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  1. Article ; Online: Obituary of Prof. Uli Theopold, 1957-2023.

    Engström, Ylva / Lemaitre, Bruno / Hultmark, Dan

    Journal of innate immunity

    2024  Volume 16, Issue 1, Page(s) 31–32

    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2454158-8
    ISSN 1662-8128 ; 1662-811X
    ISSN (online) 1662-8128
    ISSN 1662-811X
    DOI 10.1159/000535642
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6727: Show issues Location:
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  2. Article ; Online: Hematopoietic plasticity mapped in

    Hultmark, Dan / Andó, István

    eLife

    2022  Volume 11

    Abstract: Hemocytes, similar to vertebrate blood cells, play important roles in insect development and immunity, but it is not well understood how they perform their tasks. New technology, in particular single-cell transcriptomic analysis in combination ... ...

    Abstract Hemocytes, similar to vertebrate blood cells, play important roles in insect development and immunity, but it is not well understood how they perform their tasks. New technology, in particular single-cell transcriptomic analysis in combination with
    MeSH term(s) Animals ; Bombyx ; Drosophila ; Drosophila melanogaster/genetics ; Hematopoiesis/genetics ; Hemocytes ; Insecta
    Language English
    Publishing date 2022-08-03
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.78906
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  3. Article ; Online: Cellular Immunity of

    Cinege, Gyöngyi / Fodor, Kinga / Magyar, Lilla B / Lipinszki, Zoltán / Hultmark, Dan / Andó, István

    Cells

    2024  Volume 13, Issue 7

    Abstract: Coevolution of hosts and their parasites has shaped heterogeneity of effector hemocyte types, providing immune defense reactions with variable effectiveness. In this work, we characterize hemocytes ... ...

    Abstract Coevolution of hosts and their parasites has shaped heterogeneity of effector hemocyte types, providing immune defense reactions with variable effectiveness. In this work, we characterize hemocytes of
    MeSH term(s) Animals ; Drosophila ; Parasites ; Cell Differentiation ; Phagocytosis ; Immunity, Cellular
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13070593
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  4. Article ; Online: Editorial: Recent Advances in

    Vesala, Laura / Hultmark, Dan / Valanne, Susanna

    Frontiers in immunology

    2020  Volume 11, Page(s) 598618

    MeSH term(s) Animals ; Biological Evolution ; Biomarkers ; Drosophila/genetics ; Drosophila/immunology ; Drosophila/metabolism ; Energy Metabolism ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Cellular ; Immunity, Humoral ; Immunity, Innate ; Signal Transduction
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-10-02
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.598618
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  5. Article ; Online: Drosophila muscles regulate the immune response against wasp infection via carbohydrate metabolism.

    Yang, Hairu / Hultmark, Dan

    Scientific reports

    2017  Volume 7, Issue 1, Page(s) 15713

    Abstract: We recently found that JAK/STAT signaling in skeletal muscles is important for the immune response of Drosophila larvae against wasp infection, but it was not clear how muscles could affect the immune response. Here we show that insulin signaling is ... ...

    Abstract We recently found that JAK/STAT signaling in skeletal muscles is important for the immune response of Drosophila larvae against wasp infection, but it was not clear how muscles could affect the immune response. Here we show that insulin signaling is required in muscles, but not in fat body or hemocytes, during larval development for an efficient encapsulation response and for the formation of lamellocytes. This effect requires TOR signaling. We show that muscle tissue affects the immune response by acting as a master regulator of carbohydrate metabolism in the infected animal, via JAK/STAT and insulin signaling in the muscles, and that there is indirect positive feedback between JAK/STAT and insulin signaling in the muscles. Specifically, stimulation of JAK/STAT signaling in the muscles can rescue the deficient immune response when insulin signaling is suppressed. Our results shed new light on the interaction between metabolism, immunity, and tissue communication.
    MeSH term(s) Animals ; Carbohydrate Metabolism ; Drosophila melanogaster/immunology ; Drosophila melanogaster/metabolism ; Drosophila melanogaster/parasitology ; Glycogen/metabolism ; Insulin/metabolism ; Janus Kinases/metabolism ; Muscles/immunology ; Muscles/metabolism ; Muscles/parasitology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; STAT Transcription Factors/metabolism ; Signal Transduction ; Wasps/physiology
    Chemical Substances Insulin ; STAT Transcription Factors ; Glycogen (9005-79-2) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Janus Kinases (EC 2.7.10.2) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2017-11-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-017-15940-2
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  6. Article ; Online: A Novel Strategy for Live Detection of Viral Infection in Drosophila melanogaster.

