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  1. AU="Huo, Lijun"
  2. AU="Weinheimer, Claudia"
  3. AU="Akbari, Syed Hassan A"
  4. AU="Lutfi H. Alfarsi"
  5. AU="Maria Rosaria Campitiello"
  6. AU="Kazzi, Ziad N"
  7. AU=Jain Somya
  8. AU="Ming, Xiu-Fen"
  9. AU="Gileadi, Opher"
  10. AU="Wang, Zeng-Liang"
  11. AU=Berman Jonathan M
  12. AU="Vivienne Clark"
  13. AU=Sheridan Brian S AU=Sheridan Brian S
  14. AU="Yang, Zuyu"
  15. AU="Suzuki, Tomo"
  16. AU="Horiguchi, Akihiko"
  17. AU="Band, Rebecca"
  18. AU=Pablos Isabel AU=Pablos Isabel
  19. AU="O'Flaherty, Vincent"
  20. AU="Jérémie, Riou"
  21. AU="Ma, Yunshu"
  22. AU="Pu, Junyi"
  23. AU="Benlloch, Sara"
  24. AU="Jay D Evans"
  25. AU=Unger Jean-Pierre
  26. AU="Soday, Lior"
  27. AU="Wan, Xuan"
  28. AU="Camille Fritzell"
  29. AU=Wei Huijun
  30. AU="Levine, Morgan E"
  31. AU="Chen, Yalei"
  32. AU="Rogaeva, Ekaterina" AU="Rogaeva, Ekaterina"
  33. AU="Jain, Ishaan"
  34. AU="Chatelier, Josh"
  35. AU="Passarelli, L."
  36. AU="Marques, R"
  37. AU="Restaino, Valeria"
  38. AU="Wang, Haochen"
  39. AU=Shoib Sheikh
  40. AU=Patel Ishan
  41. AU="Mongioì, Laura M"
  42. AU="Fernández-Pacheco, Borja Camacho"
  43. AU=Waghmare Alpana AU=Waghmare Alpana
  44. AU="Peyre, Marion"
  45. AU=Mulazimoglu L
  46. AU=Roy Satyaki
  47. AU="Li Yuanyuan"
  48. AU=Khan Shehryar
  49. AU=Cole Sarah L
  50. AU="Júnior, Raimundo Nonato Colares Camargo"
  51. AU="Feeney, Judith A"

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  1. Artikel ; Online: Recent Advances of Furan and Its Derivatives Based Semiconductor Materials for Organic Photovoltaics.

    Zheng, Bing / Huo, Lijun

    Small methods

    2021  Band 5, Heft 9, Seite(n) e2100493

    Abstract: The state-of-the-art bulk-heterojunction (BHJ)-type organic solar cells (OSCs) have exhibited power conversion efficiencies (PCEs) of exceeding 18%. Thereinto, thiophene and its fused-ring derivatives play significant roles in facilitating the ... ...

    Abstract The state-of-the-art bulk-heterojunction (BHJ)-type organic solar cells (OSCs) have exhibited power conversion efficiencies (PCEs) of exceeding 18%. Thereinto, thiophene and its fused-ring derivatives play significant roles in facilitating the development of OSCs due to their excellent semiconducting natures. Furan as thiophene analogue, is a ubiquitous motif in naturally occurring organic compounds. Driven by the advantages of furan, such as less steric hindrance, good solubility, excellent stacking, strong rigidity and fluorescence, biomass derived fractions, more and more research groups focus on the furan-based materials for using in OSCs in the past decade. To systematically understand the developments of furan-based photovoltaic materials, the relationships between the molecular structures, optoelectronic properties, and photovoltaic performances for the furan-based semiconductor materials including single furan, benzofuran, benzodifuran (BDF) (containing thienobenzofuran (TBF)), naphthodifurans (NDF), and polycyclic furan are summarized. Finally, the empirical regularities and perspectives of the development of this kind of new organic semiconductor materials are extracted.
    Sprache Englisch
    Erscheinungsdatum 2021-08-16
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2366-9608
    ISSN (online) 2366-9608
    DOI 10.1002/smtd.202100493
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  2. Artikel: Ocular decompression retinopathy after phacoemulsification in a patient with primary acute angle-closure glaucoma undergoing chemotherapy.

