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Article ; Online: Invasive Exercise Hemodynamics in Patients With Dynamic Secondary Mitral Regurgitation Before Transcatheter Edge-to-Edge Repair.

El-Sabawi, Bassim / Zalawadiya, Sandip K / Barker, Colin M / Hung, Rebecca R / Lindman, Brian R / Lindenfeld, JoAnn / Goel, Kashish

The Canadian journal of cardiology

2023 Volume 40, Issue 5, Page(s) 938–940

MeSH term(s)	Humans ; Mitral Valve Insufficiency/surgery ; Mitral Valve Insufficiency/physiopathology ; Mitral Valve Insufficiency/diagnosis ; Hemodynamics/physiology ; Cardiac Catheterization/methods ; Male ; Female ; Aged ; Exercise Test/methods ; Mitral Valve/surgery ; Mitral Valve/diagnostic imaging ; Mitral Valve/physiopathology ; Heart Valve Prosthesis Implantation/methods
Language	English
Publishing date	2023-12-15
Publishing country	England
Document type	Letter
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2023.12.011
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Article: Chest Pain in a Psychiatric Patient Due to Clozapine-Induced Myopericarditis.

Laws, James L / Kim, Esther / Hung, Rebecca / Lindenfeld, JoAnn / Gupta, Richa

Case reports in cardiology

2021 Volume 2021, Page(s) 6067652

Abstract: Drug-induced myocarditis is a rare, but underrecognized complication of clozapine therapy for schizophrenia. We present a case of clozapine-induced myocarditis with recovery of cardiac function after drug cessation and summarize the literature to ... ...

Abstract	Drug-induced myocarditis is a rare, but underrecognized complication of clozapine therapy for schizophrenia. We present a case of clozapine-induced myocarditis with recovery of cardiac function after drug cessation and summarize the literature to highlight the variable presentation of this condition.
Language	English
Publishing date	2021-12-24
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627627-6
ISSN	2090-6412 ; 2090-6404
ISSN (online)	2090-6412
ISSN	2090-6404
DOI	10.1155/2021/6067652
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Article ; Online: The experience of hospital staff in applying the Gentle Persuasive Approaches to dementia care.

Hung, Lillian / Son, Cathy / Hung, Rebecca

Journal of psychiatric and mental health nursing

2018 Volume 26, Issue 1-2, Page(s) 19–28

Abstract: WHAT IS KNOWN ON THE SUBJECT?: Although the seminal work of McCormack et al. (International Practice Development Journal, 2015, 5, 1) and Nolan, Davies, Brown, Keady, and Nolan () provides useful conceptual frameworks in person-centred care, research is ... ...

