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Article: Downregulated antisense lncRNA

Chiang, Hung-Hsing / Ong, Chai-Tung / Chang, Chao-Yuan / Wu, Kuan-Li / Wu, Yu-Yuan / Lai, Jia-Chen / Shen, Tzu-Yen / Hung, Jen-Yu / Lee, Hsiao-Chen / Tsai, Ying-Ming / Hsu, Ya-Ling

American journal of cancer research

2024 Volume 14, Issue 2, Page(s) 854–868

Abstract: The poor outcome of patients with lung adenocarcinoma (LUAD) highlights the importance to identify novel effective prognostic markers and therapeutic targets. Long noncoding RNAs (lncRNAs) have generally been considered to serve important roles in ... ...

Abstract	The poor outcome of patients with lung adenocarcinoma (LUAD) highlights the importance to identify novel effective prognostic markers and therapeutic targets. Long noncoding RNAs (lncRNAs) have generally been considered to serve important roles in tumorigenesis and the development of various types of cancer, including LUAD. Here, we aimed to investigate the role of
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2589522-9
ISSN	2156-6976
ISSN	2156-6976
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Article ; Online: Clinical outcome of bevacizumab or ramucirumab combined with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors as the first line therapy in susceptible EGFR-mutated advanced non-small-cell lung.

Kuo, Chia-Yu / Tsai, Ming-Ju / Hung, Jen-Yu / Lee, Mei-Hsuan / Wu, Kuan-Li / Tsai, Yu-Chen / Chuang, Cheng-Hao / Huang, Chung-Wen / Chen, Chin-Ling / Yang, Chih-Jen / Chong, Inn-Wen

The Kaohsiung journal of medical sciences

2024

Abstract: Combining epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with an anti- vascular endothelial growth factor (VEGF) agent, bevacizumab or ramucirumab, is indicated for advanced lung adenocarcinoma harboring EGFR mutation. This study ...

Abstract	Combining epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with an anti- vascular endothelial growth factor (VEGF) agent, bevacizumab or ramucirumab, is indicated for advanced lung adenocarcinoma harboring EGFR mutation. This study aimed to show the real-world data of combination therapy and compare the effectiveness between bevacizumab and ramucirumab in combination with an EGFR-TKI. This retrospective study enrolled 47 patients diagnosed of stage IV lung adenocarcinoma with exon 19 deletion or L858R point mutation, receiving a first-line EGFR-TKI with anti-VEGF agent, including 34 (72%) and 13 (28%) patients receiving bevacizumab and ramucirumab, respectively. The response rate was similar in both groups (p = 0.38). Patients receiving bevacizumab had similar progression free survival (PFS) as those receiving ramucirumab (median PFS: 21.9 vs. 24.2 months, p = 0.4871); similar finding was noted in overall survival (OS) (median OS: 33.5 months vs. not reached, p = 0.4618). Patients receiving ramucirumab experienced a significantly high-grade hypertension compared to those receiving bevacizumab (p = 0.0351). Multivariable Cox regression analysis found independent risk factors for worse PFS included poorer ECOG performance status, multiple (≥3) metastatic sites, brain metastasis, and pleural metastasis/effusion, while the type of anti-VEGF agent was not a risk factor. Pericardial metastasis/effusion was the only one independent risk factor for worse OS. In summary, ramucirumab may have similar effectiveness as bevacizumab in combination with an EGFR-TKI as first line therapy for advanced lung adenocarcinoma harboring susceptible EGFR mutation. Further large-scale registry-based cohort studies may be needed to validate our findings.
Language	English
Publishing date	2024-03-25
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	639302-0
ISSN	2410-8650 ; 0257-5655
ISSN (online)	2410-8650
ISSN	0257-5655
DOI	10.1002/kjm2.12822
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Article: Clinical outcomes of Atezolizumab Therapy for Previously-Treated Advanced-Stage Non-Small Cell Lung Cancer: A Real-World Study in Taiwan.

Wu, Shang-Gin / Chiang, Chi-Lu / Wang, Chin-Chou / Hung, Jen-Yu / Hsia, Te-Chun / Kuo, Chih-Hsi / Shih, Jin-Yuan

Journal of Cancer

2022 Volume 13, Issue 9, Page(s) 2922–2932

Abstract: Immune checkpoint inhibitors (ICIs) are the standard treatment for non-small-cell lung cancer (NSCLC). We assessed the clinical prognostic factors in NSCLC patients receiving atezolizumab as a second- or later-line (2L+) treatment. Data were ... ...