    Chen, Yi-Lin / Yang, Xiao-Nan / Liu, Ying-Li / Li, Wen-Tao / Huo, Li-Jun

    International journal of ophthalmology

    2024  Band 17, Heft 2, Seite(n) 397–400

    Sprache Englisch
    Erscheinungsdatum 2024-02-18
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 2663246-9
    ISSN 2227-4898 ; 2222-3959
    ISSN (online) 2227-4898
    ISSN 2222-3959
    DOI 10.18240/ijo.2024.02.25
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  3. Artikel ; Online: The Effect of Bovine Trypsin on the Adhesion and pH of Dental Plaque Biofilms: An In Vitro Study.

    Meng, Xinhui / Huang, Yinxue / Zhou, Jing / Yin, Xintong / Han, Qunchao / Huo, Lijun / Lei, Yayan

    International dental journal

    2024  

    Abstract: Objective: The aim of this study was to investigate the effect of bovine trypsin on the adhesion and pH of dental plaque biofilms.: Methods: A multispecies dental plaque biofilm model and a single-species dental plaque biofilm model were established ... ...

    Abstract Objective: The aim of this study was to investigate the effect of bovine trypsin on the adhesion and pH of dental plaque biofilms.
    Methods: A multispecies dental plaque biofilm model and a single-species dental plaque biofilm model were established in vitro. Three groups were tested: (1) blank control group (aseptic ultrapure water); (2) negative control group (1M Tris-HCl buffer, pH = 7.4); and (3) experimental group (bovine trypsin). Adhesion ability was measured using an automatic microplate reader and visualised by confocal laser scanning microscopy (CLSM). The pH was measured using a pH meter. The expression of gtfB, gtfC, and gtfD was analysed using quantitative real-time polymerase chain reaction.
    Results: Adhesion ability in the experimental group was significantly lower than that in the blank group and the negative control group (P < .05); readhesion ability in the experimental group was inhibited for a certain period of time (24-hour multispecies biofilms were inhibited from 4 to 8 hours, and the 48- and 72-hour multispecies biofilms were inhibited from 2 to 6 hours; P < .05). The decrease in pH was inhibited for a certain period of time (24-hour multispecies biofilms were inhibited from 2 to 8 hours, and the 48- and 72-hour multispecies biofilms were inhibited from 1 to 8 hours; P < .05). Expression levels of gtfB, gtfC, gtfD, and ldh in the experimental group were significantly lower than those in the blank group (P < .05).
    Conclusions: Bacterial adhesion, and readhesion, decreasd pH, and expression of adhesion- and acid-related genes by Streptococcus mutans in biofilms could be reduced by bovine trypsin for a certain period of time.
    Sprache Englisch
    Erscheinungsdatum 2024-05-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 218262-2
    ISSN 1875-595X ; 0020-6539
    ISSN (online) 1875-595X
    ISSN 0020-6539
    DOI 10.1016/j.identj.2024.04.025
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  4. Artikel ; Online: Chlorothalonil exposure compromised mouse oocyte in vitro maturation through inducing oxidative stress and activating MAPK pathway.

    Wang, Yong-Sheng / Yang, Sheng-Ji / Wan, Zi-Xuan / Shen, Ao / Ahmad, Muhammad Jamil / Chen, Ming-Yue / Huo, Li-Jun / Pan, Jun-Hua

    Ecotoxicology and environmental safety

    2024  Band 273, Seite(n) 116100

    Abstract: Chlorothalonil (CTL) is widely used in agricultural production and antifoulant additive globally due to its broad spectrum and non-systemic properties, resulting in its widespread existence in foods, soil and water. Extensive evidence demonstrated that ... ...

