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  1. Article ; Online: The Effect of Nonstress Device Noise Level on Stress Parameters in Primigravid Women: A Randomized Controlled Trial.

    Ayşenur, Turan / Nuran, Gençtürk / Cihan, Kaya / Huri, Bulut

    Journal of midwifery & women's health

    2024  Volume 69, Issue 2, Page(s) 279–286

    Abstract: Introduction: This study evaluated the effect of the noise level of the nonstress test (NST) device on stress parameters in primigravid women.: Methods: A total of 44 pregnant women participated in a randomized clinical trial between February and ... ...

    Abstract Introduction: This study evaluated the effect of the noise level of the nonstress test (NST) device on stress parameters in primigravid women.
    Methods: A total of 44 pregnant women participated in a randomized clinical trial between February and October, 2021. The participants were divided randomly into 4 equal groups using an automated web-based randomization system and ensuring allocation concealment: the control group (NST device volume turned off), intervention group I (1-35 dB(A)), intervention group II (36-60 dB(A)), and intervention group III (61 dB(A) and above). A data collection form was used to record personal information and stress parameters. Stress parameters (blood pressure, heart rate, oxygen saturation [SpO
    Results: NST sound levels above 35 dB(A) increased the average cortisol and ACTH levels in the posttest. NST sound levels were positively correlated with posttest cortisol (r = .448) and posttest glucose (r = .302). There was interaction effect on heart rate, glucose, and cortisol level by time, indicating that the intervention groups experienced a significant acceleration in heart rate, glucose, and cortisol level after a noise intervention compared with the control group.
    Discussion: Midwives should continue applying NST below 36 dB(A), considering the factors that may induce stress during the NST process.
    MeSH term(s) Humans ; Pregnancy ; Female ; Hydrocortisone ; Blood Glucose ; Glucose ; Adrenocorticotropic Hormone
    Chemical Substances Hydrocortisone (WI4X0X7BPJ) ; Blood Glucose ; Glucose (IY9XDZ35W2) ; Adrenocorticotropic Hormone (9002-60-2)
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2008180-7
    ISSN 1542-2011 ; 1526-9523
    ISSN (online) 1542-2011
    ISSN 1526-9523
    DOI 10.1111/jmwh.13581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Protective effect of resveratrol on the kidney in rats under immunosuppression with tacrolimus

    Asuman Kilitci / Huri Bulut / Gökhan Karaca / Yaşar Şahin / Muhammed Gömeç / Hüseyin Özden

    Journal of Surgery and Medicine, Vol 5, Iss 2, Pp 144-

    2021  Volume 148

    Abstract: Background/Aim: Tacrolimus is a commonly used agent for immunosuppression in organ transplantation with known nephrotoxic effects. We think that kidney-sparing therapy should be added to current treatment protocols. We aimed to observe the protective ... ...

    Abstract Background/Aim: Tacrolimus is a commonly used agent for immunosuppression in organ transplantation with known nephrotoxic effects. We think that kidney-sparing therapy should be added to current treatment protocols. We aimed to observe the protective effect of resveratrol (RSV) against the adverse effects of tacrolimus (TAC) on rat kidneys. Methods: Twenty-four rats were randomly divided into the following three groups of eight rats each: Control, TAC, and RSV. The control group was not treated in any way. Tacrolimus was administered to the TAC group. In addition to tacrolimus use, resveratrol was administered to the RSV group. At the end of the experiment, one kidney was used for histopathological examination and the other, for biochemical examination. Results were analyzed statistically. Results: IL-1β, IL-6, TNF-Alpha levels in the control group were significantly lower than those in TAC and RSV groups (IL-1; P<0.001, P<0.001, IL-6; P<0.001 P=0.002, TNF-Alpha; P<0.001, P<0.001), and those in the RSV group were significantly lower than those in the TAC group (IL-1: P=0.032, IL-6: P=0.001 TNF-Alpha: P=0.026). TAS levels of the control group were significantly higher than those of the TAC group (P=0.030). TOS and OSI levels of the control group were significantly lower than those of the TAC and RSV groups (TOS: P=0.002, P=0.012, OSI: P=0.001, P=0.004). In histopathological evaluation, the TAC group showed the highest levels of fibrosis. The differences between the control and TAC groups and the TAC and RSV groups were statistically significant (P=0.003, P=0.003). Conclusion: Resveratrol has a protective effect against the adverse effects of tacrolimus on the kidney, which may be because of its anti-inflammatory and antioxidant properties.
    Keywords anti-inflammatory ; antioxidant ; immunosuppression ; resveratrol ; tacrolimus ; Medicine ; R ; Medicine (General) ; R5-920 ; Surgery ; RD1-811
    Subject code 630
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Journal of Surgery and Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The Healing Effects of The Topical Mesenchymal Stem Cells Application on Colonic Anastomosis Subjected to Ischemia Reperfusion Injury

    Hüseyin ÖZDEN / Gökhan KARACA / Huri BULUT / Mehmet NİYAZ / Muhammed GÖMEÇ / Çağatay E. DAPHAN

    Kafkas Universitesi Veteriner Fakultesi Dergisi, Vol 27, Iss 5, Pp 595-

    2021  Volume 600

    Abstract: Intestinal ischemia reperfusion injury (IRI) is a challenging problem and it adversely affects the healing of colonic anastomosis. Our experimental study aimed to investigate the role of mesenchymal stem cells (MSC) administration in the healing of ... ...

