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  1. Article ; Online: Forecasting most deleterious nsSNPs in human

    Gautam, Heena / Verma, Ved Vrat / Husain, Syed Akhtar / Bharadwaj, Mausumi

    Systems biology in reproductive medicine

    2023  Volume 69, Issue 2, Page(s) 112–128

    Abstract: In women, the uterine cervix and corpus uteri are two main suspects, playing a major role in cancer-associated-mortality. Immunologically, Toll-like receptors (TLRs) associated with the innate immune system, can recognize pathogens and induce immune ... ...

    Abstract In women, the uterine cervix and corpus uteri are two main suspects, playing a major role in cancer-associated-mortality. Immunologically, Toll-like receptors (TLRs) associated with the innate immune system, can recognize pathogens and induce immune responses against pathogens. Cellularly, TLR9 expression occurs in immune system cells including macrophages, natural killer cells, dendritic cells, and other antigen-presenting cells. TLR9 recognizes and interacts with viral and bacterial DNA comprising cytosine-phosphate-guanine (CpG) dideoxynucleotide motif. The current study is designed to identify the most deleterious nonsynonymous single nucleotide polymorphisms (nsSNPs) in the
    MeSH term(s) Female ; Humans ; Algorithms ; Polymorphism, Single Nucleotide ; Protein Stability ; Toll-Like Receptor 9/genetics ; Computer Simulation
    Chemical Substances TLR9 protein, human ; Toll-Like Receptor 9
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2417234-0
    ISSN 1939-6376 ; 1939-6368
    ISSN (online) 1939-6376
    ISSN 1939-6368
    DOI 10.1080/19396368.2022.2148837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Prediction of pre-eclampsia in diabetic pregnant women.

    Kumar, Ashok / Vanamail, Perumal / Gupta, Ram Kumar / Husain, Syed Akhtar

    The Indian journal of medical research

    2023  Volume 157, Issue 4, Page(s) 330–344

    Abstract: Background & objectives: Gestational or preexisting diabetes is one of the risk factors of pre-eclampsia. Both are responsible for higher maternal and fetal complications. The objective was to study clinical risk factors of pre-eclampsia and biochemical ...

    Abstract Background & objectives: Gestational or preexisting diabetes is one of the risk factors of pre-eclampsia. Both are responsible for higher maternal and fetal complications. The objective was to study clinical risk factors of pre-eclampsia and biochemical markers in early pregnancy of women with diabetes mellitus (DM)/gestational diabetes mellitus (GDM) for the development of pre-eclampsia.
    Methods: The study group comprised pregnant women diagnosed with GDM before the 20 wk of gestation and DM before pregnancy and the control group had age-, parity- and period of gestation-matched healthy women. Sex hormone-binding globulin (SHBG), insulin-like growth factor-I (IGF-I) and 25-hydroxy vitamin D [25(OH)D] levels and the polymorphism of these genes was evaluated at recruitment.
    Results: Out of 2050 pregnant women, 316 (15.41%) women (296 had GDM and 20 DM before pregnancy) were included in the study group. Of these, 96 women (30.38%) in the study group and 44 (13.92%) controls developed pre-eclampsia. Multivariate logistic regression analysis indicated those who belonged to the upper middle and upper class of socio-economic status (SES) were likely to be at 4.50 and 6.10 times higher risk of developing pre-eclampsia. The risk of getting pre-eclampsia among those who had DM before pregnancy and pre-eclampsia in their previous pregnancy was about 2.34 and 4.56 times higher compared to those who had no such events, respectively. The serum biomarkers [SHBG, IGF-I and 25(OH)D] were not found to be useful in predicting pre-eclampsia in women with GDM. To predict risk of development of pre-eclampsia, the fitted risk model by backward elimination procedure was used to calculate a risk score for each patient. Receiver operating characteristic (ROC) curve for pre-eclampsia showed that area under the curve was 0.68 (95% confidence interval: 0.63-0.73); P<0.001.
    Interpretation & conclusions: The findings of this study suggested that pregnant women with diabetes were at a higher risk for pre-eclampsia. SES, history of pre-eclampsia in previous pregnancy and pre-GDM were found to be the risk factors.
    MeSH term(s) Pregnancy ; Female ; Humans ; Male ; Pre-Eclampsia/epidemiology ; Pregnant Women ; Insulin-Like Growth Factor I ; Diabetes, Gestational ; Parity ; Biomarkers
    Chemical Substances Insulin-Like Growth Factor I (67763-96-6) ; Biomarkers
    Language English
    Publishing date 2023-06-07
    Publishing country India
    Document type Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_1594_19
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  3. Article ; Online: Amalgamation of Nanotechnology for Delivery of Bioactive Constituents in Solid Tumors.

