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  1. Article ; Online: Critical Analysis of the Klass-02 Randomized Clinical Trial-Reply.

    Son, Sang-Yong / Hur, Hoon / Han, Sang-Uk

    JAMA surgery

    2023  Volume 158, Issue 5, Page(s) 561–562

    MeSH term(s) Humans ; Stomach Neoplasms/surgery ; Gastrectomy
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Randomized Controlled Trial ; Letter ; Comment
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2022.6914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Splenic hilar lymph node dissection enhances survival in Bormann type 4 gastric cancer.

    Jeong, Oh / Lee, Han Hong / Hur, Hoon / Kim, Hyoung-Il

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 15390

    Abstract: Splenic hilar (no.10) lymph node dissection during total gastrectomy is no longer recommended for advanced proximal gastric cancer. However, the treatment efficacy of no.10 lymph node dissection in Borrmann type 4 tumors remains unclear. We enrolled 539 ... ...

    Abstract Splenic hilar (no.10) lymph node dissection during total gastrectomy is no longer recommended for advanced proximal gastric cancer. However, the treatment efficacy of no.10 lymph node dissection in Borrmann type 4 tumors remains unclear. We enrolled 539 patients who underwent total gastrectomy for Borrmann type 4 tumors between 2006 and 2016 in four major institutions in Korea. We compared the long-term survival of the no.10 lymph node dissection (n = 309) and no-dissection groups (n = 230) using the propensity score (inverse probability of treatment weighting). The treatment effects of no.10 lymph node dissection were estimated in the weighted sample using the Cox proportional hazards regression model with a robust sandwich-type variance estimator. After inverse probability of treatment weighting, there were 540.4 patients in the no.10 lymph node dissection group and 532.7 in the no-dissection group. The two groups showed well-balanced baseline characteristics, including tumor node metastasis stage. The 5-year survival rates in the no.10 lymph node dissection and no-dissection groups were 45.7% and 38.6%, respectively (log-rank p = 0.036, hazard ratio 0.786, 95% confidence interval 0.630-0.982). Multivariate analysis revealed that no.10 lymph node dissection was an independent favorable prognostic factor (adjusted hazard ratio 0.747, 95% confidence interval 0.593-0.940) after adjusting for other prognostic factors. Sensitivity analyses in other inverse probability of treatment weighting models and the propensity score matching model showed similar results. Patients undergoing no.10 lymph node dissection showed improved survival compared to those without. No.10 lymph node dissection is recommended during total gastrectomy for patients with Borrmann type 4 gastric cancer.
    MeSH term(s) Humans ; Stomach Neoplasms/surgery ; Lymph Nodes/surgery ; Dissection ; Lymph Node Excision ; Propensity Score
    Language English
    Publishing date 2023-09-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-42707-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prognostic impacts of participation in prospective surgical clinical trials on surgical outcomes in gastric cancer patients.

    Song, Jeong Ho / Shin, Ho-Jung / Son, Sang-Yong / Hur, Hoon / Han, Sang-Uk

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 14914

    Abstract: Various prospective surgical trials have been conducted on treating patients with gastric cancer. In clinical practice, patients and surgeons may hesitate to participate in prospective surgical trials due to trial-related complications. In this study, we ...

    Abstract Various prospective surgical trials have been conducted on treating patients with gastric cancer. In clinical practice, patients and surgeons may hesitate to participate in prospective surgical trials due to trial-related complications. In this study, we evaluated the effects of participation in prospective surgical trials on surgical outcomes after radical gastrectomy for gastric cancer. This study included 1689 patients who underwent curative gastrectomy for gastric cancer between 2016 and 2020. The propensity score weighting (PSW) method was used to adjust for differences in baseline clinicopathological characteristics between patients who participated and those who did not participate in prospective surgical clinical trials. Perioperative outcomes and overall survival were compared between groups. Of the 1689 patients, 309 (18.3%) participated in surgical clinical trials (SCT group). Before PSW, the SCT group had a similar operation time, intraoperative blood loss, complications, major complications, and hospital stay as the non-SCT group but had superior overall survival. After PSW, overall survival and perioperative outcomes were not significantly different between the groups. The present study suggests that participation in prospective surgical trials was not associated with surgical outcomes. Patients and surgeons may participate in prospective surgical trials without fearing adverse effects on surgical outcomes.
    MeSH term(s) Humans ; Stomach Neoplasms/surgery ; Prognosis ; Prospective Studies ; Surgeons ; Treatment Outcome
    Language English
    Publishing date 2023-09-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-42123-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Prevention of Gallstones After Bariatric Surgery using Ursodeoxycholic Acid: A Narrative Review of Literatures.

    Son, Sang-Yong / Song, Jeong Ho / Shin, Ho-Jung / Hur, Hoon / Han, Sang-Uk

    Journal of metabolic and bariatric surgery

    2023  Volume 11, Issue 2, Page(s) 30–38

    Abstract: Obesity by itself is a factor in the development of gallstone disease, and periods of weight loss after bariatric surgery further increase the risk of gallstone formation. In patients with obesity, hypersecretion of cholesterol may increase the risk of ... ...