    Ekström, Jens-Ola / Hultmark, Dan

    Scientific reports

    2016  Volume 6, Page(s) 26250

    Abstract: We have created a transgenic reporter for virus infection, and used it to study Nora virus infection in Drosophila melanogaster. The transgenic construct, Munin, expresses the yeast transcription factor Gal4, tethered to a transmembrane anchor via a ... ...

    Abstract We have created a transgenic reporter for virus infection, and used it to study Nora virus infection in Drosophila melanogaster. The transgenic construct, Munin, expresses the yeast transcription factor Gal4, tethered to a transmembrane anchor via a linker that can be cleaved by a viral protease. In infected cells, liberated Gal4 will then transcribe any gene that is linked to a promoter with a UAS motif, the target for Gal4 transcription. For instance, infected cells will glow red in the offspring of a cross between the Munin stock and flies with a UAS-RFP(nls) transgene (expressing a red fluorescent protein). In such flies we show that after natural infection, via the faecal-oral route, 5-15% of the midgut cells are infected, but there is little if any infection elsewhere. By contrast, we can detect infection in many other tissues after injection of virus into the body cavity. The same principle could be applied for other viruses and it could also be used to express or suppress any gene of interest in infected cells.
    MeSH term(s) Animals ; Animals, Genetically Modified ; Drosophila Proteins/genetics ; Drosophila melanogaster/genetics ; Drosophila melanogaster/virology ; Gastrointestinal Tract/virology ; Luminescent Proteins/metabolism ; Promoter Regions, Genetic ; RNA Virus Infections/genetics ; RNA Viruses/enzymology ; Transcription Factors/genetics ; Transgenes ; Red Fluorescent Protein
    Chemical Substances Drosophila Proteins ; Luminescent Proteins ; Transcription Factors
    Language English
    Publishing date 2016-05-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep26250
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  7. Article ; Online: Tissue communication in a systemic immune response of Drosophila.

    Yang, Hairu / Hultmark, Dan

    Fly

    2016  Volume 10, Issue 3, Page(s) 115–122

    Abstract: Several signaling pathways, including the JAK/STAT and Toll pathways, are known to activate blood cells (hemocytes) in Drosophila melanogaster larvae. They are believed to regulate the immune response against infections by parasitoid wasps, such as ... ...

    Abstract Several signaling pathways, including the JAK/STAT and Toll pathways, are known to activate blood cells (hemocytes) in Drosophila melanogaster larvae. They are believed to regulate the immune response against infections by parasitoid wasps, such as Leptopilina boulardi, but how these pathways control the hemocytes is not well understood. Here, we discuss the recent discovery that both muscles and fat body take an active part in this response. Parasitoid wasp infection induces Upd2 and Upd3 secretion from hemocytes, leading to JAK/STAT activation mainly in hemocytes and in skeletal muscles. JAK/STAT activation in muscles, but not in hemocytes, is required for an efficient encapsulation of wasp eggs. This suggests that Upd2 and Upd3 are important cytokines, coordinating different tissues for the cellular immune response in Drosophila. In the fat body, Toll signaling initiates a systemic response in which hemocytes are mobilized and activated hemocytes (lamellocytes) are generated. However, the contribution of Toll signaling to the defense against wasps is limited, probably because the wasps inject inhibitors that prevent the activation of the Toll pathway. In conclusion, parasite infection induces a systemic response in Drosophila larvae involving major organ systems and probably the physiology of the entire organism.
    MeSH term(s) Animals ; Drosophila Proteins/immunology ; Drosophila Proteins/metabolism ; Drosophila melanogaster/immunology ; Drosophila melanogaster/metabolism ; Drosophila melanogaster/parasitology ; Hemocytes/immunology ; Host-Parasite Interactions/immunology ; Immunity, Cellular/immunology ; Janus Kinases/immunology ; Janus Kinases/metabolism ; Larva/immunology ; Larva/parasitology ; Muscles/immunology ; STAT Transcription Factors/immunology ; STAT Transcription Factors/metabolism ; Signal Transduction ; Transcription Factors/immunology ; Transcription Factors/metabolism ; Wasps/immunology ; Wasps/pathogenicity
    Chemical Substances Drosophila Proteins ; STAT Transcription Factors ; Transcription Factors ; Upd2 protein, Drosophila ; Upd3 protein, Drosophila ; Janus Kinases (EC 2.7.10.2) ; hop protein, Drosophila (EC 2.7.10.2)
    Language English
    Publishing date 2016-04-26
    Publishing country United States
    Document type Journal Article
    ISSN 1933-6942
    ISSN (online) 1933-6942
    DOI 10.1080/19336934.2016.1182269
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  8. Article ; Online: New ways to make a blood cell.

