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Article ; Online: Ying Yang Bao: Improving Complementary Feeding for Chinese Infants in Poor Regions.

Huo, Junsheng

Nestle Nutrition Institute workshop series

2017 Volume 87, Page(s) 131–138

Abstract: Ying Yang Bao (YYB), a complementary food supplement, has helped to rapidly improve the nutrition status of infants and young children in poor rural regions in China. The first YYB study was performed in 2001 by the International Life Sciences Institute, ...

Abstract	Ying Yang Bao (YYB), a complementary food supplement, has helped to rapidly improve the nutrition status of infants and young children in poor rural regions in China. The first YYB study was performed in 2001 by the International Life Sciences Institute, the Chinese Centers for Disease Control and Prevention, and Nestlé. In 2008, the establishment of national standards for complementary food supplements stimulated implementation of about 15 nutrition intervention projects in poor rural counties in which YYB was applied to infants and young children as home fortification for complementary feeding. Data were accumulated in different studies and showed that YYB enhanced the growth of infants with respect to both anthropometry and cognition, and decreased anemia prevalence significantly in infants aged 6-24 months. The Chinese government has launched a project named Improving Children's Nutrition in Poor Rural Regions in 2012. The project has covered more than 4 million infants aged 6-24 months in 341 counties in 21 provinces in western and middle regions by the end of 2015. This nutrition intervention in early life is rather an opportunity for a better later life. The YYB program in China might present an example for developing countries aiming to improve nutrition in early life.
Language	English
Publishing date	2017
Publishing country	Switzerland
Document type	Journal Article
ISSN	1664-2155
ISSN (online)	1664-2155
DOI	10.1159/000448962
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Effects of Ying Yang Bao on Nutritional Status of Children Aged 6-60 Months in Underdeveloped Rural Areas of China.

Feng, Jing / Wang, Yongjun / Liu, Tingting / Huo, Junsheng / Zhuo, Qin / Gong, Zhaolong

Nutrients

2024 Volume 16, Issue 2

Abstract: The Ying Yang Bao (YYB) intervention, a national policy in China, has been implemented for over two decades. Most previous studies have focused only on the short-term effects of YYB, while the long-term effects remain unexplored. This study was designed ... ...

Abstract	The Ying Yang Bao (YYB) intervention, a national policy in China, has been implemented for over two decades. Most previous studies have focused only on the short-term effects of YYB, while the long-term effects remain unexplored. This study was designed to evaluate the long-term effects of YYB in children aged 6-60 months. A sample of 4666 children was divided into intervention and control groups. Information on basic characteristics, physical examination, YYB consumption, etc., was obtained annually from 2018 to 2021. T-tests or chi-square tests were used to compare differences between the groups for continuous or categorical variables. Children in the intervention group showed greater incremental improvements in hemoglobin levels and physical development (
MeSH term(s)	Humans ; Anemia/epidemiology ; Cachexia ; China/epidemiology ; Growth Disorders ; Nutritional Status ; Infant ; Child, Preschool
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16020202
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Intervention Effect of a Soybean-Based Complementary Food Supplement on Anemic Infants in a Poor Rural Region in China: Evidence from Quasi-RCT.

Yin, Jiyong / Liu, Tingting / Sun, Jing / Huo, Junsheng / Huang, Jian

Children (Basel, Switzerland)

2023 Volume 11, Issue 1

Abstract: The soybean-based Yingyang Bao complementary food supplement represents a special nutritional improvement method for anemic infants in many intervention projects across China, while its benefits lack rigorous evidence. Using a quasi-randomized controlled ...

Abstract	The soybean-based Yingyang Bao complementary food supplement represents a special nutritional improvement method for anemic infants in many intervention projects across China, while its benefits lack rigorous evidence. Using a quasi-randomized controlled trial design, which adhered to randomization and control except for the blinding method, 248 anemic infants were divided randomly into an intervention group (128 cases received the Yingyang Bao intervention based on routine feeding) and a control group (120 cases only received routine feeding). Anthropometric indicators and 16 blood indicators were measured at baseline and 1 year after intervention. The levels of hemoglobin, 1,25-dihydroxy vitamin D, homocysteine, retinol, vitamin D
Language	English
Publishing date	2023-12-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children11010013
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Article ; Online: Prevalence of Malnutrition and Associated Factors of Stunting among 6-23-Month-Old Infants in Central Rural China in 2019.

Liu, Jing / Sun, Jing / Huang, Jian / Huo, Junsheng

International journal of environmental research and public health

2021 Volume 18, Issue 15

Abstract: This study aimed to evaluate the prevalence of malnutrition and to investigate the associated factors of stunting among 6-23-month-old infants in poor rural areas of central China. The China Nutrition Improvement Project on Children in Poor Areas was ... ...