    Abstract Obesity by itself is a factor in the development of gallstone disease, and periods of weight loss after bariatric surgery further increase the risk of gallstone formation. In patients with obesity, hypersecretion of cholesterol may increase the risk of gallstone formation, which is approximately five-fold higher than that in the general population. The incidence of gallstone formation after bariatric surgery is 10-38% and often associated with a proportional increase in the risk of developing biliary complications. Routine postoperative administration of ursodeoxycholic acid (UDCA) is recommended to prevent gallstone formation. Several randomized trials have indicated that UDCA can effectively prevent gallstones and reduce the risk of cholecystectomy after bariatric procedures. The effective daily dose of UDCA in each study ranged from 500 to 1,200 mg, and it may be considered at least during the period of rapid weight loss (first 3-6 months postoperatively) to decrease the incidence of symptomatic gallstones.
    Language English
    Publishing date 2023-02-08
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ISSN 2508-5956
    ISSN (online) 2508-5956
    DOI 10.17476/jmbs.2022.11.2.30
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Survival benefit of No. 10 lymphadenectomy with spleen preservation.

    Song, Jeong Ho / Son, Sang-Yong / Hur, Hoon / Han, Sang-Uk

    Translational cancer research

    2022  Volume 11, Issue 9, Page(s) 3015–3016

    Language English
    Publishing date 2022-09-28
    Publishing country China
    Document type Editorial
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr-22-1978
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Articulating laparoscopic instruments: are they a breakthrough that can overcome current limitations in laparoscopic gastric cancer surgery?

    Son, Sang-Yong / Rho, Chul Kyu / Hur, Hoon / Han, Sang-Uk

    Journal of minimally invasive surgery

    2022  Volume 24, Issue 1, Page(s) 5–7

    Abstract: Laparoscopic surgery is rapidly evolving with technological advances, but there are several drawbacks. An articulating device, with freedom of a perfect 360°, is attractive as a solution to overcome the restriction of instrument movement caused by ... ...

    Abstract Laparoscopic surgery is rapidly evolving with technological advances, but there are several drawbacks. An articulating device, with freedom of a perfect 360°, is attractive as a solution to overcome the restriction of instrument movement caused by straight tools. Its usefulness or efficacy should be supported by relevant scientific evidence. However, it is sometimes difficult to prove it because the factors influencing the surgical outcomes are complex and closely related to each other.
    Language English
    Publishing date 2022-05-17
    Publishing country Korea (South)
    Document type Editorial
    ISSN 2234-5248
    ISSN (online) 2234-5248
    DOI 10.7602/jmis.2021.24.1.5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Cancer-Associated Fibroblast-Induced Resistance to Chemotherapy and Radiotherapy in Gastrointestinal Cancers.

    Ham, In-Hye / Lee, Dagyeong / Hur, Hoon

    Cancers

    2021  Volume 13, Issue 5

    Abstract: In the past few decades, the role of cancer-associated fibroblasts (CAFs) in resistance to therapies for gastrointestinal (GI) cancers has emerged. Clinical studies focusing on GI cancers have revealed that the high expression of CAF-related molecules ... ...

    Abstract In the past few decades, the role of cancer-associated fibroblasts (CAFs) in resistance to therapies for gastrointestinal (GI) cancers has emerged. Clinical studies focusing on GI cancers have revealed that the high expression of CAF-related molecules within tumors is significantly correlated with unfavorable therapeutic outcomes; however, the exact mechanisms whereby CAFs enhance resistance to chemotherapy and radiotherapy in GI cancers remain unclear. The cells of origin of CAFs in GI cancers include normal resident fibroblasts, mesenchymal stem cells, endothelial cells, pericytes, and even epithelial cells. CAFs accumulated within GI cancers produce cytokines, chemokines, and growth factors involved in resistance to therapies. CAF-derived exosomes can be engaged in stroma-related resistance to treatments, and several non-coding RNAs, such as miR-92a, miR-106b, CCAL, and H19, are present in CAF-derived exosomes and transferred to GI cancer cells. The CAF-induced desmoplastic reaction interferes with drug delivery to GI cancer cells, evoking resistance to chemotherapy. However, due to the heterogeneity of CAFs in GI cancers, identifying the exact mechanism underlying CAF-induced resistance may be difficult. Recent advancements in single-cell "omics" technologies could offer clues for revealing the specific subtypes and biomarkers related to resistance.
    Language English
    Publishing date 2021-03-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13051172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Effects of deep neuromuscular block on surgical pleth index-guided remifentanil administration in laparoscopic herniorrhaphy: a prospective randomized trial.

