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  1. Book ; Online: Density functions for QuickQuant and QuickVal

    Fill, James Allen / Hung, Wei-Chun

    2021  

    Abstract: We prove that, for every $0 \leq t \leq 1$, the limiting distribution of the scale-normalized number of key comparisons used by the celebrated algorithm QuickQuant to find the $t$th quantile in a randomly ordered list has a Lipschitz continuous density ... ...

    Abstract We prove that, for every $0 \leq t \leq 1$, the limiting distribution of the scale-normalized number of key comparisons used by the celebrated algorithm QuickQuant to find the $t$th quantile in a randomly ordered list has a Lipschitz continuous density function $f_t$ that is bounded above by $10$. Furthermore, this density $f_t(x)$ is positive for every $x > \min\{t, 1 - t\}$ and, uniformly in $t$, enjoys superexponential decay in the right tail. We also prove that the survival function $1 - F_t(x) = \int_x^{\infty}\!f_t(y)\,\mathrm{d}y$ and the density function $f_t(x)$ both have the right tail asymptotics $\exp [-x \ln x - x \ln \ln x + O(x)]$. We use the right-tail asymptotics to bound large deviations for the scale-normalized number of key comparisons used by QuickQuant.

    Comment: 72 pages; submitted for publication in September, 2021
    Keywords Mathematics - Probability ; Computer Science - Data Structures and Algorithms ; 68P10 (Primary) 60E05 ; 60C05 (Secondary)
    Subject code 519
    Publishing date 2021-09-29
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The phenomenon of staphylococcal interbacterial aggregate and net structures (SIAN) in community-associated methicillin-resistant Staphylococcus aureus CA-MRSA/J.

    Wan, Tsai-Wen / Mori, Hiromitsu / Hung, Wei-Chun / Teng, Lee-Jene / Yamamoto, Tatsuo

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2022  Volume 28, Issue 11, Page(s) 1584–1589

    Abstract: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) usually causes skin and soft tissue infections (SSTIs), but occasionally causes invasive infections with a broad range of manifestations. Virulence factors and pathogenesis of CA- ... ...

    Abstract Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) usually causes skin and soft tissue infections (SSTIs), but occasionally causes invasive infections with a broad range of manifestations. Virulence factors and pathogenesis of CA-MRSA have been investigated in details with genotype ST8/SCCmecIVa (USA300), which first emerged in the United States. However, CA-MRSA evolves rapidly, with different clones dominating in different world regions; their pathogenesis remains unclear. CA-MRSA with genotype ST8/SCCmecIVl (CA-MRSA/J) emerged in 2003 in Japan, spreading widely with a fatal case. We have studied the genetic characteristics of CA-MRSA/J, and during the course of this study, we found that CA-MRSA/J has bacteriophage-like spikes with or without a hexagonal cap (spikes X and Xc). Here, we report that CA-MRSA/J strain NN55 has non-phage-like, one-μm-long/jerky spikes with or without a hexagonal cap (LSX/LSXc), and also that LSX/LSXc forms (staphylococcal) interbacterial aggregate/net structures (SIAN). Regarding the phenomenon of SIAN, NN55 first formed single short spike X, followed by multiple molecules of long and jerky LSX/LSXc, leading to the interbacterial construction of SIAN, in colonies with high cell densities. The LSX/LSXc and SIAN structures have not been reported in S. aureus. NN55 was invasive in a HEp-2 cell assay, exhibiting SIAN. The novel SIAN structures may be foci-skeletons or toxic aggregates in NN55's invasive infections. The phenomenon of SIAN suggests novel staphylococcal cell-surface dynamism, providing a new structure-and-function relationship model and advancing the understanding of CA-MRSA pathogenesis.
    MeSH term(s) Community-Acquired Infections/microbiology ; Humans ; Methicillin-Resistant Staphylococcus aureus/genetics ; Soft Tissue Infections/microbiology ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/genetics ; United States
    Language English
    Publishing date 2022-08-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2022.07.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Circulating Short-Chain Fatty Acids and Non-Alcoholic Fatty Liver Disease Severity in Patients with Type 2 Diabetes Mellitus.