Abstract	This study aimed to evaluate the prevalence of malnutrition and to investigate the associated factors of stunting among 6-23-month-old infants in poor rural areas of central China. The China Nutrition Improvement Project on Children in Poor Areas was conducted in 56 national-level poor counties of seven provinces in 2019. We performed a multivariate binary logistic regression analysis to determine the associated factors of stunting. This cross-sectional study included 17,193 infants. The overall prevalence of stunting was the highest (3.9%), followed by overweight (3.0%), underweight (2.1%), wasting (2.0%), and obesity (0.5%). Girls [OR = 0.55, 95% CI (0.46, 0.65)], infants meeting requirements of minimum diversity diet [OR = 0.81, 95% CI (0.67, 0.98)], and mothers with middle-school or high-school education and above decreased the prevalence of stunting. Infants with diarrhea in two weeks [OR = 1.26,95% CI (0.98, 1.62)] were at higher odds of stunting. The malnutrition status in the study areas was improved, and vulnerable infants were found to need additional and earlier monitoring to detect and fundamentally prevent undernutrition.
MeSH term(s)	Child ; Child, Preschool ; China/epidemiology ; Cross-Sectional Studies ; Female ; Growth Disorders/epidemiology ; Growth Disorders/etiology ; Humans ; Infant ; Malnutrition/epidemiology ; Prevalence ; Thinness/epidemiology
Language	English
Publishing date	2021-08-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph18158165
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Article ; Online: Complementary Feeding and Malnutrition among Infants and Young Children Aged 6-23 Months in Rural Areas of China.

Feng, Jing / Gong, Zhaolong / Wang, Yongjun / Huo, Junsheng / Zhuo, Qin

Nutrients

2022 Volume 14, Issue 9

Abstract: This study investigated the nutrition and complementary feeding (CF) of infants and young children (IYC) aged 6-23 months in rural areas of China in 2018 and explored the relationship between CF and nutritional status. We measured the length and weight, ... ...

Abstract	This study investigated the nutrition and complementary feeding (CF) of infants and young children (IYC) aged 6-23 months in rural areas of China in 2018 and explored the relationship between CF and nutritional status. We measured the length and weight, calculated the z-scores, and detected micronutrients in the hair. The status of CF was obtained from the respondents by a 24-h dietary recall. IYC were classified into clusters using a two-step cluster analysis. The CF and nutritional status of each cluster were analyzed and compared. The prevalence of stunting, wasting, and overweight in the IYC in rural Chinese areas was 7.1%, 3.0%, and 3.7%, respectively. The median levels of Ca, Fe, and Zn in hair were 550.10 µg/g, 62.94 µg/g, and 132.86 µg/g, respectively. The prevalence of meeting the requirements of minimum dietary diversity (MDD), minimum meal frequency (MMF), and minimum acceptable diet (MAD) was 68.9%, 77.9%, and 46.4%, respectively. IYC with a higher prevalence of MDD, MMF, and MAD were more inclined to maintain a healthy status. The prevalence of undernutrition and overweight of 6- to 23-month-old IYC in rural areas of China was low. However, lack of trace elements was evident, and MAD prevalence remained low.
MeSH term(s)	Breast Feeding ; Child ; Child, Preschool ; China/epidemiology ; Female ; Humans ; Infant ; Infant Nutritional Physiological Phenomena ; Malnutrition/epidemiology ; Nutritional Status ; Overweight/epidemiology ; Socioeconomic Factors
Language	English
Publishing date	2022-04-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14091807
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Article ; Online: Yingyangbao Reduced Anemia among Infants and Young Children Aged 6-23 Months When Delivered through a Large-Scale Nutrition Improvement Program for Children in Poor Areas in China from 2015 to 2020.

Wang, Lijuan / Huo, Junsheng / Wei, Yanli / Tang, Yanbin / Sun, Jing / Huang, Jian

Nutrients

2023 Volume 15, Issue 11

Abstract: The purpose of this study was to assess the effectiveness of intervention with Yingyangbao (YYB) on hemoglobin (Hb) and anemia status among infants and young children (IYC) aged 6-23 months (mo) through a large-scale Nutrition Improvement Program for ... ...

