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Article ; Online: How to Train Your Posture: Haptic Feedback Can be Used for Postural Adaptation of the Trunk During Upper-Limb Motor Training.

Agarwal, Rakhi / Hussain, Asif / Campolo, Domenico / Skm, Varadhan

IEEE transactions on haptics

2023 Volume 16, Issue 2, Page(s) 182–193

Abstract: Poor trunk posture, especially during long periods of sitting, could lead to problems such as Low Back Pain (LBP) and Forward Head Posture (FHP). Typical solutions are based on visual or vibration-based feedback. However, these systems could lead to ... ...

Abstract	Poor trunk posture, especially during long periods of sitting, could lead to problems such as Low Back Pain (LBP) and Forward Head Posture (FHP). Typical solutions are based on visual or vibration-based feedback. However, these systems could lead to feedback being ignored by the user and phantom vibration syndrome, respectively. In this study, we propose using haptic feedback for postural adaptation. In this two-part study, twenty-four healthy participants (age 25.87 ± 2.17 years) adapted to three different postural targets in the anterior direction while performing a unimanual reaching task using a robotic device. Results suggest a strong adaptation to the desired postural targets. Mean anterior trunk bending after the intervention is significantly different compared to baseline measurements for all postural targets. Additional analysis of movement straightness and smoothness indicates an absence of any negative interference of posture-based feedback on the performance of reaching movement. Taken together, these results suggest that haptic feedback-based systems could be used for postural adaptation applications. Also, this type of postural adaptation system can be used during the rehabilitation of stroke patients to reduce trunk compensation in lieu of typical physical constraint-based methods.
MeSH term(s)	Humans ; Young Adult ; Adult ; Feedback ; Haptic Technology ; Touch Perception ; Posture ; Upper Extremity ; Postural Balance
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article
ISSN	2329-4051
ISSN (online)	2329-4051
DOI	10.1109/TOH.2023.3248619
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Article ; Online: Haptic feedback system for postural adaptation during robotic rehabilitation of upper limb.

Agarwal, Rakhi / Hussain, Asif / Skm, Varadhan / Campolo, Domenico

IEEE ... International Conference on Rehabilitation Robotics : [proceedings

2022 Volume 2022, Page(s) 1–6

Abstract: Although trunk compensation during stroke rehabilitation is widely studied, the proposed solutions primarily include a trunk constraint, which has several disadvantages. In this study, we have proposed a haptic feedback-based system for postural training ...

Abstract	Although trunk compensation during stroke rehabilitation is widely studied, the proposed solutions primarily include a trunk constraint, which has several disadvantages. In this study, we have proposed a haptic feedback-based system for postural training during upper-limb motor rehabilitation. We have tested the proposed system on six healthy people in this preliminary study. Participants performed a simple 1-dimensional reaching task while their posture was being monitored. They received haptic feedback based on their trunk posture. Preliminary results revealed a significant decline in postural error (p<0.05) after the haptic-based training. The reduction in error was maintained even after haptic feedback was turned off. This study shows that haptic feedback could be a viable alternative to the traditional constraint-based methods for postural adaptation. Additional studies need to be conducted to further evaluate the influence of using such feedback strategies.
MeSH term(s)	Feedback ; Haptic Technology ; Humans ; Robotic Surgical Procedures ; Stroke Rehabilitation/methods ; Upper Extremity
Language	English
Publishing date	2022-09-29
Publishing country	United States
Document type	Journal Article
ISSN	1945-7901
ISSN (online)	1945-7901
DOI	10.1109/ICORR55369.2022.9896531
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Article: Let the force guide you: a performance-based adaptive algorithm for postural training using haptic feedback.

Agarwal, Rakhi / Hussain, Asif / Skm, Varadhan / Campolo, Domenico

Frontiers in human neuroscience

2022 Volume 16, Page(s) 968669

Abstract: Motor learning is an essential component of human behavior. Many different factors can influence the process of motor learning, such as the amount of practice and type of feedback. Changes in task difficulty during training can also considerably impact ... ...

