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Article ; Online: Elucidating the link between thyroid cancer and mercury exposure: a review and meta-analysis.

Webster, Alyssa M / Pinion, Dylan / Pineda, Eric / Aboueisha, Hadeel / Hussein, Mohammad H / Fawzy, Manal S / Toraih, Eman A / Kandil, Emad

Environmental science and pollution research international

2024 Volume 31, Issue 9, Page(s) 12841–12855

Abstract: Mercury (Hg) is a widely distributed and bioavailable metal of public health concern, with many known human toxicities, but data regarding mercury's influence on thyroid cancer (TC) is scarce. Mercury is known to impact several molecular pathways ... ...

Abstract	Mercury (Hg) is a widely distributed and bioavailable metal of public health concern, with many known human toxicities, but data regarding mercury's influence on thyroid cancer (TC) is scarce. Mercury is known to impact several molecular pathways implicated in carcinogenesis, and its proclivity for bioaccumulation in the thyroid suggests a potential modulatory effect. We conducted a literature/systematic review of studies between 1995-2022 intending to define better and establish relationships between these two entities, congregate the evidence for mercury's potential role in thyroid carcinogenesis, and identify populations of interest for further study. Insufficient evidence precludes definitive conclusions on dietary mercury as a TC risk factor; however, several common mechanisms affected by mercury are crucial for TC development, including biochemical, endocrine, and reactive oxygen species effects. Quantitative analysis revealed associations between TC risk and mercury exposure. In three mercury studies, average urine levels were higher in TC patients, with a mean difference of 1.86 µg/g creatinine (95% CI = 0.32-3.41). In two studies investigating exposure to elevated mercury levels, the exposed group exhibited a higher risk of developing TC, with a relative risk of 1.90 (95% CI = 1.76-2.06). In three thyroid tissue studies, mercury levels (ppm) were higher in TC patients, averaging 0.14 (0.06-0.22) in cancerous cases (N = 178) and 0.08 (0.04-0.11) in normal thyroids (N = 257). Our findings suggest an association between mercury exposure and TC risk, implying a possible predisposing factor. Further research is necessary to reveal the clinical relevance of dietary and environmental mercury exposures in TC pathogenesis.
MeSH term(s)	Humans ; Mercury/analysis ; Environmental Exposure/analysis ; Carcinogenesis ; Thyroid Neoplasms/chemically induced ; Thyroid Neoplasms/epidemiology
Chemical Substances	Mercury (FXS1BY2PGL)
Language	English
Publishing date	2024-01-26
Publishing country	Germany
Document type	Meta-Analysis ; Journal Article ; Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-32031-8
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Article: A Review and In Silico Analysis of Tissue and Exosomal Circular RNAs: Opportunities and Challenges in Thyroid Cancer.

Toraih, Eman A / Hussein, Mohammad H / Fawzy, Manal S / Kandil, Emad

Cancers

2022 Volume 14, Issue 19

Abstract: Thyroid cancer (TC) is the most common endocrine tumor. The genetic and epigenetic molecular alterations of TC have become more evident in recent years. However, a deeper understanding of the roles these molecular changes play in TC tumorigenesis and ... ...

Abstract	Thyroid cancer (TC) is the most common endocrine tumor. The genetic and epigenetic molecular alterations of TC have become more evident in recent years. However, a deeper understanding of the roles these molecular changes play in TC tumorigenesis and progression is essential in developing a successful treatment strategy and improving patients' prognoses. Circular RNAs (circRNAs), a family of non-coding RNAs, have been implicated in several aspects of carcinogenesis in multiple cancers, including TC. In the current review, we aimed to explore the clinical potential of circRNAs as putative diagnostic, prognostic, and therapeutic targets in TC. The current analyses, including genome-wide circRNA screening and functional enrichment for all deregulated circRNA expression signatures, show that circRNAs display atypical contributions, such as sponging for microRNAs, regulating transcription and translation processes, and decoying for proteins. Given their exceptional clinical advantages, such as higher stability, wider abundance, and occurrence in several body fluids, circRNAs are promising prognostic and theranostic biomarkers for TC.
Language	English
Publishing date	2022-09-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14194728
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Article: Pan-Cancer Study on Variants of Canonical miRNA Biogenesis Pathway Components: A Pooled Analysis.

Elshazli, Rami M / Toraih, Eman A / Hussein, Mohammad H / Ruiz, Emmanuelle M / Kandil, Emad / Fawzy, Manal S

Cancers

2023 Volume 15, Issue 2

Abstract: Single nucleotide polymorphisms in genes involved in microRNA processing/maturation and release may deregulate the microRNAome expression levels. We aimed to assess the relationship between miRNA machinery genetic variants and human cancer risk using ... ...