    Parveen, Rabea / Mohapatra, Sradhanjali / Ahmad, Sayeed / Husain, Syed Akhtar

    Current drug delivery

    2022  Volume 20, Issue 5, Page(s) 457–482

    Abstract: Solid tumor is one of the highly prevalent cancers among humans and the treatment is often restricted by drug resistance to chemotherapeutics. One of the main reasons might be attributed to the limited penetration ability of drugs through tumor tissues ... ...

    Abstract Solid tumor is one of the highly prevalent cancers among humans and the treatment is often restricted by drug resistance to chemotherapeutics. One of the main reasons might be attributed to the limited penetration ability of drugs through tumor tissues due to heterogeneity within the tumor microenvironment. Over the recent years, so much research has been carried out for developing phytochemicals as cancer therapeutic agents. These are well-established as potential candidates for preventing and treating cancer, especially solid tumors, but have limited clinical applications due to their large molecular size, low bioavailability, stability, and target specificity, along with other side effects when used at high concentrations. There has been a widely proposed nano delivery system of bioactive constituents to overcome these obstacles. This nanostructured system might be able to potentiate the action of plant constituents, by reducing the side effects at a lesser dose with improved efficacy. Indeed, nanosystems can deliver the bioactive constituents at a specific site in the desired concentration and avoid undesired drug exposure to normal tissues. Furthermore, these nanoparticles demonstrate high differential absorption efficiency in the target cells over normal cells by preventing them from interacting prematurely with the biological environment, enhancing the cellular uptake and retention effect in disease tissues, while decreasing the toxicity. This review discusses various treatment stratagems used for the management of solid tumors with special emphasis on nanocarrier systems as a potential treatment strategy for herbal drugs. This also covers a wide list of plants that are used for the treatment of solid tumors and cancers along with their mechanisms of action and enlists various nanocarrier systems used for different phytoconstituents. This review gives a brief idea about different plants and their constituents exploited for their anticancer/antitumor potential along with several nanocarrier systems employed for the same and gives future directions to stress the nanotechnology platform as a valuable approach for the prevention and treatment of solid tumors.
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Nanotechnology ; Pharmaceutical Preparations ; Nanoparticles ; Nanostructures ; Drug Delivery Systems ; Tumor Microenvironment
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2022-04-22
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 2185284-4
    ISSN 1875-5704 ; 1567-2018
    ISSN (online) 1875-5704
    ISSN 1567-2018
    DOI 10.2174/1567201819666220425093102
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  4. Article ; Online: Prevalence of

    Gautam, Heena / Mehta, Sumita / Nayar, Nidhi / Kumar, Neha / Husain, Syed Akhtar / Bharadwaj, Mausumi

    Systems biology in reproductive medicine

    2023  Volume 69, Issue 6, Page(s) 399–409

    Abstract: Cervical cancer (Cacx) is the second and endometrial cancer (Ec) is the third most common gynecological cancer worldwide. The present study aims to understand the complex and unexplored conditions occurring in cervix and endometrium of the female genital ...

