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  1. Article ; Online: A proposed classification system for opportunist pathogens for improved healthcare infection prevention and control risk assessments.

    Humphreys, H

    The Journal of hospital infection

    2023  Volume 142, Page(s) 136–137

    MeSH term(s) Humans ; Risk Assessment ; Infection Control
    Language English
    Publishing date 2023-08-06
    Publishing country England
    Document type Letter
    ZDB-ID 779366-2
    ISSN 1532-2939 ; 0195-6701
    ISSN (online) 1532-2939
    ISSN 0195-6701
    DOI 10.1016/j.jhin.2023.07.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1586: Show issues Location:
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  2. Article ; Online: Decision letter from other journals and peer review.

    Humphreys, Hilary

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  

    Language English
    Publishing date 2023-08-08
    Publishing country England
    Document type Letter
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.08.002
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    Zs.MO 284: Show issues

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  3. Article ; Online: Infection prevention and control advice out-of-hours.

    Humphreys, H

    The Journal of hospital infection

    2020  Volume 105, Issue 4, Page(s) 795–796

    MeSH term(s) After-Hours Care/methods ; After-Hours Care/standards ; Bacterial Infections/prevention & control ; Humans ; Infection Control/methods ; Infection Control/standards ; Infection Control/statistics & numerical data ; Ireland ; Telephone ; Tertiary Care Centers/statistics & numerical data
    Language English
    Publishing date 2020-06-02
    Publishing country England
    Document type Letter
    ZDB-ID 779366-2
    ISSN 1532-2939 ; 0195-6701
    ISSN (online) 1532-2939
    ISSN 0195-6701
    DOI 10.1016/j.jhin.2020.05.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Oxford Case Histories in Infectious Diseases and Microbiology

    Humphreys, Hilary / Irving, William L / Atkins, Bridget L / Woodhouse, Andrew F

    (Oxford Case Histories)

    2020  

    Abstract: Oxford Case Histories in Infection and Microbiology contains over 45 well structured cases, providing comprehensive coverage of the diagnostic and management dilemmas in clinical microbiology and infectious diseases. -- -- Each case comprises of a brief ... ...

    Author's details Hilary Humphreys is Professor of Clinical Microbiology at the Royal College of Surgeons in Ireland and Consultant Microbiologist in Beaumont Hospital, Dublin. He has a longstanding research interest in hospital infections, has published widely on many aspects of this and he has led a number of guideline groups in Ireland and in the UK. He has been involved in the teaching of both undergraduate and graduate entry medical students for some years as well as pharmacy students and others. He has developed online material as part of blended learning and he is a former National Specialty Director for Clinical Microbiology in Ireland. Will Irving has been Professor and Honorary Consultant in Virology at the University of Nottingham and Nottingham University Hospitals NHS Trust since 2002. His research interest is in the natural history of hepatitis C virus infection, and has published extensively on this subject. He co-chairs "HCV Research UK", a multi-centre consortium creating a national
    Series title Oxford Case Histories
    Abstract Oxford Case Histories in Infection and Microbiology contains over 45 well structured cases, providing comprehensive coverage of the diagnostic and management dilemmas in clinical microbiology and infectious diseases. -- -- Each case comprises of a brief patient history with relevant clinical examination findings, thus insuring the reader is aware of how to confirm a diagnosis rapidly, with reference throughout to laboratory techniques, advice on therapy, epidemiological features, and areas w...
    Language English
    Size 368 p.
    Edition 3
    Publisher Oxford University Press
    Document type Book
    Note PDA Manuell_5
    Format 158 x 236 x 18
    ISBN 9780198846482 ; 0198846487
    Database PDA

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  5. Article ; Online: Payment and progress in peer review.

    Humphreys, Hilary

    Lancet (London, England)

    2022  Volume 400, Issue 10347, Page(s) 159

    MeSH term(s) Humans ; Medicare ; Peer Review ; United States
    Language English
    Publishing date 2022-07-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)00921-7
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  6. Article ; Online: Quality of hospital air.