Abstract	Motor learning is an essential component of human behavior. Many different factors can influence the process of motor learning, such as the amount of practice and type of feedback. Changes in task difficulty during training can also considerably impact motor learning. Typical motor learning studies include a sequential variation of task difficulty, i.e., easy to challenging, irrespective of user performance. However, many studies have reported the importance of performance-based task difficulty variation for effective motor learning and skill transfer. A performance-based adaptive algorithm for task difficulty variation based on the challenge-point framework is proposed in this study. The algorithm is described for postural adaptation during simultaneous upper-limb training. Ten healthy participants (28 ± 2.44 years) were recruited to validate the algorithm. Participants adapted to a postural target of 20° in the anterior direction from the initial upright posture while performing a unimanual reaching task using a robotic device. Results suggest a significant decrease in postural error after training. The algorithm successfully adapted the task difficulty based on the performance of the user. The proposed algorithm could be modified for different motor skills and can be further evaluated for different applications in order to maximize the potential benefits of rehabilitation sessions.
Language	English
Publishing date	2022-11-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2425477-0
ISSN	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2022.968669
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Article: How to work up an adult patient with metabolic acidosis.

Bajwa, Gurkirpal S / Hussain, Asif / Javaid, Muhammad M

British journal of hospital medicine (London, England : 2005)

2022 Volume 83, Issue 8, Page(s) 1–11

Abstract: Metabolic acidosis is a common complication among acutely unwell hospitalised patients. Untreated, it can result in undesirable cardiovascular, respiratory and neurological consequences. Metabolic acidosis can occur as an isolated entity or coexist with ... ...

Abstract	Metabolic acidosis is a common complication among acutely unwell hospitalised patients. Untreated, it can result in undesirable cardiovascular, respiratory and neurological consequences. Metabolic acidosis can occur as an isolated entity or coexist with other acid-base disorders, making diagnosing the aetiology difficult. Accurate identification of the underlying cause is imperative for proper and timely management. A systematic approach can help simplify the assessment of patients and can aid in establishing the correct diagnosis, even in more complex cases. This article provides a practical, step-by-step guide for the assessment of adult patients with metabolic acidosis.
MeSH term(s)	Acid-Base Equilibrium ; Acidosis/diagnosis ; Acidosis/etiology ; Acidosis/therapy ; Adult ; Humans
Language	English
Publishing date	2022-08-05
Publishing country	England
Document type	Journal Article
ISSN	1750-8460
ISSN	1750-8460
DOI	10.12968/hmed.2021.0582
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Article: Chemo-metric analysis of carotenoids, chlorophylls, and antioxidant activity of

Zeb, Alam / Hussain, Asif

Heliyon

2020 Volume 6, Issue 1, Page(s) e03195

Abstract: This work determined carotenoids and chlorophylls profiles, in addition, the antioxidant potential ... ...

Abstract	This work determined carotenoids and chlorophylls profiles, in addition, the antioxidant potential of
Language	English
Publishing date	2020-01-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2020.e03195
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Article ; Online: Erythropoietin in perinatal hypoxic-ischemic encephalopathy: a systematic review and meta-analysis.

Razak, Abdul / Hussain, Asif

Journal of perinatal medicine

2019 Volume 47, Issue 4, Page(s) 478–489

Abstract: Background Erythropoietin (EPO) appears to confer neuroprotection to the injured brain. Randomized clinical trials (RCTs) have demonstrated its safety in neonates with hypoxic-ischemic encephalopathy (HIE); however, the evidence is unclear. The objective ...

