Article ; Online: A Silent Biosynthetic Gene Cluster from a Methanotrophic Bacterium Potentiates Discovery of a Substrate Promiscuous Proteusin Cyclodehydratase.
ACS chemical biology
2022 Volume 17, Issue 6, Page(s) 1577–1585
Abstract: Natural product-encoding biosynthetic gene clusters (BGCs) within microbial genomes far outnumber the known natural products; chemical products from such BGCs remain cryptic. These silent BGCs hold promise not only for the elaboration of new natural ... ...
| Abstract | Natural product-encoding biosynthetic gene clusters (BGCs) within microbial genomes far outnumber the known natural products; chemical products from such BGCs remain cryptic. These silent BGCs hold promise not only for the elaboration of new natural products but also for the discovery of useful biosynthetic enzymes. Here, we describe a genome mining strategy targeted toward the discovery of substrate promiscuous natural product biosynthetic enzymes. In the genome of the methanotrophic bacterium |
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| MeSH term(s) | Biological Products ; Multigene Family ; Peptides/metabolism |
| Chemical Substances | Biological Products ; Peptides |
| Language | English |
| Publishing date | 2022-06-06 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ISSN | 1554-8937 |
| ISSN (online) | 1554-8937 |
| DOI | 10.1021/acschembio.2c00251 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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