    Anderl, Ines / Hultmark, Dan

    eLife

    2015  Volume 4

    Abstract: In a niche under the skin in Drosophila larvae, blood cells called plasmatocytes can transform into other classes of blood cell. ...

    Abstract In a niche under the skin in Drosophila larvae, blood cells called plasmatocytes can transform into other classes of blood cell.
    MeSH term(s) Animals ; Drosophila melanogaster ; Hemocytes/cytology
    Language English
    Publishing date 2015-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.06877
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  9. Article: Insect lysozymes.

    Hultmark, D

    EXS

    1996  Volume 75, Page(s) 87–102

    Abstract: Lysozymes, related to the chicken-type lysozymes in vertebrates, are ubiquitous components in the bacteriolytic armamentarium of insects. The enzyme is normally present in the blood, and together with other bactericidal factors lysozyme is often strongly ...

    Abstract Lysozymes, related to the chicken-type lysozymes in vertebrates, are ubiquitous components in the bacteriolytic armamentarium of insects. The enzyme is normally present in the blood, and together with other bactericidal factors lysozyme is often strongly induced when the insect is infected. This response is regulated by mechanisms that are related to those that activate inflammatory, acute-phase and immune responses in mammals, and the induction of lysozyme and other factors is now being investigated as a model for innate immune reactions in general. A special adaptation is seen in flies like Musca and Drosophila. These animals live on the microorganisms in decompositing matter, and they have developed a specialized set of lysozymes that are expressed in the alimentary tract. In Drosophila, at least seven different lysozyme genes are clustered in a small region on the third chromosome. The different genes are expressed in different parts of the digestive tract, and at different time points during development, and they are highly divergent in sequence. The major lysozymes in the fly gut have acidic isoelectric points and/or pH optima, and their evolution provides an interesting parallel to the ruminants.
    MeSH term(s) Amino Acid Sequence ; Animals ; Cloning, Molecular ; Diptera/enzymology ; Evolution, Molecular ; Genes, Insect/genetics ; Insecta/enzymology ; Insecta/physiology ; Molecular Sequence Data ; Muramidase/chemistry ; Muramidase/genetics ; Muramidase/metabolism ; Phylogeny
    Chemical Substances Muramidase (EC 3.2.1.17)
    Language English
    Publishing date 1996
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1023-294X
    ISSN 1023-294X
    DOI 10.1007/978-3-0348-9225-4_6
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  10. Article ; Online: Drosophila immunity--glorious past, dynamic present and exciting future.

    Rämet, Mika / Hultmark, Dan

    Developmental and comparative immunology

    2014  Volume 42, Issue 1, Page(s) 1–2

    MeSH term(s) Animals ; Biological Evolution ; Drosophila melanogaster/immunology ; Immunity, Mucosal ; Infection/immunology ; Intestines/immunology ; Intestines/microbiology ; Intestines/virology ; Nobel Prize ; Physiology ; Symbiosis/immunology ; Toll-Like Receptors/immunology
    Chemical Substances Toll-Like Receptors
    Language English
    Publishing date 2014-01
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 752411-0
    ISSN 1879-0089 ; 0145-305X
    ISSN (online) 1879-0089
    ISSN 0145-305X
    DOI 10.1016/j.dci.2013.07.013
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