    Abstract Chlorothalonil (CTL) is widely used in agricultural production and antifoulant additive globally due to its broad spectrum and non-systemic properties, resulting in its widespread existence in foods, soil and water. Extensive evidence demonstrated that exposure to CTL induced adverse effects on organisms and in particular its reproductive toxicity has been attracted public concern. However, the influences of CTL on oocyte maturation is mysterious so far. In this study, we documented the toxic effects of CTL on oocyte in vitro maturation and the related underlying mechanisms. Exposure to CTL caused continuous activation of spindle assembly checkpoints (SAC) which in turn compromised meiotic maturation in mouse oocyte, featured by the attenuation of polar body extrusion (PBE). Detection of cytoskeletal dynamics demonstrated that CTL exposure weakened the acetylation level of α-tubulin and impaired meiotic spindle apparatus, which was responsible for the aberrant state of SAC. Meanwhile, exposure to CTL damaged the function of mitochondria, inducing the decline of ATP content and the elevation of reactive oxygen species (ROS), which thereby induced early apoptosis and DNA damage in mouse oocytes. In addition, exposure to CTL caused the alteration of the level of histone H3 methylation, indicative of the harmful effects of CTL on epigenetic modifications in oocytes. Further, the CTL-induced oxidative stress activated mitogen-activated protein kinase (MAPK) pathway and injured the maturation of oocytes. In summary, exposure to CTL damaged mouse oocyte in vitro maturation via destroying spindle assembly, inducing oxidative stress and triggering MAPK pathway activation.
    Mesh-Begriff(e) Animals ; Mice ; In Vitro Oocyte Maturation Techniques ; Mitogen-Activated Protein Kinases/metabolism ; Oxidative Stress ; Oocytes/metabolism ; Reactive Oxygen Species/metabolism ; Apoptosis ; Nitriles
    Chemische Substanzen tetrachloroisophthalonitrile (J718M71A7A) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Reactive Oxygen Species ; Nitriles
    Sprache Englisch
    Erscheinungsdatum 2024-02-16
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2024.116100
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  5. Artikel ; Online: mm9_circ_014683 regulates microglia polarization through canonical NFκB signaling pathway in diabetic retinopathy.

    Chen, Tingting / Wang, Congyao / Zhu, Wenhui / Yu, Fenfen / Dong, Xia / Su, Yihua / Huang, Jingwen / Huo, Lijun / Wan, Pengxia

    Cellular signalling

    2024  Band 117, Seite(n) 111121

    Abstract: Diabetic retinopathy (DR) is still the major cause of visual loss in working-aged people, one of the critical pathological processes are retinal microglia-mediated inflammation. Our previous study demonstrated that enhanced M1 microglial polarization was ...

