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  1. Article ; Online: Community-acquired pneumonia with Acinetobacter radioresistens bacteremia in an immunocompetent host

    Yi Hern Tan / Lishan Jessica Quah / Humaira Shafi

    Asian Pacific Journal of Tropical Medicine, Vol 12, Iss 6, Pp 288-

    A case report

    2019  Volume 290

    Abstract: Rationale: Acinetobacter radioresistens is a non-fermentative Gram-negative coccobacillus that is environmentally ubiquitous and is an uncommon cause of pneumonia in an immunocompetent patient with no known chronic medical illness. Patient concerns: A ... ...

    Abstract Rationale: Acinetobacter radioresistens is a non-fermentative Gram-negative coccobacillus that is environmentally ubiquitous and is an uncommon cause of pneumonia in an immunocompetent patient with no known chronic medical illness. Patient concerns: A middle-aged Asian male with a smoking history presented with fever and cough. Physical examination was unremarkable. Chest imaging was consistent with pulmonary parenchymal infection and blood culture grew Acinetobacter radioresistens. Diagnosis: Community acquired pneumonia with Acinetobacter radioresistens bacteremia. Interventions: The patient received a combination of intravenous and oral ampicillin-sulbactam over 2 weeks. Outcomes: Repeat blood cultures showed resolution of bacteremia. Completion of antimicrobial treatment saw resolution of respiratory symptoms and radiological pneumonic changes. Lessons: Acinetobacter radioresistens causing community-acquired pneumonia in an immunocompetent host has never been described before. It may be a novel emerging infectious agent in pulmonary infections. Its clinical course in this immunocompetent patient appears to be relatively benign.
    Keywords acinetobacter baumanii ; blaoxa-23 gene ; carbapenem-hydrolyzing oxacillinases ; rare respiratory infections ; Arctic medicine. Tropical medicine ; RC955-962
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A Suggested Approach To The Diagnosis Of Urinary Tract Infection And Empiric Use Of Antibiotics Among Hospitalized Older Adults With Acute Confusion And Or Underlying Cognitive And Communication Deficits

    Farooq Akram / Humaira Shafi / Stephen Paul Wilkinson / Yeo Li Fang / Kangqi Ng / Roshni Sadashiv Gokhale / Helen Oh May Lin

    Australasian Medical Journal , Vol 13, Iss 7, Pp 229-

    2020  Volume 233

    Abstract: Background The true incidence of urinary tract infection (UTI) among hospitalized older adults remains unknown. Aims We aim to present an approach to improve correct identification of UTI diagnosis and empiric use of antibiotics among those who are ... ...

    Abstract Background The true incidence of urinary tract infection (UTI) among hospitalized older adults remains unknown. Aims We aim to present an approach to improve correct identification of UTI diagnosis and empiric use of antibiotics among those who are unable to provide history. Methods A comprehensive review of the literature was undertaken. Results Our suggested approach appears safe and likely to enhance diagnostic accuracy and judicious use of antibiotics among hospitalized older adults. Conclusion Our suggested approach is based on best available literature evidence but requires validation in clinical studies.
    Keywords uti ; confusion ; antibiotics ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Australasian Medical Journal pty ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: A suggested approach to the diagnosis of urinary tract infection and empiric use of antibiotics among hospitalized older adults with acute confusion and or underlying cognitive and communication deficits

    Farooq Akram / Humaira Shafi / Stephen Paul Wilkinson / Yeo Li Fang / Kangqi Ng / Roshni Sadashiv Gokhale / Helen Oh May Lin

    Australasian Medical Journal , Vol 13, Iss 10, Pp 229-

    2020  Volume 233

    Abstract: Background The true incidence of urinary tract infection (UTI) among hospitalized older adults remains unknown. Aims We aim to present an approach to improve correct identification of UTI diagnosis and empiric use of antibiotics among those who are ... ...