Abstract	WHAT IS KNOWN ON THE SUBJECT?: Although the seminal work of McCormack et al. (International Practice Development Journal, 2015, 5, 1) and Nolan, Davies, Brown, Keady, and Nolan () provides useful conceptual frameworks in person-centred care, research is needed to understand how theoretical concepts can be applied into practice to support dementia care. Also, evidence is needed to demonstrate the impacts of implementing person-centred care and staff experiences. WHAT DOES THIS PAPER ADD TO EXISTING KNOWLEDGE?: This paper adds to the emerging work that is providing a greater understanding of how team education in practice can make a difference in building capacity to improve dementia care. We offer timely evidence and useful insights into how an education programme, Gentle Persuasive Approaches (GPA), was implemented ("what worked" and "how") in a large Canadian hospital to improve knowledge and skills among staff in dementia care. The GPA education helped hospital staff enact person-centred care by cultivating shared values and a learning environment to change attitudes, practices and conditions for continuous practice development. WHAT ARE THE IMPLICATIONS FOR PRACTICE?: Mental health nurses in advance practice are well positioned to lead dementia education and advocate for person-centred care in hospitals. Hospital leaders are responsible for providing resources to cultivate a supportive environment for continuous learning to ensure the workforce gains the capacity to meet the changing demands and needs of the ageing population. System support is essential for creating conditions to enable person-centred care. ABSTRACT: Introduction Hospital staff lacks knowledge and skills in dementia care. There is a need to understand how person-centred care theory can be operationalized in staff's practices to improve dementia care. Aims To describe the staff's experiences of learning and applying the Gentle Persuasive Approaches (GPA) to enact person-centred care in a hospital. Methods Mixed methods, including posteducation survey and focus groups, were used. Thematic analysis was conducted to identify themes that describe participants' experiences. Results Three hundred and ten staff and leaders in a hospital participated in the GPA education and completed a posteducation survey (n = 297). After 1 year, two follow-up focus groups were conducted with interdisciplinary staff (n = 24) across medicine and mental health programmes. Our analysis identified three themes to enable person-centred care: (a) changing attitudes, (b) changing practices and (c) changing conditions. Discussion This study contributes to the literature by providing evidence of how an education programme was implemented in a large Canadian hospital to build capacity for dementia care. Joint education for interprofessional staff offers value in enabling person-centred care. Implication Mental health nurses are in position to lead dementia education and advocate for person-centred care in hospitals. Staff need structural support to engage in team learning for practice improvement.
MeSH term(s)	Attitude of Health Personnel ; Canada ; Dementia/therapy ; Health Knowledge, Attitudes, Practice ; Hospitals, Urban ; Humans ; Patient-Centered Care/standards ; Personnel, Hospital/standards ; Professional-Patient Relations
Language	English
Publishing date	2018-12-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1328479-4
ISSN	1365-2850 ; 1351-0126
ISSN (online)	1365-2850
ISSN	1351-0126
DOI	10.1111/jpm.12504
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Article ; Online: Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure: The 3T Trial.

Cox, Zachary L / Hung, Rebecca / Lenihan, Daniel J / Testani, Jeffrey M

JACC. Heart failure

2019 Volume 8, Issue 3, Page(s) 157–168

Abstract: Objectives: This study compared combination diuretic strategies in acute heart failure (AHF) complicated by diuretic resistance (DR).: Background: Combination diuretic regimens to overcome loop DR are commonly used but with limited evidence.: ... ...

Abstract	Objectives: This study compared combination diuretic strategies in acute heart failure (AHF) complicated by diuretic resistance (DR). Background: Combination diuretic regimens to overcome loop DR are commonly used but with limited evidence. Methods: This study was a randomized, double-blinded trial in 60 patients hospitalized with AHF and intravenous (IV) loop DR. Patients were randomized to oral metolazone, IV chlorothiazide, or tolvaptan therapy. All patients received concomitant high-dose IV infusions of furosemide. The primary outcome was 48-h weight loss. Results: The cohort exhibited DR prior to enrollment, producing 1,188 ± 476 ml of urine in 12 h during high-dose loop diuretic therapy (IV furosemide: 612 ± 439 mg/day). All 3 interventions significantly improved diuretic efficacy (p < 0.001). Compared to metolazone (4.6 ± 2.7 kg), neither IV chlorothiazide (5.8 ± 2.7 kg; 1.2 kg [95% confidence interval (CI)]: -2.9 to 0.6; p = 0.292) nor tolvaptan (4.1 ± 3.3 kg; 0.5 kg [95% CI: -1.5 to 2.4; p = 0.456) resulted in more weight loss at 48 h. Median (interquartile range [IQR]) cumulative urine output increased significantly and did not differ among those receiving metolazone (7.78 [IQR: 6.59 to 10.10] l) and chlorothiazide (8.77 [IQR: 7.37 to 10.86] l; p = 0.245) or tolvaptan (9.70 [IQR: 6.36 to 13.81] l; p = 0.160). Serum sodium decreased less with tolvaptan than with metolazone (+4 ± 5 vs. -1 ± 3 mEq/l; p = 0.001), but 48-h spot urine sodium was lower with tolvaptan (58 ± 25 mmol/l) than with metolazone (104 ± 16 mmol/l; p = 0.002) and with chlorothiazide (117 ± 14 mmol/l; p < 0.001). Conclusions: In this moderately sized DR trial, weight loss was excellent with the addition of metolazone, IV chlorothiazide, or tolvaptan to loop diuretics, without a detectable between-group difference. (Comparison of Oral or Intravenous Thiazides vs. tolvaptan in Diuretic Resistant Decompensated Heart Failure [3T]; NCT02606253).
MeSH term(s)	Administration, Oral ; Aged ; Chlorothiazide/administration & dosage ; Diuretics/administration & dosage ; Dose-Response Relationship, Drug ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Furosemide/administration & dosage ; Heart Failure/drug therapy ; Humans ; Infusions, Intravenous ; Male ; Metolazone/administration & dosage ; Middle Aged ; Prospective Studies ; Retrospective Studies ; Tolvaptan/administration & dosage ; Treatment Outcome
Chemical Substances	Diuretics ; Tolvaptan (21G72T1950) ; Chlorothiazide (77W477J15H) ; Furosemide (7LXU5N7ZO5) ; Metolazone (TZ7V40X7VX)
Language	English
Publishing date	2019-12-11
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	2705621-1
ISSN	2213-1787 ; 2213-1779
ISSN (online)	2213-1787
ISSN	2213-1779
DOI	10.1016/j.jchf.2019.09.012
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Article: Impacts of Participation in Community-Based Physical Activity Programs on Cognitive Functions of Children and Youth with Neurodevelopmental Disabilities: A Scoping Review.