Abstract	Immune checkpoint inhibitors (ICIs) are the standard treatment for non-small-cell lung cancer (NSCLC). We assessed the clinical prognostic factors in NSCLC patients receiving atezolizumab as a second- or later-line (2L+) treatment. Data were retrospectively collected for NSCLC patients treated with atezolizumab from July 2017 to June 2019 at six medical centers in Taiwan. Clinical characteristics, treatment course and responses of patients were recorded. A total of 128 NSCLC patients received 2L+ atezolizumab, and the outcomes included a response rate of 10.2%, median progression-free survival (mPFS) of 3.5 months, and median overall survival (mOS) of 10.7 months. Eleven patients who had received osimertinib treatment before atezolizumab had a shorter mPFS (2.3
Language	English
Publishing date	2022-07-18
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.74617
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Article ; Online: LINC02323 facilitates development of lung squamous cell carcinoma by miRNA sponge and RBP dysregulation and links to poor prognosis.

Wu, Kuan-Li / Tsai, Ying-Ming / Huang, Yung-Chi / Wu, Yu-Yuan / Chang, Chao-Yuan / Liu, Yu-Wei / Hsu, Ya-Ling / Hung, Jen-Yu

Thoracic cancer

2022 Volume 14, Issue 4, Page(s) 407–418

Abstract: Background: The poor outcome of patients with lung squamous cell carcinoma (LUSC) highlights the importance of the identification of novel effective prognostic markers and therapeutic targets. Long noncoding RNAs (lncRNAs) have generally been considered ...

Abstract	Background: The poor outcome of patients with lung squamous cell carcinoma (LUSC) highlights the importance of the identification of novel effective prognostic markers and therapeutic targets. Long noncoding RNAs (lncRNAs) have generally been considered to serve important roles in tumorigenesis and the development of various types of cancer, including LUSC. Methods: Here, we aimed to investigate the role of LINC02323 in LUSC and its potential mechanisms by performing comprehensive bioinformatic analyses. Results: LINC02323 was elevated and positively associated with unfavorable prognosis of LUSC patients. LINC02323 exerted oncogenic function by competitively binding to miR-1343-3p and miR-6783-3p, thereby upregulating L1CAM expression. Indeed, we also determined that LINC02323 could interact with the RNA-binding protein DDX3X, which regulates various stages of RNA expression and processing. Conclusion: Taken together, we identified that LINC02323 and its indirect target L1CAM can act as novel biomarkers for determining the prognosis of patients with LUSC and thus deserves further study.
MeSH term(s)	Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Neural Cell Adhesion Molecule L1/genetics ; Neural Cell Adhesion Molecule L1/metabolism ; Gene Expression Regulation, Neoplastic ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Prognosis ; RNA, Long Noncoding/genetics ; Lung/pathology
Chemical Substances	MicroRNAs ; Neural Cell Adhesion Molecule L1 ; RNA, Long Noncoding
Language	English
Publishing date	2022-12-14
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/1759-7714.14760
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Article ; Online: Characterization of the pleural microenvironment niche and cancer transition using single-cell RNA sequencing in EGFR-mutated lung cancer.

Wu, Yu-Yuan / Hsu, Ya-Ling / Huang, Yung-Chi / Su, Yue-Chiu / Wu, Kuan-Li / Chang, Chao-Yuan / Ong, Chai-Tung / Lai, Jia-Chen / Shen, Tzu-Yen / Lee, Tai-Huang / Hung, Jen-Yu / Tsai, Ying-Ming

Theranostics

2023 Volume 13, Issue 13, Page(s) 4412–4429

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Lung Neoplasms/genetics ; Pleural Effusion ; Carcinogenesis ; Sequence Analysis, RNA ; ErbB Receptors ; Tumor Microenvironment/genetics
Chemical Substances	ErbB Receptors (EC 2.7.10.1) ; EGFR protein, human (EC 2.7.10.1)
Language	English
Publishing date	2023-08-06
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.85084
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Article ; Online: Upregulated enhancer of rudimentary homolog promotes epithelial‑mesenchymal transition and cancer cell migration in lung adenocarcinoma.

Tsai, Ying-Ming / Wu, Kuan-Li / Huang, Yung-Chi / Wu, Yu-Yuan / Chang, Chao-Yuan / Chang, Yung-Yun / Chiang, Hung-Hsing / Liu, Lian-Xiu / Hung, Jen-Yu

Molecular medicine reports

2023 Volume 29, Issue 1

Abstract: Lung adenocarcinoma (LUAD) is one of the deadliest cancers regarding both mortality rate and number of deaths and warrants greater effort in the development of potential therapeutic targets. The enhancer of rudimentary homolog ( ...