Abstract	Single nucleotide polymorphisms in genes involved in microRNA processing/maturation and release may deregulate the microRNAome expression levels. We aimed to assess the relationship between miRNA machinery genetic variants and human cancer risk using integrative bioinformatics analyses to identify the role of these genes in cancer aggressiveness. Mutations of 8176 pan-cancer samples were retrieved from 33 studies in "TCGA" database, and a Cox regression model for survival was performed. Next, 22 computationally identified variants within 11 genes were selected based on their high citation rate and MAF. Relevant articles through March 2020 were included. Pooled estimates under the five genetic association models were calculated. Publication bias and heterogeneity between articles were evaluated. Trial Sequential Analysis (TSA) was applied to assess the power and reliability of the draw conclusions. TCGA patients with different cancer types revealed significant alterations in miRNA machinery genes, with mutation frequency ranging from 0.6-13% of samples. RAN was associated with LN metastasis, while TARBP2 and PIWIL1 gene mutations exhibited better overall survival. In the meta-analysis, 45 articles (74,593 cases and 89,198 controls) met the eligibility criteria. Pooled analysis revealed an increased cancer risk with DROSHArs10719G, RANrs3803012G, DGCR8rs417309A, and GEMIN3rs197414A. In contrast, both DICER1rs1057035T and GEMIN4rs2743048G conferred protection against developing cancer. TSA showed the cumulative evidence is inadequate, and the addition of further primary studies is necessary. This study suggests a potential role of miRNA biogenesis genes in cancer development/prognosis. Further functional studies may reveal biological explanations for the differential risks of the machinery variants in different cancer types.
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15020338
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Article ; Online: Survival benefits of extensive surgery in patients with papillary thyroid microcarcinoma.

Herrera, Marcela / Hussein, Mohammad H / Persons, Emily / Alias, Magdy Ramy / Rabee, Abdelrahman / Sayed, Abdullah / Toraih, Eman / Kandil, Emad

American journal of surgery

2023 Volume 229, Page(s) 99–105

Abstract: Background: Despite the guidelines recommending thyroid lobectomy, many papillary thyroid microcarcinoma (PTMC) patients still undergo total thyroidectomy. PTMC's optimal treatment remains unclear. We aimed to determine whether total thyroidectomy ... ...

Abstract	Background: Despite the guidelines recommending thyroid lobectomy, many papillary thyroid microcarcinoma (PTMC) patients still undergo total thyroidectomy. PTMC's optimal treatment remains unclear. We aimed to determine whether total thyroidectomy improves outcomes compared to less extensive surgery. Methods: We analyzed 6064 PTMC adult patients from the Surveillance, Epidemiology, and End Results (SEER) database (2000-2019) who underwent either total thyroidectomy (n = 3652) or less extensive surgery (n = 2412). Endpoints were overall survival, cancer-specific survival, and recurrence. Results: Total thyroidectomy patients had a 5.2 % mortality rate versus 8.1 % with less extensive surgery. Recurrence occurred in 1 (0.03 %) total thyroidectomy patient compared to 24 (1.0 %) less extensive surgery patients (HR 0.07, p = 0.01). Median survival was 8.1 years for total thyroidectomy versus 8.8 years for less extensive surgery. Overall survival favored total thyroidectomy (p = 0.001) but cancer-specific survival did not differ. Conclusion: Although total thyroidectomy may not improve cancer-specific survival, it lowers recurrence risk and confers an overall survival advantage for PTMC patients. These findings may help guide surgical decisions.
MeSH term(s)	Adult ; Humans ; Thyroid Neoplasms/pathology ; Thyroidectomy/methods ; Carcinoma, Papillary/surgery ; Carcinoma, Papillary/pathology ; Databases, Factual ; Retrospective Studies
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2023.11.001
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Article: An analysis of characteristic discharges for the Adaim River (Iraq) in multiyear period

Hussein, Mohammad H / Hameed, Iman A

River research and applications. 2019 May, v. 35, no. 4

2019

Abstract: A major River Tigris tributary in Iraq, the Adaim River, has a Mediterranean river flow regime with a total basin area of 12,482 km2. The river catchment responds almost immediately to rainfall with apparently minimum storage (i.e. flashy stream). The ... ...