Gitimoghaddam, Mojgan / Vanderloo, Leigh M / Hung, Rebecca / Ryce, Andrea / McKellin, William / Miller, Anton / Collet, Jean-Paul

Brain sciences

2021 Volume 11, Issue 2

Abstract: This review paper aimed to undertake an extensive exploration of the extent, range, and nature of research activities regarding the effect and emerging evidence in the field of physical activity interventions on cognitive development among children and ... ...

Abstract	This review paper aimed to undertake an extensive exploration of the extent, range, and nature of research activities regarding the effect and emerging evidence in the field of physical activity interventions on cognitive development among children and youth (0-17.99 years) with neurodevelopmental disorders (NDD), and to help identify key gaps in research and determine precise research questions for future investigations. To carry out this scoping review, five electronic databases were searched. A total of 12,097 articles were retrieved via search efforts with an additional 93 articles identified from the identified review papers. Sixty articles were eligible for inclusion. The results of this scoping review revealed many positive key cognitive outcomes related to physical activity including, but not limited to: focus, attention, self-control, cognitive process, and alertness. No studies reported a negative association between physical activity and cognitive outcomes. Based on the findings from this scoping review, physical activity appears to have a favorable impact on the cognitive outcomes of children and youth with NDD.
Language	English
Publishing date	2021-02-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci11020195
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Article ; Online: Arrhythmias as Presentation of Genetic Cardiomyopathy.

Lukas Laws, J / Lancaster, Megan C / Ben Shoemaker, M / Stevenson, William G / Hung, Rebecca R / Wells, Quinn / Marshall Brinkley, D / Hughes, Sean / Anderson, Katherine / Roden, Dan / Stevenson, Lynne W

Circulation research

2022 Volume 130, Issue 11, Page(s) 1698–1722

Abstract: There is increasing evidence regarding the prevalence of genetic cardiomyopathies, for which arrhythmias may be the first presentation. Ventricular and atrial arrhythmias presenting in the absence of known myocardial disease are often labelled as ... ...