    Abstract Cervical cancer (Cacx) is the second and endometrial cancer (Ec) is the third most common gynecological cancer worldwide. The present study aims to understand the complex and unexplored conditions occurring in cervix and endometrium of the female genital tract caused due to the infection of the
    MeSH term(s) Female ; Humans ; Human Papillomavirus Viruses ; Uterine Cervical Neoplasms/epidemiology ; Papillomavirus Infections/complications ; Papillomavirus Infections/epidemiology ; Chlamydia trachomatis ; Prevalence ; Endometrium
    Language English
    Publishing date 2023-09-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2417234-0
    ISSN 1939-6376 ; 1939-6368
    ISSN (online) 1939-6376
    ISSN 1939-6368
    DOI 10.1080/19396368.2023.2247517
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    Zs.A 1377: Show issues Location:
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  5. Article ; Online: HPTLC Stability Indicating Analytical Method of Andrographolide and 5-fluorouracil with Network Pharmacology Analysis against Cancer.

    Malik, Zoya / Parveen, Rabea / Zahiruddin, Sultan / Gaurav / Husain, Syed Akhtar / Ahmad, Sayeed

    Combinatorial chemistry & high throughput screening

    2023  

    Abstract: Background: Herbal drugs when used in combination with chemotherapeutic drugs can reduce the side effects and increase the efficacy by acting on multiple targets. Andrographolide (AG), a diterpene lactone isolated from Andrographis paniculata Nees, is a ...

    Abstract Background: Herbal drugs when used in combination with chemotherapeutic drugs can reduce the side effects and increase the efficacy by acting on multiple targets. Andrographolide (AG), a diterpene lactone isolated from Andrographis paniculata Nees, is a bioactive compound with anticancer potential, and 5-fluorouracil (FU), a pyrimidine analogue, is used in the treatment of cancer. Both drugs are used to formulate combination nanoformulation to increase absorption, thereby increasing their oral bioavailability.
    Objective: The study aimed to develop and validate stability indicating simultaneous HPTLC method for quantification of FU and AG in combination nanoformulation along with in silico docking and network pharmacology analysis to understand the interaction between the drugs and cancer targets.
    Methods: Chromatographic separation was performed using mobile phase chloroform: methanol: formic acid (9: 0.5: 0.5, v/v/v) on HPTLC silica plates 60 F254 as a stationary phase using UV-Vis detector and HPTLC scanner at 254 nm. Further, in silico docking analysis was performed to predict the binding affinity of AG and FU with different proteins and network pharmacology to find out the exact biomolecular relationship of AG and FU in alleviating cancer.
    Results: The data from the calibration curve showed a good linear regression relationship with r² = 0.9981 (FU) and r² = 0.9977 (AG) in the concentration range of 0.1-2.0 µg/mL. The developed method was validated according to the ICH guidelines. Stability studies showed changes in peak patterns and areas. Bioinformatic and network pharmacology analyses of AG and FU with target proteins and genes associated with cancer play a multimechanistic role in alleviating cancer.
    Conclusion: The developed method has been concluded to be robust, simple, precise, reproducible, accurate, and stability indicating for simultaneous quantification of AG and FU, and the molecular interaction studies have further indicated that the combination nanoformulation of AG and FU could be effective against cancer.
    Language English
    Publishing date 2023-06-09
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2064785-2
    ISSN 1875-5402 ; 1386-2073
    ISSN (online) 1875-5402
    ISSN 1386-2073
    DOI 10.2174/1386207326666230609104038
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    Zs.A 5577: Show issues Location:
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  6. Article ; Online: Receptor-Mediated Targeting in Breast Cancer through Solid Lipid Nanoparticles and Its Mechanism.

    Malik, Zoya / Parveen, Rabea / Abass, Sageer / Irfan, Mohammad / Husain, Syed Akhtar / Ahmad, Sayeed

    Current drug metabolism

    2022  

    Abstract: Nanoparticles have gained prominence in many areas and domains world-wide such as metallic NP, carbon-dots, quantum dots, polymeric NP, nano-suspension, nanocrystals, solid lipid nanoparticles (SLN), etc. and have been applied in the field of medicine as ...