Abstract	Background Erythropoietin (EPO) appears to confer neuroprotection to the injured brain. Randomized clinical trials (RCTs) have demonstrated its safety in neonates with hypoxic-ischemic encephalopathy (HIE); however, the evidence is unclear. The objective of this study was to examine the role of EPO in perinatal HIE by a systematic review and meta-analysis. Methods Database search included Embase, MEDLINE, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Cochrane Central Register of Controlled Trials (CENTRAL). RCTs reporting a death, neurodevelopmental outcomes or brain injury were included. Two authors extracted the data independently from included studies and assessed the level of evidence (LOE). Results Six RCTs (EPO=5 and darbepoetin α=1) involving 454 neonates were included. A trend toward a lower risk of death was identified in infants treated with EPO [EPO with or without hypothermia: five RCTs, 368 participants, relative risk (RR) 0.74, 95% confidence interval (CI) 0.47-1.19, LOE-low; EPO without hypothermia: four RCTs, 318 participants, RR 0.89, 95% CI 0.49-1.32, LOE-low]. EPO treatment without hypothermia compared to placebo resulted in a reduced risk of cerebral palsy (two RCTs, 230 participants, RR 0.47, 95% CI 0.27-0.80, LOE-moderate) and moderate to severe cognitive impairment (two RCTs, 226 participants, RR 0.49, 95% CI 0.28-0.85, LOE-moderate). A reduced risk of brain injury was identified in EPO treated infants (EPO with or without hypothermia, two RCTs, 148 participants, RR 0.70, 95% CI 0.53-0.92, LOE-moderate). Conclusion EPO administration in neonates with perinatal HIE reduces the risk of brain injury, cerebral palsy and cognitive impairment. The evidence is limited to suggest its role as an adjuvant to hypothermia. Larger powered trials are underway to overcome this limitation.
MeSH term(s)	Brain Injuries/etiology ; Brain Injuries/prevention & control ; Erythropoietin/therapeutic use ; Humans ; Hypoxia-Ischemia, Brain/complications ; Hypoxia-Ischemia, Brain/mortality ; Infant, Newborn ; Infant, Premature ; Neurodevelopmental Disorders/etiology ; Neurodevelopmental Disorders/prevention & control
Chemical Substances	Erythropoietin (11096-26-7)
Language	English
Publishing date	2019-02-21
Publishing country	Germany
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	123512-6
ISSN	1619-3997 ; 0300-5577 ; 0936-174X
ISSN (online)	1619-3997
ISSN	0300-5577 ; 0936-174X
DOI	10.1515/jpm-2018-0360
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Article ; Online: Lactoferrin Supplementation to Prevent Late-Onset Sepsis in Preterm Infants: A Meta-Analysis.

Razak, Abdul / Hussain, Asif

American journal of perinatology

2019 Volume 38, Issue 3, Page(s) 283–290

Abstract: Objective: This study aimed to systematically review and meta-analyze the role of lactoferrin supplementation to prevent late-onset sepsis (LOS) in preterm infants.: Study design: Database search include PubMed, Web of Science, and Cochrane central ... ...

Abstract	Objective: This study aimed to systematically review and meta-analyze the role of lactoferrin supplementation to prevent late-onset sepsis (LOS) in preterm infants. Study design: Database search include PubMed, Web of Science, and Cochrane central for randomized clinical trial (RCTs). The Cochrane Grading of Recommendations Assessment, Development, and Evaluation methodology was used for summarizing the results. Results: Ten RCTs involving 3,679 infants were included. Lactoferrin supplementation with or without probiotics decreased all LOS (relative risk [RR]: 0.56; 95% confidence interval [CI]: 0.36-0.86; Conclusion: Low to moderate quality evidence suggests that lactoferrin supplementation reduces LOS in preterm infants. Further research is needed to improve the certainty in the evidence.
MeSH term(s)	Administration, Oral ; Age of Onset ; Bronchopulmonary Dysplasia/epidemiology ; Cause of Death ; Enteral Nutrition ; Enterocolitis, Necrotizing/epidemiology ; Enterocolitis, Necrotizing/prevention & control ; Humans ; Infant ; Infant Mortality/trends ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases/prevention & control ; Lactoferrin/administration & dosage ; Mycoses/epidemiology ; Mycoses/prevention & control ; Probiotics/administration & dosage ; Randomized Controlled Trials as Topic ; Retinopathy of Prematurity/epidemiology ; Sepsis/epidemiology ; Sepsis/prevention & control
Chemical Substances	Lactoferrin (EC 3.4.21.-)
Language	English
Publishing date	2019-09-17
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	605671-4
ISSN	1098-8785 ; 0735-1631
ISSN (online)	1098-8785
ISSN	0735-1631
DOI	10.1055/s-0039-1696676
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Article ; Online: Directed Evolution of the UDP-Glycosyltransferase UGT

Zhang, Chenhao / Cai, Yongchao / Zhang, Zehua / Zheng, Nan / Zhou, Huimin / Su, Yumeng / Du, Shuang / Hussain, Asif / Xia, Xiaole

Journal of agricultural and food chemistry

2024 Volume 72, Issue 3, Page(s) 1640–1650

Abstract: The O-glycosylation of polyphenols for the synthesis of glycosides has garnered substantial attention in food research applications. However, the practical utility of UDP-glycosyltransferases (UGTs) is significantly hindered by their low catalytic ... ...

