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  1. Article ; Online: A promising preclinical model for TERT promoter mutation in glioblastoma.

    Huse, Jason T

    Neuro-oncology

    2022  Volume 24, Issue 12, Page(s) 2076–2077

    MeSH term(s) Humans ; Glioblastoma/genetics ; Telomere Shortening ; Brain Neoplasms/genetics ; Telomerase/genetics ; Telomerase/metabolism ; Mutation
    Chemical Substances Telomerase (EC 2.7.7.49) ; TERT protein, human (EC 2.7.7.49)
    Language English
    Publishing date 2022-07-02
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noac167
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    Zs.A 5307: Show issues Location:
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  2. Article ; Online: Classification of adult-type diffuse gliomas: Impact of the World Health Organization 2021 update.

    Whitfield, Benjamin T / Huse, Jason T

    Brain pathology (Zurich, Switzerland)

    2022  Volume 32, Issue 4, Page(s) e13062

    Abstract: Over the last decade, developments in molecular profiling have radically altered the diagnosis, classification, and management of numerous cancer types, with primary brain tumors being no exception. Although historically brain tumors have been classified ...

    Abstract Over the last decade, developments in molecular profiling have radically altered the diagnosis, classification, and management of numerous cancer types, with primary brain tumors being no exception. Although historically brain tumors have been classified based on their morphological characteristics, recent advances have allowed refinement of tumor classification based on molecular alterations. This shift toward molecular classification of primary brain tumors is reflected in the 2021 5
    MeSH term(s) Adult ; Brain Neoplasms/pathology ; Central Nervous System Neoplasms/diagnosis ; Central Nervous System Neoplasms/pathology ; Glioma/pathology ; Humans ; Isocitrate Dehydrogenase/genetics ; Mutation ; World Health Organization
    Chemical Substances Isocitrate Dehydrogenase (EC 1.1.1.41)
    Language English
    Publishing date 2022-03-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1051484-3
    ISSN 1750-3639 ; 1015-6305
    ISSN (online) 1750-3639
    ISSN 1015-6305
    DOI 10.1111/bpa.13062
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    Zs.A 3585: Show issues Location:
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  3. Article ; Online: The epigenetic dysfunction underlying malignant glioma pathogenesis.

    Dharmaiah, Sharvari / Huse, Jason T

    Laboratory investigation; a journal of technical methods and pathology

    2022  Volume 102, Issue 7, Page(s) 682–690

    Abstract: Comprehensive molecular profiling has dramatically transformed the diagnostic neuropathology of brain tumors. Diffuse gliomas, the most common and deadly brain tumor variants, are now classified by highly recurrent biomarkers instead of ... ...

    Abstract Comprehensive molecular profiling has dramatically transformed the diagnostic neuropathology of brain tumors. Diffuse gliomas, the most common and deadly brain tumor variants, are now classified by highly recurrent biomarkers instead of histomorphological characteristics. Several of the key molecular alterations driving glioma classification involve epigenetic dysregulation at a fundamental level, implicating fields of biology not previously thought to play major roles glioma pathogenesis. This article will review the major epigenetic alterations underlying malignant gliomas, their likely mechanisms of action, and potential strategies for their therapeutic targeting.
    MeSH term(s) Biomarkers ; Biomarkers, Tumor ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Epigenesis, Genetic ; Glioma/genetics ; Glioma/pathology ; Humans
    Chemical Substances Biomarkers ; Biomarkers, Tumor
    Language English
    Publishing date 2022-02-12
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80178-1
    ISSN 1530-0307 ; 0023-6837
    ISSN (online) 1530-0307
    ISSN 0023-6837
    DOI 10.1038/s41374-022-00741-7
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  4. Article ; Online: The epigenetic dysfunction underlying malignant glioma pathogenesis

    Dharmaiah, Sharvari / Huse, Jason T.

    United States & Canadian Academy of Pathology Laboratory Investigation. 2022 July, v. 102, no. 7 p.682-690

    2022  

    Abstract: Comprehensive molecular profiling has dramatically transformed the diagnostic neuropathology of brain tumors. Diffuse gliomas, the most common and deadly brain tumor variants, are now classified by highly recurrent biomarkers instead of ... ...

