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Article ; Online: Immunization and Vaccination

Hussain, Saira

Psychiatry of Pandemics

Abstract: Vaccines have been recognized as one of the most successful public health measures. In this chapter, we provide a historical overview of immunization measures and discuss the basics of immunization and vaccination in the context of a pandemic outbreak. ... ...

Abstract	Vaccines have been recognized as one of the most successful public health measures. In this chapter, we provide a historical overview of immunization measures and discuss the basics of immunization and vaccination in the context of a pandemic outbreak. We will also discuss vaccine hesitancy, the factors that lead to vaccine acceptance and refusal, the determinants of individual decision-making about vaccination, and strategies of how to approach it on an individual, community, and global level.
Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1007/978-3-030-15346-5_13
Database	COVID19

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Article ; Online: 'The burden is very much on yourself': A qualitative study to understand the illness and treatment burden of hearing loss across the life course.

Smith, Sian K / Pryce, Helen / O'Connell, Georgina Burns / Hussain, Saira / Shaw, Rachel / Straus, Jean

Health expectations : an international journal of public participation in health care and health policy

2024 Volume 27, Issue 3, Page(s) e14067

Abstract: Introduction: Hearing loss is a chronic health condition that rises sharply with age. The way people respond to and cope with health conditions is influenced by their capacity to perform illness and treatment-related work. The aim was to explore the ... ...

Abstract	Introduction: Hearing loss is a chronic health condition that rises sharply with age. The way people respond to and cope with health conditions is influenced by their capacity to perform illness and treatment-related work. The aim was to explore the cumulative burdens of living with hearing loss and the resources mobilised to ease the burdens. Methods: A qualitative design was used with semi-structured interviews (online or in-person) with participants recruited through audiology services and nonclinical services, such as lip-reading classes. Forty-six participants with hearing loss aged between 16 and 96 years were interviewed. An abductive approach, informed by May et al.'s burden of treatment theory, was used to analyse the data. Results: The illness burden involved participants working to make sense of their hearing loss, engaging in emotional work in response to changes in sound, social interactions and identity and coping with the daily frustrations required to communicate with others. Abandonment and uncertainty characterised the treatment burden; participants engaged in emotional work to adjust to hearing technology and deal with the uncertainty of how their hearing might progress. To ameliorate the burdens, participants drew on internal resources (psychological, health literacy, cognitive) and external resources (social support, financial, information, technology). Conclusions: The workload of hearing loss appears largely devolved to the patient and is not always visible. Our work indicates the need to widen approaches in audiological care through the implementation of lifeworld-led care, family-centred care and peer support to build support for those with hearing loss. Patient or public contribution: We developed the project in consultation with members of the public who have lived experience of hearing loss recruited through Aston University and volunteer links to audiology services. We also consulted people more likely to be affected by hearing loss adults including adults with learning disabilities, older adults in residential care and people from South Asia (Bangladeshi, Indian and Pakistani communities). These individuals commented on the study aims, interview schedule and participant recruitment practices. One of our co-authors (expert by experience) contributed to the development and interpretation of themes and preparation of the final manuscript.
MeSH term(s)	Humans ; Qualitative Research ; Female ; Adult ; Middle Aged ; Male ; Aged ; Hearing Loss/psychology ; Hearing Loss/therapy ; Cost of Illness ; Adaptation, Psychological ; Aged, 80 and over ; Adolescent ; Interviews as Topic ; Young Adult
Language	English
Publishing date	2024-05-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2119434-8
ISSN	1369-7625 ; 1369-6513
ISSN (online)	1369-7625
ISSN	1369-6513
DOI	10.1111/hex.14067
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Zs.A 5896: Show issues

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Article ; Online: A Cytomegalovirus (CMV) Case Study to Promote Interprofessional Learning (IPL) Between Audiology and Biomedical Science Students in Higher Education.

Bashir, Amreen / Pallett, Ross / Rana, Karan Singh / Hussain, Saira

British journal of biomedical science

2023 Volume 80, Page(s) 11680

Abstract: Modern and effective patient care requires specialist healthcare professionals working together. Interprofessional learning (IPL) seeks to provide opportunities for different healthcare disciplines to learn with, from and about each other. This study ... ...

