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  1. Article ; Online: Gender-specific hip strength disparities correlate with injury patterns in NCAA men's and women's soccer players.

    Bakal, David R / Hussain, Farah S / Dzierzawski, Justin T / Meyer, Daniel T / Dawson, Holli E / Olufade, Oluseun A

    PM & R : the journal of injury, function, and rehabilitation

    2024  Volume 16, Issue 4, Page(s) 347–355

    Abstract: Background: In National Collegiate Athletic Association (NCAA) soccer athletes, men have higher rates of hip and groin strains, whereas women have higher rates of knee ligament injuries. Strength imbalances of the hip and thigh, specifically in agonist- ... ...

    Abstract Background: In National Collegiate Athletic Association (NCAA) soccer athletes, men have higher rates of hip and groin strains, whereas women have higher rates of knee ligament injuries. Strength imbalances of the hip and thigh, specifically in agonist-antagonist muscles, are known risk factors for these injuries.
    Objective: To perform hip and thigh strength assessments in NCAA soccer players to evaluate for differences between genders and correlations with gender-specific injury patterns.
    Design: With a handheld dynamometer, weight-normalized isometric strength of six muscle groups (hip abductors, hip adductors, hip flexors, hip extensors, knee flexors, knee extensors) was calculated in NCAA soccer players. The strength ratio of each agonist-antagonist muscle was also calculated (hip abductors/adductors, hip flexors/extensors, knee extensors/flexors).
    Participants: Thirty-six NCAA soccer players (18 men, 18 women) from a single NCAA Division III institution.
    Interventions: Not applicable.
    Main outcome measures: Weight-normalized strength of six muscle groups and their agonist-antagonist strength ratios were compared between genders using linear mixed-effects models.
    Results: Compared with male players, female players had decreased weight-normalized strength for hip abduction (0.170 vs. 0.204, p = .012) and hip extension (0.172 vs. 0.211, p = .021). Otherwise, weight-normalized strength was similar between genders. When comparing agonist-antagonist strength ratios, there was a significant difference between female and male players for hip flexion:extension (1.70 vs. 1.35, p = .008), whereas the hip abduction: adduction ratio did not reach statistical significance (1.45 vs. 1.62, p = .080).
    Conclusions: NCAA male and female soccer players had different hip strength profiles that fit their injury patterns. Male NCAA soccer players have higher rates of hip and groin strains, and men in the cohort had strength ratios that were deficient in the hip flexors and adductors compared with women. Female NCAA soccer players have higher rates of knee sprains and anterior cruciate ligament tears, and women in the cohort had strength ratios that were deficient in the hip abductors and extensors, which function to stabilize the knee. These strength disparities could be the focus of future gender-specific soccer injury prevention programs.
    MeSH term(s) Humans ; Male ; Female ; Soccer/injuries ; Sprains and Strains ; Athletic Injuries/epidemiology ; Lower Extremity ; Universities ; Muscle Strength
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2608988-9
    ISSN 1934-1563 ; 1934-1482
    ISSN (online) 1934-1563
    ISSN 1934-1482
    DOI 10.1002/pmrj.13150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Is Diastasis Recti Abdominis Associated With Low Back Pain? A Systematic Review.

    Sokunbi, Gbolabo / Camino-Willhuber, Gaston / Paschal, Philip K / Olufade, Oluseun / Hussain, Farah S / Shue, Jennifer / Abjornson, Celeste / Zelenty, William D / Lebl, Darren R / Cammisa, Frank P / Girardi, Federico P / Hughes, Alexander P / Sama, Andrew A

    World neurosurgery

    2023  Volume 174, Page(s) 119–125

    Abstract: Background: Low back pain (LBP) is a common cause of disability worldwide; multiple causes and risk factors have been proposed in the genesis of back pain. Some studies reported an association between diastasis recti abdominis (DRA), a surrogate for ... ...

    Abstract Background: Low back pain (LBP) is a common cause of disability worldwide; multiple causes and risk factors have been proposed in the genesis of back pain. Some studies reported an association between diastasis recti abdominis (DRA), a surrogate for decreased core strength muscle, and low back pain. We aimed to investigate the relationship between DRA and LBP through a systematic review.
    Methods: A systematic review of the literature of clinical studies in English literature was conducted. PubMed, Cochrane, and Embase databases were used to conduct the search up to January 2022. The strategy included the following keywords: "Lower Back Pain" AND "Diastasis Recti" OR "Rectus abdominis" OR "abdominal wall" OR "paraspinal musculature".
    Results: From 207 records initially found, 34 were suitable for full review. Thirteen studies were finally included in this review, with a total of 2,820 patients. Five studies found a positive association between DRA and LBP (5 of 13 = 38.5%) whereas 8 studies did not find any association between DRA and LBP (8 of 13 = 61.5%).
    Conclusions: Of the studies included in this systematic review, 61.5% did not find an association between DRA and LBP whereas a positive correlation was observed in 38.5% of studies included. Based on the quality of the studies included in our review, better studies are warranted to understand the association between DRA and LBP.
    MeSH term(s) Humans ; Rectus Abdominis ; Low Back Pain/epidemiology ; Low Back Pain/etiology ; Diastasis, Muscle/complications ; Abdominal Wall ; Muscle Strength
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2023.03.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pharmacologic Treatment of Pediatric Anxiety Disorders.