    Abstract Background The true incidence of urinary tract infection (UTI) among hospitalized older adults remains unknown. Aims We aim to present an approach to improve correct identification of UTI diagnosis and empiric use of antibiotics among those who are unable to provide history. Methods A comprehensive review of the literature was undertaken. Results Our suggested approach appears safe and likely to enhance diagnostic accuracy and judicious use of antibiotics among hospitalized older adults. Conclusion Our suggested approach is based on best available literature evidence but requires validation in clinical studies.
    Keywords uti ; confusion ; antibiotics ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Australasian Medical Journal pty ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: COVID-19 and Undiagnosed Pre-diabetes or Diabetes Mellitus Among International Migrant Workers in Singapore.

    Tee, Louis Y / Alhamid, Sharifah Munirah / Tan, Jeriel L / Oo, Theik Di / Chien, Jaime / Galinato, Primavera / Tan, Seow Yen / Humaira, Shafi / Fong, Raymond Kok Choon / Puar, Troy H / Loh, Wann Jia / Santosa, Anindita / Khoo, Joan / Rosario, Barbara Helen

    Frontiers in public health

    2020  Volume 8, Page(s) 584249

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adult ; COVID-19/diagnosis ; COVID-19/epidemiology ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; Humans ; Male ; Middle Aged ; Prediabetic State/diagnosis ; Prediabetic State/epidemiology ; Retrospective Studies ; Risk Assessment ; SARS-CoV-2/isolation & purification ; Singapore/epidemiology ; Transients and Migrants/statistics & numerical data ; Undiagnosed Diseases/epidemiology ; Young Adult
    Language English
    Publishing date 2020-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.584249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Disentangling etiologies of CNS infections in Singapore using multiple correspondence analysis and random forest

    Raphaël M. Zellweger / Sophie Yacoub / Yvonne F. Z. Chan / Derek Soon / Humaira Shafi / Say Tat Ooi / Monica Chan / Leslie Jacobson / October M. Sessions / Angela Vincent / Jenny Guek Hong Low / Eng Eong Ooi / Linfa Wang / Limin Wijaya / Kevin Tan / the Singapore Neurologic Infections Program (SNIP)

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Volume 12

    Abstract: Abstract Central nervous system (CNS) infections cause substantial morbidity and mortality worldwide, with mounting concern about new and emerging neurologic infections. Stratifying etiologies based on initial clinical and laboratory data would ... ...

    Abstract Abstract Central nervous system (CNS) infections cause substantial morbidity and mortality worldwide, with mounting concern about new and emerging neurologic infections. Stratifying etiologies based on initial clinical and laboratory data would facilitate etiology-based treatment rather than relying on empirical treatment. Here, we report the epidemiology and clinical outcomes of patients with CNS infections from a prospective surveillance study that took place between 2013 and 2016 in Singapore. Using multiple correspondence analysis and random forest, we analyzed the link between clinical presentation, laboratory results, outcome and etiology. Of 199 patients, etiology was identified as infectious in 110 (55.3%, 95%-CI 48.3–62.0), immune-mediated in 10 (5.0%, 95%-CI 2.8–9.0), and unknown in 79 patients (39.7%, 95%-CI 33.2–46.6). The initial presenting clinical features were associated with the prognosis at 2 weeks, while laboratory-related parameters were related to the etiology of CNS disease. The parameters measured were helpful to stratify etiologies in broad categories, but were not able to discriminate completely between all the etiologies. Our results suggest that while prognosis of CNS is clearly related to the initial clinical presentation, pinpointing etiology remains challenging. Bio-computational methods which identify patterns in complex datasets may help to supplement CNS infection diagnostic and prognostic decisions.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: COVID-19 and Undiagnosed Pre-diabetes or Diabetes Mellitus Among International Migrant Workers in Singapore

    Tee, Louis Y. / Alhamid, Sharifah Munirah / Tan, Jeriel L. / Oo, Theik Di / Chien, Jaime / Galinato, Primavera / Tan, Seow Yen / Humaira, Shafi / Fong, Raymond Kok Choon / Puar, Troy H. / Loh, Wann Jia / Santosa, Anindita / Khoo, Joan / Rosario, Barbara Helen

    Frontiers in Public Health

    2020  Volume 8

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.584249
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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