Abstract	Modern and effective patient care requires specialist healthcare professionals working together. Interprofessional learning (IPL) seeks to provide opportunities for different healthcare disciplines to learn with, from and about each other. This study focused on the delivery and evaluation of a cytomegalovirus (CMV) case study workshop to facilitate IPL between two Health and Care Professions Council (HCPC) regulated courses: Biomedical Science and Audiology. The 2 h online workshop consisted of 1) defining the roles, responsibilities and skills of the two healthcare professions, 2) the structure of the Biomedical Science and Audiology departments, 3) routes to HCPC registration, 4) core curriculum of both degree programmes and 5) interpreting interdisciplinary data related to a CMV patient case. The workshop was interactive, with the virtual learning environment promoting peer discussions and the use of online polling. Student responses were collected through an online questionnaire. A total of 108 respondents completed a post-event survey and Mann-Whitney
MeSH term(s)	Humans ; Cytomegalovirus ; Audiology ; Interprofessional Relations ; Students ; Cytomegalovirus Infections/diagnosis
Language	English
Publishing date	2023-11-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1152119-3
ISSN	2474-0896 ; 0967-4845
ISSN (online)	2474-0896
ISSN	0967-4845
DOI	10.3389/bjbs.2023.11680
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Zs.A 225: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Enhancing audiology students' understanding of person-centered care: insights from an multi-national virtual student conference.

Mahomed-Asmail, Faheema / Nicholson, Nannette / Metcalfe, Louise / Rutherford, Cherilee / Alet Graham, Marien / Watson, Victoria / Regan, Catherine / Hussain, Saira

International journal of audiology

2024 , Page(s) 1–7

Abstract: Objective: This project sought to investigate the impact of a multi-national peer learning initiative in facilitating a student-led conference on person-centred care (PCC). The primary objective was to assess students' comprehension of PCC elements ... ...

Abstract	Objective: This project sought to investigate the impact of a multi-national peer learning initiative in facilitating a student-led conference on person-centred care (PCC). The primary objective was to assess students' comprehension of PCC elements before and after engaging in the opportunity, with a concurrent evaluation of the efficacy of the opportunity. Design: A mixed-methods study protocol was followed. Following the conference, participants completed a four-part survey including (a) demographics, (b) retrospective pre-post Likert scale, (c) Likert rating of conference experience and (d) five open-ended questions. Study sample: One hundred and four participants (92.4% female) with a mean age of 21 years (0.07 SD) participated in the study. Results: A significant difference in awareness pre-post conference was demonstrated across all topics (WSR, p < 0.001) with participants satisfied with the conference. Qualitative analysis revealed three main themes: (a) application of PCC; (b) perspectives of PCC; and () barriers to PCC; with nine sub-themes. Conclusion: The conference was beneficial in enhancing students' awareness of topics and principles of PCC. Innovative pedagogical approaches should be considered in order to enhance healthcare education allowing future clinicians to better meet the dynamic needs of their clients.
Language	English
Publishing date	2024-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2073098-6
ISSN	1708-8186 ; 1499-2027
ISSN (online)	1708-8186
ISSN	1499-2027
DOI	10.1080/14992027.2024.2344097
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Zs.A 549: Show issues

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Article ; Online: Exploring how parents of children with unilateral hearing loss make habilitation decisions: a qualitative study.

Hussain, Saira / Pryce, Helen / Neary, Amy / Hall, Amanda

International journal of audiology

2020 Volume 60, Issue 3, Page(s) 183–190

Abstract: Objective: This study sought to explore the decision making needs of parents managing the hearing and communication needs of children with unilateral hearing loss.: Design: An inductive, qualitative method was used. The data were analysed using a ... ...

Abstract	Objective: This study sought to explore the decision making needs of parents managing the hearing and communication needs of children with unilateral hearing loss. Design: An inductive, qualitative method was used. The data were analysed using a constant comparative approach, consistent with Grounded Theory method. Study sample: Twenty one families participated in interviews yielding data on twenty two children. Each of these families had at least one child with unilateral hearing loss. The age range of the children varied from four months to sixteen years old. All parents were English speaking and received care from National Health Service Audiology departments across the United Kingdom. Results: Parents valued professionals' opinions, but information provision was inconsistent. As their children mature, parents increasingly valued their child's input. Parent-child discussions focussed on how different management strategies fit their child's preferences. Parents were proactive in obtaining professional advice, and integrating this with their own iterative assessment of their child's performance. Conclusions: Decision making is an iterative process. Parents make nuanced decisions which aim to preserve a sense of what is normal for them. Clinicians need to recognise the parental view, including where it may contrast with a medicalised or clinical view.
MeSH term(s)	Communication ; Hearing Loss, Unilateral ; Humans ; Infant ; Parents ; Qualitative Research ; State Medicine
Language	English
Publishing date	2020-08-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2073098-6
ISSN	1708-8186 ; 1499-2027
ISSN (online)	1708-8186
ISSN	1499-2027
DOI	10.1080/14992027.2020.1804080
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Zs.A 549: Show issues

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Article ; Online: Electron cryotomography of SARS-CoV-2 virions reveals cylinder-shaped particles with a double layer RNP assembly.