Abstract	Lung adenocarcinoma (LUAD) is one of the deadliest cancers regarding both mortality rate and number of deaths and warrants greater effort in the development of potential therapeutic targets. The enhancer of rudimentary homolog (
MeSH term(s)	Humans ; Adenocarcinoma of Lung/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Lung Neoplasms/pathology ; Proteomics ; Tumor Microenvironment
Chemical Substances	ERH protein, human
Language	English
Publishing date	2023-11-24
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2023.13132
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Article ; Online: Increased risk of major depressive disorder in sleep apnea patients in Taiwan.

Chen, Chia-Min / Kuo, Chia-Yu / Wu, Meng-Ni / Hung, Jen-Yu / Hsu, Chung-Yao / Tsai, Ming-Ju

Scientific reports

2021 Volume 11, Issue 1, Page(s) 765

Abstract: The association between sleep apnea (SA) and depression had been reported in a few previous studies. However, whether SA increases the risk of major depressive disorder (MDD) has not been studied comprehensively in a large-scale study. We performed this ... ...

Abstract	The association between sleep apnea (SA) and depression had been reported in a few previous studies. However, whether SA increases the risk of major depressive disorder (MDD) has not been studied comprehensively in a large-scale study. We performed this population-based cohort study to assess the association between SA and MDD. We identified adult patients having SA from the Taiwan National Health Insurance Research Database and excluded those having MDD before SA diagnosis. Thirty control subjects were randomly selected to match to each SA patient by age and sex. Totally, 10,259 SA patients were matched to 102,590 control subjects. The incidence rate and cumulative incidence of MDD were significantly higher in SA patients than in the control subjects (both p < 0.0001). Multivariable Cox regression analysis showed that SA remained an independent risk factor for incident MDD after adjusting for age, sex, residency, income level, and comorbidities (hazard ratio = 2.9 [95% CI 2.8-3.1], p < 0.0001). In summary, SA patients have an increased risk to develop MDD. Physicians caring for SA patients must pay attention to their psychosocial health status.
MeSH term(s)	Adult ; Algorithms ; Cohort Studies ; Comorbidity ; Databases, Factual ; Depressive Disorder, Major/epidemiology ; Depressive Disorder, Major/etiology ; Depressive Disorder, Major/pathology ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Risk Factors ; Sleep Apnea Syndromes/complications ; Sleep Apnea Syndromes/epidemiology ; Sleep Apnea Syndromes/pathology ; Taiwan/epidemiology
Language	English
Publishing date	2021-01-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-80759-3
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Article ; Online: Ambient Cumulative PM2.5 Exposure and the Risk of Lung Cancer Incidence and Mortality: A Retrospective Cohort Study.

Huang, Hung-Ling / Chuang, Yung-Hsin / Lin, Tzu-Hsuan / Lin, Changqing / Chen, Yen-Hsu / Hung, Jen-Yu / Chan, Ta-Chien

International journal of environmental research and public health

2021 Volume 18, Issue 23

Abstract: Smoking, sex, air pollution, lifestyle, and diet may act independently or in concert with each other to contribute to the different outcomes of lung cancer (LC). This study aims to explore their associations with the carcinogenesis of LC, which will be ... ...

Abstract	Smoking, sex, air pollution, lifestyle, and diet may act independently or in concert with each other to contribute to the different outcomes of lung cancer (LC). This study aims to explore their associations with the carcinogenesis of LC, which will be useful for formulating further preventive strategies. This retrospective, longitudinal follow-up cohort study was carried out by connecting to the MJ Health Database, Taiwan Cancer Registry database, and Taiwan cause of death database from 2000 to 2015. The studied subjects were persons attending the health check-ups, distributed throughout the main island of Taiwan. Cox proportional hazards regression models were used to investigate the risk factors associated with LC development and mortality after stratifying by smoking status, with a special emphasis on ambient two-year average PM
MeSH term(s)	Air Pollutants/adverse effects ; Air Pollutants/analysis ; Air Pollution/adverse effects ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Follow-Up Studies ; Humans ; Incidence ; Lung Neoplasms/etiology ; Lung Neoplasms/mortality ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Retrospective Studies ; Risk Factors
Chemical Substances	Air Pollutants ; Particulate Matter
Language	English
Publishing date	2021-11-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph182312400
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Article: Ubiquitin Conjugating Enzyme E2 H (UBE2H) Is Linked to Poor Outcomes and Metastasis in Lung Adenocarcinoma.