Abstract	A major River Tigris tributary in Iraq, the Adaim River, has a Mediterranean river flow regime with a total basin area of 12,482 km2. The river catchment responds almost immediately to rainfall with apparently minimum storage (i.e. flashy stream). The river daily hydrograph showed a daily peak flow of 1,476 m3/s with substantial seasonal and random variability; the flow duration curve followed the two‐parameter lognormal probability distribution. Gamma and the two‐parameter Weibull probability distributions fitted the monthly mean river discharge for the period 1937–2012 well. Normal and gamma probability distributions were found to appropriately describe the distribution of the annual mean river discharge for the same period. Gumbel extreme value, Log Pearson type III, and the two‐parameter lognormal distributions gave a reasonable fit to the annual maximum discharge record for the river. A regression formula was used to fit the annual minimum discharge record, which has a significant number of zero values. There was a positive and significant correlation (r = 0.77) between the annual mean discharge at the measuring site and seasonal rainfall measured at Karkuk meteorological station located in the north central part of the basin. The rainfall record at Karkuk showed a significant decline in seasonal rainfall after 1993.
Keywords	basins ; hydrograph ; lognormal distribution ; rain ; river flow ; rivers ; streams ; watersheds ; Iraq
Language	English
Dates of publication	2019-05
Size	p. 375-385.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2072626-0
ISSN	1535-1459
ISSN	1535-1459
DOI	10.1002/rra.3422
Database	NAL-Catalogue (AGRICOLA)

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Article: Diagnostic utility of

Riccio, Isabel R / LaForteza, Alexandra C / Hussein, Mohammad H / Linhuber, Joshua P / Issa, Peter P / Staav, Jonathan / Fawzy, Manal S / Toraih, Eman A / Kandil, Emad

EXCLI journal

2024 Volume 23, Page(s) 283–299

Abstract: ... ...

Abstract	RAS
Language	English
Publishing date	2024-02-15
Publishing country	Germany
Document type	Journal Article ; Review
ISSN	1611-2156
ISSN	1611-2156
DOI	10.17179/excli2024-6975
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Article ; Online: Association of Angio-LncRNAs MIAT rs1061540/MALAT1 rs3200401 Molecular Variants with Gensini Score in Coronary Artery Disease Patients Undergoing Angiography.

Elwazir, Mohamed Y / Hussein, Mohammad H / Toraih, Eman A / Al Ageeli, Essam / Esmaeel, Safya E / Fawzy, Manal S / Faisal, Salwa

Biomolecules

2022 Volume 12, Issue 1

Abstract: Long non-coding RNAs (lncRNAs) have emerged as essential biomolecules with variable diagnostic and/or prognostic utility in several diseases, including coronary artery disease (CAD). We aimed for the first time to investigate the potential association of ...

Abstract	Long non-coding RNAs (lncRNAs) have emerged as essential biomolecules with variable diagnostic and/or prognostic utility in several diseases, including coronary artery disease (CAD). We aimed for the first time to investigate the potential association of five angiogenesis-related lncRNAs (PUNISHER, SENCR, MIAT, MALAT1, and GATA6-AS) variants with CAD susceptibility and/or severity. TaqMan Real-Time genotyping for PUNISHER rs12318065A/C, SENCR rs12420823C/T, MIAT rs1061540C/T, MALAT1 rs3200401T/C, and GATA6-AS1 rs73390820A/G were run on the extracted genomic DNA from 100 unrelated patients with stable CAD undergoing diagnostic coronary angiography and from 100 controls. After adjusting covariates, the studied variants showed no association with disease susceptibility; however, MIATT/T genotype was associated with a more severe Gensini score. In contrast, MALAT1T/C heterozygosity was associated with a lower score. The lipid profile, and to a lesser extent smoking status, male sex, weight, hypertension, and MALAT1 (T > C) (negative correlation), explained the variance between patients/control groups via a principal component analysis. Incorporating the principal components into a logistic regression model to predict CAD yielded a 0.92 AUC. In conclusion: MIAT rs1061540 and MALAT1 rs3200401 variants were associated with CAD severity and Gensini score in the present sample of the Egyptian population. Further large multi-center and functional analyses are needed to confirm the results and identify the underlying molecular mechanisms.
MeSH term(s)	Coronary Angiography ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/genetics ; Genotype ; Humans ; Male ; Neovascularization, Pathologic ; RNA, Long Noncoding/genetics
Chemical Substances	Miat long non-coding RNA ; RNA, Long Noncoding
Language	English
Publishing date	2022-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom12010137
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Article: Thyroid Carcinoma: A Review for 25 Years of Environmental Risk Factors Studies.

Kruger, Eva / Toraih, Eman A / Hussein, Mohammad H / Shehata, Shaimaa A / Waheed, Amani / Fawzy, Manal S / Kandil, Emad

Cancers

2022 Volume 14, Issue 24

Abstract: Environmental factors are established contributors to thyroid carcinomas. Due to their known ability to cause cancer, exposure to several organic and inorganic chemical toxicants and radiation from nuclear weapons, fallout, or medical radiation poses a ... ...