Abstract	There is increasing evidence regarding the prevalence of genetic cardiomyopathies, for which arrhythmias may be the first presentation. Ventricular and atrial arrhythmias presenting in the absence of known myocardial disease are often labelled as idiopathic, or lone. While ventricular arrhythmias are well-recognized as presentation for arrhythmogenic cardiomyopathy in the right ventricle, the scope of arrhythmogenic cardiomyopathy has broadened to include those with dominant left ventricular involvement, usually with a phenotype of dilated cardiomyopathy. In addition, careful evaluation for genetic cardiomyopathy is also warranted for patients presenting with frequent premature ventricular contractions, conduction system disease, and early onset atrial fibrillation, in which most detected genes are in the cardiomyopathy panels. Sudden death can occur early in the course of these genetic cardiomyopathies, for which risk is not adequately tracked by left ventricular ejection fraction. Only a few of the cardiomyopathy genotypes implicated in early sudden death are recognized in current indications for implantable cardioverter defibrillators which otherwise rely upon a left ventricular ejection fraction ≤0.35 in dilated cardiomyopathy. The genetic diagnoses impact other aspects of clinical management such as exercise prescription and pharmacological therapy of arrhythmias, and new therapies are coming into clinical investigation for specific genetic cardiomyopathies. The expansion of available genetic information and implications raises new challenges for genetic counseling, particularly with the family member who has no evidence of a cardiomyopathy phenotype and may face a potentially negative impact of a genetic diagnosis. Discussions of risk for both probands and relatives need to be tailored to their numeric literacy during shared decision-making. For patients presenting with arrhythmias or cardiomyopathy, extension of genetic testing and its implications will enable cascade screening, intervention to change the trajectory for specific genotype-phenotype profiles, and enable further development and evaluation of emerging targeted therapies.
MeSH term(s)	Atrial Fibrillation ; Cardiomyopathies/diagnosis ; Cardiomyopathies/genetics ; Cardiomyopathies/therapy ; Cardiomyopathy, Dilated/diagnosis ; Cardiomyopathy, Dilated/genetics ; Cardiomyopathy, Dilated/therapy ; Death, Sudden ; Death, Sudden, Cardiac/prevention & control ; Humans ; Stroke Volume ; Ventricular Function, Left
Language	English
Publishing date	2022-05-26
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80100-8
ISSN	1524-4571 ; 0009-7330 ; 0931-6876
ISSN (online)	1524-4571
ISSN	0009-7330 ; 0931-6876
DOI	10.1161/CIRCRESAHA.122.319835
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Ui IV Zs.70: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Ui IV Zs.60: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Outcomes in patients with cardiac amyloidosis and implantable cardioverter-defibrillator.

Kim, Eun-Jeong / Holmes, Benjamin B / Huang, Shi / Lugo, Ricardo / Al Aboud, Asad / Goodman, Stacey / Hung, Rebecca R / Slosky, David / Stevenson, William G / Michaud, Gregory F / John, Roy M

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

2020 Volume 22, Issue 8, Page(s) 1216–1223

Abstract: Aims: Cardiac amyloidosis (CA) is associated with increased mortality due to arrhythmias, heart failure, and electromechanical dissociation. However, the role of an implantable cardioverter-defibrillator (ICD) remains unclear. We conducted case-control ... ...

Abstract	Aims: Cardiac amyloidosis (CA) is associated with increased mortality due to arrhythmias, heart failure, and electromechanical dissociation. However, the role of an implantable cardioverter-defibrillator (ICD) remains unclear. We conducted case-control study to assess survival in CA patients with and without a primary prevention ICD and compared outcomes to an age, sex, and device implant year-matched non-CA group with primary prevention ICD. Methods and results: There were 91 subjects with CA [mean age= 71.2 ± 10.2, female 22.0%, 49 AL with Mayo Stage 2.9 ± 1.0, 41 transthyretin amyloidosis (ATTR), 1 other] followed by Vanderbilt Amyloidosis centre. Patients with ICD (n = 23) were compared with those without (n = 68) and a non-amyloid group with ICD (n = 46). All subjects with ICD had implantation for primary prevention. Mean left ventricular ejection fraction was 36.2% ± 14.4% in CA with ICD, 41.0% ± 10.6% in CA without ICD, and 33.5% ± 14.4% in non-CA patients. Over 3.5 ± 3.1 years, 6 (26.1%) CA, and 12 (26.1%) non-CA subjects received ICD therapies (P = 0.71). Patients with CA had a significantly higher mortality (43.9% vs. 17.4%, P = 0.002) compared with the non-CA group. Mean time from device implantation to death was 21.8 months in AL and 22.8 months in ATTR patients. There was no significant difference in mortality between CA patients who did and did not receive an ICD (39.0% vs. 46.0%, P = 0.59). Conclusions: Despite comparable event rates patients with CA had a significantly higher mortality and ICDs were not associated with longer survival. With the emergence of effective therapy for AL amyloidosis, further study of ICD is needed in this group.
MeSH term(s)	Aged ; Aged, 80 and over ; Amyloidosis/diagnosis ; Amyloidosis/therapy ; Case-Control Studies ; Death, Sudden, Cardiac ; Defibrillators, Implantable ; Female ; Humans ; Middle Aged ; Risk Factors ; Stroke Volume ; Treatment Outcome ; Ventricular Function, Left
Language	English
Publishing date	2020-06-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1449879-0
ISSN	1532-2092 ; 1099-5129
ISSN (online)	1532-2092
ISSN	1099-5129
DOI	10.1093/europace/euaa094
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Article ; Online: Patisiran Treatment in Patients with Transthyretin Cardiac Amyloidosis.