    Abstract Diabetic retinopathy (DR) is still the major cause of visual loss in working-aged people, one of the critical pathological processes are retinal microglia-mediated inflammation. Our previous study demonstrated that enhanced M1 microglial polarization was involved in retinal inflammation in DR, but the detailed mechanism needs further investigation. Circular RNAs (circRNAs) are important kind of noncoding RNAs involved in the regulation of various cell biological processes. Herein, the circRNA expression profiles of BV2 mouse microglia treated with or without glucose were detected, and a total of 347 differentially expressed circRNAs were identified in glucose-treated BV2 cells. The key circRNA mm9_circ_014683 increased after glucose stimulation. Inhibiting or overexpressing mm9_circ_014683 showed no effect on the proliferation and apoptosis of microglia. Inhibiting mm9_circ_014683 impeded M1 polarization and promoted M2 polarization, and overexpressing mm9_circ_014683 showed the opposite effect. A total of 216 differentially expressed genes were identified in mm9_circ_014683-knockdown BV2 cells, which were enriched in several signaling pathways, including the NFκB signaling pathway. Moreover, mm9_circ_014683 positively regulated the canonical, NFκB signaling pathway. Besides, mm9_circ_014683 was highly expressed in the retinal microglia of diabetic mice, and intraocular injection of Lv-circRNA inhibited M1 but enhanced M2 retinal microglial polarization. In conclusion, mm9_circ_014683 regulates microglial polarization through the canonical NFκB signaling pathway in diabetic retinopathy. This study may provide insight into the pathogenesis and treatment of DR.
    Mesh-Begriff(e) Humans ; Animals ; Mice ; Aged ; Diabetic Retinopathy/metabolism ; RNA, Circular/genetics ; RNA, Circular/metabolism ; Microglia/metabolism ; Diabetes Mellitus, Experimental/pathology ; Signal Transduction ; Inflammation/metabolism ; Glucose/pharmacology ; Glucose/metabolism ; MicroRNAs/metabolism
    Chemische Substanzen RNA, Circular ; Glucose (IY9XDZ35W2) ; MicroRNAs
    Sprache Englisch
    Erscheinungsdatum 2024-02-27
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1002702-6
    ISSN 1873-3913 ; 0898-6568
    ISSN (online) 1873-3913
    ISSN 0898-6568
    DOI 10.1016/j.cellsig.2024.111121
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  6. Artikel ; Online: Neddylation inhibition affects early embryonic development by disrupting maternal-to-zygotic transition and mitochondrial function in mice.

    Liu, Mingxiao / Ding, Zhiming / Sun, Peihao / Zhou, Shuo / Wu, Hanxiao / Huo, Lijun / Yang, Liguo / Davis, John S / Liang, Aixin

    Theriogenology

    2024  Band 220, Seite(n) 1–11

    Abstract: Post-translational modifications (PTMs) are critical for early development in mice because early cleavage-stage embryos are characterized by transcriptional inactivity. Neddylation is an important ubiquitin-like PTM that regulates multiple biophysical ... ...

    Abstract Post-translational modifications (PTMs) are critical for early development in mice because early cleavage-stage embryos are characterized by transcriptional inactivity. Neddylation is an important ubiquitin-like PTM that regulates multiple biophysical processes. However, the exact roles of neddylation in regulating early embryonic development remain largely unknown. In the present study, we found that inhibition of neddylation by specific inhibitor MLN4924 led to severe arrest of early embryonic development. Transcriptomic analysis showed that neddylation inhibition changed the expression of 3959 genes at the 2-cell stage. Importantly, neddylation inhibition blocked zygotic genome activation and maternal mRNA degradation, thus disrupting the maternal-to-zygotic transition. Moreover, inhibition of neddylation induced mitochondrial dysfunction including aberrant mitochondrial distribution, decreased mitochondrial membrane potential, and reduced ATP content. Further analysis showed that inhibition of neddylation resulted in the accumulation of reactive oxygen species and superoxide anion, thereby resulting in oxidative stress and severe DNA damage at the 2-cell stage. Overall, this study demonstrates that neddylation is vital for early embryonic development in mice. Our findings suggest that proper neddylation regulation is essential for the timely inter-stage transition during early embryonic development.
    Mesh-Begriff(e) Mice ; Animals ; Protein Processing, Post-Translational ; Embryonic Development ; Mitochondria
    Sprache Englisch
    Erscheinungsdatum 2024-02-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 189232-0
    ISSN 1879-3231 ; 0093-691X
    ISSN (online) 1879-3231
    ISSN 0093-691X
    DOI 10.1016/j.theriogenology.2024.02.029
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  7. Artikel ; Online: Maternal exposure to DON during lactation induces testicular toxicity in pubertal and adult offspring mice.

    Sun, Peihao / Liu, Mingxiao / Zhou, Shuo / Yang, Liguo / Xie, Shiyong / Riaz, Hasan / Huo, Lijun / Liang, Aixin

    Ecotoxicology and environmental safety

    2024  Band 279, Seite(n) 116468

    Abstract: Deoxynivalenol (DON), a type B trichothecene mycotoxin, commonly occurs in cereal grains, and poses significant health risks to humans and animals. Numerous studies reveal its obvious toxic effects on male reproductive performance as well as its ability ... ...