    Abstract Nanoparticles have gained prominence in many areas and domains world-wide such as metallic NP, carbon-dots, quantum dots, polymeric NP, nano-suspension, nanocrystals, solid lipid nanoparticles (SLN), etc. and have been applied in the field of medicine as nanomedicine with promising results. Rise in global cancer mortality rate has been an issue since long with female breast cancer as one of the most detected cancers. No permanent treatment has been developed till date that could combat breast cancer with minimum side effects that are not long-lasting as there is not any proper technique through which the anticancer drugs can recognize benign or malignant or normal cells that causes systematic toxicity. Advancement in technology has led to the discovery of many biological pathways and mechanisms. Tumor cells or cancer cells overexpress some high-affinity receptors that can be targeted to deliver the anticancer drugs at specific site using these pathways and mechanisms. Solid lipid nanoparticles (SLN) are among some of the excellent drug delivery systems, especially stealth SLN (sSLN). SLN when conjugated with a ligand (called as sSLN) has affinity and specificity towards a specific receptor, and can deliver the drug in breast cancer cells overexpressing the receptors. Using this technique, various investigations have reported better anti-breast cancer activity than simple SLN (non-conjugated to ligand or no receptor targeting). This review includes the investigations and data on receptor-mediated targeting in breast cancer from 2010 to 2021 by searching different databases. Overall, information on SLN in different cancers are reviewed. Effectiveness of sSLN is discussed with in vivo studies, pharmacokinetics, biodistribution, and stability. Investigations included in this review demonstrate that sSLN delivers the drug by overcoming the biological barriers and shows enhanced and better activity than non-conjugated SLN that also verifies that lesser concentration of drug can show anti-breast cancer activity. The efficacy of medicines could be increased with lower cancer deaths through stealth-SLN. Due to the low cost of synthesis, biocompatibility and easy to formulate, more study is needed in vitro and in vivo so that this novel technique could be utilized in the treatment of human breast cancer.
    Language English
    Publishing date 2022-04-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2064815-7
    ISSN 1875-5453 ; 1389-2002
    ISSN (online) 1875-5453
    ISSN 1389-2002
    DOI 10.2174/1389200223666220416213639
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    Zs.A 5584: Show issues Location:
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  7. Article ; Online: Synergy based Extracts of Medicinal Plants: Future Antimicrobials to Combat Multidrug Resistance.

    Abass, Sageer / Parveen, Rabea / Irfan, Mohammad / Jan, Bisma / Husain, Syed Akhtar / Ahmad, Sayeed

    Current pharmaceutical biotechnology

    2022  Volume 23, Issue 13, Page(s) 1527–1540

    Abstract: The use of herbal medicines and supplements in the last thirty years has increased enormously. Herbal medication has demonstrated promising and effective potential against various diseases. Herbal and phytoconstituent medications are gaining popularity ... ...

    Abstract The use of herbal medicines and supplements in the last thirty years has increased enormously. Herbal medication has demonstrated promising and effective potential against various diseases. Herbal and phytoconstituent medications are gaining popularity globally and many people are adopting herbal remedies to deal with different health issues. The indiscriminate use of antibiotics, due to the development of antimicrobial resistance, poses an unprecedented problem for human civilization. Bacterial infections are difficult to cure because of the propensity of microbes to acquire resistance to a wide range of antimicrobial drugs. New compounds are being explored and quantified for possible antibacterial activity with little or no side effects. Researchers are investigating the range of therapeutic plants mentioned in Unani, Ayurveda, and Siddha around the globe. Known and commonly acclaimed global databases such as PubMed, Research Gate, Science Direct, Google Scholar were searched using different search strings such as Indian medicinal plants, multidrug resistance (MDR), thin layer chromatography (TLC), antimicrobials, and Synergism were used in diverse combinations to reclaim numerous citations associated with this area. Thus, the current review aims to shed a light on the information of medicinal plants as a potential foundation of herbal drugs and elucidate how synergism and TLC bioautography play a crucial role in finding antimicrobial compounds.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/therapeutic use ; Drug Resistance, Multiple ; Humans ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plants, Medicinal/chemistry
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Plant Extracts
    Language English
    Publishing date 2022-01-21
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/1389201023666220126115656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6212: Show issues Location:
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  8. Article ; Online: Therapeutic importance of