    Abstract Intestinal ischemia reperfusion injury (IRI) is a challenging problem and it adversely affects the healing of colonic anastomosis. Our experimental study aimed to investigate the role of mesenchymal stem cells (MSC) administration in the healing of colonic anastomosis. A total of 33 rats were grouped as Control, IRI and MSC treatment groups. Three rats were reserved for obtaining MSCs. Colonic resection and anastomosis procedure was performed in all groups. Anastomotic line was wrapped with MSCs impregnated spongostan after colonic anastomosis in the rats of the MSC treatment group. All rats were sacrificed and anastomotic line were sampled for examination on the post operative seventh day. Tissue hydroxyproline (HP) levels and anastomotic bursting pressures were statistically compared. Anastomotic bursting pressures were found to be significantly high in MSC treatment group rats. The lowest anastomotic bursting pressure was detected in IRI group rats. Hydroxyproline content of the anastomotic sites were also found to be significantly higher in the rats of the MSC treatment group when compared with the IRI group rats. Our study showed that the detrimental effects of IRI on the healing process of colonic anastomosis in an experimental model may be alleviated with the treatment of MSCs.
    Keywords anastomotic leakage ; colonic anastomosis ; hydroxyproline ; i̇schemia reperfusion injury ; mesenchymal stem cell ; Veterinary medicine ; SF600-1100
    Subject code 630 ; 610
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher University of Kafkas
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A low direct electrical signal attenuates oxidative stress and inflammation in septic rats.

    Savas Ustunova / Ebru Haciosmanoglu / Huri Bulut / Birsen Elibol / Aysu Kilic / Rumeysa Hekimoglu / Serkan Tunc / Rabia Atmaca / Irem Kaygusuz / Sevil Tunc / Gulcin Beyza Tunc / Ismail Meral

    PLoS ONE, Vol 16, Iss 9, p e

    2021  Volume 0257177

    Abstract: Electrical stimulation is proposed to exert an antimicrobial effect according to studies performed using bacterial and cell cultures. Therefore, we investigated the effects of electrification on inflammation in septic rats. Twenty-eight male Wistar ... ...

    Abstract Electrical stimulation is proposed to exert an antimicrobial effect according to studies performed using bacterial and cell cultures. Therefore, we investigated the effects of electrification on inflammation in septic rats. Twenty-eight male Wistar albino rats were divided into 4 groups: healthy control (C), electrified healthy (E), sepsis (S), and electrified sepsis (SE) groups. Staphylococcus aureus (1 x 109 colonies) in 1 ml of medium was intraperitoneally injected into rats to produce a sepsis model. The rats in the E and SE groups were exposed to a low direct electrical signal (300 Hz and 2.5 volts) for 40 min and 1 and 6 h after bacterial infection. Immediately after the second electrical signal application, blood and tissue samples of the heart, lung, and liver were collected. An antibacterial effect of a low direct electrical signal was observed in the blood of rats. The effects of electrical signals on ameliorating changes in the histological structure of tissues, blood pH, gases, viscosity and cell count, activities of some important enzymes, oxidative stress parameters, inflammation and tissue apoptosis were observed in the SE group compared to the S group. Low direct electrical signal application exerts antibacterial, antioxidant, anti-inflammatory and antiapoptotic effects on septic rats due to the induction of electrolysis in body fluids without producing any tissue damage.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Healing of Ischemic Colon Anastomosis in Rats Could Be Provided by Administering Dexpanthenol or Coenzyme Q10

    Faruk Pehlivanlı / Oktay Aydin / Gökhan Karaca / Gülçin Aydin / Tuba Devrim / Huri Bulut / Bülent Bakar / Çağatay Erden Daphan

    Journal of Clinical Medicine, Vol 7, Iss 7, p

    2018  Volume 161

    Abstract: Background: In this study, the effectiveness of dexpanthenol and coenzyme Q10 (CoQ10) on the healing of ischemic colon anastomosis was investigated. Methods: Forty eight male Wistar Albino rats were divided into four equal groups (Sham-S, Sham-I, DXP, ... ...

    Abstract Background: In this study, the effectiveness of dexpanthenol and coenzyme Q10 (CoQ10) on the healing of ischemic colon anastomosis was investigated. Methods: Forty eight male Wistar Albino rats were divided into four equal groups (Sham-S, Sham-I, DXP, Q10). Following full layer colon resection, single layer colon anastomosis, without creating ischemia, was performed on the Sham-S group. The same experimental model was performed on remaining groups after ischemia was created. Intraperitoneal dexpanthenol and CoQ10 was administered to the DXP and Q10 groups once a day for three days. Ten days later, all colon anastomoses were investigated histopathologically and biochemically, as well as their burst pressure values, in all sacrificed rats. Results: The highest burst pressure value was observed in the Sham-S group, decreasing from high to low in the DXP, Q10, and Sham-I groups, respectively (p = 0.008). Furthermore, tissue hydroxyproline (p = 0.001) level values were significantly different among the groups. Additionally, histopathological analysis revealed a significant difference among groups regarding reepithelization (p = 0.027) and polymorphonuclear leukocyte density (p = 0.022). Conclusions: This preliminary study has shown that ischemia-reperfusion injury may impair the healing of colon anastomosis and it has been concluded that dexpanthenol and CoQ10 may have positive effects on the healing of ischemic colon anastomosis in rat, although re-epithelization may be adversely affected using CoQ10.
    Keywords dexpanthenol ; Coenzyme coenzyme Q10 ; anastomosis ; colon ; ischemia ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2018-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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