    Tsai, Hui-Ju / Hung, Wei-Chun / Hung, Wei-Wen / Lee, Yen-Jung / Chen, Yo-Chia / Lee, Chun-Ying / Tsai, Yi-Chun / Dai, Chia-Yen

    Nutrients

    2023  Volume 15, Issue 7

    Abstract: 1) Background: Non-alcoholic fatty liver disease (NAFLD) is a major global health concern. The increasing prevalence of NAFLD has been related to type 2 diabetes mellitus (T2D). However, the relationship between short-chain fatty acids (SCFAs) and NAFLD ...

    Abstract (1) Background: Non-alcoholic fatty liver disease (NAFLD) is a major global health concern. The increasing prevalence of NAFLD has been related to type 2 diabetes mellitus (T2D). However, the relationship between short-chain fatty acids (SCFAs) and NAFLD severity is ambiguous in T2D subjects. This study aimed to explore the association of SCFAs with the severity of NAFLD in T2D patients. (2) Methods: We employed echography to examine the severity of hepatic steatosis. The serum levels of nine SCFAs, namely, formate, acetate, propionate, butyrate, isobutyrate, methylbutyrate, valerate, isovalerate, and methylvalerate, were measured using gas chromatography mass spectrometry. (3) Results: A total of 259 T2D patients was enrolled in this cross-sectional study. Of these participants, 117 with moderate to severe NAFLD had lower levels of formate, isobutyrate, and methylbutyrate than the 142 without NAFLD or with mild NAFLD. Lower circulating levels of isobutyrate and methylbutyrate were associated with an increased severity of NAFLD. A relationship between NAFLD severity and circulating isobutyrate and methylbutyrate levels was found independently of a glycated hemoglobin (HbA1C) level of 7.0%. (4) Conclusion: Circulating levels of isobutyrate and methylbutyrate were significantly and negatively correlated with NAFLD severity in the enrolled T2D patients. SCFAs may be related to NAFLD severity in T2D patients.
    MeSH term(s) Humans ; Fatty Acids, Volatile/blood ; Non-alcoholic Fatty Liver Disease/blood ; Diabetes Mellitus, Type 2/blood ; Ultrasonography ; Fatty Liver/diagnostic imaging ; Isobutyrates/blood ; Cross-Sectional Studies ; Male ; Female ; Adult ; Middle Aged ; Aged ; Aged, 80 and over
    Chemical Substances Fatty Acids, Volatile ; Isobutyrates
    Language English
    Publishing date 2023-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15071712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of Different LED Light Spectra on Growth and Immunity of the Japanese Eel (

    Lin, Yen-Ting / Hung, Wei-Chun / Yeh, Yin-Fu / Lu, Kuang-Mao / Cherng, Ding-Hwa / Han, Yu-San

    Zoological studies

    2023  Volume 62, Page(s) e28

    Abstract: Indoor recirculating aquaculture systems make light control possible and enable the usage of specific coloured lights to promote the growth and immunity of aquaculture species. Five different LED wavelengths (white light [460 nm], red light [622 nm], ... ...

    Abstract Indoor recirculating aquaculture systems make light control possible and enable the usage of specific coloured lights to promote the growth and immunity of aquaculture species. Five different LED wavelengths (white light [460 nm], red light [622 nm], green light [517 nm], blue light [467 nm], and the dark) were used in this study to evaluate growth and immunity in the glass eel stage of two high-valued anguillid species, Japanese eel (
    Language English
    Publishing date 2023-06-16
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 2105348-0
    ISSN 1810-522X ; 1810-522X
    ISSN (online) 1810-522X
    ISSN 1810-522X
    DOI 10.6620/ZS.2023.62-28
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Potentials of organic tellurium-containing compound AS101 to overcome carbapenemase-producing Escherichia coli.

