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  1. Article ; Online: Mediators of socioeconomic differences in overweight and obesity among youth in Ireland and the UK (2011-2021): a systematic review.

    Cronin, Frances M / Hurley, Sinead M / Buckley, Thomas / Mancebo Guinea Arquez, Delfina / Lakshmanan, Naeha / O'Gorman, Alice / Layte, Richard / Stanistreet, Debbi

    BMC public health

    2022  Volume 22, Issue 1, Page(s) 1585

    Abstract: Background: By 2025, adult obesity prevalence is projected to increase in 44 of 53 of European-region countries. Childhood obesity tracks directly onto adult obesity, and children of low socioeconomic position families are at disproportionately higher ... ...

    Abstract Background: By 2025, adult obesity prevalence is projected to increase in 44 of 53 of European-region countries. Childhood obesity tracks directly onto adult obesity, and children of low socioeconomic position families are at disproportionately higher risk of being obese compared with their more affluent peers. A previous review of research from developed countries identified factors mediating this relationship. This systematic review updates and extends those findings specifically within the context of Ireland and the United Kingdom.
    Objective: The aim of this systematic review is to summarise peer-reviewed research completed in Ireland and the United Kingdom between 2011-2021 examining mediators of socioeconomic differentials in adiposity outcomes for youth.
    Design: An electronic search of four databases, Ovid MEDLINE, Embase, Web of Science and EBSCOhost was conducted. Quantitative studies, published in the English language, examining mediators of socioeconomic differentials in adiposity outcomes in youth, and conducted in Ireland and the United Kingdom between 2011-2021 were included. An appraisal of study quality was completed. The systematic review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
    Results: Following screening, a total of 23 papers were eligible for inclusion. Results indicate socioeconomic differentials for Ireland and the United Kingdom follow similar patterns to other developed countries and have similar mediating factors including early life and parent-level factors. However, this review identified additional factors that mediate the relationship, namely access to green space and favorable neighborhood conditions. Identifying these factors present further opportunities for potential interventions and confirm the requirement for tailored and appropriate research and interventions for Ireland and the United Kingdom.
    Conclusion: This review identified several modifiable factors that should be considered when planning interventions aimed at reducing socioeconomic differentials in adiposity among youth in Ireland and the United Kingdom. Support was found for interventions to be made as early as possible in an at-risk child's life, with the prenatal and preschool periods considered the most efficacious. Results were equivocal about the role of physical activity in the risk of childhood overweight and obesity. While multi-country analyses provide excellent overviews, country- or area-specific research may produce more nuanced, and potentially more powerful findings, which can help better inform policy responses and interventions.
    MeSH term(s) Adolescent ; Adult ; Child ; Child, Preschool ; Educational Status ; Exercise ; Female ; Humans ; Ireland/epidemiology ; Overweight/epidemiology ; Pediatric Obesity/epidemiology ; Pregnancy
    Language English
    Publishing date 2022-08-20
    Publishing country England
    Document type Journal Article ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-022-14004-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Dynamics of Platelet Activation during the Progression of Streptococcal Sepsis.

    Hurley, Sinead M / Lutay, Nataliya / Holmqvist, Bo / Shannon, Oonagh

    PloS one

    2016  Volume 11, Issue 9, Page(s) e0163531

    Abstract: Platelets contribute to inflammation however, the role of platelet activation during the pathophysiological response to invasive bacterial infection and sepsis is not clear. Herein, we have investigated platelet activation in a mouse model of invasive ... ...

    Abstract Platelets contribute to inflammation however, the role of platelet activation during the pathophysiological response to invasive bacterial infection and sepsis is not clear. Herein, we have investigated platelet activation in a mouse model of invasive Streptococcus pyogenes infection at 5, 12, and 18 hours post infection and correlated this to parameters of infection. The platelet population in ex-vivo blood samples showed no increased integrin activation or surface presentation of CD62P, however platelet-neutrophil complex formation and plasma levels of CD62P were increased during bacterial dissemination and the progression of sepsis, indicating that platelet activation had occurred in vivo. Platelet-neutrophil complex formation was the most discriminatory marker of platelet activation. Platelet-neutrophil complexes were increased above baseline levels during early sepsis but decreased to significantly lower levels than baseline during late sepsis. The removal of these complexes from the circulation coincided with a significant increase in organ damage and the accumulation of platelets in the liver sinusoids, suggesting that platelet activation in the circulation precedes accumulation of platelets in damaged organs. The results demonstrate that monitoring platelet activation using complementary methods may provide prognostic information during the pathogenesis of invasive S. pyogenes infection.
    Language English
    Publishing date 2016-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0163531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Platelet-Dependent Neutrophil Function Is Dysregulated by M Protein from Streptococcus pyogenes.

    Hurley, Sinéad M / Kahn, Fredrik / Nordenfelt, Pontus / Mörgelin, Matthias / Sørensen, Ole E / Shannon, Oonagh

    Infection and immunity

    2015  Volume 83, Issue 9, Page(s) 3515–3525

    Abstract: Platelets are rapidly responsive sentinel cells that patrol the bloodstream and contribute to the host response to infection. Platelets have been reported to form heterotypic aggregates with leukocytes and may modulate their function. Here, we have ... ...