    Humphreys, H

    The Journal of hospital infection

    2019  Volume 104, Issue 3, Page(s) 300–301

    MeSH term(s) Air Pollution ; Air Pollution, Indoor ; Critical Care ; Hospitals ; Humans ; Longitudinal Studies
    Language English
    Publishing date 2019-11-22
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 779366-2
    ISSN 1532-2939 ; 0195-6701
    ISSN (online) 1532-2939
    ISSN 0195-6701
    DOI 10.1016/j.jhin.2019.11.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Plasma-activated liquid as a potential decontaminant in healthcare: assessment of antibacterial activity and use with cleaning cloths.

    Fallon, M / Kennedy, S / Daniels, S / Humphreys, H

    The Journal of hospital infection

    2024  Volume 145, Page(s) 218–223

    Abstract: Background: Cold air plasma (CAP) can generate plasma-activated liquids (PALs) with high concentrations of reactive oxygen (ROS) and nitrogen species (RNS), e.g., nitrites, with antimicrobial properties.: Aim: We investigated the concentrations of ... ...

    Abstract Background: Cold air plasma (CAP) can generate plasma-activated liquids (PALs) with high concentrations of reactive oxygen (ROS) and nitrogen species (RNS), e.g., nitrites, with antimicrobial properties.
    Aim: We investigated the concentrations of ROS and RNS in saline PAL. We assessed planktonic bacterial inactivation by PAL and the decontamination of contaminated cleaning cloths.
    Methods: Phosphate-buffered saline (PBS) was treated with an air-driven CAP jet for 90 or 300 s to generate PAL. The ROS and RNS were measured using quantitative fluorescent (2,7-dichlorofluorescin diacetate) and colourimetric (Greiss) assays. Isolates of MRSA and Escherichia coli were incubated in PAL overnight and inactivation measured through colony forming unit (cfu) assays. Sections of cleaning cloths were incubated with MRSA and E. coli, and treated with PAL for 1 h. Bacterial inactivation was measured through resazurin reduction assays.
    Results: Nitrites increased from 0.1 μM in untreated PBS to 49.1 μM and to 94.0 μM in 90- and 300-s CAP-treated PAL, respectively. ROS increased from 30 μM in untreated PBS to 75 μM and to 103 μM in 90- and 300-s CAP-treated PAL, respectively. 90-s PAL reduced MRSA and E. coli viability (P<0.05) and 300-s PAL resulted in more than a 7-log reduction of both. One-hour treatment of contaminated cleaning cloths in PAL resulted in a 55% and 73% reduction in viable MRSA and E. coli, respectively (P<0.05).
    Conclusion: Inactivation of planktonic bacteria correlated with ROS and RNS concentrations. PAL reduced bacteria contaminated cleaning cloths. PAL has potential as a hospital disinfectant, including cleaning cloths.
    MeSH term(s) Humans ; Disinfection/methods ; Escherichia coli ; Nitrites ; Reactive Oxygen Species ; Bacteria ; Anti-Bacterial Agents/pharmacology ; Delivery of Health Care
    Chemical Substances Nitrites ; Reactive Oxygen Species ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 779366-2
    ISSN 1532-2939 ; 0195-6701
    ISSN (online) 1532-2939
    ISSN 0195-6701
    DOI 10.1016/j.jhin.2024.01.008
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  8. Article ; Online: Patients, public perceptions and political pressures in the prioritization of surveillance of healthcare-associated infection.

    Humphreys, H

    The Journal of hospital infection

    2018  Volume 101, Issue 1, Page(s) 47–48

    MeSH term(s) Cross Infection/epidemiology ; Cross Infection/prevention & control ; Epidemiological Monitoring ; Health Knowledge, Attitudes, Practice ; Health Policy ; Health Priorities ; Humans ; Infection Control/methods ; Patient Participation
    Language English
    Publishing date 2018-08-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 779366-2
    ISSN 1532-2939 ; 0195-6701
    ISSN (online) 1532-2939
    ISSN 0195-6701
    DOI 10.1016/j.jhin.2018.07.046
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  9. Article ; Online: Infection prevention and control considerations regarding ventilation in acute hospitals.

