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  1. Article ; Online: New Diagnostic Criteria for Gestational Diabetes Mellitus and Pregnancy Outcomes in Korea.

    Hur, Kyu Yeon

    Diabetes & metabolism journal

    2020  Volume 43, Issue 6, Page(s) 763–765

    MeSH term(s) Diabetes, Gestational ; Female ; Glucose Tolerance Test ; Humans ; Pregnancy ; Pregnancy Outcome ; Republic of Korea
    Language English
    Publishing date 2020-01-02
    Publishing country Korea (South)
    Document type Editorial ; Comment
    ZDB-ID 2602402-0
    ISSN 2233-6087 ; 2233-6079
    ISSN (online) 2233-6087
    ISSN 2233-6079
    DOI 10.4093/dmj.2019.0247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A randomized controlled trial of an app-based intervention on physical activity and glycemic control in people with type 2 diabetes.

    Kim, Gyuri / Kim, Seohyun / Lee, You-Bin / Jin, Sang-Man / Hur, Kyu Yeon / Kim, Jae Hyeon

    BMC medicine

    2024  Volume 22, Issue 1, Page(s) 185

    Abstract: Background: We investigated the effects of a physical activity encouragement intervention based on a smartphone personal health record (PHR) application (app) on step count increases, glycemic control, and body weight in patients with type 2 diabetes ( ... ...

    Abstract Background: We investigated the effects of a physical activity encouragement intervention based on a smartphone personal health record (PHR) application (app) on step count increases, glycemic control, and body weight in patients with type 2 diabetes (T2D).
    Methods: In this 12-week, single-center, randomized controlled, 12-week extension study, patients with T2D who were overweight or obese were randomized using ratio 1:2 to a group using a smartphone PHR app (control group) or group using the app and received individualized motivational text messages (intervention group) for 12 weeks. During the extension period, the sending of the encouraging text messages to the intervention group was discontinued. The primary outcome was a change in daily step count after 12 weeks and analyzed by independent t-test. The secondary outcomes included HbA1c, fasting glucose, and body weight analyzed by paired or independent t-test.
    Results: Of 200 participants, 62 (93.9%) and 118 (88.1%) in the control and intervention group, respectively, completed the 12-week main study. The change in daily step count from baseline to week 12 was not significantly different between the two groups (P = 0.365). Among participants with baseline step counts < 7,500 steps per day, the change in the mean daily step count at week 12 in the intervention group (1,319 ± 3,020) was significantly larger than that in control group (-139 ± 2,309) (P = 0.009). At week 12, HbA1c in the intervention group (6.7 ± 0.5%) was significantly lower than that in control group (6.9 ± 0.6%, P = 0.041) and at week 24, changes in HbA1c from baseline were significant in both groups but, comparable between groups. Decrease in HbA1c from baseline to week 12 of intervention group was greater in participants with baseline HbA1c ≥ 7.5% (-0.81 ± 0.84%) compared with those with baseline HbA1c < 7.5% (-0.22 ± 0.39%) (P for interaction = 0.014). A significant reduction in body weight from baseline to week 24 was observed in both groups without significant between-group differences (P = 0.370).
    Conclusions: App-based individualized motivational intervention for physical activity did not increase daily step count from baseline to week 12, and the changes in HbA1c levels from baseline to week 12 were comparable.
    Trial registration: ClinicalTrials.gov (NCT03407222).
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/therapy ; Male ; Middle Aged ; Female ; Glycemic Control/methods ; Mobile Applications ; Aged ; Exercise/physiology ; Adult ; Blood Glucose/metabolism ; Glycated Hemoglobin/metabolism ; Glycated Hemoglobin/analysis ; Body Weight/physiology ; Smartphone ; Text Messaging
    Chemical Substances Blood Glucose ; Glycated Hemoglobin
    Language English
    Publishing date 2024-05-01
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2131669-7
    ISSN 1741-7015 ; 1741-7015
    ISSN (online) 1741-7015
    ISSN 1741-7015
    DOI 10.1186/s12916-024-03408-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Lysosomal Ca

    Oh, Soo-Jin / Hwang, Yeseong / Hur, Kyu Yeon / Lee, Myung-Shik

    Cell death discovery

    2023  Volume 9, Issue 1, Page(s) 100

    Abstract: While the mechanism of lipotoxicity by palmitic acid (PA), an effector of metabolic stress in vitro and in vivo, has been extensively investigated, molecular details of lipotoxicity are still not fully characterized. Since recent studies reported that PA ...