    Abstract Platelets are rapidly responsive sentinel cells that patrol the bloodstream and contribute to the host response to infection. Platelets have been reported to form heterotypic aggregates with leukocytes and may modulate their function. Here, we have investigated platelet-neutrophil complex formation and neutrophil function in response to distinct agonists. The endogenous platelet activator thrombin gave rise to platelet-dependent neutrophil activation, resulting in enhanced phagocytosis and bacterial killing. Streptococcus pyogenes is an important causative agent of severe infectious disease, which can manifest as sepsis and septic shock. M1 protein from S. pyogenes also mediated platelet-neutrophil complex formation; however, these neutrophils were dysfunctional and exhibited diminished chemotactic ability and bacterial killing. This reveals an important agonist-dependent neutrophil dysfunction during platelet-neutrophil complex formation and highlights the role of platelets during the immune response to streptococcal infection.
    MeSH term(s) Adult ; Antigens, Bacterial/immunology ; Antigens, Bacterial/metabolism ; Bacterial Outer Membrane Proteins/immunology ; Bacterial Outer Membrane Proteins/metabolism ; Blood Platelets/immunology ; Carrier Proteins/immunology ; Carrier Proteins/metabolism ; Enzyme-Linked Immunosorbent Assay ; Female ; Flow Cytometry ; Humans ; Male ; Microscopy, Electron, Scanning ; Microscopy, Fluorescence ; Neutrophil Activation/immunology ; Neutrophils/immunology ; Phagocytosis ; Platelet Activation/immunology ; Streptococcal Infections/immunology ; Streptococcal Infections/metabolism ; Streptococcus pyogenes/immunology ; Streptococcus pyogenes/metabolism ; Thrombin/immunology
    Chemical Substances Antigens, Bacterial ; Bacterial Outer Membrane Proteins ; Carrier Proteins ; streptococcal M protein ; Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2015-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.00508-15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Active but inoperable thrombin is accumulated in a plasma protein layer surrounding Streptococcus pyogenes.

    Naudin, Clément / Hurley, Sinead M / Malmström, Erik / Plug, Tom / Shannon, Oonagh / Meijers, Joost C M / Mörgelin, Matthias / Björck, Lars / Herwald, Heiko

    Thrombosis and haemostasis

    2015  Volume 114, Issue 4, Page(s) 717–726

    Abstract: Activation of thrombin is a critical determinant in many physiological and pathological processes including haemostasis and inflammation. Under physiological conditions many of these functions are involved in wound healing or eradication of an invading ... ...

    Abstract Activation of thrombin is a critical determinant in many physiological and pathological processes including haemostasis and inflammation. Under physiological conditions many of these functions are involved in wound healing or eradication of an invading pathogen. However, when activated systemically, thrombin can contribute to severe and life-threatening conditions by causing complications such as multiple multi-organ failure and disseminated intravascular coagulation. In the present study we investigated how the activity of thrombin is modulated when it is bound to the surface of Streptococcus pyogenes. Our data show that S. pyogenes bacteria become covered with a proteinaceous layer when incubated with human plasma, and that thrombin is a constituent of this layer. Though the coagulation factor is found attached to the bacteria with a functional active site, thrombin has lost its capacity to interact with its natural substrates and inhibitors. Thus, the interaction of bacteria with human plasma renders thrombin completely inoperable at the streptococcal surface. This could represent a host defense mechanism to avoid systemic activation of coagulation which could be otherwise induced when bacteria enter the circulation and cause systemic infection.
    MeSH term(s) Antithrombins/pharmacology ; Bacterial Proteins/metabolism ; Blood Coagulation/drug effects ; Carboxypeptidase B2/metabolism ; Enzyme Activation ; Fibrinogen/metabolism ; Host-Pathogen Interactions ; Humans ; Protein Binding ; Protein C/metabolism ; Streptococcal Infections/blood ; Streptococcus pyogenes/metabolism ; Streptococcus pyogenes/pathogenicity ; Thrombin/antagonists & inhibitors ; Thrombin/metabolism
    Chemical Substances Antithrombins ; Bacterial Proteins ; Protein C ; Fibrinogen (9001-32-5) ; Carboxypeptidase B2 (EC 3.4.17.20) ; Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2015-10
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 518294-3
    ISSN 0340-6245
    ISSN 0340-6245
    DOI 10.1160/TH15-02-0127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Active but inoperable thrombin is accumulated in a plasma protein layer surrounding Streptococcus pyogenes

    Naudin, Clément / Hurley, Sinead M. / Malmström, Erik / Plug, Tom / Shannon, Oonagh / Meijers, Joost C.M. / Mörgelin, Matthias / Björck, Lars / Herwald, Heiko

    Thrombosis and Haemostasis

    2015  Volume 113, Issue 04, Page(s) 717–726

    Abstract: Activation of thrombin is a critical determinant in many physiological and pathological processes including haemostasis and inflammation. Under physiological conditions many of these functions are involved in wound healing or eradication of an invading ... ...

    Abstract Activation of thrombin is a critical determinant in many physiological and pathological processes including haemostasis and inflammation. Under physiological conditions many of these functions are involved in wound healing or eradication of an invading pathogen. However, when activated systemically, thrombin can contribute to severe and life-threatening conditions by causing complications such as multiple multi-organ failure and disseminated intravascular coagulation. In the present study we investigated how the activity of thrombin is modulated when it is bound to the surface of Streptococcus pyogenes. Our data show that S. pyogenes bacteria become covered with a proteinaceous layer when incubated with human plasma, and that thrombin is a constituent of this layer. Though the coagulation factor is found attached to the bacteria with a functional active site, thrombin has lost its capacity to interact with its natural substrates and inhibitors. Thus, the interaction of bacteria with human plasma renders thrombin completely inoperable at the streptococcal surface. This could represent a host defense mechanism to avoid systemic activation of coagulation which could be otherwise induced when bacteria enter the circulation and cause systemic infection.
    Keywords Thrombin ; fibrinogen ; proteolysis ; coagulation
    Language English
    Publishing date 2015-01-01
    Publisher Schattauer GmbH
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1160/TH15-02-0127
    Database Thieme publisher's database

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