model induced by acetic acid in mice was used to evaluate the repair effects and potential mechanism of human umbilical cord-derived MSCs (hUC-MSCs) and hUC-MSCs derived conditioned medium (hUC-MSC-CM). We found that hUC-MSCs and hUC-MSC-CM treatment significantly repaired morphological characteristics of CGU, improved proliferation and decreased apoptosis of gastric cells, and promoted the generation of new blood vessels in granulation tissues. In addition, we could detect the homing of MSCs in gastric tissue, and MSCs may differentiate into Lgr5-positive cells. As well as this, in vitro experiments showed that hUC-MSC-CM could promote cell proliferation, stimulate cell cycle progression, and reduce the incidence of apoptosis. The transcriptome of cells and the iTRAQ proteome of gastric tissues suggest that MSCs may play a therapeutic role by increasing the expression of TRIM29. Additionally, it was found that knocking down TRIM29 significantly decreased the ameliorative effects of hUC-MSC-CM on cell apoptosis. As a result of further molecular experiments, it was found that TRIM29 is capable of phosphorylating Erk/Akt in specific cell type. As a whole, it appears that hUC-MSCs can be an effective therapeutic approach for promoting gastric ulcer healing and may exert therapeutic effects in the form of paracrine and differentiation into gastric cells.
Keywords	Internal medicine ; RC31-1245
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration, invasion, and self-renewal

Huiyun Liu / Daniel Heller-Trulli / Claire L. Moore

iScience, Vol 25, Iss 8, Pp 104804- (2022)

2022

Abstract: Summary: Cleavage by the endonuclease CPSF73 and polyadenylation of nascent RNA is an essential step in co-transcriptional mRNA maturation. Recent work has surprisingly identified CPSF73 as a promising drug target for inhibiting the growth of specific ... ...

Abstract	Summary: Cleavage by the endonuclease CPSF73 and polyadenylation of nascent RNA is an essential step in co-transcriptional mRNA maturation. Recent work has surprisingly identified CPSF73 as a promising drug target for inhibiting the growth of specific cancers, triggering further studies on understanding CPSF73 regulation and functions in cells. Here, we report that a HECT-like E3 ligase, UBE3D, participates in stabilizing CPFS73 protein by preventing its ubiquitin-mediated degradation by the proteasome. Depletion of UBE3D leads to CPSF73 downregulation, a pre-mRNA cleavage defect, and dysregulated gene expression in cells. UBE3D dysfunction or chemical inactivation of CPSF73 inhibited migration and invasion as well as stem cell renewal phenotypes in vitro in triple-negative breast cancer cells. In addition, genetic overexpression of CPSF73 promoted breast cancer stemness and knocking down CPSF73 inhibited stem cell renewal properties. Together, our findings indicate that targeting the pre-mRNA processing nuclease CPSF73 has potential for breast cancer therapy.
Keywords	Biological sciences ; molecular biology ; cell biology ; cancer ; Science ; Q
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of Light Obstruction from Street Lighting in Road Scenes

Jingzhi Ren / Yongqiang Li / Huiyun Liu / Kanghong Li / Daoqian Hao / Zhiyao Wang

Remote Sensing, Vol 15, Iss 24, p

2023 Volume 5655

Abstract: As urban greenery improves and the ecological environment is continuously optimized, road facilities are also impacted to varying degrees. For example, as vegetation grows, it causes varying degrees of obstruction to the lighting facilities on the roads. ...

Abstract	As urban greenery improves and the ecological environment is continuously optimized, road facilities are also impacted to varying degrees. For example, as vegetation grows, it causes varying degrees of obstruction to the lighting facilities on the roads. This article is based on vehicle-mounted LiDAR data and focuses on the point cloud data characteristics of different objects. Using appropriate modeling techniques, it accurately models road surfaces, green belts, streetlights, and other objects. On the Lumion platform, this system creates a 3D visualization of road scenes and examines the interplay between objects and lighting space, analyzing lit areas. Leveraging the precise 3D spatial relationships found in point clouds, it determines the effective illumination area on the ground from streetlights after object obstruction, comparing it to the theoretical illumination area. This not only visualizes the road scene but also quantifies the lighting obstruction rate. Furthermore, it assesses the lighting conditions in road scenes based on illuminance distribution, offering scientific insights and suggestions for enhancing road lighting.
Keywords	vehicle-mounted LiDAR ; point cloud ; model construction ; virtual representation ; lighting occlusion analysis ; Science ; Q
Subject code	380
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of biogas slurry fertilization on fruit economic traits and soil nutrients of Camellia oleifera Abel.