    Abstract Deoxynivalenol (DON), a type B trichothecene mycotoxin, commonly occurs in cereal grains, and poses significant health risks to humans and animals. Numerous studies reveal its obvious toxic effects on male reproductive performance as well as its ability to transfer from the lactating mother to the suckling offspring through colostrum and milk. The objective of this study was to evaluate the toxic effect of lactational DON exposure on testicular morphology, hormonal levels, inflammation, apoptosis and proliferation of germ cells, tight junction, and sperm quality in male offspring. Sixty-six male offspring mice from lactating dams exposed to DON were euthanized at PND 21 and PND 70 to investigate the reproductive toxicity. Our results indicated that maternal DON exposure had a significant impact on the weight and volume of the testes, caused testicular histopathology, and reduced testosterone levels by downregulating expressions of StAR, CYP11A1, and CYP17A1 in male offspring. We also found that maternal DON exposure led to testicular inflammation in male offspring, which was attributed to increased levels of inflammatory markers, including IL-1β, IL-6, TNF-α, and IFN-γ. Maternal DON exposure resulted in impaired tight junctions of Sertoli cells in male offspring, as evidenced by decreased expressions of ZO-1, Occludin, and Claudin-3. In addition, maternal DON exposure caused a reduction in the number of Sertoli cells and germ cells, ultimately leading to decreased sperm count and quality in adult male offspring. Collectively, these findings provide compelling evidence that maternal exposure to DON during lactation causes testicular toxicity in both pubertal and adult male offspring.
    Sprache Englisch
    Erscheinungsdatum 2024-05-21
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2024.116468
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  8. Artikel ; Online: Asymmetric Wettability Mediated Patterning of Single Crystalline Nematic Liquid Crystal and P-N Heterojunction Toward a Broadband Photodetector.

    Yue, Yuchen / Yang, Jiaxin / Zheng, Bing / Huo, Lijun / Dong, Huanli / Wang, Jingxia / Jiang, Lei

    ACS applied materials & interfaces

    2023  Band 15, Heft 10, Seite(n) 13371–13379

    Abstract: The well aligned and precise patterning of liquid crystals (LCs) are considered as two key challenges for large-scale and high-efficiency integrated optoelectronic devices. However, owing to the uncontrollable liquid flow and dewetting process in the ... ...

    Abstract The well aligned and precise patterning of liquid crystals (LCs) are considered as two key challenges for large-scale and high-efficiency integrated optoelectronic devices. However, owing to the uncontrollable liquid flow and dewetting process in the conventional techniques, most of the reported research is mainly focused on simple sematic LCs, which are composed of terthiophenes or benzothieno[3, 2-b][1] benzothiophene backbone; only a few works are carried out on the complicated LCs. Herein, an efficient strategy was introduced to control the liquid flow and alignment of LCs and realized precise and high-quality patterning of A-π-D-π-A BTR, based on the asymmetric wettability interface. Through this strategy, the large-area and well-aligned BTR microwires array was fabricated, which exhibited highly ordered molecular packing and improved charge transport performance. Furthermore, the integration of BTR and PC
    Sprache Englisch
    Erscheinungsdatum 2023-03-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c21664
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  9. Artikel ; Online: The management of gingival fenestration: A series of three cases.

    Ren, Xuefeng / Liu, Tao / Huo, Lijun / Rao, Nanquan / Wang, Lixiao / Luo, Qi / Zhang, Mingzhu

    The International journal of periodontics & restorative dentistry

    2023  

    Abstract: Objectives: The aim of this article is to introduce three treatments for patients with gingival fenestration as a result of chronic apical periodontitis. Gingival fenestration is a relatively uncommon soft tissue lesion in which the root apex is exposed ...