Abstract	The purpose of this study was to assess the effectiveness of intervention with Yingyangbao (YYB) on hemoglobin (Hb) and anemia status among infants and young children (IYC) aged 6-23 months (mo) through a large-scale Nutrition Improvement Program for Children in Poor Areas (NIPCPA) in China from 2015 to 2020. Five rounds of cross-sectional surveys were conducted using a stratified and multi-stage probability proportional to size sampling of IYC in 2015, 2017, 2018, 2019 and 2020. Multivariable regression analyses were fitted to determine the effectiveness of the YYB intervention on Hb and anemia, respectively. A total of 36,325, 40,027, 43,831, 44,375 and 46,050 IYC aged 6-23 mo were included, and the prevalence of anemia was 29.7%, 26.9%, 24.1%, 21.2% and 18.1% in 2015, 2017, 2018, 2019 and 2020, respectively. Compared with the results in 2015, the Hb concentrations significantly improved and anemia prevalence significantly decreased among IYC in 2017, 2018, 2019, and 2020 (
MeSH term(s)	Humans ; Child ; Infant ; Child, Preschool ; Dietary Supplements ; Cross-Sectional Studies ; Rural Population ; Anemia/epidemiology ; Anemia/prevention & control ; Hemoglobins/analysis ; China/epidemiology ; Prevalence
Chemical Substances	Hemoglobins
Language	English
Publishing date	2023-06-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15112634
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Article ; Online: Yingyangbao Intervention Was Associated with the Improvement of Body Growth and Nutrition Status of Infants and Young Children in Poor Rural Areas of China: The Annual Comparison from 2012 to 2020.

Wang, Ou / Huang, Jian / Huo, Junsheng / Chen, Di / Xu, Yifan / Sun, Jing

Nutrients

2023 Volume 15, Issue 10

Abstract: Yingyangbao (YYB) is a soy-based micronutrient-fortified powder used in the Nutrition Improvement Project on Children in Poor Areas of China. After the baseline study in 2012, YYB intervention gradually spread to 21 provinces in China. From 2015 to 2020, ...

Abstract	Yingyangbao (YYB) is a soy-based micronutrient-fortified powder used in the Nutrition Improvement Project on Children in Poor Areas of China. After the baseline study in 2012, YYB intervention gradually spread to 21 provinces in China. From 2015 to 2020, a secular trend study was carried out to evaluate the body growth and nutritional status of 6-23-month-old infants and young children (IYC) under YYB intervention. The aim of this research was to investigate whether YYB intervention was associated with the improvement of body growth and development in large populations from broad areas with national and multi-year survey results. The anthropometric data collected in the baseline study and cross-sectional surveys were compared, and the correlation between YYB intake amount and body growth were analyzed. Compared with the results of the baseline study, the 6-23-month-old IYC under YYB intervention showed a significant increase in body weight, body length and Z scores since 2015, and the stunting rate decreased from 9.7% in 2012 to 5.3% in 2020. Significantly positive correlations were observed between the YYB intake amount and the body growth indicators. Therefore, YYB intervention was associated with the improvement of body growth and nutrition status of Chinese IYC. In the future, long-term and continuous efforts are still needed to further reveal the health benefits of YYB in depth.
MeSH term(s)	Humans ; Infant ; Child ; Child, Preschool ; Nutritional Status ; Dietary Supplements ; Anemia ; Cross-Sectional Studies ; Rural Population ; China
Language	English
Publishing date	2023-05-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15102350
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Article ; Online: Construction and Evaluation of a Novel MAP Immunoassay for 9 Nutrition-and-Health-Related Protein Markers Based on Multiplex Liquid Protein Chip Technique.

Yin, Jiyong / Niu, Jiangping / Huo, Junsheng / Sun, Jing / Huang, Jian / Sun, Chaoqun

Nutrients

2023 Volume 15, Issue 6

Abstract: We attempted to construct and evaluate a novel detection method to realize simultaneous detection based on a multiplex liquid protein chip technique for nine nutrition-and-health-related protein markers to meet the requirement of an accurate, ... ...

Abstract	We attempted to construct and evaluate a novel detection method to realize simultaneous detection based on a multiplex liquid protein chip technique for nine nutrition-and-health-related protein markers to meet the requirement of an accurate, simultaneous and comprehensive analysis of the proteomics of nutrition and health. The lower limits of detection, biological limits of detection and regression equations of serum ferritin (SF), soluble transferrin receptor (sTfR), c-reactive protein (CRP), retinol-binding protein4 (RBP4), apolipoprotein B (ApoB), alpha-fetoprotein (AFP), prealbumin (PA), carcino-embryonic antigen (CEA) and D-Dimmer (D-D) were determined after a series of optimal experiments. Then, the results of the methodological evaluation for this novel method indicated that the accuracies were between 70.12% and 127.07%, the within-run precisions were between 0.85% and 7.31%, the between-run precisions were between 3.53% and 19.07%, the correlation coefficients between this method and other methods were above 0.504 (
MeSH term(s)	Protein Array Analysis ; Immunoassay/methods ; C-Reactive Protein/metabolism ; Bilirubin
Chemical Substances	C-Reactive Protein (9007-41-4) ; Bilirubin (RFM9X3LJ49)
Language	English
Publishing date	2023-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15061522
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Article: [Geographical distribution characteristics of one carbon metabolic pathway related single nucleotide polymorphisms].