    Abstract While the mechanism of lipotoxicity by palmitic acid (PA), an effector of metabolic stress in vitro and in vivo, has been extensively investigated, molecular details of lipotoxicity are still not fully characterized. Since recent studies reported that PA can exert lysosomal stress in addition to well-known ER and mitochondrial stress, we studied the role of lysosomal events in lipotoxicity by PA, focusing on lysosomal Ca
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article
    ISSN 2058-7716
    ISSN 2058-7716
    DOI 10.1038/s41420-023-01379-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Safety and Effectiveness of Dulaglutide in the Treatment of Type 2 Diabetes Mellitus: A Korean Real-World Post-Marketing Study.

    Han, Jeonghee / Lee, Woo Je / Hur, Kyu Yeon / Cho, Jae Hyoung / Lee, Byung Wan / Park, Cheol-Young

    Diabetes & metabolism journal

    2024  

    Abstract: Background: To investigate the real-world safety and effectiveness of dulaglutide in Korean adults with type 2 diabetes mellitus (T2DM).: Methods: This was a real-world, prospective, non-interventional post-marketing safety study conducted from May ... ...

    Abstract Background: To investigate the real-world safety and effectiveness of dulaglutide in Korean adults with type 2 diabetes mellitus (T2DM).
    Methods: This was a real-world, prospective, non-interventional post-marketing safety study conducted from May 26, 2015 to May 25, 2021 at 85 Korean healthcare centers using electronic case data. Data on patients using dulaglutide 0.75 mg/0.5 mL or the dulaglutide 1.5 mg/0.5 mL single-use pens were collected and pooled. The primary objective was to report the frequency and proportion of adverse and serious adverse events that occurred. The secondary objective was to monitor the effectiveness of dulaglutide at 12 and 24 weeks by evaluating changes in glycosylated hemoglobin (HbA1c ), fasting plasma glucose, and body weight.
    Results: Data were collected from 3,067 subjects, and 3,022 subjects who received ≥1 dose (of any strength) of dulaglutide were included in the safety analysis set (53% female, mean age 56 years; diabetes duration 11.2 years, mean HbA1c 8.8%). The number of adverse events reported was 819; of these, 68 (8.3%) were serious adverse events. One death was reported. Adverse events were mostly mild in severity; 60.81% of adverse events were considered related to dulaglutide. This study was completed by 72.73% (2,198/3,022) of subjects. At 12/24 weeks there were significant (P<0.0001) reductions from baseline in least-squares mean HbA1c (0.96%/0.95%), fasting blood glucose (26.24/24.43 mg/dL), and body weight (0.75/1.21 kg).
    Conclusion: Dulaglutide was generally well tolerated and effective in real-world Korean individuals with T2DM. The results from this study contribute to the body of evidence for dulaglutide use in this population.
    Language English
    Publishing date 2024-02-02
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2602402-0
    ISSN 2233-6087 ; 2233-6087
    ISSN (online) 2233-6087
    ISSN 2233-6087
    DOI 10.4093/dmj.2023.0030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Multicenter, Randomized, Open-Label Study to Compare the Effects of Gemigliptin Add-on or Escalation of Metformin Dose on Glycemic Control and Safety in Patients with Inadequately Controlled Type 2 Diabetes Mellitus Treated with Metformin and SGLT-2 Inhibitors (SO GOOD Study).