    Yang, Tsung-Ying / Hung, Wei-Chun / Tsai, Tsung-Han / Lu, Po-Liang / Wang, Sheng-Fan / Wang, Liang-Chun / Lin, Yu-Tzu / Tseng, Sung-Pin

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

    2023  Volume 56, Issue 5, Page(s) 1016–1025

    Abstract: Background: The issue of carbapenem-resistant Escherichia coli was aggravated yearly. The previous studies reported the varied but critical epidemiology of carbapenem-resistant E. coli among which the carbapenemase-producing strains were regarded as one ...

    Abstract Background: The issue of carbapenem-resistant Escherichia coli was aggravated yearly. The previous studies reported the varied but critical epidemiology of carbapenem-resistant E. coli among which the carbapenemase-producing strains were regarded as one of the most notorious issues. AS101, an organic tellurium-containing compound undergoing clinical trials, was revealed with antibacterial activities. However, little is known about the antibacterial effect of AS101 against carbapenemase-producing E. coli (CPEC).
    Materials and methods: The minimum inhibitory concentration (MIC) of AS101 against the 15 isolates was examined using a broth microdilution method. The scanning electron microscopy, pharmaceutical manipulations, reactive oxygen species level, and DNA fragmentation assay were carried out to investigate the antibacterial mechanism. The sepsis mouse model was employed to assess the in vivo treatment effect.
    Results: The bla
    Conclusion: The in vitro activities, mechanisms, and in vivo study of AS101 against CPEC were unveiled. Our finding provided further evidence for the antibiotic development of AS101.
    Language English
    Publishing date 2023-07-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1497590-7
    ISSN 1995-9133 ; 1684-1182 ; 0253-2662
    ISSN (online) 1995-9133
    ISSN 1684-1182 ; 0253-2662
    DOI 10.1016/j.jmii.2023.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Exploring the Relationship between Gut Microbiome Composition and Blood Indole-3-acetic Acid in Hemodialysis Patients.

    Wu, Ping-Hsun / Tseng, Yu-Fang / Liu, Wangta / Chuang, Yun-Shiuan / Tai, Chi-Jung / Tung, Chun-Wei / Lai, Kean-Yee / Kuo, Mei-Chuan / Chiu, Yi-Wen / Hwang, Shang-Jyh / Hung, Wei-Chun / Lin, Yi-Ting

    Biomedicines

    2024  Volume 12, Issue 1

    Abstract: Indole-3-acetic acid (IAA), a protein-bound uremic toxin resulting from gut microbiota-driven tryptophan metabolism, increases in hemodialysis (HD) patients. IAA may induce endothelial dysfunction, inflammation, and oxidative stress, elevating ... ...

    Abstract Indole-3-acetic acid (IAA), a protein-bound uremic toxin resulting from gut microbiota-driven tryptophan metabolism, increases in hemodialysis (HD) patients. IAA may induce endothelial dysfunction, inflammation, and oxidative stress, elevating cardiovascular and cognitive risk in HD patients. However, research on the microbiome-IAA association is limited. This study aimed to explore the gut microbiome's relationship with plasma IAA levels in 72 chronic HD patients aged over 18 (August 2016-January 2017). IAA levels were measured using tandem mass spectrometry, and gut microbiome analysis utilized 16s rRNA next-generation sequencing. Linear discriminative analysis effect size and random forest analysis distinguished microbial species linked to IAA levels. Patients with higher IAA levels had reduced microbial diversity. Six microbial species significantly associated with IAA levels were identified;
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12010148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Association Between Trimethylamine N-oxide and Adverse Kidney Outcomes and Overall Mortality in Type 2 Diabetes Mellitus.

    Yu, Ping-Shaou / Wu, Ping-Hsun / Hung, Wei-Wen / Lin, Ming-Yen / Zhen, Yen-Yi / Hung, Wei-Chun / Chang, Jer-Ming / Tsai, Jong-Rung / Chiu, Yi-Wen / Hwang, Shang-Jyh / Tsai, Yi-Chun

    The Journal of clinical endocrinology and metabolism

    2024  

    Abstract: Context: Type 2 diabetes (T2D) is the major contributor to chronic kidney disease and end-stage kidney disease (ESKD). The influence of trimethylamine N-oxide (TMAO) on kidney outcomes in T2D remains unclear.: Objective: To examine the association ... ...