Lu You / Shuqin Yu / Huiyun Liu / Chutian Wang / Zengliang Zhou / Ling Zhang / Dongnan Hu

PLoS ONE, Vol 14, Iss 5, p e

2019 Volume 0208289

Abstract: Camellia oleifera Abel (C. oleifera) absorb nutrients from surrounding soils and its yield is highly influenced by these nutrients and by fertilizer application. Thus, the soil nutrients play a central role in C. oleifera production. This study ... ...

Abstract	Camellia oleifera Abel (C. oleifera) absorb nutrients from surrounding soils and its yield is highly influenced by these nutrients and by fertilizer application. Thus, the soil nutrients play a central role in C. oleifera production. This study investigated the effects of biogas slurry applications on soil nutrients and economic traits of C. oleifera fruits. Five different amounts of biogas slurry (0, 10, 20, 30, or 40 kg/plant/year, three applications per year) were used as fertilizer for C. oleifera plants in 2015 and 2016. The nutrients of rhizosphere soil and the economic traits, including fruit yield, seed rate, and oil yield of C. oleifera fruit, were measured each year. The results showed that fertilization with biogas slurry significantly increased soil organic matter, available nitrogen (N), phosphorus (P), and potassium (K) both in 2015 and 2016. Increases in soil available N, P, and K were maximal in the highest slurry application group followed by the second highest application group. The oil yield correlated with the content of soil available P in both 2015 and 2016, and with soil organic matter in 2015. Fertilization with biogas slurry decreased the saturated fatty acid content in fruit but had no effect on the unsaturated fatty acid content. In conclusion, fertilization with biogas slurry increased rhizosphere soil nutrients and fruit economic traits of C. oleifera and rates of at least30 kg/plant/year had the most positive effects. This study expands the knowledge of fertilization with biogas slurry in C. oleifera production.
Keywords	Medicine ; R ; Science ; Q
Subject code	630 ; 580
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Generation of markerâfree transgenic hexaploid wheat via an Agrobacteriumâmediated coâtransformation strategy in commercial Chinese wheat varieties

Wang, Ke / Huiyun Liu / Lipu Du / Xingguo Ye

Plant biotechnology journal. 2017 May, v. 15, no. 5

2017

Abstract: Genotype specificity is a big problem lagging the development of efficient hexaploid wheat transformation system. Increasingly, the biosecurity of genetically modified organisms is garnering public attention, so the generation of markerâfree transgenic ...

Abstract	Genotype specificity is a big problem lagging the development of efficient hexaploid wheat transformation system. Increasingly, the biosecurity of genetically modified organisms is garnering public attention, so the generation of markerâfree transgenic plants is very important to the eventual potential commercial release of transgenic wheat. In this study, 15 commercial Chinese hexaploid wheat varieties were successfully transformed via an Agrobacteriumâmediated method, with efficiency of up to 37.7%, as confirmed by the use of Quickstix strips, histochemical staining, PCR analysis and Southern blotting. Of particular interest, markerâfree transgenic wheat plants from various commercial Chinese varieties and their Fâ hybrids were successfully obtained for the first time, with a frequency of 4.3%, using a plasmid harbouring two independent TâDNA regions. The average coâintegration frequency of the gus and the bar genes located on the two independent TâDNA regions was 49.0% in Tâ plants. We further found that the efficiency of generating markerâfree plants was related to the number of bar gene copies integrated in the genome. Markerâfree transgenic wheat plants were identified in the progeny of three transgenic lines that had only one or two bar gene copies. Moreover, silencing of the bar gene was detected in 30.7% of Tâ positive plants, but the gus gene was never found to be silenced in Tâ plants. Bisulphite genomic sequencing suggested that DNA methylation in the 35S promoter of the bar gene regulatory region might be the main reason for bar gene silencing in the transgenic plants.
Keywords	biosecurity ; DNA methylation ; gene silencing ; genes ; genotype ; hexaploidy ; hybrids ; plasmids ; polymerase chain reaction ; progeny ; promoter regions ; Southern blotting ; staining ; transfer DNA ; transgenic plants ; Triticum aestivum ; wheat ; China
Language	English
Dates of publication	2017-05
Size	p. 614-623.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2136367-5
ISSN	1467-7652 ; 1467-7644
ISSN (online)	1467-7652
ISSN	1467-7644
DOI	10.1111/pbi.12660
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Controlling and modelling the wetting properties of III-V semiconductor surfaces using re-entrant nanostructures

