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  1. Article: Salapoliisin työtä mikroskoopin ääressä - ihobiopsia johdatti kuppadiagnoosiin.

    Huotari-Orava, Riitta

    Duodecim; laaketieteellinen aikakauskirja

    2013  Volume 129, Issue 10, Page(s) 1103–1106

    Abstract: Skin biopsy is one of the most important diagnostic tools in dermatologic disorders. It is, however, necessary to combine histological findings with the clinical picture, and diagnosis will not necessarily be reached even from a technically successful ... ...

    Title translation Skin biopsy as a clue - case report.
    Abstract Skin biopsy is one of the most important diagnostic tools in dermatologic disorders. It is, however, necessary to combine histological findings with the clinical picture, and diagnosis will not necessarily be reached even from a technically successful biopsy without proper referral data. We describe a case in which biopsies taken from the skin rash of a febrile middle-aged man led to the correct tracks and the syphilis diagnosis was reached in collaboration with the clinician.
    MeSH term(s) Biopsy/methods ; Diagnosis, Differential ; Humans ; Male ; Middle Aged ; Syphilis, Cutaneous/diagnosis ; Syphilis, Cutaneous/pathology
    Language Finnish
    Publishing date 2013
    Publishing country Finland
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 127604-9
    ISSN 0012-7183
    ISSN 0012-7183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Melatonin immunoreactivity of epidermal skin is higher in the evening than morning but does not account for erythema sensitivity.

    Nikkola, Veera / Huotari-Orava, Riitta / Joronen, Heli / Grönroos, Mari / Kautiainen, Hannu / Ylianttila, Lasse / Snellman, Erna / Partonen, Timo

    Chronobiology international

    2022  Volume 40, Issue 2, Page(s) 132–144

    Abstract: The skin is a site of melatonin synthesis, and melatonin has a role in protecting against ultraviolet radiation-induced damage. Ultraviolet B (UVB) induced erythema seems to vary between morning and evening. We investigated whether epidermal melatonin ... ...

    Abstract The skin is a site of melatonin synthesis, and melatonin has a role in protecting against ultraviolet radiation-induced damage. Ultraviolet B (UVB) induced erythema seems to vary between morning and evening. We investigated whether epidermal melatonin immunoreactivities in the morning differed from those in the evening, and whether UVB-induced erythema was associated with these melatonin immunoreactivities in healthy volunteers. Erythema sensitivity of the skin was determined in the morning and in the evening by scoring the Minimal Erythema Dose and quantifying the erythema index (EI). We took biopsies from the non-UVB-exposed skin of healthy volunteers (n = 39) in the morning and in the evening to study melatonin immunoreactivity with immunohistochemistry (IHC). In the IHC staining, there was more melatonin immunoreactivity in the evening than in the morning (
    MeSH term(s) Humans ; Melatonin ; Ultraviolet Rays ; Circadian Rhythm ; Skin ; Erythema
    Chemical Substances Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2022-12-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 998996-1
    ISSN 1525-6073 ; 0742-0528
    ISSN (online) 1525-6073
    ISSN 0742-0528
    DOI 10.1080/07420528.2022.2157733
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  3. Article: Expression of Estrogen-Related Receptors in Localized Provoked Vulvodynia.

    Aalto, Anu / Huotari-Orava, Riitta / Luhtala, Satu / Mäenpää, Johanna / Staff, Synnöve

    BioResearch open access

    2020  Volume 9, Issue 1, Page(s) 13–21

    Abstract: Eight percent of women suffer from vulvodynia, a chronic pain condition with unknown etiology. Inflammation and dysregulation of estrogen signaling have been suggested to play a role in the pathogenesis of localized provoked vulvodynia (LPV). Therefore, ... ...

    Abstract Eight percent of women suffer from vulvodynia, a chronic pain condition with unknown etiology. Inflammation and dysregulation of estrogen signaling have been suggested to play a role in the pathogenesis of localized provoked vulvodynia (LPV). Therefore, the aim of the study was to analyze protein expression levels of estrogen-related receptors ERRα, ERRß, ERRγ, estrogen receptor (ERα), and progesterone receptor (PRα) and CD3-positive T cells in the vulvar vestibulum obtained from women suffering from LPV in comparison to healthy, unaffected controls. Vulvar vestibulum tissue specimens were obtained from LPV patients (
    Language English
    Publishing date 2020-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2662245-2
    ISSN 2164-7860 ; 2164-7844
    ISSN (online) 2164-7860
    ISSN 2164-7844
    DOI 10.1089/biores.2019.0049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Increased Incidence of Cutaneous Vasculitic Ulcers: 30-year Results from a Population-based Retrospective Study.