    Yi, In Kyong / Kim, Jin-Soo / Hur, Hoon / Han, Do-Gyun / Kim, Ji Eun

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 19176

    Abstract: Deep neuromuscular block (NMB) has been increasingly utilized, but its role in reducing intraoperative opioid requirement has yet to be investigated. Surgical pleth index (SPI) quantifies nociception. We investigated the effects of deep NMB on SPI-guided ...

    Abstract Deep neuromuscular block (NMB) has been increasingly utilized, but its role in reducing intraoperative opioid requirement has yet to be investigated. Surgical pleth index (SPI) quantifies nociception. We investigated the effects of deep NMB on SPI-guided remifentanil administration in laparoscopic herniorrhaphy. Total 128 patients undergoing laparoscopic inguinal herniorrhaphy were randomly allocated to two groups of NMB: deep (n = 64) and moderate (n = 64). The remifentanil dose was assessed during intubation, from skin incision until CO
    MeSH term(s) Humans ; Remifentanil ; Neuromuscular Blockade ; Herniorrhaphy ; Pneumoperitoneum ; Prospective Studies ; Laparoscopy
    Chemical Substances Remifentanil (P10582JYYK)
    Language English
    Publishing date 2022-11-10
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-23876-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Does bisphenol-A affect alteration of gut microbiome after bariatric/metabolic surgery?: a comparative metagenomic analysis in a long-term high-fat diet induced-obesity rat model.

    Son, Sang-Yong / Wang, Bo / Hur, Hoon / Kim, Hyung-Ho / Han, Sang-Uk

    Annals of surgical treatment and research

    2022  Volume 102, Issue 6, Page(s) 342–352

    Abstract: Purpose: Bisphenol A (BPA) is a widely used environmental contaminant that is associated with type 2 diabetes mellitus and a shift of gut microbial community. However, little is known about the influence of BPA on gut microbial changes related to ... ...

    Abstract Purpose: Bisphenol A (BPA) is a widely used environmental contaminant that is associated with type 2 diabetes mellitus and a shift of gut microbial community. However, little is known about the influence of BPA on gut microbial changes related to bariatric surgery. We investigated whether long-term exposure to dietary BPA causing alterations of gut microbiome occurred after bariatric surgery.
    Methods: Six-week-old male Wistar rats were fed either a high-fat diet (HFD) or HFD + BPA for 40 weeks. Then sleeve gastrectomy (SG) or Roux-en Y gastric bypass (RYGB) was performed in each diet group and observed for 12 weeks postoperatively. Fecal samples were collected at the 40th weeks and 12th postoperative weeks. Using 16S ribosomal RNA gene sequencing analysis on fecal samples, a comparative metagenomic analysis on gut microbiome composition was performed.
    Results: Long-term exposure to HFD with BPA showed higher body weight change and higher level of fasting blood sugar after 40 weeks-diet challenge than those of the HFD only group. After bariatric surgeries, mean body weight of the HFD with BPA group was significantly higher than the HFD only group, but there was no difference between the SG and RYGB groups. The metagenomic analyses demonstrated that long-term exposure to dietary BPA did not affect significant alterations of gut microbiome before and after bariatric surgery, compared with the HFD groups.
    Conclusion: Our results highlighted that BPA was a risk factor for obesity and may contribute to glucose intolerance, but it did not affect alterations of gut microbiome after bariatric/metabolic surgery.
    Language English
    Publishing date 2022-06-07
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3012234-X
    ISSN 2288-6796 ; 2288-6575
    ISSN (online) 2288-6796
    ISSN 2288-6575
    DOI 10.4174/astr.2022.102.6.342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Secondary Primary Cancer after Primary Gastric Cancer: Literature Review and Big Data Analysis Using the Health Insurance Review and Assessment Service (HIRA) Database of Republic of Korea.

    Song, Jeong Ho / Lee, Yeonkyoung / Heo, Jaesung / Son, Sang-Yong / Hur, Hoon / Han, Sang-Uk

    Cancers

    2022  Volume 14, Issue 24

    Abstract: Advances in cancer screening and early detection, as well as improvements in surgical techniques and therapeutics, have contributed to decreasing gastric cancer mortality. The number of gastric cancer survivors continues to rise; however, long-term ... ...

    Abstract Advances in cancer screening and early detection, as well as improvements in surgical techniques and therapeutics, have contributed to decreasing gastric cancer mortality. The number of gastric cancer survivors continues to rise; however, long-term follow-up has revealed an increase in the risk of post-gastrectomy symptoms or other health problems, such as extra-gastric secondary primary cancer (SPC), in these survivors. Therefore, evidence-based screening for new primary cancer is needed in these populations; however, the incidence of SPC varies by country or continent and its characteristics have not been clearly reported. The characteristics of SPC are of increasing interest to both treatment providers and gastric cancer survivors; thus, this literature review explores not only the epidemiology and biology of SPC but also clinical and biological factors that influence its prognosis.
    Language English
    Publishing date 2022-12-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14246165
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