Maurer, Mathew S / Kale, Parag / Fontana, Marianna / Berk, John L / Grogan, Martha / Gustafsson, Finn / Hung, Rebecca R / Gottlieb, Robert L / Damy, Thibaud / González-Duarte, Alejandra / Sarswat, Nitasha / Sekijima, Yoshiki / Tahara, Nobuhiro / Taylor, Mark S / Kubanek, Milos / Donal, Erwan / Palecek, Tomas / Tsujita, Kenichi / Tang, W H Wilson /

Yu, Wen-Chung / Obici, Laura / Simões, Marcus / Fernandes, Fábio / Poulsen, Steen Hvitfeldt / Diemberger, Igor / Perfetto, Federico / Solomon, Scott D / Di Carli, Marcelo / Badri, Prajakta / White, Matthew T / Chen, Jihong / Yureneva, Elena / Sweetser, Marianne T / Jay, Patrick Y / Garg, Pushkal P / Vest, John / Gillmore, Julian D

The New England journal of medicine

2023 Volume 389, Issue 17, Page(s) 1553–1565

Abstract: Background: Transthyretin amyloidosis, also called ATTR amyloidosis, is associated with accumulation of ATTR amyloid deposits in the heart and commonly manifests as progressive cardiomyopathy. Patisiran, an RNA interference therapeutic agent, inhibits ... ...

Abstract	Background: Transthyretin amyloidosis, also called ATTR amyloidosis, is associated with accumulation of ATTR amyloid deposits in the heart and commonly manifests as progressive cardiomyopathy. Patisiran, an RNA interference therapeutic agent, inhibits the production of hepatic transthyretin. Methods: In this phase 3, double-blind, randomized trial, we assigned patients with hereditary, also known as variant, or wild-type ATTR cardiac amyloidosis, in a 1:1 ratio, to receive patisiran (0.3 mg per kilogram of body weight) or placebo once every 3 weeks for 12 months. A hierarchical procedure was used to test the primary and three secondary end points. The primary end point was the change from baseline in the distance covered on the 6-minute walk test at 12 months. The first secondary end point was the change from baseline to month 12 in the Kansas City Cardiomyopathy Questionnaire-Overall Summary (KCCQ-OS) score (with higher scores indicating better health status). The second secondary end point was a composite of death from any cause, cardiovascular events, and change from baseline in the 6-minute walk test distance over 12 months. The third secondary end point was a composite of death from any cause, hospitalizations for any cause, and urgent heart failure visits over 12 months. Results: A total of 360 patients were randomly assigned to receive patisiran (181 patients) or placebo (179 patients). At month 12, the decline in the 6-minute walk distance was lower in the patisiran group than in the placebo group (Hodges-Lehmann estimate of median difference, 14.69 m; 95% confidence interval [CI], 0.69 to 28.69; P = 0.02); the KCCQ-OS score increased in the patisiran group and declined in the placebo group (least-squares mean difference, 3.7 points; 95% CI, 0.2 to 7.2; P = 0.04). Significant benefits were not observed for the second secondary end point. Infusion-related reactions, arthralgia, and muscle spasms occurred more often among patients in the patisiran group than among those in the placebo group. Conclusions: In this trial, administration of patisiran over a period of 12 months resulted in preserved functional capacity in patients with ATTR cardiac amyloidosis. (Funded by Alnylam Pharmaceuticals; APOLLO-B ClinicalTrials.gov number, NCT03997383.).
MeSH term(s)	Humans ; Cardiomyopathies/drug therapy ; Cardiomyopathies/etiology ; Cardiomyopathies/genetics ; Cardiomyopathies/metabolism ; Prealbumin/genetics ; Prealbumin/metabolism ; RNA, Small Interfering/therapeutic use ; Amyloidosis, Familial/complications ; Amyloidosis, Familial/drug therapy ; Amyloidosis, Familial/genetics ; Liver/metabolism ; Double-Blind Method ; Amyloidosis/complications ; Amyloidosis/drug therapy ; Amyloidosis/genetics
Chemical Substances	patisiran (50FKX8CB2Y) ; Prealbumin ; RNA, Small Interfering
Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Randomized Controlled Trial ; Clinical Trial, Phase III ; Journal Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMoa2300757
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Article: Endothelial IKK beta signaling is required for monocyte adhesion under laminar flow conditions.