    Abstract Objectives: The aim of this article is to introduce three treatments for patients with gingival fenestration as a result of chronic apical periodontitis. Gingival fenestration is a relatively uncommon soft tissue lesion in which the root apex is exposed in the oral environment after the destruction of the overlying buccal bone plate and mucosa. At present, no clear etiology or treatment guidelines exist for gingival fenestration. This article reports three successfully treated cases of gingival fenestration associated with chronic periapical infection. This report can help contribute to treatment guidelines for gingival fenestration.
    Methods: All cases were treated with apicoectomy in conjunction with a connective tissue graft (CTG). According to the different conditions of the patients, we used some slightly different treatment methods during the operation. In case 1, we treated gingival fenestration in the mandibular left first premolar by endodontic therapy with root-end resection and retrograde filling and regenerative surgical therapy using a xenograft and CTG. In case 2, we treated gingival fenestration in the maxillary left lateral incisor by endodontic therapy with root-end resection and retrograde filling in vitro and regenerative surgical therapy using advanced platelet-rich fibrin (A-PRF) and CTG. In case 3, we treated gingival fenestration in the mandibular left second premolar by endodontic therapy with root-end resection and retrograde filling and regenerative surgical therapy using CTG.
    Results: Endodontic treatment was combined with periodontal surgery to achieve predictable treatment results. After 13 to 25 months of follow-up, all cases showed that the gingival fenestration had healed well, and the patients had no discomfort.
    Conclusions: These three cases show the possibility of using apical excision combined with a CTG and/or bone graft/PRF in the treatment of gingival fenestration. Reporting these three cases may help advance the field of treatments for gingival fenestration.
    Sprache Englisch
    Erscheinungsdatum 2023-10-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1945-3388
    ISSN (online) 1945-3388
    DOI 10.11607/prd.6861
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  10. Artikel ; Online: Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells.

    Feng, Hai-Wei / Zhao, Yu / Gao, Yan-Ling / Liu, Dong-Teng / Huo, Li-Jun

    Asian journal of andrology

    2023  

    Abstract: Abstract: Meiosis is the process of producing haploid gametes through a series of complex chromosomal events and the coordinated action of various proteins. The mitochondrial protease complex (ClpXP), which consists of caseinolytic mitochondrial matrix ... ...

    Abstract Abstract: Meiosis is the process of producing haploid gametes through a series of complex chromosomal events and the coordinated action of various proteins. The mitochondrial protease complex (ClpXP), which consists of caseinolytic mitochondrial matrix peptidase X (ClpX) and caseinolytic protease P (ClpP) and mediates the degradation of misfolded, damaged, and oxidized proteins, is essential for maintaining mitochondrial homeostasis. ClpXP has been implicated in meiosis regulation, but its precise role is currently unknown. In this study, we engineered an inducible male germ cell-specific knockout caseinolytic mitochondrial matrix peptidase X (ClpxcKO) mouse model to investigate the function of ClpX in meiosis. We found that disrupting Clpx in male mice induced germ cell apoptosis and led to an absence of sperm in the epididymis. Specifically, it caused asynapsis of homologous chromosomes and impaired meiotic recombination, resulting in meiotic arrest in the zygotene-to-pachytene transition phase. The loss of ClpX compromised the double-strand break (DSB) repair machinery by markedly reducing the recruitment of DNA repair protein RAD51 homolog 1 (RAD51) to DSB sites. This dysfunction may be due to an insufficient supply of energy from the aberrant mitochondria in ClpxcKO spermatocytes, as discerned by electron microscopy. Furthermore, ubiquitination signals on chromosomes and the expression of oxidative phosphorylation subunits were both significantly attenuated in ClpxcKO spermatocytes. Taken together, we propose that ClpX is essential for maintaining mitochondrial protein homeostasis and ensuring homologous chromosome pairing, synapsis, and recombination in spermatocytes during meiotic prophase I.
    Sprache Englisch
    Erscheinungsdatum 2023-10-17
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 2075824-8
    ISSN 1745-7262 ; 1008-682X
    ISSN (online) 1745-7262
    ISSN 1008-682X
    DOI 10.4103/aja202343
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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