    Hussain, Farah S / Dobson, Eric T / Strawn, Jeffrey R

    Current treatment options in psychiatry

    2016  Volume 3, Issue 2, Page(s) 151–160

    Abstract: The last decade has seen considerable advances in the treatment of anxiety disorders in children and adolescents and a considerable expansion of the evidence base for psychopharmacologic in this population. The extant data suggest that, for fear-based ... ...

    Abstract The last decade has seen considerable advances in the treatment of anxiety disorders in children and adolescents and a considerable expansion of the evidence base for psychopharmacologic in this population. The extant data suggest that, for fear-based anxiety disorders (
    Language English
    Publishing date 2016-04-22
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2196-3061
    ISSN 2196-3061
    DOI 10.1007/s40501-016-0076-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Emergency Transfers: An Important Predictor of Adverse Outcomes in Hospitalized Children.

    Hussain, Farah S / Sosa, Tina / Ambroggio, Lilliam / Gallagher, Regan / Brady, Patrick W

    Journal of hospital medicine

    2019  Volume 14, Issue 8, Page(s) 482–485

    Abstract: In-hospital arrests are uncommon in pediatrics, making it difficult to identify the risk factors for unrecognized deterioration and to determine the effectiveness of rapid response systems. An emergency transfer (ET) is a transfer from an acute care ... ...

    Abstract In-hospital arrests are uncommon in pediatrics, making it difficult to identify the risk factors for unrecognized deterioration and to determine the effectiveness of rapid response systems. An emergency transfer (ET) is a transfer from an acute care floor to an intensive care unit (ICU) where the patient received intubation, inotropes, or ≥3 fluid boluses in the first hour after arrival or before transfer. Improvement science work has reduced ETs, but ETs have not been validated against important health outcomes. This case-control study aimed to determine the predictive validity of an ET for outcomes in a free-standing children's hospital. Controls were matched in terms of age, hospital unit, and time of year. Patients who experienced an ET had a significantly higher likelihood of in-hospital mortality (22% vs 9%), longer ICU length of stay (4.9 vs 2.2 days), and longer posttransfer length of stay (26.4 vs 14.7 days) compared with controls (P < .03 for each).
    MeSH term(s) Case-Control Studies ; Child ; Child, Hospitalized ; Clinical Deterioration ; Female ; Hospital Mortality/trends ; Hospitals, Pediatric ; Humans ; Intensive Care Units, Pediatric/statistics & numerical data ; Length of Stay/statistics & numerical data ; Male ; Outcome Assessment, Health Care/statistics & numerical data ; Patient Transfer ; Risk Factors
    Language English
    Publishing date 2019-06-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2233783-0
    ISSN 1553-5606 ; 1553-5592
    ISSN (online) 1553-5606
    ISSN 1553-5592
    DOI 10.12788/jhm.3219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The enteric microbiota regulates jejunal Paneth cell number and function without impacting intestinal stem cells.

    Schoenborn, Alexi A / von Furstenberg, Richard J / Valsaraj, Smrithi / Hussain, Farah S / Stein, Molly / Shanahan, Michael T / Henning, Susan J / Gulati, Ajay S

    Gut microbes

    2018  Volume 10, Issue 1, Page(s) 45–58

    Abstract: Paneth cells (PCs) are epithelial cells found in the small intestine, next to intestinal stem cells (ISCs) at the base of the crypts. PCs secrete antimicrobial peptides (AMPs) that regulate the commensal gut microbiota. In contrast, little is known ... ...