    Abstract Comprehensive molecular profiling has dramatically transformed the diagnostic neuropathology of brain tumors. Diffuse gliomas, the most common and deadly brain tumor variants, are now classified by highly recurrent biomarkers instead of histomorphological characteristics. Several of the key molecular alterations driving glioma classification involve epigenetic dysregulation at a fundamental level, implicating fields of biology not previously thought to play major roles glioma pathogenesis. This article will review the major epigenetic alterations underlying malignant gliomas, their likely mechanisms of action, and potential strategies for their therapeutic targeting.
    Keywords biomarkers ; brain ; brain neoplasms ; epigenetics ; glioma ; laboratories ; neuropathology ; pathogenesis ; therapeutics
    Language English
    Dates of publication 2022-07
    Size p. 682-690.
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 80178-1
    ISSN 1530-0307 ; 0023-6837
    ISSN (online) 1530-0307
    ISSN 0023-6837
    DOI 10.1038/s41374-022-00741-7
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  5. Article ; Online: The Evolving Classification of Diffuse Gliomas: World Health Organization Updates for 2021.

    Perez, Alejandro / Huse, Jason T

    Current neurology and neuroscience reports

    2021  Volume 21, Issue 12, Page(s) 67

    Abstract: Purpose of review: The upcoming 2021 World Health Organization (WHO) Classification of Tumours of the Central Nervous System will feature numerous changes in classification, diagnostic criteria, nomenclature, and grading of diffuse gliomas. This article ...

    Abstract Purpose of review: The upcoming 2021 World Health Organization (WHO) Classification of Tumours of the Central Nervous System will feature numerous changes in classification, diagnostic criteria, nomenclature, and grading of diffuse gliomas. This article reviews these changes and the clinical and molecular findings underlying them.
    Recent findings: Since the publication of the 2016 World Health Organization (WHO) Classification of Tumours of the Central Nervous System, research has led to new insights into how molecular changes impact both the classification and grading of CNS tumors. The continued integration of molecular and histopathological features has led to changes in diagnostic criteria and grading for various tumors. In the new 2021 WHO CNS tumor classification scheme, diffuse gliomas will be classified as either adult-type diffuse gliomas, pediatric-type diffuse high-grade gliomas, or pediatric-type diffuse low-grade gliomas. The upcoming changes in the classification of adult-type and pediatric-type diffuse gliomas allow for more effective communication of both diagnostic and prognostic information, and-particularly in the case of pediatric-type diffuse gliomas-may suggest possible targeted strategies for therapeutic intervention.
    MeSH term(s) Adult ; Brain Neoplasms/genetics ; Central Nervous System Neoplasms/genetics ; Child ; Glioma/genetics ; Humans ; Mutation ; Prognosis ; World Health Organization
    Language English
    Publishing date 2021-11-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057363-7
    ISSN 1534-6293 ; 1528-4042
    ISSN (online) 1534-6293
    ISSN 1528-4042
    DOI 10.1007/s11910-021-01153-8
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    Zs.A 5549: Show issues Location:
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  6. Article ; Online: Establishing a Robust Molecular Taxonomy for Diffuse Gliomas of Adulthood.

    Huse, Jason T

    Surgical pathology clinics

    2016  Volume 9, Issue 3, Page(s) 379–390

    Abstract: The comprehensive molecular profiling of cancer has dramatically altered conceptions of numerous tumor types, particularly with regard to their fundamental classification. In the case of primary brain tumors, the widespread use of disease-defining ... ...

    Abstract The comprehensive molecular profiling of cancer has dramatically altered conceptions of numerous tumor types, particularly with regard to their fundamental classification. In the case of primary brain tumors, the widespread use of disease-defining biomarker sets is profoundly reshaping existing diagnostic entities that had been designated solely by histopathological criteria for decades. This review describes recent progress for diffusely infiltrating gliomas of adulthood, the most common primary brain tumor variants. More specifically, it details how routine incorporation of a handful of highly prevalent molecular alterations robustly designates refined subclasses of glioma that transcend conventional histopathological designations.
    MeSH term(s) Biomarkers, Tumor/genetics ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Chromosome Deletion ; Chromosomes, Human, Pair 1/genetics ; Chromosomes, Human, Pair 19/genetics ; DNA Helicases/genetics ; Glioblastoma/genetics ; Glioblastoma/pathology ; Glioma/genetics ; Glioma/pathology ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Isocitrate Dehydrogenase/genetics ; Mutation/genetics ; Nuclear Proteins/genetics ; Prognosis ; Promoter Regions, Genetic ; Telomerase/genetics ; X-linked Nuclear Protein
    Chemical Substances Biomarkers, Tumor ; Nuclear Proteins ; Isocitrate Dehydrogenase (EC 1.1.1.41) ; IDH1 protein, human (EC 1.1.1.42.) ; TERT protein, human (EC 2.7.7.49) ; Telomerase (EC 2.7.7.49) ; DNA Helicases (EC 3.6.4.-) ; ATRX protein, human (EC 3.6.4.12) ; X-linked Nuclear Protein (EC 3.6.4.12)
    Language English
    Publishing date 2016-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1875-9157
    ISSN (online) 1875-9157
    DOI 10.1016/j.path.2016.04.005
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  7. Article ; Online: An international perspective on the management of glioblastoma.