Calder, Lesley J / Calcraft, Thomas / Hussain, Saira / Harvey, Ruth / Rosenthal, Peter B

Communications biology

2022 Volume 5, Issue 1, Page(s) 1210

Abstract: SARS-CoV-2 is a lipid-enveloped Betacoronavirus and cause of the Covid-19 pandemic. To study the three-dimensional architecture of the virus, we perform electron cryotomography (cryo-ET) on SARS-Cov-2 virions and three variants revealing particles of ... ...

Abstract	SARS-CoV-2 is a lipid-enveloped Betacoronavirus and cause of the Covid-19 pandemic. To study the three-dimensional architecture of the virus, we perform electron cryotomography (cryo-ET) on SARS-Cov-2 virions and three variants revealing particles of regular cylindrical morphology. The ribonucleoprotein particles packaging the genome in the virion interior form a dense, double layer assembly with a cylindrical shape related to the overall particle morphology. This organisation suggests structural interactions important to virus assembly.
MeSH term(s)	Humans ; SARS-CoV-2 ; Pandemics ; Electrons ; Cryoelectron Microscopy/methods ; COVID-19 ; Virion
Language	English
Publishing date	2022-11-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-022-04183-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Protease Inhibitors Purified from the Canola Meal Extracts of Two Genetically Diverse Genotypes Exhibit Antidiabetic and Antihypertension Properties.

Hussain, Saira / Rehman, Ata Ur / Luckett, David J / Naqvi, Syed Muhammad Saqlan / Blanchard, Christopher L

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 7

Abstract: Valorization of vegetable oil waste residues is gaining importance due to their high protein and polyphenol contents. Protease inhibitors (PIs), proteins from these abundantly available waste residues, have recently gained importance in treating chronic ... ...

Abstract	Valorization of vegetable oil waste residues is gaining importance due to their high protein and polyphenol contents. Protease inhibitors (PIs), proteins from these abundantly available waste residues, have recently gained importance in treating chronic diseases. This research aimed to use canola meal of genetically diverse
MeSH term(s)	Amino Acid Sequence ; Antihypertensive Agents/chemistry ; Antihypertensive Agents/isolation & purification ; Antihypertensive Agents/pharmacology ; Brassica napus/chemistry ; Brassica napus/genetics ; Brassica napus/metabolism ; Dipeptidyl Peptidase 4/chemistry ; Dipeptidyl Peptidase 4/metabolism ; Enzyme Assays ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/isolation & purification ; Enzyme Inhibitors/pharmacology ; Genotype ; Humans ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/isolation & purification ; Hypoglycemic Agents/pharmacology ; Isoelectric Focusing ; Kinetics ; Liquid-Liquid Extraction/methods ; Peptidyl-Dipeptidase A/chemistry ; Peptidyl-Dipeptidase A/metabolism ; Plant Extracts/chemistry
Chemical Substances	Antihypertensive Agents ; Enzyme Inhibitors ; Hypoglycemic Agents ; Plant Extracts ; Dipeptidyl Peptidase 4 (EC 3.4.14.5) ; ACE protein, human (EC 3.4.15.1) ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
Language	English
Publishing date	2021-04-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26072078
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Article ; Online: Protocol for a qualitative study exploring the lived experience of hearing loss and patient reported experience in the UK: the HeLP study.

Pryce, Helen / Smith, Sian Karen / Burns-O'Connell, Georgina / Shaw, Rachel / Hussain, Saira / Banks, Jonathan / Hall, Amanda / Knibb, Rebecca / Greenwood, Rosemary / Straus, Jean

BMJ open

2023 Volume 13, Issue 6, Page(s) e069363

Abstract: Introduction: Worldwide, hearing loss is a significant public health issue and one of the most common chronic health conditions experienced by older adults. Hearing loss is associated with communication difficulties, social withdrawal, isolation and ... ...

Abstract	Introduction: Worldwide, hearing loss is a significant public health issue and one of the most common chronic health conditions experienced by older adults. Hearing loss is associated with communication difficulties, social withdrawal, isolation and lower quality of life. Although hearing aid technology has improved significantly, the workload of managing hearing aids has increased. The aim of this qualitative study is to develop a novel theory of people's lived experience of hearing loss across the lifespan. Methods: Eligible participants will be young people and adults aged 16 years and above who have a hearing loss and carers/family members of people with a hearing loss. This study will use individual, in-depth face-to-face or online interviews. With participants' permission, interviews will be audio-recorded and transcribed verbatim. A grounded theory approach to concurrent data gathering and analysis will develop grouped codes and categories and link these to provide a novel theory to describe the experience of hearing loss. Ethics and dissemination: The study was approved by the West of Scotland Research Ethics Service (approval date: 6 May 2022 ref: 22/WS/0057) and the Health Research Authority and Health and Care Research Wales Approval (approval date: 14 June 2022; IRAS project ID: 308816). The research will inform the development of a Patient Reported Experience Measure to improve the information and support given to patients. Findings will be disseminated through peer-reviewed articles and at academic conferences, as well as to our patient and public involvement groups, healthcare professionals, audiology services and local commissioners.
MeSH term(s)	Humans ; Aged ; Adolescent ; Quality of Life ; Hearing Loss/rehabilitation ; Hearing Aids ; Qualitative Research ; Deafness ; Scotland ; Patient Reported Outcome Measures
Language	English
Publishing date	2023-06-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-069363
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Article ; Online: Protocol for the development and validation of a patient-reported experience measure (PREM) for people with hearing loss: the PREM-HeLP.