    Abstract Paneth cells (PCs) are epithelial cells found in the small intestine, next to intestinal stem cells (ISCs) at the base of the crypts. PCs secrete antimicrobial peptides (AMPs) that regulate the commensal gut microbiota. In contrast, little is known regarding how the enteric microbiota reciprocally influences PC function. In this study, we sought to characterize the impact of the enteric microbiota on PC biology in the mouse small intestine. This was done by first enumerating jejunal PCs in germ-free (GF) versus conventionally raised (CR) mice. We next evaluated the possible functional consequences of altered PC biology in these experimental groups by assessing epithelial proliferation, ISC numbers, and the production of AMPs. We found that PC numbers were significantly increased in CR versus GF mice; however, there were no differences in ISC numbers or cycling activity between groups. Of the AMPs assessed, only Reg3γ transcript expression was significantly increased in CR mice. Intriguingly, this increase was abrogated in cultured CR versus GF enteroids, and could not be re-induced with various bacterial ligands. Our findings demonstrate the enteric microbiota regulates PC function by increasing PC numbers and inducing Reg3γ expression, though the latter effect may not involve direct interactions between bacteria and the intestinal epithelium. In contrast, the enteric microbiota does not appear to regulate jejunal ISC census and proliferation. These are critical findings for investigators using GF mice and the enteroid system to study PC and ISC biology.
    MeSH term(s) Animals ; Antimicrobial Cationic Peptides/genetics ; Antimicrobial Cationic Peptides/metabolism ; Cell Count ; Cell Proliferation ; Female ; Gastrointestinal Microbiome ; Germ-Free Life ; Intestinal Mucosa/cytology ; Intestine, Small/cytology ; Intestine, Small/microbiology ; Mice, Inbred C57BL ; Multipotent Stem Cells/cytology ; Pancreatitis-Associated Proteins/genetics ; Paneth Cells/cytology ; Paneth Cells/metabolism ; Transcription, Genetic
    Chemical Substances Antimicrobial Cationic Peptides ; Pancreatitis-Associated Proteins ; Reg3g protein, mouse
    Language English
    Publishing date 2018-07-11
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2575755-6
    ISSN 1949-0984 ; 1949-0984
    ISSN (online) 1949-0984
    ISSN 1949-0984
    DOI 10.1080/19490976.2018.1474321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Structured training program on confocal laser endomicroscopy for pancreatic cystic lesions: a multicenter prospective study among early-career endosonographers (with video).

    Machicado, Jorge D / Napoleon, Bertrand / Akshintala, Venkata / Bazarbashi, Ahmad Najdat / Bilal, Mohammad / Corral, Juan E / Dugum, Mohannad / Han, Samuel / Hussain, Farah S / Johnson, Alyson M / Jovani, Manol / Kolb, Jennifer M / Leonor, Paul / Lee, Peter J / Mulki, Ramzi / Shah, Hamza / Singh, Harkirat / Sánchez-Luna, Sergio A / Shah, Shawn L /
    Singla, Anand / Vargas, Eric J / Tielleman, Thomas / Nikahd, Melica / Fry, Megan / Culp, Stacey / Krishna, Somashekar G

    Gastrointestinal endoscopy

    2023  Volume 98, Issue 6, Page(s) 953–964

    Abstract: Background and aims: Data on how to teach endosonographers needle-based confocal laser endomicroscopy (nCLE)-guided histologic diagnosis of pancreatic cystic lesions (PCLs) are limited. Hence, we developed and tested a structured educational program to ... ...

    Abstract Background and aims: Data on how to teach endosonographers needle-based confocal laser endomicroscopy (nCLE)-guided histologic diagnosis of pancreatic cystic lesions (PCLs) are limited. Hence, we developed and tested a structured educational program to train early-career endosonographers in nCLE-guided diagnosis of PCLs.
    Methods: Twenty-one early-career nCLE-naïve endosonographers watched a teaching module outlining nCLE criteria for diagnosing PCLs. Participants then reviewed 80 high-yield nCLE videos, recorded diagnoses, and received expert feedback (phase 1). Observers were then randomized to a refresher feedback session or self-learning at 4 weeks. Eight weeks after training, participants independently assessed the same 80 nCLE videos without feedback and provided histologic predictions (phase 2). Diagnostic performance of nCLE to differentiate mucinous versus nonmucinous PCLs and to diagnose specific subtypes were analyzed using histopathology as the criterion standard. Learning curves were determined using cumulative sum analysis.
    Results: Accuracy and diagnostic confidence for differentiating mucinous versus nonmucinous PCLs improved as endosonographers progressed through nCLE videos in phase 1 (P < .001). Similar trends were observed with the diagnosis of PCL subtypes. Most participants achieved competency interpreting nCLE, requiring a median of 38 assessments (range, 9-67). During phase 2, participants independently differentiated PCLs with high accuracy (89%), high confidence (83%), and substantial interobserver agreement (κ = .63). Accuracy for nCLE-guided PCL subtype diagnoses ranged from 82% to 96%. The learned nCLE skills did not deteriorate at 8 weeks and were not impacted by a refresher session.
    Conclusions: We developed a practical, effective, and durable educational intervention to train early-career endosonographers in nCLE-guided diagnosis of PCLs.
    MeSH term(s) Humans ; Prospective Studies ; Endoscopic Ultrasound-Guided Fine Needle Aspiration ; Microscopy, Confocal ; Pancreatic Cyst/diagnostic imaging ; Pancreatic Cyst/pathology ; Lasers
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Multicenter Study ; Randomized Controlled Trial ; Video-Audio Media ; Journal Article
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2023.07.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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