Yen, Meng-Chi / Wu, Kuan-Li / Liu, Yu-Wei / Chang, Yung-Yun / Chang, Chao-Yuan / Hung, Jen-Yu / Tsai, Ying-Ming / Hsu, Ya-Ling

Biology

2021 Volume 10, Issue 5

Abstract: The prognosis of patients with metastatic lung adenocarcinoma (LUAD) is poor. Although novel lung cancer treatments have been developed for metastatic LUAD, not all patients are fit to receive these treatments. The present study aimed to identify the ... ...

Abstract	The prognosis of patients with metastatic lung adenocarcinoma (LUAD) is poor. Although novel lung cancer treatments have been developed for metastatic LUAD, not all patients are fit to receive these treatments. The present study aimed to identify the novel regulatory genes in metastatic LUAD. Because the pleural cavity is a frequent metastasis site of LUAD, the adjacent non-tumor tissue, primary tumor tissue, and metastatic lung tumor tissue in the pleura of a single patient with LUAD were collected. The gene expression profiles of the collected samples were further analyzed via RNA sequencing and bioinformatic analysis. A high expression level of ubiquitin conjugating enzyme E2 H (UBE2H), a hypoxia-mediated gene, was identified in the metastatic malignant pleural tumor. After accessing the survival data in patients with lung adenocarcinoma through online databases, a high UBE2H expression was associated with poor survival for LUAD. UBE2H knockdown in two lung adenocarcinoma cell lines suppressed the cell migration capacity and reversed the epithelial-mesenchymal transition (EMT) signaling pathway. A high expression of UBE2H-targeting microRNAs, including miR-101, miR-30a, miR-30b, miR-328, and miR-497, were associated with a favorable prognosis. Moreover, the UBE2H expression revealed a significant correlation with the copy number variation. Taken together, the presence of UBE2H regulated the EMT program and metastasis in LUAD.
Language	English
Publishing date	2021-04-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology10050378
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Article ; Online: Risk of pneumothorax in pneumoconiosis patients in Taiwan: a retrospective cohort study.

Pan, Jo-Hui / Cheng, Chih-Hung / Wang, Chao-Ling / Dai, Chia-Yen / Sheu, Chau-Chyun / Tsai, Ming-Ju / Hung, Jen-Yu / Chong, Inn-Wen

BMJ open

2021 Volume 11, Issue 10, Page(s) e054098

Abstract: Objectives: This study was conducted to explore the association between pneumoconiosis and pneumothorax.: Design: Retrospective cohort study.: Setting: Nationwide population-based study using the Taiwan National Health Insurance Database.: ... ...

Abstract	Objectives: This study was conducted to explore the association between pneumoconiosis and pneumothorax. Design: Retrospective cohort study. Setting: Nationwide population-based study using the Taiwan National Health Insurance Database. Participants: A total of 2333 pneumoconiosis patients were identified (1935 patients for propensity score (PS)-matched cohort) and matched to 23 330 control subjects by age and sex (7740 subjects for PS-matched cohort). Primary and secondary outcome measures: The incidence and the cumulative incidence of pneumothorax. Results: Both incidence and the cumulative incidence of pneumothorax were significantly higher in the pneumoconiosis patients as compared with the control subjects (p<0.0001). For multivariable Cox regression analysis adjusted for age, sex, residency, income level and other comorbidities, patients with pneumoconiosis exhibited a significantly higher risk of pneumothorax than those without pneumoconiosis (HR 3.05, 95% CI 2.18 to 4.28, p<0.0001). The male sex, heart disease, peripheral vascular disease, chronic pulmonary disease and connective tissue disease were risk factors for developing pneumothorax in pneumoconiosis patients. Conclusions: Our study revealed a higher risk of pneumothorax in pneumoconiosis patients and suggested potential risk factors in these patients. Clinicians should be aware about the risk of pneumothorax in pneumoconiosis patients.
MeSH term(s)	Cohort Studies ; Comorbidity ; Humans ; Incidence ; Male ; Pneumoconiosis/complications ; Pneumoconiosis/epidemiology ; Pneumothorax/epidemiology ; Pneumothorax/etiology ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; Taiwan/epidemiology
Language	English
Publishing date	2021-10-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-054098
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