    Kimpimäki, Teija / Huotari-Orava, Riitta / Antonen, Jaakko / Vaalasti, Annikki

    Acta dermato-venereologica

    2017  Volume 97, Issue 5, Page(s) 653–654

    Language English
    Publishing date 2017--08
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-2608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Diurnal Preference Contributes to Maximal UVB Sensitivity by the Hour of the Day in Human Skin In Vivo.

    Raita, Annina / Häggqvist, Iina-Maria / Joronen, Heli / Nikkola, Veera / Huotari-Orava, Riitta / Ylianttila, Lasse / Kautiainen, Hannu / Snellman, Erna / Pasternack, Rafael / Partonen, Timo

    The Journal of investigative dermatology

    2022  Volume 142, Issue 8, Page(s) 2289–2291.e5

    MeSH term(s) Humans ; Skin ; Ultraviolet Rays/adverse effects
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2022.01.021
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  6. Article ; Online: Narrow-band ultraviolet B radiation induces the expression of β-endorphin in human skin in vivo.

    Jussila, Anna / Huotari-Orava, Riitta / Ylianttila, Lasse / Partonen, Timo / Snellman, Erna

    Journal of photochemistry and photobiology. B, Biology

    2016  Volume 155, Page(s) 104–108

    Abstract: Background: Ultraviolet radiation (UVR) from the sun and solaria has addictive properties that may develop into dependence. In mice, UVR addiction was connected to β-endorphin (β-END) formed in the skin after UVR exposure. In humans, the formation of β- ... ...

    Abstract Background: Ultraviolet radiation (UVR) from the sun and solaria has addictive properties that may develop into dependence. In mice, UVR addiction was connected to β-endorphin (β-END) formed in the skin after UVR exposure. In humans, the formation of β-END in skin keratinocytes has not been confirmed in vivo.
    Objective: To determine with immunohistochemistry if sub-erythematous narrow-band UV-B (NB-UV-B) exposures stimulate p53 mediated expression of pro-opiomelanocortin (POMC), β-END and α-melanocyte stimulating hormone (α-MSH) in human skin keratinocytes in vivo.
    Methods: Within 12 healthy volunteers, 7 received a single 1 standard erythema dose (SED) of NB-UV-B on their whole body, and 5 volunteers received a cumulative dose of 3 SED delivered on two subsequent days i.e., 1+2 SED. Skin biopsies were taken immediately before the first exposure and at 24h from the last UV-B exposure to assess p53, β-END, POMC, and α-MSH expression.
    Results: Nuclear p53 expression increased in all samples taken at 24h after NB-UV-B exposure. UV-B irradiation also increased epidermal β-END expression in 11 out of 12 samples taken at 24h after UV-B exposure. The brownish staining was localized in the cytoplasm of keratinocytes and around the nuclei, being more pronounced in the basal cell layers. POMC and α-MSH staining showed no obvious meaningful increase since only one section of each showed any change compared with basal levels.
    Conclusions: Our study is the first to show that UV-B exposures increase β-END expression in epidermal keratinocytes of human skin in vivo, which could be the link to proposed UVR addiction.
    MeSH term(s) Adult ; Epidermis/metabolism ; Epidermis/pathology ; Epidermis/radiation effects ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Pro-Opiomelanocortin/metabolism ; Skin/metabolism ; Skin/pathology ; Skin/radiation effects ; Tumor Suppressor Protein p53/metabolism ; Ultraviolet Rays ; alpha-MSH/metabolism ; beta-Endorphin/metabolism
    Chemical Substances Tumor Suppressor Protein p53 ; alpha-MSH (581-05-5) ; beta-Endorphin (60617-12-1) ; Pro-Opiomelanocortin (66796-54-1)
    Language English
    Publishing date 2016-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 623022-2
    ISSN 1873-2682 ; 1011-1344
    ISSN (online) 1873-2682
    ISSN 1011-1344
    DOI 10.1016/j.jphotobiol.2016.01.007
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  7. Article ; Online: Circadian Time Effects on NB-UVB-Induced Erythema in Human Skin In Vivo.