    Kim, Hae Jin / Noh, Jung Hyun / Moon, Min Kyong / Choi, Sung Hee / Ko, Seung-Hyun / Rhee, Eun-Jung / Hur, Kyu Yeon / Jeong, In-Kyung

    Journal of diabetes research

    2024  Volume 2024, Page(s) 8915591

    Abstract: Background: We aimed to compare efficacy and safety between gemigliptin add-on and escalation of the metformin dose in patients with inadequately controlled type 2 diabetes mellitus (T2DM) despite treatment with metformin and SGLT2 inhibitors.: ... ...

    Abstract Background: We aimed to compare efficacy and safety between gemigliptin add-on and escalation of the metformin dose in patients with inadequately controlled type 2 diabetes mellitus (T2DM) despite treatment with metformin and SGLT2 inhibitors.
    Methods: This study was a multicenter, randomized, open-label, active-controlled, parallel-group comparative study. Patients with T2DM uncontrolled on metformin and SGLT2 inhibitors were randomized to receive gemigliptin 50 mg as an add-on (GEM group,
    Results: At weeks 12 and 24, the reduction in HbA1c levels was significantly greater in the GEM group than in the MET group (GEM vs. MET = -0.64% ± 0.34% vs. -0.36% ± 0.50%,
    Conclusions: Gemigliptin add-on therapy may be more effective than metformin dose escalation in patients with T2DM insufficiently controlled using metformin and SGLT2 inhibitors, without safety concerns. This trial is registered with CRIS_number: KCT0003520.
    MeSH term(s) Humans ; Blood Glucose ; Diabetes Mellitus, Type 2/drug therapy ; Double-Blind Method ; Drug Therapy, Combination ; Glycated Hemoglobin ; Glycemic Control ; Hypoglycemic Agents/administration & dosage ; Metformin/administration & dosage ; Piperidones ; Pyrimidines ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Treatment Outcome
    Chemical Substances Blood Glucose ; Glycated Hemoglobin ; Hypoglycemic Agents ; LC15-0444 ; Metformin (9100L32L2N) ; Piperidones ; Pyrimidines ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ZDB-ID 2711897-6
    ISSN 2314-6753 ; 2314-6753
    ISSN (online) 2314-6753
    ISSN 2314-6753
    DOI 10.1155/2024/8915591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Is GDF15 a Novel Biomarker to Predict the Development of Prediabetes or Diabetes?

    Hur, Kyu Yeon

    Diabetes & metabolism journal

    2014  Volume 38, Issue 6, Page(s) 437–438

    Language English
    Publishing date 2014-12
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2602402-0
    ISSN 2233-6087 ; 2233-6079
    ISSN (online) 2233-6087
    ISSN 2233-6079
    DOI 10.4093/dmj.2014.38.6.437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Correction: Mitochondrial event as an ultimate step in ferroptosis.

    Oh, Soo-Jin / Ikeda, Masataka / Ide, Tomomi / Hur, Kyu Yeon / Lee, Myung-Shik

    Cell death discovery

    2022  Volume 8, Issue 1, Page(s) 422

    Language English
    Publishing date 2022-10-20
    Publishing country United States
    Document type Published Erratum
    ISSN 2058-7716
    ISSN 2058-7716
    DOI 10.1038/s41420-022-01223-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Influence of Pre-Pregnancy Underweight Body Mass Index on Fetal Abdominal Circumference, Estimated Weight, and Pregnancy Outcomes in Gestational Diabetes Mellitus.

    Kim, Minji / Hur, Kyu-Yeon / Choi, Suk-Joo / Oh, Soo-Young / Roh, Cheong-Rae

    Diabetes & metabolism journal

    2022  Volume 46, Issue 3, Page(s) 499–505

    Abstract: This study aimed to determine the influence of pre-pregnancy body mass index on pregnancy outcomes in gestational diabetes mellitus (GDM), comparing underweight patients with GDM with normal weight patients with GDM. Maternal baseline characteristics, ... ...