    Abstract Context: Type 2 diabetes (T2D) is the major contributor to chronic kidney disease and end-stage kidney disease (ESKD). The influence of trimethylamine N-oxide (TMAO) on kidney outcomes in T2D remains unclear.
    Objective: To examine the association between fasting serum TMAO levels and adverse kidney outcomes in patients with T2D.
    Methods: Between October 2016 and June 2020, patients with T2D were recruited and monitored every 3 months until December 2021. Serum TMAO levels were assessed using liquid chromatography-mass spectrometry. The primary kidney outcomes were doubling of serum creatinine levels or progression to ESKD necessitating dialysis; the secondary kidney outcome was a rapid 30% decline in estimated glomerular filtration rate within 2 years. All-cause mortality was also evaluated.
    Results: Among the 440 enrolled patients with T2D, those in the highest serum TMAO tertile (≥0.88 μM) were older, had a longer diabetes duration, elevated blood urea nitrogen, and lower estimated glomerular filtration rate. Over a median follow-up period of 4 years, 26 patients (5.9%) had a doubling of serum creatinine level or progression to ESKD. After propensity score weighting, the patients in the highest serum TMAO tertile had a 6.45-fold increase in the risk of doubling of serum creatinine levels or progression to ESKD and 5.86-fold elevated risk of rapid decline in kidney function compared with those in the lowest tertile. Additionally, the stepwise increase in serum TMAO was associated with all-cause mortality.
    Conclusion: Patients with T2D with elevated circulating TMAO levels are at higher risk of doubling serum creatinine, progressing to ESKD, and mortality. TMAO is a potential biomarker for kidney function progression and mortality in patients with T2D.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Successful treatment with daptomycin and ceftaroline of heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) endocarditis: a case report.

    Lin, Shang-Yi / Hung, Wei-Chun / Lo, Shih-Hao / Tseng, Yi-Ting / Lu, Po-Liang

    Journal of global antimicrobial resistance

    2021  Volume 27, Page(s) 335–336

    MeSH term(s) Cephalosporins ; Daptomycin/pharmacology ; Endocarditis/drug therapy ; Humans ; Staphylococcus aureus ; Vancomycin-Resistant Staphylococcus aureus ; Ceftaroline
    Chemical Substances Cephalosporins ; Daptomycin (NWQ5N31VKK)
    Language English
    Publishing date 2021-11-24
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2021.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The first invasive

    Tsai, Yu-Te / Lu, Po-Liang / Tang, Hung-Jen / Huang, Chung-Hao / Hung, Wei-Chun / Tseng, Yi-Ting / Lee, Kun-Mu / Lin, Shang-Yi

    Emerging microbes & infections

    2022  Volume 11, Issue 1, Page(s) 1867–1875

    Abstract: ... Candida ... ...

    Abstract Candida auris
    MeSH term(s) Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Candida/genetics ; Candida auris ; Candidiasis ; Candidiasis, Invasive/drug therapy ; Candidiasis, Invasive/epidemiology ; Humans ; Microbial Sensitivity Tests ; Taiwan/epidemiology
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2022.2100280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Staphylococcus taiwanensis

    Lin, Yu-Tzu / Hung, Wei-Chun / Wan, Tsai-Wen / Li, Hsin / Lee, Tai-Fen / Hsueh, Po-Ren / Teng, Lee-Jene

    International journal of systematic and evolutionary microbiology

    2022  Volume 72, Issue 2

    Abstract: A novel coagulase- ... ...

    Abstract A novel coagulase-negative
    MeSH term(s) Bacterial Typing Techniques ; Base Composition ; Blood/microbiology ; DNA, Bacterial/genetics ; Fatty Acids/chemistry ; Humans ; Nucleic Acid Hybridization ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Staphylococcus/classification ; Staphylococcus/isolation & purification ; Taiwan
    Chemical Substances DNA, Bacterial ; Fatty Acids ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2022-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2002336-4
    ISSN 1466-5034 ; 1466-5026
    ISSN (online) 1466-5034
    ISSN 1466-5026
    DOI 10.1099/ijsem.0.005262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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