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  1. Article ; Online: Impact of Cardiopulmonary Bypass Time and Aortic Cross Clamp Time on Immediate PostOperative Outcomes in Patients with Congenital Heart Disease Undergoing Open Heart Surgery

    Nazish Alisher / Rajab Ali Khokhar / Mujeeb Ur Rehman / Abdul Sattar Shaikh / Hussain Bux Korejo / Rumana Sangi

    Pakistan Armed Forces Medical Journal, Vol 73, Iss

    2023  Volume 2

    Abstract: Objective: to find out the impact of cardiopulmonary bypass time (CPBT) and aortic cross-clamp time (ACCT) on immediate post-operative outcomes in patients with congenital heart disease (CHD) undergoing open heart surgery at a tertiary care centre. Study ...

    Abstract Objective: to find out the impact of cardiopulmonary bypass time (CPBT) and aortic cross-clamp time (ACCT) on immediate post-operative outcomes in patients with congenital heart disease (CHD) undergoing open heart surgery at a tertiary care centre. Study Design: Prospective longitudinal study. Place and Duration of the Study: Department of Paediatric, Cardiac Intensive Care Unit, National Institute of Cardiovascular Diseases (NICVD), Karachi Pakistan, from Jul to Dec 2021. Methodology: We enrolled 104 patients of both genders up to any age with CHD undergoing open heart surgeries. At the time of admission, age, gender, body weight, presence of cyanosis and types of CHDs were noted. Duration of mechanical ventilation, pediatric cardiac intensive care unit (PCICU) stay, and mortality was recorded. Baseline characteristics and postsurgery parameters were compared about CPBT and ACCT. Results: Of 104 patients, 58(55.8%) were males. Overall, the mean age was 7.9±5.1 years. Cyanosis was noted in 34(32.7%) cases. Mean CPBT was 74.6±42.9 minutes, while the mean ACCT was 43.5±29.5 minutes. Most types of CHDs were noted to be tetralogy of Fallot (ToF) 28(26.9%). An increase in the duration of CPBT and ACCT was found to have a significant association with post-surgical morbidity (p<0.001). Conclusion: Increased cardiopulmonary bypass time and aortic cross-clamp time were found to have a significant association with post-surgical morbidity and outcomes among cases undergoing open heart surgeries for congenital heart diseases.
    Keywords Cardiopulmonary bypass time ; aortic cross-clamp time ; congenital heart disease ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Army Medical College Rawalpindi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Incidence, clinical profile and short term outcome of cerebral abscess in cyanotic congenital heart diseases

    Rumana Sangi / Aliya Kemal Ahsan / Abdul Sattar Shaikh / Ali Raza / Hussain Bux Korejo / Veena Kumari / Musarat Nazir Sandano / Ume Rubab Sandano

    Heliyon, Vol 9, Iss 12, Pp e22198- (2023)

    2023  

    Abstract: Background: Brain abscess is a serious infection of brain parenchyma in patients with cyanotic congenital heart disease (CCHD) and around 25–46 % of unrepaired CCHD patients develop brain abscess. Aim of this study was to determine the incidence, ... ...

    Abstract Background: Brain abscess is a serious infection of brain parenchyma in patients with cyanotic congenital heart disease (CCHD) and around 25–46 % of unrepaired CCHD patients develop brain abscess. Aim of this study was to determine the incidence, clinical features, microbiology and factors associated with early and short term outcome of cerebral abscess in CCHD. Method: ology: This is a retrospective study, conducted at Pediatric cardiology department, National Institute of Cardiovascular Diseases (NICVD) Karachi. The data was collected from January 2019 to December 2021. All CCHD patients between 1 and 25 years of age were included. Data of patients with cerebral abscess was reviewed. Results: Among the 544 pediatric patients hospitalized in the last two years, brain abscesses were identified in 51 (9.3 %). Polycythemia (31.4 %) was the most significant contributing factor, especially in patients aged above 10 years. The most frequently seen CCHD was tetralogy of fallot (TOF) 60.8 %. Majority of the patients (84.3 %) had a single abscess while 15.7 % had multiple abscesses. E coli (9.7 %) was the most common isolated pathogen. Immediate complication identified was cerebral edema in 22 (43.1 %). Four patients (7.8 %) died, 47 (92.2 %) patients completed treatment course. 45.1 % had complete recovery however, 17 (33.3 %) had neurological deficits, 8 (15.7 %) had seizures and 2 (3.9 %) patients had residual abscess. Prolonged hospitalization was observed in patients of age group <10 years. Conclusion: In patients with underlying CCHD,early referrals and intervention are key to mitigating the severe consequences of cerebral abscesses and can drastically improve patient outcomes.
    Keywords Incidence ; Brain abscess ; CCHD and outcome ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 610 ; 616
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Risk Factors for Kernicterus in Neonatal Jaundice

    Hussain Bux Korejo / Ghulam Rasool Bhurgri / Sikander Bhand / Muhammad Ali Qureshi / Ghulam Mustafa Dahri / Raj Kumar Chohan

    Gomal Journal of Medical Sciences, Vol 8, Iss

    2010  Volume 1

    Abstract: Background: Kernicterus is a neurologic syndrome resulting from deposition of unconjugated bilirubin in the basal ganglia and brain stem nuclei. The aim of this study was to identify the risk factors for kernicterus in neonatal jaundice. Material & ... ...

    Abstract Background: Kernicterus is a neurologic syndrome resulting from deposition of unconjugated bilirubin in the basal ganglia and brain stem nuclei. The aim of this study was to identify the risk factors for kernicterus in neonatal jaundice. Material & Methods: It was a cross-sectional study carried out at the neonatal intensive care unit of National Institute of Child Health, Karachi, from 27th September, 2006 to 26th September, 2007. One hundred diagnosed cases of kernicterus were included. Procedure was explained to the parents and informed consent was taken. Neonates with congenital anomalies of central nervous system and meningitis were excluded. Results: Out of 100 cases 62 were males and 38 females. Age range was 1-15 days. Out of these, 56 were in range of 1-5 days. Prematurity was seen in 39. Fifty-five neonates were of low birth weight. Hypothermia was seen in 44. Home delivery was conducted in 60 cases. Haemolysis was seen in 30 and sepsis in 52. Mean for bilirubin was 27.4 with range 14.5-48.4mg/dl. Conclusion: Majority of patients with kernicterus are delivered at home and present in late stage. Infection, prematurity and low birth weight are common risk factors.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2010-06-01T00:00:00Z
    Publisher Gomal Medical College, D.I.Khan, Pakistan
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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