Meiler, Steffen E / Hung, Rebecca R / Gerszten, Robert E / Gianetti, Jacopo / Li, Ling / Matsui, Takashi / Gimbrone, Michael A / Rosenzweig, Anthony

Journal of molecular and cellular cardiology

2002 Volume 34, Issue 3, Page(s) 349–359

Abstract: Endothelial activation induces expression of pro-inflammatory molecules that are thought to play an important role in atherogenesis through enhanced vascular monocyte recruitment. Many pro-inflammatory endothelial signals are transcriptionally regulated ... ...

Abstract	Endothelial activation induces expression of pro-inflammatory molecules that are thought to play an important role in atherogenesis through enhanced vascular monocyte recruitment. Many pro-inflammatory endothelial signals are transcriptionally regulated by members of the NF- kappa B family. The serine-threonine kinase, IKK beta, can mediate NF- kappa B activation although several alternative pathways exist. To test whether IKK beta is necessary for cytokine activation of human vascular endothelium and endothelial recruitment of human monocytes under laminar flow, we constructed a recombinant adenoviral vector carrying a dominant negative mutant of IKK beta (Ad.dnIKK beta) to transduce human umbilical vein endothelial cells (HUVEC) in vitro. We found that dnIKK beta expression effectively blocked NF-kappa B activation as assessed by nuclear translocation of NF-kappa B, I kappa B degradation, and NF-kappa B dependent reporter expression, without affecting activation of the other relevant signaling pathways, SAPK/JNK and p38. Furthermore, overexpression of dnIKK beta in TNF-alpha-stimulated HUVEC blocked induction of the surface adhesion molecules E-selectin, ICAM-1, and VCAM-1. Under simulated physiologic flow conditions, both firm adhesion and rolling of human peripheral monocytes on dnIKK beta-transduced endothelial monolayers were markedly inhibited. We conclude that IKK beta is necessary for the cytokine-induced inflammatory phenotype of human endothelium and endothelial recruitment of human monocytes under flow.
MeSH term(s)	Adenoviridae ; Cell Adhesion ; Cells, Cultured ; E-Selectin/metabolism ; Endothelium, Vascular/cytology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/enzymology ; Endothelium, Vascular/metabolism ; Genetic Vectors ; Humans ; I-kappa B Kinase ; Intercellular Adhesion Molecule-1/metabolism ; Monocytes/cytology ; Mutation ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/metabolism ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Regional Blood Flow/physiology ; Signal Transduction ; Tumor Necrosis Factor-alpha/pharmacology ; Vascular Cell Adhesion Molecule-1/metabolism
Chemical Substances	E-Selectin ; NF-kappa B ; Tumor Necrosis Factor-alpha ; Vascular Cell Adhesion Molecule-1 ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; CHUK protein, human (EC 2.7.11.10) ; I-kappa B Kinase (EC 2.7.11.10) ; IKBKB protein, human (EC 2.7.11.10) ; IKBKE protein, human (EC 2.7.11.10)
Language	English
Publishing date	2002-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	80157-4
ISSN	1095-8584 ; 0022-2828
ISSN (online)	1095-8584
ISSN	0022-2828
DOI	10.1006/jmcc.2001.1519
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