Wing H. Ng / Yao Lu / Huiyun Liu / Claire J. Carmalt / Ivan P. Parkin / Anthony J. Kenyon

Scientific Reports, Vol 8, Iss 1, Pp 1-

2018 Volume 8

Abstract: Abstract Inorganic semiconductors such as III-V materials are very important in our everyday life as they are used for manufacturing optoelectronic and microelectronic components with important applications span from energy harvesting to ... ...

Abstract	Abstract Inorganic semiconductors such as III-V materials are very important in our everyday life as they are used for manufacturing optoelectronic and microelectronic components with important applications span from energy harvesting to telecommunications. In some applications, these components are required to operate in harsh environments. In these cases, having waterproofing capability is essential. Here we demonstrate design and control of the wettability of indium phosphide based multilayer material (InP/InGaAs/InP) using re-entrant structures fabricated by a fast electron beam lithography technique. This patterning technique enabled us to fabricate highly uniform nanostructure arrays with at least one order of magnitude shorter patterning times compared to conventional electron beam lithography methods. We reduced the surface contact fraction significantly such that the water droplets may be completely removed from our nanostructured surface. We predicted the wettability of our patterned surface by modelling the adhesion energies between the water droplet and both the patterned surface and the dispensing needle. This is very useful for the development of coating-free waterproof optoelectronic and microelectronic components where the coating may hinder the performance of such devices and cause problems with semiconductor fabrication compatibility.
Keywords	Medicine ; R ; Science ; Q
Subject code	620
Language	English
Publishing date	2018-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Continuous-wave quantum dot photonic crystal lasers grown on on-axis Si (001)

Taojie Zhou / Mingchu Tang / Guohong Xiang / Boyuan Xiang / Suikong Hark / Mickael Martin / Thierry Baron / Shujie Pan / Jae-Seong Park / Zizhuo Liu / Siming Chen / Zhaoyu Zhang / Huiyun Liu

Nature Communications, Vol 11, Iss 1, Pp 1-

2020 Volume 7

Abstract: Fabricating semiconductor photonic lasers based on III-V materials are challenging because of the material mismatch with silicon. Here the authors monolithically grow quantum-dot-based photonic crystal membrane lasers directly on an on-axis silicon ... ...

Abstract	Fabricating semiconductor photonic lasers based on III-V materials are challenging because of the material mismatch with silicon. Here the authors monolithically grow quantum-dot-based photonic crystal membrane lasers directly on an on-axis silicon substrate.
Keywords	Science ; Q
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Continuous-wave quantum dot photonic crystal lasers grown on on-axis Si (001)

Taojie Zhou / Mingchu Tang / Guohong Xiang / Boyuan Xiang / Suikong Hark / Mickael Martin / Thierry Baron / Shujie Pan / Jae-Seong Park / Zizhuo Liu / Siming Chen / Zhaoyu Zhang / Huiyun Liu

Nature Communications, Vol 11, Iss 1, Pp 1-

2020 Volume 7

Abstract	Fabricating semiconductor photonic lasers based on III-V materials are challenging because of the material mismatch with silicon. Here the authors monolithically grow quantum-dot-based photonic crystal membrane lasers directly on an on-axis silicon substrate.
Keywords	Science ; Q
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: MoS₂–OH Bilayer-Mediated Growth of Inch-Sized Monolayer MoS₂ on Arbitrary Substrates

Zhu, Juntong / Hao Xu / Guifu Zou / Wan Zhang / Ruiqing Chai / Jinho Choi / Jiang Wu / Huiyun Liu / Guozhen Shen / Hongyou Fan

Journal of the American Chemical Society. 2019 Mar. 08, v. 141, no. 13

2019

Abstract: Due to remarkable electronic property, optical transparency, and mechanical flexibility, monolayer molybdenum disulfide (MoS₂) has been demonstrated to be promising for electronic and optoelectronic devices. To date, the growth of high-quality and large- ... ...