    Abbas, Zahra / Mustafa, Saad / Khan, Mohd Faisal / Khan, Mohammad Aasif / Massey, Sheersh / Dev, Kapil / Khan, Asifa / Parveen, Shabana / Husain, Syed Akhtar

    Natural product research

    2023  , Page(s) 1–15

    Abstract: Aim: To summarise a detailed up-to-date review of the traditional uses, phytoconstituents, and pharmacological activities of various parts of : Materials and methods: Google Scholar, PubMed, PubChem, Elsevier, King Draw, indianbiodiversity.org.: ... ...

    Abstract Aim: To summarise a detailed up-to-date review of the traditional uses, phytoconstituents, and pharmacological activities of various parts of
    Materials and methods: Google Scholar, PubMed, PubChem, Elsevier, King Draw, indianbiodiversity.org.
    Result: The phytochemical analysis of
    Conclusion: Knowledge of the phytoconstituents, non-medicinal and medicinal traditional uses, pharmacological activities, and products obtained from
    Language English
    Publishing date 2023-11-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2023.2273914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Retraction Note to: Impact of maternal nutrition in hepatitis E infection in pregnancy.

    Kumar, Ashok / Sharma, Sheetal / Kar, Premashish / Agarwal, Sarita / Ramji, Siddhartha / Husain, Syed Akhtar / Prasad, Sudha / Sharma, Shashi

    Archives of gynecology and obstetrics

    2023  Volume 307, Issue 3, Page(s) 999

    Language English
    Publishing date 2023-02-02
    Publishing country Germany
    Document type Retraction of Publication
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-023-06920-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Phytocompounds Targeting Metabolic Reprogramming in Cancer: An Assessment of Role, Mechanisms, Pathways, and Therapeutic Relevance

    Khan, Asifa / Siddiqui, Shumaila / Husain, Syed Akhtar / Mazurek, Sybille / Iqbal, Mohammad Askandar

    Journal of agricultural and food chemistry. 2021 June 16, v. 69, no. 25

    2021  

    Abstract: The metabolism of cancer is remarkably different from that of normal cells and confers a variety of benefits, including the promotion of other cancer hallmarks. As the rewired metabolism is a near-universal property of cancer cells, efforts are underway ... ...

    Abstract The metabolism of cancer is remarkably different from that of normal cells and confers a variety of benefits, including the promotion of other cancer hallmarks. As the rewired metabolism is a near-universal property of cancer cells, efforts are underway to exploit metabolic vulnerabilities for therapeutic benefits. In the continued search for safer and effective ways of cancer treatment, structurally diverse plant-based compounds have gained substantial attention. Here, we present an extensive assessment of the role of phytocompounds in modulating cancer metabolism and attempt to make a case for the use of plant-based compounds in targeting metabolic vulnerabilities of cancer. We discuss the pharmacological interactions of phytocompounds with major metabolic pathways and evaluate the role of phytocompounds in the regulation of growth signaling and transcriptional programs involved in the metabolic transformation of cancer. Lastly, we examine the potential of these compounds in the clinical management of cancer along with limitations and challenges.
    Keywords cancer therapy ; food chemistry ; metabolism ; transcription (genetics)
    Language English
    Dates of publication 2021-0616
    Size p. 6897-6928.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.1c01173
    Database NAL-Catalogue (AGRICOLA)

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