Zhang, Chunhong / Huo, Junsheng / Sun, Jing / Huang, Jian

Wei sheng yan jiu = Journal of hygiene research

2020 Volume 49, Issue 1, Page(s) 123–131

Abstract: Objective: To analyze geographical distribution characteristics of folate metabolism related single nucleotide polymorphisms.: Methods: This work made a statistical analysis of MTHFR and MTRR gene polymorphism distribution about Chinese Han and ... ...

Abstract	Objective: To analyze geographical distribution characteristics of folate metabolism related single nucleotide polymorphisms. Methods: This work made a statistical analysis of MTHFR and MTRR gene polymorphism distribution about Chinese Han and minority childbearing age women in 16 provinces and 2 municipalities from 64 published Chinese literatures, depicted the regional distributive characteristics of the two gene polymorphisms, and analyzed the association with neural tube defects status for a long time in China. Results: By summarizing and analyzing single nucleotide polymorphisms of MTHFR C677 T in Chinese Han and minority childbearing age women in 16 provinces and 2 municipalities, the results showed that MTHFR 677 TT and 677 T allele frequency increased steadily from south to north, MTHFR 1298 CC occupied a very small proportion. Through interaction analysis of A1298 C and C677 T, the result showed that two genes presented a linkage imbalance, and TT/AA frequency distribution presented a gradually decreasing trend from north to south, and there were no TT/AC, TT/CC, and CT/CC nationwide, it was found that MTRR 66 AA accounted from 34% to 58%, with the northern part slightly higher than the southern part. And MTRR 66 GG was between 5% and 17%. Conclusion: We could pay attention to gene polymorphism risk assessment to reduce neural tube defects for childbearing age women, in order to provide powerful human genetics data support for improving the birth population quality and national public health policy.
MeSH term(s)	Carbon ; China ; Female ; Ferredoxin-NADP Reductase/genetics ; Gene Frequency ; Genetics, Population ; Genotype ; Geography ; Humans ; Metabolic Networks and Pathways ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics ; Polymorphism, Single Nucleotide
Chemical Substances	Carbon (7440-44-0) ; methionine synthase reductase (EC 1.18.1.-) ; Ferredoxin-NADP Reductase (EC 1.18.1.2) ; MTHFR protein, human (EC 1.5.1.20) ; Methylenetetrahydrofolate Reductase (NADPH2) (EC 1.5.1.20)
Language	Chinese
Publishing date	2020-04-10
Publishing country	China
Document type	Journal Article
ZDB-ID	1050909-4
ISSN	1000-8020
ISSN	1000-8020
DOI	10.19813/j.cnki.weishengyanjiu.2020.01.022
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Article ; Online: Prevalence and Temporal Trend (2016-2018) of Anaemia among 6-23-Month-Old Infants and Young Children in China.

Liu, Jing / Huo, Junsheng / Liu, Zengyan / Sun, Jing / Huang, Jian

International journal of environmental research and public health

2021 Volume 18, Issue 4

Abstract: Anaemia is a public health problem that can lead to various harmful effects on physical and neurodevelopment in infants and young children (IYC). This study aimed to investigate trends of anaemia and haemoglobin concentration among 6- to 23-month-old ... ...

Abstract	Anaemia is a public health problem that can lead to various harmful effects on physical and neurodevelopment in infants and young children (IYC). This study aimed to investigate trends of anaemia and haemoglobin concentration among 6- to 23-month-old Chinese IYC from 2016 to 2018. We used data from the China Nutrition Improvement Project on Children in Poor Areas (CNIPCPA), conducted in 142 national-level poor counties of 20 provinces, autonomous regions, and municipalities from 2016 to 2018. Our study included 103,621 6- to 23-month-old IYC selected by a stratified multistage cluster sampling design. There were 26,303, 33,443, and 43,875 IYC in the survey in 2016, 2017, and 2018, respectively. The overall prevalence of anaemia was 27.0% in the three years. The prevalence of anaemia was 28.0%, 27.2%, and 26.2%, and the mean haemoglobin (Hb) was 11.82, 11.81, and 11.88 g/dL in 2016, 2017, and 2018, respectively. The prevalence of anaemia was highest in 6- to 11-month-olds, and declined with age. There was a gap in the education level between parents. However, the percentage of education improved in the rural areas of China. The prevalence of anaemia decreased significantly in the three years, which shows that prevention and control actions achieved the initial results.
MeSH term(s)	Anemia/epidemiology ; Child ; Child, Preschool ; China/epidemiology ; Cities ; Hemoglobins/analysis ; Humans ; Infant ; Prevalence
Chemical Substances	Hemoglobins
Language	English
Publishing date	2021-02-19
Publishing country	Switzerland
Document type	Journal Article
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph18042041
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