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  1. Article ; Online: Genomic Recombination of SARS-CoV-2 Subvariants BA.5.2.48 and BF.7.14 - China, 2023.

    Zhang, Zhongxian / Li, Han / Ma, Hongxia / Wang, Wenling / Gao, Dawei / Ye, Fei / Huo, Weibang / Chen, Yuda / Wu, Changcheng / Tan, Wenjie

    China CDC weekly

    2023  Volume 5, Issue 14, Page(s) 318–320

    Language English
    Publishing date 2023-05-10
    Publishing country China
    Document type Journal Article
    ISSN 2096-7071
    ISSN (online) 2096-7071
    DOI 10.46234/ccdcw2023.058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Characterization of whole genomes from recently emerging Mpox cases in several regions of China, 2023.

    Wu, Changcheng / Cui, Lunbiao / Pan, Yang / Lv, Ziquan / Yao, Mingxiao / Wang, Wenling / Ye, Fei / Huo, Weibang / Zhao, Li / Huang, Baoying / Zhu, Fengcai / Lu, Roujian / Deng, Yao / Wang, Quanyi / Tan, Wenjie

    Science China. Life sciences

    2023  

    Language English
    Publishing date 2023-11-24
    Publishing country China
    Document type Letter
    ZDB-ID 2546732-3
    ISSN 1869-1889 ; 1674-7305
    ISSN (online) 1869-1889
    ISSN 1674-7305
    DOI 10.1007/s11427-023-2485-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Rapid identification of full-length genome and tracing variations of monkeypox virus in clinical specimens based on mNGS and amplicon sequencing.

    Wu, Changcheng / A, Ruhan / Ye, Sheng / Ye, Fei / Huo, Weibang / Lu, Roujian / Tang, Yue / Yang, Jianwei / Meng, Xuehong / Tang, Yun / Chen, Shuang / Zhao, Li / Huang, Baoying / Zhang, Zhongxian / Chen, Yuda / Li, Dongfang / Wang, Wenling / Shan, Ke-Jia / Lu, Jian /
    Tan, Wenjie

    Virologica Sinica

    2023  Volume 39, Issue 1, Page(s) 134–143

    Abstract: The monkeypox virus (MPXV) has triggered a current outbreak globally. Genome sequencing of MPXV and rapid tracing of genetic variants will benefit disease diagnosis and control. It is a significant challenge but necessary to optimize the strategy and ... ...

    Abstract The monkeypox virus (MPXV) has triggered a current outbreak globally. Genome sequencing of MPXV and rapid tracing of genetic variants will benefit disease diagnosis and control. It is a significant challenge but necessary to optimize the strategy and application of rapid full-length genome identification and to track variations of MPXV in clinical specimens with low viral loads, as it is one of the DNA viruses with the largest genome and the most AT-biased, and has a significant number of tandem repeats. Here we evaluated the performance of metagenomic and amplicon sequencing techniques, and three sequencing platforms in MPXV genome sequencing based on multiple clinical specimens of five mpox cases in Chinese mainland. We rapidly identified the full-length genome of MPXV with the assembly of accurate tandem repeats in multiple clinical specimens. Amplicon sequencing enables cost-effective and rapid sequencing of clinical specimens to obtain high-quality MPXV genomes. Third-generation sequencing facilitates the assembly of the terminal tandem repeat regions in the monkeypox virus genome and corrects a common misassembly in published sequences. Besides, several intra-host single nucleotide variations were identified in the first imported mpox case. This study offers an evaluation of various strategies aimed at identifying the complete genome of MPXV in clinical specimens. The findings of this study will significantly enhance the surveillance of MPXV.
    MeSH term(s) Humans ; Monkeypox virus/genetics ; Mpox (monkeypox)/diagnosis
    Language English
    Publishing date 2023-12-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1011219-4
    ISSN 1995-820X ; 1000-3223 ; 1003-5125
    ISSN (online) 1995-820X
    ISSN 1000-3223 ; 1003-5125
    DOI 10.1016/j.virs.2023.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4175: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Differentiation and characterization of rhesus monkey atrial and ventricular cardiomyocytes from induced pluripotent stem cells.

    Zhang, Xiaoqian / Cao, Henghua / Bai, Shuyun / Huo, Weibang / Ma, Yue

    Stem cell research

    2017  Volume 20, Page(s) 21–29

    Abstract: The combination of non-human primate animals and their induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) provides not only transplantation models for cell-based therapy of heart diseases, but also opportunities for heart-related drug ... ...

    Abstract The combination of non-human primate animals and their induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) provides not only transplantation models for cell-based therapy of heart diseases, but also opportunities for heart-related drug research on both cellular and animal levels. However, the subtypes and electrophysiology properties of non-human primate iPSC-CMs hadn't been detailed characterized. In this study, we generated rhesus monkey induced pluripotent stem cells (riPSCs), and efficiently differentiated them into ventricular or atrial cardiomyocytes by modulating retinoic acid (RA) pathways. Our results revealed that the electrophysiological characteristics and response to canonical drugs of riPSC-CMs were similar with those of human pluripotent stem cell derived CMs. Therefore, rhesus monkeys and their iPSC-CMs provide a powerful and practicable system for heart related biomedical research.
    Language English
    Publishing date 2017-04
    Publishing country England
    Document type Journal Article
    ISSN 1876-7753
    ISSN (online) 1876-7753
    DOI 10.1016/j.scr.2017.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Efficient Differentiation of TBX18

    Zhao, Jianmin / Cao, Henghua / Tian, Luyang / Huo, Weibang / Zhai, Kui / Wang, Pei / Ji, Guangju / Ma, Yue

    Stem cells and development

    2017  Volume 26, Issue 7, Page(s) 528–540

    Abstract: The epicardium promotes neovascularization and cardiomyocyte regeneration by generating vascular smooth muscle cells (SMCs) and producing regenerative factors after adult heart infarction. It is therefore a potential cell resource for repair of the ... ...

    Abstract The epicardium promotes neovascularization and cardiomyocyte regeneration by generating vascular smooth muscle cells (SMCs) and producing regenerative factors after adult heart infarction. It is therefore a potential cell resource for repair of the injured heart. However, the epicardium also participates in fibrosis and scarring of the injured heart, complicating its use in regenerative medicine. In this study, we report coexpression of TBX18 and WT1 in the majority of epicardial cells during mouse embryonic epicardial development. Furthermore, we describe a convenient chemically defined, immunogen-free, small molecule-based method for generating TBX18
    MeSH term(s) Animals ; Cell Differentiation/physiology ; Fibroblasts/cytology ; Humans ; Mice ; Myocytes, Cardiac/cytology ; Myocytes, Smooth Muscle/cytology ; Pericardium/cytology ; Pluripotent Stem Cells/cytology ; Repressor Proteins/genetics ; T-Box Domain Proteins/genetics ; WT1 Proteins/genetics
    Chemical Substances Repressor Proteins ; T-Box Domain Proteins ; Tbx18 protein, human ; Tbx18 protein, mouse ; WT1 Proteins ; WT1 protein, human ; WT1 protein, mouse
    Language English
    Publishing date 2017-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2142214-X
    ISSN 1557-8534 ; 1547-3287
    ISSN (online) 1557-8534
    ISSN 1547-3287
    DOI 10.1089/scd.2016.0208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3616: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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