Abstract	Due to remarkable electronic property, optical transparency, and mechanical flexibility, monolayer molybdenum disulfide (MoS₂) has been demonstrated to be promising for electronic and optoelectronic devices. To date, the growth of high-quality and large-scale monolayer MoS₂ has been one of the main challenges for practical applications. Here we present a MoS₂–OH bilayer-mediated method that can fabricate inch-sized monolayer MoS₂ on arbitrary substrates. This approach relies on a layer of hydroxide groups (−OH) that are preferentially attached to the (001) surface of MoS₂ to form a MoS₂–OH bilayer structure for growth of large-area monolayer MoS₂ during the growth process. Specifically, the hydroxide layer impedes vertical growth of MoS₂ layers along the [001] zone axis, promoting the monolayer growth of MoS₂, constrains growth of the MoS₂ monolayer only in the lateral direction into larger area, and effectively reduces sulfur vacancies and defects according to density functional theory calculations. Finally, the hydroxide groups advantageously prevent the MoS₂ from interface oxidation in air, rendering high-quality MoS₂ monolayers with carrier mobility up to ∼30 cm² V–¹ s–¹. Using this approach, inch-sized uniform monolayer MoS₂ has been fabricated on the sapphire and mica and high-quality monolayer MoS₂ of single-crystalline domains exceeding 200 μm has been grown on various substrates including amorphous SiO₂ and quartz and crystalline Si, SiC, Si₃N₄, and graphene This method provides a new opportunity for the monolayer growth of other two-dimensional transition metal dichalcogenides such as WS₂ and MoSe₂.
Keywords	air ; density functional theory ; graphene ; mica ; molybdenum disulfide ; oxidation ; quartz ; silicon ; silicon carbide ; silicon nitride ; sulfur
Language	English
Dates of publication	2019-0308
Size	p. 5392-5401.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.9b00047
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comprehensive Identification and Bread-Making Quality Evaluation of Common Wheat Somatic Variation Line AS208 on Glutenin Composition.

Huiyun Liu / Ke Wang / Lele Xiao / Shunli Wang / Lipu Du / Xinyou Cao / Xiaoxiang Zhang / Yang Zhou / Yueming Yan / Xingguo Ye

PLoS ONE, Vol 11, Iss 1, p e

2016 Volume 0146933

Abstract: High molecular weight glutenin subunits (HMW-GSs) are important seed storage proteins in wheat (Triticum aestivum) that determine wheat dough elasticity and processing quality. Clarification of the defined effectiveness of HMW-GSs is very important to ... ...

Abstract	High molecular weight glutenin subunits (HMW-GSs) are important seed storage proteins in wheat (Triticum aestivum) that determine wheat dough elasticity and processing quality. Clarification of the defined effectiveness of HMW-GSs is very important to breeding efforts aimed at improving wheat quality. To date, there have no report on the expression silencing and quality effects of 1Bx20 and 1By20 at the Glu-B1 locus in wheat. A wheat somatic variation line, AS208, in which both 1Bx20 and 1By20 at Glu-B1 locus were silenced, was developed recently in our laboratory. Evaluation of agronomic traits and seed storage proteins by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and reversed-phase high performance liquid chromatography (RP-HPLC) indicated that AS208 was highly similar to its parental cultivar Lunxuan987 (LX987), with the exception that the composition and expression of HMW-GSs was altered. The 1Bx20 and 1By20 in AS208 were further identified to be missing by polymerase chain reaction (PCR) and quantitative real-time RT-PCR (qRT-PCR) assays. Based on the PCR results for HMW-GS genes and their promoters in AS208 compared with LX987, 1Bx20 and 1By20 were speculated to be deleted in AS208 during in vitro culture. Quality analysis of this line with Mixograph, Farinograph, and Extensograph instruments, as well as analysis of bread-making quality traits, demonstrated that the lack of the genes encoding 1Bx20 and 1By20 caused various negative effects on dough processing and bread-making quality traits, including falling number, dough stability time, mixing tolerance index, crude protein values, wet gluten content, bread size, and internal cell structure. AS208 can potentially be used in the functional dissection of other HMW-GSs as a plant material with desirable genetic background, and in biscuit making industry as a high-quality weak gluten wheat source.
Keywords	Medicine ; R ; Science ; Q
Subject code	572
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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