Abstract	The O-glycosylation of polyphenols for the synthesis of glycosides has garnered substantial attention in food research applications. However, the practical utility of UDP-glycosyltransferases (UGTs) is significantly hindered by their low catalytic efficiency and suboptimal regioselectivity. The concurrent optimization of the regioselectivity and activity during the glycosylation of polyphenols presents a formidable challenge. Here, we addressed the long-standing activity-regioselectivity tradeoff in glycosyltransferase UGT
MeSH term(s)	Glycosyltransferases ; Glycosides ; Uridine Diphosphate ; Glucosides ; Phenols ; Polyphenols ; Benzyl Alcohols
Chemical Substances	Glycosyltransferases (EC 2.4.-) ; gastrodin (5YS9U2W3RQ) ; Glycosides ; Uridine Diphosphate (58-98-0) ; Glucosides ; Phenols ; Polyphenols ; Benzyl Alcohols
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c07850
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Zs.A 1172: Show issues

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Article ; Online: Computer-Aided Reconstruction and Application of

Zhou, Huimin / Cai, Yongchao / Long, Mengfei / Zheng, Nan / Zhang, Zehua / You, Cuiping / Hussain, Asif / Xia, Xiaole

Journal of agricultural and food chemistry

2024 Volume 72, Issue 2, Page(s) 1213–1227

Abstract: β-1,4-Endoxylanase is the most critical hydrolase for xylan degradation during lignocellulosic biomass utilization. However, its poor stability and activity in hot and alkaline environments hinder its widespread application. In this study, BhS7Xyl ... ...

Abstract	β-1,4-Endoxylanase is the most critical hydrolase for xylan degradation during lignocellulosic biomass utilization. However, its poor stability and activity in hot and alkaline environments hinder its widespread application. In this study, BhS7Xyl from
MeSH term(s)	Hot Temperature ; Alkalies ; Bacillus ; Endo-1,4-beta Xylanases/genetics ; Endo-1,4-beta Xylanases/metabolism ; Hydrolysis ; Enzyme Stability ; Hydrogen-Ion Concentration
Chemical Substances	Alkalies ; Endo-1,4-beta Xylanases (EC 3.2.1.8)
Language	English
Publishing date	2024-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c08221
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Article: Phytochemical analysis and gastroprotective effect of Stellaria media (L.) Vill. methanolic extract on piroxicam-induced gastric ulcer in Wistar rats.

Aleem, Abdul / Aslam, Bilal / Alim, Muhammad Bilal / Hussain, Asif / Faisal, Muhammad Naeem / Sindhu, Zia-Ud-Din

Pakistan journal of pharmaceutical sciences

2023 Volume 36, Issue 5, Page(s) 1425–1434

Abstract: Stellaria media L. has traditionally been used to treat inflammatory and gastrointestinal ailments. This study aimed to phytochemically characterize the S. media extract and explore its anti-ulcer efficacy against piroxicam-induced stomach lesions in ... ...

Abstract	Stellaria media L. has traditionally been used to treat inflammatory and gastrointestinal ailments. This study aimed to phytochemically characterize the S. media extract and explore its anti-ulcer efficacy against piroxicam-induced stomach lesions in Wistar rats. Phytochemical analysis was performed and antioxidant capacity of extract was determined using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. In vivo, piroxicam (30mg/kg) was administered to induce gastric ulceration. Gastro protective effect of S. media extract was observed at 150, 300 and 450mg/kg, respectively. While omeprazole (20mg/kg) was used as a conventional anti-ulcer drug. After oral treatment for 14 days, stomach acidic secretions, ulcerogenic indices, hematological markers and oxidative stress parameters were assessed along with histological examination. The existence of polyphenol contents in S. media extract was confirmed in correlation to a marked DPPH inhibition (IC
MeSH term(s)	Rats ; Animals ; Stomach Ulcer/chemically induced ; Stomach Ulcer/drug therapy ; Stomach Ulcer/prevention & control ; Piroxicam/pharmacology ; Rats, Wistar ; Methanol/chemistry ; Stellaria ; Plant Extracts/chemistry ; Phytotherapy ; Antioxidants/chemistry ; Anti-Ulcer Agents/therapeutic use ; Phytochemicals/therapeutic use ; Gastric Mucosa
Chemical Substances	Piroxicam (13T4O6VMAM) ; Methanol (Y4S76JWI15) ; Plant Extracts ; Antioxidants ; Anti-Ulcer Agents ; Phytochemicals
Language	English
Publishing date	2023-11-01
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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