    Nikkola, Veera / Grönroos, Mari / Huotari-Orava, Riitta / Kautiainen, Hannu / Ylianttila, Lasse / Karppinen, Toni / Partonen, Timo / Snellman, Erna

    The Journal of investigative dermatology

    2017  Volume 138, Issue 2, Page(s) 464–467

    MeSH term(s) Biopsy ; Circadian Clocks/physiology ; Cryptochromes/metabolism ; DNA Repair/radiation effects ; Dose-Response Relationship, Radiation ; Erythema/etiology ; Erythema/pathology ; Erythema/physiopathology ; Healthy Volunteers ; Humans ; Photoperiod ; Skin/pathology ; Skin/physiopathology ; Skin/radiation effects ; Tumor Suppressor Protein p53/metabolism ; Ultraviolet Rays/adverse effects
    Chemical Substances CRY1 protein, human ; CRY2 protein, human ; Cryptochromes ; TP53 protein, human ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2017-08-24
    Publishing country United States
    Document type Letter
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2017.08.016
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  8. Article ; Online: Cold panniculitis in Finnish horse riders.

    Pekki, Anu / Sauni, Riitta / Vaalasti, Annikki / Toivio, Pauliina / Huotari-Orava, Riitta / Hasan, Taina

    Acta dermato-venereologica

    2011  Volume 91, Issue 4, Page(s) 463–464

    MeSH term(s) Adolescent ; Adult ; Age Factors ; Animals ; Biopsy ; Chi-Square Distribution ; Female ; Finland/epidemiology ; Horses ; Humans ; Logistic Models ; Panniculitis/diagnosis ; Panniculitis/epidemiology ; Panniculitis/etiology ; Prevalence ; Risk Assessment ; Risk Factors ; Sex Factors ; Skin/pathology ; Smoking/adverse effects ; Sports ; Surveys and Questionnaires
    Language English
    Publishing date 2011-06
    Publishing country Sweden
    Document type Letter
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-1081
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  9. Article ; Online: Childhood lichen sclerosus--a challenge for clinicians.

    Lagerstedt, Maria / Karvinen, Kaisa / Joki-Erkkilä, Minna / Huotari-Orava, Riitta / Snellman, Erna / Laasanen, Satu-Leena

    Pediatric dermatology

    2013  Volume 30, Issue 4, Page(s) 444–450

    Abstract: Childhood lichen sclerosus (LS) is a rare and often misdiagnosed inflammatory dermatitis with an unpredictable course. The complications of LS are architectural changes of the vulva; malignant transformation is possible. The objective of our study was to ...

    Abstract Childhood lichen sclerosus (LS) is a rare and often misdiagnosed inflammatory dermatitis with an unpredictable course. The complications of LS are architectural changes of the vulva; malignant transformation is possible. The objective of our study was to define the background and the long-term course of childhood LS. A registery study identified 44 children with LS treated at Tampere University Hospital, Tampere, Finland, from 1982 to 2010. A questionnaire was sent to the identified patients and 15 responded. The clinical depiction of LS varied significantly. LS was diagnosed in only 16% of the patients at the referring unit. Autoimmune disorders were observed in 6 of the 44 patients. High prevalences of Turner's syndrome (2/44) and kidney disease (2/44) were noted. The majority of the patients were treated with topical corticosteroids. Eight developed architectural changes of the vulva. The questionnaire revealed that three of six patients who were asymptomatic at the end of the registery study follow-up experienced a recurrence of symptoms. None of them were undergoing follow-up. Nine of the 15 patients reported reduced quality of life. Childhood LS is a heterogeneous disease with a remarkable effect on quality of life. The misdiagnosis of childhood LS is common. The association between LS and autoimmune diseases should be noted. The high prevalence of Turner's syndrome raises questions regarding the influence of low estrogen levels on the development of LS. The prognosis cannot be predicted, so long-term follow-up is recommended. New tools for diagnosis and surveillance are needed.
    MeSH term(s) Adolescent ; Biopsy ; Child ; Child, Preschool ; Comorbidity ; Dysuria/epidemiology ; Dysuria/pathology ; Female ; Follow-Up Studies ; Humans ; Lichen Sclerosus et Atrophicus/epidemiology ; Lichen Sclerosus et Atrophicus/pathology ; Male ; Prevalence ; Pruritus/epidemiology ; Pruritus/pathology ; Registries/statistics & numerical data ; Vulvar Diseases/epidemiology ; Vulvar Diseases/pathology
    Language English
    Publishing date 2013-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.12109
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