Article ; Online: Sonolysis in Prevention of Brain Infarction During Cardiac Surgery (SONORESCUE): Randomized, Controlled Trial.
2016 Volume 95, Issue 20, Page(s) e3615
Abstract: Here, we examined whether intraoperative sonolysis can alter the risk of new ischemic lesions in the insonated brain artery territory during coronary artery bypass grafting (CABG) or valve surgery.Silent brain ischemic lesions could be detected in as ... ...
| Abstract | Here, we examined whether intraoperative sonolysis can alter the risk of new ischemic lesions in the insonated brain artery territory during coronary artery bypass grafting (CABG) or valve surgery.Silent brain ischemic lesions could be detected in as many as two-thirds of patients after CABG or valve surgery.Patients indicated for CABG or valve surgery were allocated randomly to sonolysis (60 patients, 37 males; mean age, 65.3 years) of the right middle cerebral artery (MCA) during cardiac surgery and control group (60 patients, 37 males; mean age, 65.3 years). Neurologic examination, cognitive function tests, and brain magnetic resonance imaging (MRI) were conducted before intervention as well as 24 to 72 hours and 30 days after surgery.New ischemic lesions on control diffusion-weighted MRI in the insonated MCA territory ≥0.5 mL were significantly less frequent in the sonolysis group than in the control group (13.3% vs 26.7%, P = 0.109). The sonolysis group exhibited significantly reduced median volume of new brain ischemic lesions (P = 0.026). Stenosis of the internal carotid artery ≥50% and smoking were independent predictors of new brain ischemic lesions ≥0.5 mL (odds ratio = 5.685 [1.272-25.409], P = 0.023 and 4.698 [1.092-20.208], P = 0.038, respectively). Stroke or transient ischemic attack occurred only in 2 control patients (P = 0.496). No significant differences were found in scores for postintervention cognitive tests (P > 0.05).This study provides class-II evidence that sonolysis during CABG or valve surgery reduces the risk of larger, new ischemic lesions in the brain.www.clinicaltrials.gov (NCT01591018). |
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| MeSH term(s) | Aged ; Brain Infarction/diagnostic imaging ; Brain Infarction/etiology ; Brain Infarction/prevention & control ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/prevention & control ; Coronary Artery Bypass/adverse effects ; Diffusion Magnetic Resonance Imaging ; Female ; Humans ; Intraoperative Complications/diagnostic imaging ; Intraoperative Complications/etiology ; Intraoperative Complications/prevention & control ; Male ; Middle Aged ; Middle Cerebral Artery/diagnostic imaging ; Neuroimaging ; Neuropsychological Tests ; Prospective Studies ; Ultrasonic Therapy ; Ultrasonography, Doppler |
| Language | English |
| Publishing date | 2016-06-22 |
| Publishing country | United States |
| Document type | Journal Article ; Randomized Controlled Trial |
| ZDB-ID | 80184-7 |
| ISSN | 1536-5964 ; 0025-7974 |
| ISSN (online) | 1536-5964 |
| ISSN | 0025-7974 |
| DOI | 10.1097/MD.0000000000003615 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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