    Humphreys, Hilary

    Infection prevention in practice

    2021  Volume 3, Issue 4, Page(s) 100180

    Abstract: Infection prevention and control team members (IPCTM) are often intimidated by aspects of ventilation as they relate to healthcare, because they consider them technical and outside their area of comfort and expertise. However, engineers, estates ... ...

    Abstract Infection prevention and control team members (IPCTM) are often intimidated by aspects of ventilation as they relate to healthcare, because they consider them technical and outside their area of comfort and expertise. However, engineers, estates departments and planners need IPCTM input to ensure appropriate design and use. The main areas of importance centre on the operating theatre, the provision of air-controlled ventilated isolation rooms, and how to respond to major outbreaks/pandemics. Concentrating on basic principles of infection prevention and control, developing relationships with key departments and individuals, and applying best practice to these and other areas as they arise, are of great value. Some background, information and suggestions are provided for IPCTM with a view to providing simple practical advice in these areas.
    Language English
    Publishing date 2021-10-20
    Publishing country England
    Document type Journal Article
    ISSN 2590-0889
    ISSN (online) 2590-0889
    DOI 10.1016/j.infpip.2021.100180
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  10. Article ; Online: Nutritional drinks and enteral feeds promote the growth of carbapenemase-producing Enterobacterales in conditions that simulate disposal in hospital sinks.

    Kearney, A / Humphreys, H / Fitzgerald-Hughes, D

    The Journal of hospital infection

    2023  Volume 139, Page(s) 74–81

    Abstract: Background: Studies have shown that nutritional products are discarded via handwash sinks by healthcare workers, and this practice may promote bacterial growth, including growth of pathogens such as carbapenemase-producing Enterobacterales (CPE). ... ...

    Abstract Background: Studies have shown that nutritional products are discarded via handwash sinks by healthcare workers, and this practice may promote bacterial growth, including growth of pathogens such as carbapenemase-producing Enterobacterales (CPE). Outbreaks and acquisition of CPE in nosocomial settings are associated with negative outcomes for patients and hospitals.
    Objectives: To investigate the potential growth-promoting effect of nutritional support drinks (NSDs) and enteral tube-feed products (ETFPs) on CPE.
    Methods: Six different CPE strains were grown in five different diluted NSDs, five different diluted ETFPs, Mueller-Hinton broth (MHB) and M9 minimal salts media to simulate discarding a small volume of nutritional product in a u-bend, already containing liquid. CPE were enumerated at 0 h, 6 h and 24 h, and compared using two-way analysis of variance and Dunett test, with confidence levels at 95%. Spearman's r was used to measure the strength of correlation between component concentrations in nutritional products and CPE growth.
    Results: All NSDs and ETFPs promoted CPE growth that exceeded both M9 (negative growth control) and MHB (positive growth control). In several cases, growth in NSDs/ETFPs was significantly greater compared with growth in MHB.
    Conclusion: Nutritional products support CPE growth under in-vitro conditions. The propensity of CPE to survive in drain pipework suggests that inappropriate product disposal may further nourish established CPE in these environmental reservoirs. The growth observed in diluted NSDs and ETFPs shows that modifiable practices should be optimized to mitigate the potential risk of CPE transmission from these reservoirs.
    MeSH term(s) Humans ; Enteral Nutrition ; beta-Lactamases/analysis ; Bacterial Proteins/analysis ; Gammaproteobacteria ; Hospitals ; Enterobacteriaceae Infections/microbiology
    Chemical Substances carbapenemase (EC 3.5.2.6) ; beta-Lactamases (EC 3.5.2.6) ; Bacterial Proteins
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 779366-2
    ISSN 1532-2939 ; 0195-6701
    ISSN (online) 1532-2939
    ISSN 0195-6701
    DOI 10.1016/j.jhin.2023.05.008
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