    Abstract This study aimed to determine the influence of pre-pregnancy body mass index on pregnancy outcomes in gestational diabetes mellitus (GDM), comparing underweight patients with GDM with normal weight patients with GDM. Maternal baseline characteristics, ultrasonographic results, and pregnancy and neonatal outcomes were reviewed in 946 women with GDM with singleton pregnancies. Underweight patients with GDM showed a benign course in most aspects during pregnancy, except for developing a higher risk of giving birth to small for gestational age neonates. Underweight women with GDM required less insulin treatment, had a higher rate of vaginal delivery, and had a lower rate of cesarean delivery. In addition, their neonates were more likely to have fetal abdominal circumference and estimated fetal weight below the 10th percentile both at the time of GDM diagnosis and before delivery. Notably, their risk for preeclampsia and macrosomia were lower. Collectively, our data suggest that underweight women with GDM may require a different approach in terms of diagnosis and management throughout their pregnancy.
    MeSH term(s) Body Mass Index ; Diabetes, Gestational/diagnosis ; Female ; Fetal Macrosomia/epidemiology ; Humans ; Infant, Newborn ; Pregnancy ; Pregnancy Outcome ; Thinness/complications
    Language English
    Publishing date 2022-01-24
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2602402-0
    ISSN 2233-6087 ; 2233-6087
    ISSN (online) 2233-6087
    ISSN 2233-6087
    DOI 10.4093/dmj.2021.0059
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  9. Article: Mitochondrial event as an ultimate step in ferroptosis.

    Oh, Soo-Jin / Ikeda, Masataka / Ide, Tomomi / Hur, Kyu Yeon / Lee, Myung-Shik

    Cell death discovery

    2022  Volume 8, Issue 1, Page(s) 414

    Abstract: In ferroptosis, the roles of mitochondria have been controversial. To explore the role of mitochondrial events in ferroptosis, we employed mitochondrial DNA-depleted ... ...

    Abstract In ferroptosis, the roles of mitochondria have been controversial. To explore the role of mitochondrial events in ferroptosis, we employed mitochondrial DNA-depleted ρ
    Language English
    Publishing date 2022-10-08
    Publishing country United States
    Document type Journal Article
    ISSN 2058-7716
    ISSN 2058-7716
    DOI 10.1038/s41420-022-01199-8
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  10. Article: Impact of continuous glucose monitoring on glycemic control and its derived metrics in type 1 diabetes: a longitudinal study.

    Cho, So Hyun / Kim, Seohyun / Lee, You-Bin / Jin, Sang-Man / Hur, Kyu Yeon / Kim, Gyuri / Kim, Jae Hyeon

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1165471

    Abstract: Aim: We explored the effectiveness of continuous glucose monitoring for 1 year on glycated A1c reduction in adults with type 1 diabetes mellitus.: Methods: We included type 1 diabetes mellitus adults who were either new continuous glucose monitoring ... ...

    Abstract Aim: We explored the effectiveness of continuous glucose monitoring for 1 year on glycated A1c reduction in adults with type 1 diabetes mellitus.
    Methods: We included type 1 diabetes mellitus adults who were either new continuous glucose monitoring users (
    Results: The change in glycated A1c from baseline to 12 months was -0.5% ± 1.0% for the continuous glucose monitoring user group (
    Conclusion: In this longitudinal study of type 1 diabetes mellitus adults, the use of continuous glucose monitoring for 1 year showed a significant reduction in glycated A1c in real-world practice.
    MeSH term(s) Adult ; Humans ; Diabetes Mellitus, Type 1/therapy ; Blood Glucose ; Hypoglycemic Agents ; Glycated Hemoglobin ; Hypoglycemia ; Blood Glucose Self-Monitoring ; Longitudinal Studies ; Glycemic Control
    Chemical Substances Blood Glucose ; Hypoglycemic Agents ; Glycated Hemoglobin
    Language English
    Publishing date 2023-05-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1165471
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