Abstract	Environmental factors are established contributors to thyroid carcinomas. Due to their known ability to cause cancer, exposure to several organic and inorganic chemical toxicants and radiation from nuclear weapons, fallout, or medical radiation poses a threat to global public health. Halogenated substances like organochlorines and pesticides can interfere with thyroid function. Like phthalates and bisphenolates, polychlorinated biphenyls and their metabolites, along with polybrominated diethyl ethers, impact thyroid hormones biosynthesis, transport, binding to target organs, and impair thyroid function. A deeper understanding of environmental exposure is crucial for managing and preventing thyroid cancer. This review aims to investigate the relationship between environmental factors and the development of thyroid cancer.
Language	English
Publishing date	2022-12-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14246172
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Article: Analysis of MIR27A (rs11671784) Variant Association with Systemic Lupus Erythematous.

Khired, Zenat Ahmed / Kattan, Shahad W / Alzahrani, Ahmad Khuzaim / Milebary, Ahmad J / Hussein, Mohammad H / Qusti, Safaa Y / Alshammari, Eida M / Toraih, Eman A / Fawzy, Manal S

Life (Basel, Switzerland)

2023 Volume 13, Issue 3

Abstract: Multiple microRNAs (miRs) are associated with systemic autoimmune disease susceptibility/phenotype, including systemic lupus erythematosus (SLE). With this work, we aimed to unravel the association of the miR-27a gene (MIR27A) rs11671784G/A variant with ... ...

Abstract	Multiple microRNAs (miRs) are associated with systemic autoimmune disease susceptibility/phenotype, including systemic lupus erythematosus (SLE). With this work, we aimed to unravel the association of the miR-27a gene (MIR27A) rs11671784G/A variant with SLE risk/severity. One-hundred sixty-three adult patients with SLE and matched controls were included. A TaqMan allelic discrimination assay was applied for MIR27A genotyping. Logistic regression models were run to test the association with SLE susceptibility/risk. Genotyping of 326 participants revealed that the heterozygote form was the most common genotype among the study cohort, accounting for 72% of the population (n = 234), while A/A and G/G represented 15% (n = 49) and 13% (n = 43), respectively. Similarly, the most prevalent genotype among cases was the A/G genotype, which was present in approximately 93.3% of cases (n = 152). In contrast, only eight and three patients had A/A and G/G genotypes, respectively. The MIR27A rs11671784 variant conferred protection against the development of SLE in several genetic models, including heterozygous (G/A vs. A/A; OR = 0.10, 95% CI = 0.05-0.23), dominant (G/A + G/G vs. AA; OR = 0.15, 95% CI = 0.07-0.34), and overdominant (G/A vs. A/A + G/G; OR = 0.07, 95% CI = 0.04-0.14) models. However, the G/G genotype was associated with increased SLE risk in the recessive model (G/G vs. A/A+ G/G; OR = 17.34, 95% CI = 5.24-57.38). Furthermore, the variant showed significant associations with musculoskeletal and mucocutaneous manifestations in the patient cohort (
Language	English
Publishing date	2023-03-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13030701
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Article: Osseous Metastases in Thyroid Cancer: Unveiling Risk Factors, Disease Outcomes, and Treatment Impact.

Khired, Zenat Ahmed / Hussein, Mohammad H / Jishu, Jessan A / Toreih, Ahmed A / Shaalan, Aly A M / Ismail, Mohammed M / Fawzy, Manal S / Toraih, Eman A

Cancers

2023 Volume 15, Issue 14

Abstract: Bone is the second most common site of metastasis in patients with thyroid cancer (TC) and dramatically impacts overall survival and quality of life with no definitive cure, yet there is no extensive study of the demographic and clinical risk factors in ... ...

Abstract	Bone is the second most common site of metastasis in patients with thyroid cancer (TC) and dramatically impacts overall survival and quality of life with no definitive cure, yet there is no extensive study of the demographic and clinical risk factors in the recent literature. Data regarding 120,754 TC patients with bone metastasis were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate analyses were used to identify the risk factors of bone metastasis occurring in various histologies of TC. Cox regression was performed to analyze the influence of bone metastasis on overall survival. Hazard ratios were computed to analyze the association between bone metastasis and the primary outcomes. Of the 120,754 records collected from the SEER database from 2000 to 2019, 976 (0.8%) presented with bone metastasis, with occurrence being the greatest in patients of age ≥ 55 years (OR = 5.63, 95%CI = 4.72-6.71), males (OR = 2.60, 95%CI = 2.27-2.97), Blacks (OR = 2.38, 95%CI = 1.95-2.9) and Asian or Pacific Islanders (OR = 1.90, 95%CI = 1.58-2.27), and single marital status. TC patients presenting with bone metastasis (HR = 2.78, 95%CI = 2.34-3.3) or concurrent bone and brain metastases (HR = 1.62, 95%CI = 1.03-2.55) had a higher mortality risk. Older age, gender, race, and single marital status were associated with bone metastasis and poorer prognosis in TC patients at initial diagnosis. Understanding such risk factors can potentially assist clinicians in making early diagnoses and personalized treatment plans, as well as researchers in developing more therapeutic protocols.
Language	English
Publishing date	2023-07-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15143557
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