    Lukas, Rimas V / Razis, Evangelia D / Huse, Jason T

    Chinese clinical oncology

    2021  Volume 10, Issue 4, Page(s) 40

    MeSH term(s) Brain Neoplasms/therapy ; Glioblastoma/therapy ; Humans ; Internationality ; Temozolomide
    Chemical Substances Temozolomide (YF1K15M17Y)
    Language English
    Publishing date 2021-09-20
    Publishing country China
    Document type Journal Article
    ZDB-ID 2828547-5
    ISSN 2304-3873 ; 2304-3873
    ISSN (online) 2304-3873
    ISSN 2304-3873
    DOI 10.21037/cco-21-107
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  8. Article: Sirtuin 2 inhibition modulates chromatin landscapes genome-wide to induce senescence in ATRX-deficient malignant glioma.

    Malgulwar, Prit Benny / Danussi, Carla / Dharmaiah, Sharvari / Johnson, William E / Rao, Arvind / Huse, Jason T

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Inactivating mutations in : One sentence summary: Our study demonstrates that SIRT2 inhibition promotes senescence in ATRX-deficient glioma model systems through global epigenomic remodeling, impacting key downstream transcriptional profiles. ...

    Abstract Inactivating mutations in
    One sentence summary: Our study demonstrates that SIRT2 inhibition promotes senescence in ATRX-deficient glioma model systems through global epigenomic remodeling, impacting key downstream transcriptional profiles.
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.09.523324
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  9. Article ; Online: TERT promoter mutation designates biologically aggressive primary glioblastoma.

    Huse, Jason T

    Neuro-oncology

    2015  Volume 17, Issue 1, Page(s) 5–6

    MeSH term(s) Female ; Glioblastoma/genetics ; Glioblastoma/mortality ; Humans ; Male ; Mutation ; Telomerase/genetics
    Chemical Substances Telomerase (EC 2.7.7.49)
    Language English
    Publishing date 2015-01
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/nou318
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  10. Article ; Online: Collision tumor: Multinodular and vacuolating neuronal tumor with isocitrate dehydrogenase-mutant diffuse astrocytoma.

    Kumar, Vinodh A / Perez, Alejandro / Young, Angela L / Jones, Julia / O'Brien, Barbara J / Lang, Frederick F / Huse, Jason T / Fuller, Gregory N

    Neuropathology : official journal of the Japanese Society of Neuropathology

    2024  

    Abstract: Herein, we report a case of a collision tumor involving a multinodular and vacuolating neuronal tumor (MVNT) and a diffuse astrocytoma. A collision tumor between these two entities has not previously been reported. The patient is a 35-year-old woman who ... ...

    Abstract Herein, we report a case of a collision tumor involving a multinodular and vacuolating neuronal tumor (MVNT) and a diffuse astrocytoma. A collision tumor between these two entities has not previously been reported. The patient is a 35-year-old woman who presented with new-onset hearing loss and ringing in her right ear. Magnetic resonance imaging identified a non-enhancing mass involving the gray matter and subcortical white matter of the left middle frontal gyrus. Additionally, tiny clustered nodules were noted along the underlying subcortical ribbon and superficial subcortical white matter of the left superior frontal gyrus. The patient underwent a left frontal craniotomy and complete resection of the mass. Histologic examination of the resected specimen demonstrated a collision tumor consisting of a diffuse astrocytoma (isocitrate dehydrogenase [IDH] mutant, central nervous system [CNS] World Health Organization [WHO] grade 2) and an MVNT, with the latter demonstrating characteristic morphologic and immunohistochemical features.
    Language English
    Publishing date 2024-02-27
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 1483794-8
    ISSN 1440-1789 ; 0919-6544
    ISSN (online) 1440-1789
    ISSN 0919-6544
    DOI 10.1111/neup.12968
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