Pryce, Helen / Smith, Sian Karen / Burns-O'Connell, Georgina / Knibb, Rebecca / Greenwood, Rosemary / Shaw, Rachel / Hussain, Saira / Banks, Jonathan / Hall, Amanda / Straus, Jean / Noble, Sian

BMJ open

2023 Volume 13, Issue 11, Page(s) e075229

Abstract: Introduction: Hearing loss is a common chronic health condition and adversely affects communication and social function resulting in loneliness, social isolation and depression. We know little about the patient experience of living with hearing loss and ...

Abstract	Introduction: Hearing loss is a common chronic health condition and adversely affects communication and social function resulting in loneliness, social isolation and depression. We know little about the patient experience of living with hearing loss and their views on the quality of the audiology service. In this study, we will develop and validate the first patient-reported experience measure (PREM) to understand patients' experiences of living with hearing loss and their healthcare interactions with audiology services. Methods and analysis: We will develop the PREM in three phases: (1) development of PREM prototype (items/statements) derived from previous qualitative work and narrative review, (2) cognitive interview testing of the PREM prototype using a 'think aloud' technique to examine the acceptability and comprehensibility of the tool and refine accordingly and (3) psychometric testing of the modified PREM with 300 participants to assess the reliability and validity of the tool using Rasch analyses with sequential item reduction. Eligible participants will be young people and adults aged 16 years and over who have hearing loss. Participants will be recruited from three clinical sites located in England (Bath, Bristol) and Scotland (Tayside) and non-clinical settings (eg, lip-reading classes, residential care settings, national charity links, social media). Ethics and dissemination: The study was approved by the West of Scotland Research Ethics Service (approval date: 6 May 2022; ref: 22/WS/0057) and the Health Research Authority and Health and Care Research Wales (HCRW) Approval (approval date: 14 June 2022; IRAS project ID: 308816). Findings will be shared with our patient and public involvement groups, academics, audiology communities and services and local commissioners via publications and presentations. The PREM will be made available to clinicians and researchers without charge.
MeSH term(s)	Adult ; Humans ; Adolescent ; Reproducibility of Results ; Hearing Loss/diagnosis ; Deafness ; England ; Patient Reported Outcome Measures ; Review Literature as Topic
Language	English
Publishing date	2023-11-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-075229
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Article ; Online: Reduced sialidase activity of influenza A(H3N2) neuraminidase associated with positively charged amino acid substitutions.

Hussain, Saira / Daniels, Rodney S / Wharton, Stephen A / Howell, Steven / Halai, Chandrika / Kunzelmann, Simone / Whittaker, Lynne / McCauley, John W

The Journal of general virology

2021 Volume 102, Issue 10

Abstract: Neuraminidase (NA) inhibitors (NAI), oseltamivir and zanamivir, are the main antiviral medications for influenza and monitoring of susceptibility to these antivirals is routinely done by determining 50 % inhibitory concentrations ( ... ...

Abstract	Neuraminidase (NA) inhibitors (NAI), oseltamivir and zanamivir, are the main antiviral medications for influenza and monitoring of susceptibility to these antivirals is routinely done by determining 50 % inhibitory concentrations (IC
MeSH term(s)	Amino Acid Substitution ; Antiviral Agents/pharmacology ; Enzyme Inhibitors/pharmacology ; Genes, Viral ; Glycosylation ; High-Throughput Nucleotide Sequencing ; Influenza A Virus, H3N2 Subtype/drug effects ; Influenza A Virus, H3N2 Subtype/enzymology ; Influenza A Virus, H3N2 Subtype/genetics ; Kinetics ; Models, Molecular ; Neuraminidase/antagonists & inhibitors ; Neuraminidase/chemistry ; Neuraminidase/genetics ; Neuraminidase/metabolism ; Oseltamivir/pharmacology ; Protein Conformation ; Zanamivir/pharmacology
Chemical Substances	Antiviral Agents ; Enzyme Inhibitors ; Oseltamivir (20O93L6F9H) ; Neuraminidase (EC 3.2.1.18) ; Zanamivir (L6O3XI777I)
Language	English
Publishing date	2021-11-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219316-4
ISSN	1465-2099 ; 0022-1317
ISSN (online)	1465-2099
ISSN	0022-1317
DOI	10.1099/jgv.0.001648
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